MIF4G domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AR75_LEIMU

TriTrypDb:

LmxM.17.1030

Length:

819

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	532	536	PF00656	0.412
CLV_C14_Caspase3-7	638	642	PF00656	0.441
CLV_MEL_PAP_1	109	115	PF00089	0.659
CLV_NRD_NRD_1	143	145	PF00675	0.570
CLV_NRD_NRD_1	293	295	PF00675	0.630
CLV_NRD_NRD_1	415	417	PF00675	0.652
CLV_NRD_NRD_1	424	426	PF00675	0.575
CLV_NRD_NRD_1	752	754	PF00675	0.425
CLV_NRD_NRD_1	96	98	PF00675	0.506
CLV_PCSK_KEX2_1	143	145	PF00082	0.570
CLV_PCSK_KEX2_1	430	432	PF00082	0.586
CLV_PCSK_KEX2_1	752	754	PF00082	0.425
CLV_PCSK_KEX2_1	96	98	PF00082	0.506
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.586
CLV_PCSK_SKI1_1	668	672	PF00082	0.423
CLV_PCSK_SKI1_1	710	714	PF00082	0.385
DEG_Nend_Nbox_1	1	3	PF02207	0.613
DOC_ANK_TNKS_1	380	387	PF00023	0.501
DOC_ANK_TNKS_1	54	61	PF00023	0.579
DOC_MAPK_gen_1	143	151	PF00069	0.618
DOC_MAPK_gen_1	430	436	PF00069	0.581
DOC_MAPK_MEF2A_6	791	800	PF00069	0.392
DOC_PP2B_PxIxI_1	486	492	PF00149	0.502
DOC_PP4_FxxP_1	213	216	PF00568	0.639
DOC_USP7_MATH_1	186	190	PF00917	0.621
DOC_USP7_MATH_1	204	208	PF00917	0.538
DOC_USP7_MATH_1	232	236	PF00917	0.639
DOC_USP7_MATH_1	454	458	PF00917	0.684
DOC_USP7_MATH_1	565	569	PF00917	0.382
DOC_USP7_UBL2_3	426	430	PF12436	0.585
DOC_USP7_UBL2_3	567	571	PF12436	0.370
DOC_WW_Pin1_4	252	257	PF00397	0.625
DOC_WW_Pin1_4	275	280	PF00397	0.653
DOC_WW_Pin1_4	483	488	PF00397	0.517
DOC_WW_Pin1_4	612	617	PF00397	0.349
DOC_WW_Pin1_4	649	654	PF00397	0.495
DOC_WW_Pin1_4	67	72	PF00397	0.790
DOC_WW_Pin1_4	806	811	PF00397	0.465
LIG_14-3-3_CanoR_1	200	208	PF00244	0.641
LIG_14-3-3_CanoR_1	327	331	PF00244	0.676
LIG_14-3-3_CanoR_1	416	421	PF00244	0.688
LIG_14-3-3_CanoR_1	425	434	PF00244	0.646
LIG_14-3-3_CanoR_1	465	470	PF00244	0.573
LIG_14-3-3_CanoR_1	519	525	PF00244	0.513
LIG_14-3-3_CanoR_1	719	727	PF00244	0.414
LIG_14-3-3_CanoR_1	784	789	PF00244	0.491
LIG_APCC_ABBA_1	80	85	PF00400	0.619
LIG_BIR_III_2	393	397	PF00653	0.699
LIG_BRCT_BRCA1_1	298	302	PF00533	0.580
LIG_BRCT_BRCA1_1	578	582	PF00533	0.493
LIG_BRCT_BRCA1_1	614	618	PF00533	0.344
LIG_BRCT_BRCA1_1	683	687	PF00533	0.331
LIG_deltaCOP1_diTrp_1	559	563	PF00928	0.392
