Hydrolase, alpha/beta fold family-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase, alpha/beta fold family-like protein

Species:

Leishmania mexicana

UniProt:

E9AR73_LEIMU

TriTrypDb:

LmxM.17.1010

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 35
NetGPI	no	yes: 0, no: 35

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AR73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR73

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	34
GO:0016787	hydrolase activity	2	34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.361
CLV_NRD_NRD_1	26	28	PF00675	0.471
CLV_NRD_NRD_1	265	267	PF00675	0.517
CLV_PCSK_SKI1_1	28	32	PF00082	0.424
CLV_PCSK_SKI1_1	287	291	PF00082	0.305
DEG_APCC_DBOX_1	177	185	PF00400	0.432
DEG_SCF_TRCP1_1	80	85	PF00400	0.381
DOC_CKS1_1	90	95	PF01111	0.399
DOC_CYCLIN_RxL_1	153	161	PF00134	0.277
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.288
DOC_MAPK_gen_1	253	263	PF00069	0.379
DOC_MAPK_MEF2A_6	256	263	PF00069	0.458
DOC_MAPK_MEF2A_6	304	312	PF00069	0.469
DOC_PP1_RVXF_1	285	292	PF00149	0.412
DOC_PP2B_LxvP_1	269	272	PF13499	0.318
DOC_USP7_MATH_1	188	192	PF00917	0.257
DOC_USP7_MATH_1	230	234	PF00917	0.258
DOC_WW_Pin1_4	101	106	PF00397	0.358
DOC_WW_Pin1_4	225	230	PF00397	0.562
DOC_WW_Pin1_4	89	94	PF00397	0.347
LIG_14-3-3_CanoR_1	156	161	PF00244	0.292
LIG_14-3-3_CanoR_1	178	182	PF00244	0.334
LIG_14-3-3_CanoR_1	278	283	PF00244	0.355
LIG_Actin_WH2_2	303	318	PF00022	0.253
LIG_BIR_III_4	121	125	PF00653	0.395
LIG_BRCT_BRCA1_1	83	87	PF00533	0.348
LIG_Clathr_ClatBox_1	73	77	PF01394	0.189
LIG_DLG_GKlike_1	156	163	PF00625	0.347
LIG_eIF4E_1	120	126	PF01652	0.141
LIG_eIF4E_1	90	96	PF01652	0.228
LIG_FHA_1	178	184	PF00498	0.402
LIG_FHA_1	90	96	PF00498	0.324
LIG_FHA_2	112	118	PF00498	0.308
LIG_FHA_2	24	30	PF00498	0.398
LIG_FHA_2	34	40	PF00498	0.390
LIG_FHA_2	83	89	PF00498	0.331
LIG_GBD_Chelix_1	47	55	PF00786	0.432
LIG_Integrin_RGD_1	207	209	PF01839	0.277
LIG_LIR_Apic_2	168	174	PF02991	0.286
LIG_LIR_Apic_2	88	93	PF02991	0.395
LIG_LIR_Gen_1	15	24	PF02991	0.453
LIG_LIR_Gen_1	69	76	PF02991	0.412
LIG_LIR_Nem_3	102	106	PF02991	0.317
LIG_LIR_Nem_3	121	126	PF02991	0.399
LIG_LIR_Nem_3	15	20	PF02991	0.420
LIG_LIR_Nem_3	31	37	PF02991	0.319
LIG_LIR_Nem_3	69	75	PF02991	0.289
LIG_LIR_Nem_3	84	90	PF02991	0.397
LIG_NRBOX	62	68	PF00104	0.251
LIG_Pex14_1	58	62	PF04695	0.245
LIG_PTB_Apo_2	65	72	PF02174	0.187
LIG_SH2_CRK	34	38	PF00017	0.451
LIG_SH2_GRB2like	273	276	PF00017	0.270
LIG_SH2_NCK_1	116	120	PF00017	0.393
LIG_SH2_PTP2	171	174	PF00017	0.283
LIG_SH2_SRC	273	276	PF00017	0.283
LIG_SH2_STAP1	116	120	PF00017	0.228
LIG_SH2_STAT5	113	116	PF00017	0.282
LIG_SH2_STAT5	171	174	PF00017	0.565
LIG_SH2_STAT5	198	201	PF00017	0.494
LIG_SH2_STAT5	72	75	PF00017	0.256
LIG_SH3_3	286	292	PF00018	0.366
LIG_SH3_3	37	43	PF00018	0.407
LIG_SH3_3	53	59	PF00018	0.357
LIG_SUMO_SIM_anti_2	159	165	PF11976	0.233
LIG_SUMO_SIM_anti_2	180	185	PF11976	0.536
LIG_SUMO_SIM_par_1	156	161	PF11976	0.274
LIG_SUMO_SIM_par_1	179	185	PF11976	0.292
LIG_TYR_ITIM	32	37	PF00017	0.439
MOD_CDK_SPxxK_3	225	232	PF00069	0.283
MOD_CK1_1	165	171	PF00069	0.338
MOD_CK1_1	81	87	PF00069	0.352
MOD_CK2_1	23	29	PF00069	0.346
MOD_Cter_Amidation	264	267	PF01082	0.472
MOD_GlcNHglycan	167	170	PF01048	0.421
MOD_GlcNHglycan	232	235	PF01048	0.311
MOD_GlcNHglycan	80	83	PF01048	0.355
MOD_GSK3_1	158	165	PF00069	0.279
MOD_GSK3_1	78	85	PF00069	0.328
MOD_N-GLC_1	223	228	PF02516	0.282
MOD_NEK2_1	137	142	PF00069	0.346
MOD_NEK2_1	158	163	PF00069	0.307
MOD_NEK2_1	294	299	PF00069	0.376
MOD_NEK2_1	51	56	PF00069	0.371
MOD_NEK2_2	188	193	PF00069	0.277
MOD_PK_1	278	284	PF00069	0.216
MOD_PKA_2	177	183	PF00069	0.495
MOD_PKA_2	78	84	PF00069	0.349
MOD_Plk_1	28	34	PF00069	0.355
MOD_Plk_4	111	117	PF00069	0.306
MOD_Plk_4	158	164	PF00069	0.252
MOD_Plk_4	278	284	PF00069	0.349
MOD_Plk_4	51	57	PF00069	0.406
MOD_ProDKin_1	101	107	PF00069	0.358
MOD_ProDKin_1	225	231	PF00069	0.564
MOD_ProDKin_1	89	95	PF00069	0.347
MOD_SUMO_rev_2	209	217	PF00179	0.307
TRG_ENDOCYTIC_2	303	306	PF00928	0.446
TRG_ENDOCYTIC_2	34	37	PF00928	0.335
TRG_ENDOCYTIC_2	72	75	PF00928	0.314
TRG_ER_diArg_1	5	8	PF00400	0.346
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.247

