Mak10 subunit, NatC N-terminal acetyltransferase-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mak10 subunit, NatC N(alpha)-terminal acetyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AR70_LEIMU

TriTrypDb:

LmxM.17.0980

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031248	protein acetyltransferase complex	3	12
GO:0031414	N-terminal protein acetyltransferase complex	4	12
GO:0031417	NatC complex	5	12
GO:0032991	protein-containing complex	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902493	acetyltransferase complex	4	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AR70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR70

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	12
GO:0006474	N-terminal protein amino acid acetylation	5	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0017196	N-terminal peptidyl-methionine acetylation	6	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018206	peptidyl-methionine modification	6	12
GO:0019538	protein metabolic process	3	12
GO:0031365	N-terminal protein amino acid modification	5	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043543	protein acylation	5	12
GO:0044238	primary metabolic process	2	12
GO:0051604	protein maturation	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.446
CLV_C14_Caspase3-7	576	580	PF00656	0.459
CLV_NRD_NRD_1	201	203	PF00675	0.397
CLV_NRD_NRD_1	346	348	PF00675	0.436
CLV_NRD_NRD_1	406	408	PF00675	0.471
CLV_NRD_NRD_1	432	434	PF00675	0.405
CLV_NRD_NRD_1	676	678	PF00675	0.450
CLV_NRD_NRD_1	682	684	PF00675	0.478
CLV_NRD_NRD_1	732	734	PF00675	0.464
CLV_PCSK_KEX2_1	217	219	PF00082	0.503
CLV_PCSK_KEX2_1	346	348	PF00082	0.443
CLV_PCSK_KEX2_1	354	356	PF00082	0.387
CLV_PCSK_KEX2_1	406	408	PF00082	0.471
CLV_PCSK_KEX2_1	432	434	PF00082	0.388
CLV_PCSK_KEX2_1	544	546	PF00082	0.479
CLV_PCSK_KEX2_1	682	684	PF00082	0.518
CLV_PCSK_KEX2_1	734	736	PF00082	0.566
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.484
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.399
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.601
CLV_PCSK_PC1ET2_1	734	736	PF00082	0.543
CLV_PCSK_SKI1_1	137	141	PF00082	0.439
CLV_PCSK_SKI1_1	148	152	PF00082	0.487
CLV_PCSK_SKI1_1	203	207	PF00082	0.359
CLV_PCSK_SKI1_1	284	288	PF00082	0.370
CLV_PCSK_SKI1_1	316	320	PF00082	0.261
CLV_PCSK_SKI1_1	346	350	PF00082	0.570
CLV_PCSK_SKI1_1	394	398	PF00082	0.537
CLV_PCSK_SKI1_1	407	411	PF00082	0.475
CLV_PCSK_SKI1_1	614	618	PF00082	0.578
CLV_PCSK_SKI1_1	99	103	PF00082	0.486
DEG_APCC_DBOX_1	136	144	PF00400	0.419
DEG_APCC_DBOX_1	345	353	PF00400	0.433
DEG_APCC_DBOX_1	636	644	PF00400	0.388
DEG_APCC_KENBOX_2	522	526	PF00400	0.446
DEG_Nend_UBRbox_3	1	3	PF02207	0.643
DEG_SPOP_SBC_1	150	154	PF00917	0.546
DEG_SPOP_SBC_1	188	192	PF00917	0.485
DEG_SPOP_SBC_1	667	671	PF00917	0.454
DOC_ANK_TNKS_1	681	688	PF00023	0.555
DOC_CKS1_1	264	269	PF01111	0.609
DOC_CYCLIN_RxL_1	313	323	PF00134	0.272