LIG_DLG_GKlike_1	416	423	PF00625	0.524
LIG_EH1_1	508	516	PF00400	0.417
LIG_EVH1_2	603	607	PF00568	0.483
LIG_FHA_1	350	356	PF00498	0.676
LIG_FHA_1	468	474	PF00498	0.513
LIG_FHA_1	583	589	PF00498	0.354
LIG_FHA_1	662	668	PF00498	0.401
LIG_FHA_1	765	771	PF00498	0.436
LIG_FHA_1	778	784	PF00498	0.507
LIG_FHA_2	403	409	PF00498	0.667
LIG_FHA_2	578	584	PF00498	0.435
LIG_FHA_2	609	615	PF00498	0.426
LIG_Integrin_RGD_1	263	265	PF01839	0.566
LIG_LIR_Apic_2	212	216	PF02991	0.636
LIG_LIR_Gen_1	100	109	PF02991	0.662
LIG_LIR_Gen_1	131	139	PF02991	0.689
LIG_LIR_Gen_1	558	569	PF02991	0.341
LIG_LIR_Gen_1	635	644	PF02991	0.352
LIG_LIR_Gen_1	734	743	PF02991	0.417
LIG_LIR_Nem_3	131	135	PF02991	0.812
LIG_LIR_Nem_3	207	213	PF02991	0.642
LIG_LIR_Nem_3	299	305	PF02991	0.630
LIG_LIR_Nem_3	558	564	PF02991	0.348
LIG_LIR_Nem_3	573	577	PF02991	0.552
LIG_LIR_Nem_3	615	621	PF02991	0.334
LIG_LIR_Nem_3	635	639	PF02991	0.352
LIG_LIR_Nem_3	734	740	PF02991	0.434
LIG_LIR_Nem_3	79	83	PF02991	0.518
LIG_LIR_Nem_3	85	91	PF02991	0.510
LIG_PALB2_WD40_1	556	564	PF16756	0.401
LIG_PDZ_Class_1	814	819	PF00595	0.419
LIG_PTB_Apo_2	165	172	PF02174	0.549
LIG_PTB_Apo_2	74	81	PF02174	0.658
LIG_PTB_Phospho_1	165	171	PF10480	0.551
LIG_SH2_CRK	18	22	PF00017	0.501
LIG_SH2_CRK	698	702	PF00017	0.361
LIG_SH2_GRB2like	516	519	PF00017	0.444
LIG_SH2_PTP2	627	630	PF00017	0.360
LIG_SH2_STAT5	435	438	PF00017	0.614
LIG_SH2_STAT5	516	519	PF00017	0.444
LIG_SH2_STAT5	6	9	PF00017	0.630
LIG_SH2_STAT5	627	630	PF00017	0.384
LIG_SH2_STAT5	739	742	PF00017	0.402
LIG_SH3_3	37	43	PF00018	0.750
LIG_SH3_3	56	62	PF00018	0.576
LIG_SH3_3	703	709	PF00018	0.425
LIG_SUMO_SIM_anti_2	794	800	PF11976	0.447
LIG_SxIP_EBH_1	763	774	PF03271	0.420
LIG_TRAF2_1	529	532	PF00917	0.443
LIG_TYR_ITIM	696	701	PF00017	0.362
LIG_WRC_WIRS_1	113	118	PF05994	0.592
LIG_WRC_WIRS_1	210	215	PF05994	0.636
LIG_WRC_WIRS_1	98	103	PF05994	0.670
MOD_CK1_1	100	106	PF00069	0.647
MOD_CK1_1	115	121	PF00069	0.526
MOD_CK1_1	131	137	PF00069	0.740
MOD_CK1_1	138	144	PF00069	0.661
MOD_CK1_1	170	176	PF00069	0.786
MOD_CK1_1	209	215	PF00069	0.671
MOD_CK1_1	235	241	PF00069	0.602
MOD_CK1_1	248	254	PF00069	0.595
MOD_CK1_1	255	261	PF00069	0.468
MOD_CK1_1	278	284	PF00069	0.569