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	30%	75%
A0A0N0P3S4	Leptomonas seymouri	40%	89%
A0A0N1PA10	Leptomonas seymouri	42%	95%
A0A0N1PCQ2	Leptomonas seymouri	54%	100%
A0A0S4JQB3	Bodo saltans	37%	95%
A0A1X0NSR3	Trypanosomatidae	37%	72%
A0A1X0NSS6	Trypanosomatidae	42%	100%
A0A3Q8IAY1	Leishmania donovani	41%	83%
A0A3R7KKJ0	Trypanosoma rangeli	44%	100%
A0A3S5IRR1	Trypanosoma rangeli	32%	80%
A0A3S7WUJ3	Leishmania donovani	87%	96%
A0A3S7WUK0	Leishmania donovani	30%	75%
A0A3S7X1K2	Leishmania donovani	45%	93%
A0A422NS41	Trypanosoma rangeli	38%	75%
A4H956	Leishmania braziliensis	57%	100%
A4H959	Leishmania braziliensis	31%	100%
A4H960	Leishmania braziliensis	38%	100%
A4HGL0	Leishmania braziliensis	44%	100%
A4HXH8	Leishmania infantum	87%	96%
A4HXI1	Leishmania infantum	30%	75%
A4HXI2	Leishmania infantum	41%	83%
A4I3N6	Leishmania infantum	45%	93%
C5CN82	Variovorax paradoxus (strain S110)	26%	100%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	81%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	75%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	83%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	93%
Q48MQ7	Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)	28%	100%
Q4Q8A8	Leishmania major	45%	100%
Q4QE86	Leishmania major	42%	100%
Q4QE87	Leishmania major	31%	100%
Q4QE90	Leishmania major	84%	100%
Q4ZXS0	Pseudomonas syringae pv. syringae (strain B728a)	26%	100%
Q54528	Streptomyces purpurascens	26%	100%
Q54809	Streptomyces peucetius	24%	100%
Q55217	Streptomyces sp. (strain C5)	24%	100%
Q7CWX3	Agrobacterium fabrum (strain C58 / ATCC 33970)	25%	100%
V5AZB9	Trypanosoma cruzi	40%	75%
V5BER0	Trypanosoma cruzi	45%	100%
V5BNU9	Trypanosoma cruzi	29%	80%