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.408
DOC_CYCLIN_yCln2_LP_2	163	166	PF00134	0.625
DOC_CYCLIN_yCln2_LP_2	508	514	PF00134	0.390
DOC_MAPK_gen_1	544	550	PF00069	0.456
DOC_MAPK_gen_1	590	596	PF00069	0.460
DOC_MAPK_RevD_3	418	433	PF00069	0.420
DOC_PP1_RVXF_1	196	202	PF00149	0.341
DOC_PP2B_LxvP_1	163	166	PF13499	0.650
DOC_PP2B_LxvP_1	46	49	PF13499	0.519
DOC_PP4_FxxP_1	597	600	PF00568	0.433
DOC_PP4_MxPP_1	1	4	PF00568	0.763
DOC_USP7_MATH_1	172	176	PF00917	0.644
DOC_USP7_MATH_1	187	191	PF00917	0.469
DOC_USP7_MATH_1	272	276	PF00917	0.552
DOC_USP7_MATH_1	320	324	PF00917	0.453
DOC_USP7_MATH_1	334	338	PF00917	0.485
DOC_USP7_MATH_1	461	465	PF00917	0.600
DOC_USP7_MATH_1	573	577	PF00917	0.510
DOC_USP7_MATH_1	600	604	PF00917	0.478
DOC_USP7_MATH_1	626	630	PF00917	0.560
DOC_USP7_MATH_1	636	640	PF00917	0.519
DOC_USP7_MATH_1	666	670	PF00917	0.585
DOC_USP7_MATH_1	81	85	PF00917	0.589
DOC_USP7_UBL2_3	23	27	PF12436	0.402
DOC_WD40_RPTOR_TOS_1	496	501	PF00400	0.503
DOC_WW_Pin1_4	189	194	PF00397	0.463
DOC_WW_Pin1_4	263	268	PF00397	0.485
DOC_WW_Pin1_4	387	392	PF00397	0.477
LIG_14-3-3_CanoR_1	242	246	PF00244	0.563
LIG_14-3-3_CanoR_1	379	385	PF00244	0.445
LIG_14-3-3_CanoR_1	398	403	PF00244	0.292
LIG_14-3-3_CanoR_1	406	416	PF00244	0.353
LIG_14-3-3_CanoR_1	433	439	PF00244	0.573
LIG_14-3-3_CanoR_1	473	478	PF00244	0.518
LIG_14-3-3_CanoR_1	632	640	PF00244	0.578
LIG_14-3-3_CanoR_1	668	676	PF00244	0.456
LIG_Actin_WH2_2	373	390	PF00022	0.547
LIG_BRCT_BRCA1_1	532	536	PF00533	0.505
LIG_Clathr_ClatBox_1	296	300	PF01394	0.520
LIG_Clathr_ClatBox_1	417	421	PF01394	0.377
LIG_Clathr_ClatBox_1	604	608	PF01394	0.471
LIG_deltaCOP1_diTrp_1	13	22	PF00928	0.493
LIG_eIF4E_1	582	588	PF01652	0.488
LIG_eIF4E_1	66	72	PF01652	0.477
LIG_FHA_1	183	189	PF00498	0.501
LIG_FHA_1	206	212	PF00498	0.340
LIG_FHA_1	266	272	PF00498	0.489
LIG_FHA_1	448	454	PF00498	0.490
LIG_FHA_1	532	538	PF00498	0.568
LIG_FHA_1	689	695	PF00498	0.457
LIG_FHA_1	72	78	PF00498	0.587
LIG_FHA_2	12	18	PF00498	0.483
LIG_FHA_2	435	441	PF00498	0.554
LIG_FHA_2	502	508	PF00498	0.402
LIG_FHA_2	670	676	PF00498	0.398
LIG_FXI_DFP_1	113	117	PF00024	0.489
LIG_LIR_Apic_2	337	343	PF02991	0.446
LIG_LIR_Apic_2	353	359	PF02991	0.442
LIG_LIR_Apic_2	595	600	PF02991	0.418
LIG_LIR_Gen_1	110	120	PF02991	0.472
LIG_LIR_Gen_1	13	22	PF02991	0.609
LIG_LIR_Gen_1	158	168	PF02991	0.619
LIG_LIR_Gen_1	440	449	PF02991	0.438
LIG_LIR_Gen_1	94	103	PF02991	0.493
LIG_LIR_Nem_3	110	116	PF02991	0.419
LIG_LIR_Nem_3	13	18	PF02991	0.567
LIG_LIR_Nem_3	158	164	PF02991	0.576
LIG_LIR_Nem_3	281	286	PF02991	0.452
LIG_LIR_Nem_3	292	296	PF02991	0.383
LIG_LIR_Nem_3	310	315	PF02991	0.234
LIG_LIR_Nem_3	440	444	PF02991	0.440
LIG_LIR_Nem_3	94	98	PF02991	0.515
LIG_NRBOX	208	214	PF00104	0.500
LIG_NRBOX	67	73	PF00104	0.424
LIG_Pex14_1	513	517	PF04695	0.369
LIG_Pex14_2	201	205	PF04695	0.450
LIG_Pex14_2	308	312	PF04695	0.421
LIG_SH2_CRK	283	287	PF00017	0.444
LIG_SH2_CRK	340	344	PF00017	0.611