MOD_CK1_1	288	294	PF00069	0.525
MOD_CK1_1	397	403	PF00069	0.740
MOD_CK1_1	673	679	PF00069	0.421
MOD_CK1_1	720	726	PF00069	0.389
MOD_CK2_1	402	408	PF00069	0.662
MOD_CK2_1	458	464	PF00069	0.495
MOD_CK2_1	526	532	PF00069	0.472
MOD_CK2_1	577	583	PF00069	0.398
MOD_CK2_1	608	614	PF00069	0.437
MOD_CK2_1	673	679	PF00069	0.483
MOD_CK2_1	744	750	PF00069	0.439
MOD_CMANNOS	560	563	PF00535	0.323
MOD_Cter_Amidation	414	417	PF01082	0.691
MOD_DYRK1A_RPxSP_1	252	256	PF00069	0.489
MOD_GlcNHglycan	137	140	PF01048	0.658
MOD_GlcNHglycan	146	149	PF01048	0.678
MOD_GlcNHglycan	184	187	PF01048	0.608
MOD_GlcNHglycan	202	205	PF01048	0.573
MOD_GlcNHglycan	247	250	PF01048	0.672
MOD_GlcNHglycan	280	283	PF01048	0.704
MOD_GlcNHglycan	287	290	PF01048	0.647
MOD_GlcNHglycan	298	301	PF01048	0.617
MOD_GlcNHglycan	385	389	PF01048	0.802
MOD_GlcNHglycan	456	459	PF01048	0.672
MOD_GlcNHglycan	461	464	PF01048	0.639
MOD_GlcNHglycan	480	484	PF01048	0.406
MOD_GlcNHglycan	52	55	PF01048	0.749
MOD_GlcNHglycan	552	555	PF01048	0.402
MOD_GlcNHglycan	62	65	PF01048	0.606
MOD_GlcNHglycan	675	678	PF01048	0.452
MOD_GlcNHglycan	688	691	PF01048	0.314
MOD_GlcNHglycan	757	760	PF01048	0.438
MOD_GlcNHglycan	9	12	PF01048	0.589
MOD_GSK3_1	130	137	PF00069	0.786
MOD_GSK3_1	182	189	PF00069	0.624
MOD_GSK3_1	196	203	PF00069	0.608
MOD_GSK3_1	248	255	PF00069	0.661
MOD_GSK3_1	394	401	PF00069	0.716
MOD_GSK3_1	421	428	PF00069	0.660
MOD_GSK3_1	454	461	PF00069	0.612
MOD_GSK3_1	465	472	PF00069	0.472
MOD_GSK3_1	479	486	PF00069	0.438
MOD_GSK3_1	492	499	PF00069	0.497
MOD_GSK3_1	555	562	PF00069	0.366
MOD_GSK3_1	608	615	PF00069	0.372
MOD_GSK3_1	669	676	PF00069	0.392
MOD_GSK3_1	682	689	PF00069	0.200
MOD_GSK3_1	717	724	PF00069	0.403
MOD_GSK3_1	744	751	PF00069	0.391
MOD_N-GLC_1	167	172	PF02516	0.667
MOD_N-GLC_1	402	407	PF02516	0.671
MOD_N-GLC_1	421	426	PF02516	0.562
MOD_N-GLC_1	459	464	PF02516	0.569
MOD_N-GLC_1	465	470	PF02516	0.445
MOD_N-GLC_1	517	522	PF02516	0.298
MOD_N-GLC_1	608	613	PF02516	0.409
MOD_NEK2_1	151	156	PF00069	0.663
MOD_NEK2_1	182	187	PF00069	0.643
MOD_NEK2_1	245	250	PF00069	0.744
MOD_NEK2_1	469	474	PF00069	0.440
MOD_NEK2_1	478	483	PF00069	0.386
MOD_NEK2_1	50	55	PF00069	0.671
MOD_NEK2_1	577	582	PF00069	0.401