LIG_SH2_CRK	356	360	PF00017	0.418
LIG_SH2_CRK	361	365	PF00017	0.452
LIG_SH2_CRK	619	623	PF00017	0.554
LIG_SH2_GRB2like	514	517	PF00017	0.387
LIG_SH2_PTP2	95	98	PF00017	0.492
LIG_SH2_SRC	95	98	PF00017	0.492
LIG_SH2_STAP1	449	453	PF00017	0.467
LIG_SH2_STAP1	630	634	PF00017	0.457
LIG_SH2_STAP1	649	653	PF00017	0.440
LIG_SH2_STAT5	103	106	PF00017	0.385
LIG_SH2_STAT5	113	116	PF00017	0.275
LIG_SH2_STAT5	118	121	PF00017	0.436
LIG_SH2_STAT5	135	138	PF00017	0.385
LIG_SH2_STAT5	240	243	PF00017	0.487
LIG_SH2_STAT5	416	419	PF00017	0.361
LIG_SH2_STAT5	449	452	PF00017	0.466
LIG_SH2_STAT5	485	488	PF00017	0.363
LIG_SH2_STAT5	514	517	PF00017	0.423
LIG_SH2_STAT5	582	585	PF00017	0.491
LIG_SH2_STAT5	715	718	PF00017	0.459
LIG_SH2_STAT5	95	98	PF00017	0.438
LIG_SH3_2	317	322	PF14604	0.377
LIG_SH3_3	1	7	PF00018	0.718
LIG_SH3_3	261	267	PF00018	0.469
LIG_SH3_3	314	320	PF00018	0.406
LIG_SH3_3	716	722	PF00018	0.457
LIG_SUMO_SIM_anti_2	208	215	PF11976	0.371
LIG_SUMO_SIM_anti_2	230	238	PF11976	0.468
LIG_SUMO_SIM_anti_2	499	504	PF11976	0.524
LIG_SUMO_SIM_par_1	295	301	PF11976	0.278
LIG_SUMO_SIM_par_1	475	482	PF11976	0.462
LIG_SUMO_SIM_par_1	592	598	PF11976	0.433
LIG_SUMO_SIM_par_1	603	608	PF11976	0.448
LIG_SUMO_SIM_par_1	88	94	PF11976	0.380
LIG_SxIP_EBH_1	544	554	PF03271	0.492
LIG_TRAF2_1	157	160	PF00917	0.505
LIG_TRFH_1	161	165	PF08558	0.601
LIG_TYR_ITIM	617	622	PF00017	0.550
LIG_UBA3_1	286	294	PF00899	0.387
LIG_UBA3_1	348	354	PF00899	0.490
LIG_UBA3_1	593	601	PF00899	0.443
LIG_WRC_WIRS_1	290	295	PF05994	0.505
LIG_WRC_WIRS_1	493	498	PF05994	0.414
MOD_CDK_SPxK_1	263	269	PF00069	0.482
MOD_CDK_SPxxK_3	387	394	PF00069	0.513
MOD_CK1_1	263	269	PF00069	0.482
MOD_CK1_1	292	298	PF00069	0.459
MOD_CK1_1	30	36	PF00069	0.625
MOD_CK1_1	448	454	PF00069	0.418
MOD_CK1_1	578	584	PF00069	0.424
MOD_CK1_1	603	609	PF00069	0.419
MOD_CK1_1	669	675	PF00069	0.425
MOD_CK1_1	79	85	PF00069	0.455
MOD_CK2_1	154	160	PF00069	0.462
MOD_CK2_1	172	178	PF00069	0.591
MOD_CK2_1	216	222	PF00069	0.487
MOD_CK2_1	44	50	PF00069	0.498
MOD_CK2_1	501	507	PF00069	0.384
MOD_CK2_1	669	675	PF00069	0.385
MOD_GlcNHglycan	280	283	PF01048	0.574
MOD_GlcNHglycan	46	49	PF01048	0.510
MOD_GlcNHglycan	57	60	PF01048	0.513
MOD_GlcNHglycan	583	586	PF01048	0.460
MOD_GlcNHglycan	597	600	PF01048	0.462
MOD_GlcNHglycan	634	637	PF01048	0.525
MOD_GlcNHglycan	702	705	PF01048	0.600
MOD_GlcNHglycan	725	728	PF01048	0.580
MOD_GlcNHglycan	78	81	PF01048	0.420
MOD_GSK3_1	105	112	PF00069	0.519
MOD_GSK3_1	150	157	PF00069	0.419
MOD_GSK3_1	212	219	PF00069	0.512
MOD_GSK3_1	447	454	PF00069	0.454
MOD_GSK3_1	472	479	PF00069	0.466
MOD_GSK3_1	553	560	PF00069	0.460
MOD_GSK3_1	603	610	PF00069	0.350
MOD_GSK3_1	632	639	PF00069	0.563
MOD_LATS_1	97	103	PF00433	0.494
MOD_N-GLC_1	11	16	PF02516	0.571
MOD_N-GLC_1	128	133	PF02516	0.461
MOD_N-GLC_1	154	159	PF02516	0.585
MOD_N-GLC_1	334	339	PF02516	0.553
MOD_N-GLC_1	524	529	PF02516	0.408
MOD_NEK2_1	109	114	PF00069	0.402