MOD_NEK2_1	584	589	PF00069	0.297
MOD_NEK2_1	608	613	PF00069	0.468
MOD_NEK2_1	640	645	PF00069	0.401
MOD_NEK2_1	712	717	PF00069	0.418
MOD_NEK2_2	177	182	PF00069	0.679
MOD_PIKK_1	216	222	PF00454	0.621
MOD_PIKK_1	326	332	PF00454	0.771
MOD_PIKK_1	362	368	PF00454	0.619
MOD_PIKK_1	577	583	PF00454	0.453
MOD_PIKK_1	670	676	PF00454	0.476
MOD_PK_1	294	300	PF00069	0.606
MOD_PKA_1	294	300	PF00069	0.655
MOD_PKA_1	416	422	PF00069	0.651
MOD_PKA_1	425	431	PF00069	0.562
MOD_PKA_2	326	332	PF00069	0.796
MOD_PKA_2	464	470	PF00069	0.436
MOD_PKA_2	496	502	PF00069	0.458
MOD_PKA_2	50	56	PF00069	0.670
MOD_PKA_2	518	524	PF00069	0.507
MOD_PKA_2	555	561	PF00069	0.429
MOD_PKA_2	744	750	PF00069	0.539
MOD_Plk_1	167	173	PF00069	0.664
MOD_Plk_1	401	407	PF00069	0.659
MOD_Plk_1	465	471	PF00069	0.391
MOD_Plk_1	582	588	PF00069	0.324
MOD_Plk_1	608	614	PF00069	0.405
MOD_Plk_1	640	646	PF00069	0.404
MOD_Plk_1	84	90	PF00069	0.482
MOD_Plk_2-3	402	408	PF00069	0.662
MOD_Plk_4	177	183	PF00069	0.643
MOD_Plk_4	473	479	PF00069	0.390
MOD_Plk_4	565	571	PF00069	0.331
MOD_Plk_4	682	688	PF00069	0.331
MOD_Plk_4	712	718	PF00069	0.422
MOD_Plk_4	76	82	PF00069	0.676
MOD_ProDKin_1	252	258	PF00069	0.626
MOD_ProDKin_1	275	281	PF00069	0.656
MOD_ProDKin_1	483	489	PF00069	0.509
MOD_ProDKin_1	612	618	PF00069	0.346
MOD_ProDKin_1	649	655	PF00069	0.493
MOD_ProDKin_1	67	73	PF00069	0.788
MOD_ProDKin_1	806	812	PF00069	0.473
MOD_SUMO_rev_2	775	783	PF00179	0.460
TRG_DiLeu_BaEn_1	794	799	PF01217	0.435
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.501
TRG_ENDOCYTIC_2	171	174	PF00928	0.635
TRG_ENDOCYTIC_2	210	213	PF00928	0.574
TRG_ENDOCYTIC_2	5	8	PF00928	0.632
TRG_ENDOCYTIC_2	627	630	PF00928	0.303
TRG_ENDOCYTIC_2	698	701	PF00928	0.360
TRG_ENDOCYTIC_2	714	717	PF00928	0.364
TRG_ER_diArg_1	142	144	PF00400	0.630
TRG_ER_diArg_1	752	754	PF00400	0.406
TRG_ER_diArg_1	771	774	PF00400	0.536
TRG_ER_diArg_1	783	786	PF00400	0.588
TRG_ER_diArg_1	95	97	PF00400	0.503
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHP8	Leptomonas seymouri	58%	100%
A0A1X0NU85	Trypanosomatidae	37%	100%
A0A3S7WUI6	Leishmania donovani	91%	100%
A4H958	Leishmania braziliensis	76%	99%
A4HXI0	Leishmania infantum	91%	100%
Q4QE88	Leishmania major	93%	100%