MOD_NEK2_1	151	156	PF00069	0.550
MOD_NEK2_1	205	210	PF00069	0.349
MOD_NEK2_1	212	217	PF00069	0.458
MOD_NEK2_1	348	353	PF00069	0.440
MOD_NEK2_1	419	424	PF00069	0.436
MOD_NEK2_1	434	439	PF00069	0.590
MOD_NEK2_1	531	536	PF00069	0.561
MOD_NEK2_1	553	558	PF00069	0.404
MOD_NEK2_1	688	693	PF00069	0.411
MOD_NEK2_1	728	733	PF00069	0.475
MOD_PIKK_1	107	113	PF00454	0.494
MOD_PIKK_1	501	507	PF00454	0.392
MOD_PIKK_1	71	77	PF00454	0.364
MOD_PKA_1	216	222	PF00069	0.541
MOD_PKA_1	735	741	PF00069	0.580
MOD_PKA_2	241	247	PF00069	0.460
MOD_PKA_2	472	478	PF00069	0.485
MOD_PKA_2	557	563	PF00069	0.566
MOD_PKA_2	636	642	PF00069	0.475
MOD_PKA_2	667	673	PF00069	0.329
MOD_PKB_1	733	741	PF00069	0.557
MOD_Plk_1	11	17	PF00069	0.510
MOD_Plk_1	172	178	PF00069	0.585
MOD_Plk_1	28	34	PF00069	0.508
MOD_Plk_1	334	340	PF00069	0.550
MOD_Plk_1	445	451	PF00069	0.386
MOD_Plk_1	524	530	PF00069	0.522
MOD_Plk_1	578	584	PF00069	0.518
MOD_Plk_1	607	613	PF00069	0.323
MOD_Plk_1	99	105	PF00069	0.489
MOD_Plk_4	109	115	PF00069	0.507
MOD_Plk_4	207	213	PF00069	0.420
MOD_Plk_4	260	266	PF00069	0.576
MOD_Plk_4	292	298	PF00069	0.462
MOD_Plk_4	334	340	PF00069	0.470
MOD_Plk_4	419	425	PF00069	0.440
MOD_Plk_4	451	457	PF00069	0.405
MOD_Plk_4	473	479	PF00069	0.482
MOD_Plk_4	537	543	PF00069	0.516
MOD_Plk_4	578	584	PF00069	0.507
MOD_Plk_4	600	606	PF00069	0.459
MOD_Plk_4	99	105	PF00069	0.522
MOD_ProDKin_1	189	195	PF00069	0.454
MOD_ProDKin_1	263	269	PF00069	0.482
MOD_ProDKin_1	387	393	PF00069	0.476
MOD_SUMO_for_1	26	29	PF00179	0.572
MOD_SUMO_rev_2	243	253	PF00179	0.558
MOD_SUMO_rev_2	47	56	PF00179	0.469
MOD_SUMO_rev_2	584	593	PF00179	0.469
TRG_DiLeu_BaEn_1	159	164	PF01217	0.611
TRG_DiLeu_BaEn_1	230	235	PF01217	0.392
TRG_DiLeu_BaEn_1	589	594	PF01217	0.401
TRG_DiLeu_BaEn_4	63	69	PF01217	0.569
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.372
TRG_DiLeu_BaLyEn_6	611	616	PF01217	0.458
TRG_ENDOCYTIC_2	113	116	PF00928	0.340
TRG_ENDOCYTIC_2	283	286	PF00928	0.371
TRG_ENDOCYTIC_2	361	364	PF00928	0.376
TRG_ENDOCYTIC_2	416	419	PF00928	0.455
TRG_ENDOCYTIC_2	514	517	PF00928	0.378
TRG_ENDOCYTIC_2	619	622	PF00928	0.545
TRG_ENDOCYTIC_2	95	98	PF00928	0.515
TRG_ER_diArg_1	198	201	PF00400	0.399
TRG_ER_diArg_1	346	348	PF00400	0.408
TRG_ER_diArg_1	405	407	PF00400	0.474
TRG_ER_diArg_1	432	434	PF00400	0.388
TRG_ER_diArg_1	681	683	PF00400	0.543
TRG_ER_diArg_1	732	735	PF00400	0.581
TRG_NES_CRM1_1	230	245	PF08389	0.415
TRG_NES_CRM1_1	288	300	PF08389	0.512
TRG_NES_CRM1_1	491	505	PF08389	0.421
TRG_Pf-PMV_PEXEL_1	394	399	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y3	Leptomonas seymouri	80%	100%
A0A0S4IMZ6	Bodo saltans	33%	100%
A0A1X0NSS7	Trypanosomatidae	52%	100%
A0A3R7M3C6	Trypanosoma rangeli	49%	100%
A0A3S7WUK2	Leishmania donovani	95%	100%
A4H953	Leishmania braziliensis	91%	100%
A4HXH5	Leishmania infantum	95%	100%
C9ZP62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
Q4QE93	Leishmania major	94%	100%
V5D6H5	Trypanosoma cruzi	49%	100%