PlsC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AR64_LEIMU

TriTrypDb:

LmxM.17.0910

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0012505	endomembrane system	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AR64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR64

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0036149	phosphatidylinositol acyl-chain remodeling	7	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046488	phosphatidylinositol metabolic process	6	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.544
CLV_NRD_NRD_1	387	389	PF00675	0.392
CLV_NRD_NRD_1	462	464	PF00675	0.378
CLV_NRD_NRD_1	470	472	PF00675	0.433
CLV_PCSK_FUR_1	460	464	PF00082	0.364
CLV_PCSK_FUR_1	468	472	PF00082	0.412
CLV_PCSK_KEX2_1	194	196	PF00082	0.264
CLV_PCSK_KEX2_1	333	335	PF00082	0.161
CLV_PCSK_KEX2_1	387	389	PF00082	0.358
CLV_PCSK_KEX2_1	462	464	PF00082	0.383
CLV_PCSK_KEX2_1	468	470	PF00082	0.425
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.139
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.161
CLV_PCSK_PC7_1	383	389	PF00082	0.369
CLV_PCSK_SKI1_1	178	182	PF00082	0.236
CLV_PCSK_SKI1_1	2	6	PF00082	0.299
CLV_PCSK_SKI1_1	338	342	PF00082	0.276
CLV_PCSK_SKI1_1	359	363	PF00082	0.296
CLV_PCSK_SKI1_1	37	41	PF00082	0.530
CLV_PCSK_SKI1_1	434	438	PF00082	0.414
CLV_PCSK_SKI1_1	462	466	PF00082	0.377
CLV_Separin_Metazoa	175	179	PF03568	0.339
DEG_APCC_DBOX_1	416	424	PF00400	0.322
DEG_APCC_DBOX_1	60	68	PF00400	0.310
DEG_MDM2_SWIB_1	415	423	PF02201	0.324
DEG_Nend_UBRbox_1	1	4	PF02207	0.616
DOC_CDC14_PxL_1	164	172	PF14671	0.510
DOC_CKS1_1	274	279	PF01111	0.437
DOC_CYCLIN_RxL_1	175	183	PF00134	0.477
DOC_CYCLIN_RxL_1	332	343	PF00134	0.522
DOC_MAPK_gen_1	122	130	PF00069	0.395
DOC_MAPK_gen_1	293	299	PF00069	0.562
DOC_MAPK_gen_1	387	395	PF00069	0.515
DOC_MAPK_MEF2A_6	122	130	PF00069	0.379
DOC_PP1_RVXF_1	134	140	PF00149	0.437
DOC_PP1_RVXF_1	193	200	PF00149	0.522
DOC_PP2B_LxvP_1	117	120	PF13499	0.573
DOC_USP7_MATH_1	4	8	PF00917	0.561
DOC_USP7_UBL2_3	190	194	PF12436	0.408
DOC_WW_Pin1_4	203	208	PF00397	0.522
DOC_WW_Pin1_4	216	221	PF00397	0.522
DOC_WW_Pin1_4	273	278	PF00397	0.580
DOC_WW_Pin1_4	405	410	PF00397	0.285
LIG_14-3-3_CanoR_1	150	160	PF00244	0.555
LIG_14-3-3_CanoR_1	417	426	PF00244	0.312
LIG_14-3-3_CanoR_1	78	84	PF00244	0.484
LIG_Actin_RPEL_3	410	429	PF02755	0.244
LIG_Actin_WH2_2	435	451	PF00022	0.459
LIG_APCC_ABBA_1	209	214	PF00400	0.443
LIG_BIR_III_4	85	89	PF00653	0.376
LIG_BRCT_BRCA1_1	342	346	PF00533	0.374
LIG_CaM_IQ_9	455	471	PF13499	0.595
LIG_deltaCOP1_diTrp_1	138	146	PF00928	0.426
LIG_eIF4E_1	390	396	PF01652	0.399
LIG_FHA_1	147	153	PF00498	0.453
LIG_FHA_1	204	210	PF00498	0.459
LIG_FHA_1	245	251	PF00498	0.439
LIG_FHA_1	34	40	PF00498	0.292
LIG_FHA_1	346	352	PF00498	0.545
LIG_FHA_2	274	280	PF00498	0.456
LIG_FHA_2	80	86	PF00498	0.543
LIG_GBD_Chelix_1	425	433	PF00786	0.249
LIG_LIR_Apic_2	273	277	PF02991	0.595
LIG_LIR_Gen_1	138	147	PF02991	0.426
LIG_LIR_Gen_1	445	455	PF02991	0.548
LIG_LIR_Nem_3	108	113	PF02991	0.567
LIG_LIR_Nem_3	142	146	PF02991	0.479
LIG_LIR_Nem_3	408	414	PF02991	0.367
LIG_LIR_Nem_3	445	450	PF02991	0.537
LIG_LYPXL_yS_3	110	113	PF13949	0.385
LIG_MAD2	115	123	PF02301	0.573
LIG_MLH1_MIPbox_1	342	346	PF16413	0.374
LIG_PCNA_PIPBox_1	193	202	PF02747	0.477
LIG_Pex14_1	139	143	PF04695	0.451
LIG_Pex14_1	385	389	PF04695	0.567
LIG_Pex14_2	414	418	PF04695	0.368
LIG_Pex14_2	432	436	PF04695	0.435
LIG_REV1ctd_RIR_1	412	421	PF16727	0.387
LIG_SH2_CRK	274	278	PF00017	0.613
LIG_SH2_CRK	390	394	PF00017	0.572
LIG_SH2_NCK_1	81	85	PF00017	0.489
LIG_SH2_STAP1	141	145	PF00017	0.510
LIG_SH2_STAP1	229	233	PF00017	0.524
LIG_SH2_STAT3	389	392	PF00017	0.551
LIG_SH2_STAT5	141	144	PF00017	0.510
LIG_SH2_STAT5	145	148	PF00017	0.471
LIG_SH2_STAT5	158	161	PF00017	0.346
LIG_SH2_STAT5	179	182	PF00017	0.437
LIG_SH2_STAT5	272	275	PF00017	0.493
LIG_SH2_STAT5	34	37	PF00017	0.371
LIG_SH2_STAT5	38	41	PF00017	0.376
LIG_SH2_STAT5	447	450	PF00017	0.565
LIG_SH2_STAT5	63	66	PF00017	0.371
LIG_SH2_STAT5	81	84	PF00017	0.393
LIG_SH3_2	120	125	PF14604	0.533
LIG_SH3_3	113	119	PF00018	0.511
LIG_SH3_3	230	236	PF00018	0.466
LIG_SH3_3	238	244	PF00018	0.415
LIG_SH3_3	378	384	PF00018	0.596
LIG_SH3_3	396	402	PF00018	0.330
LIG_SH3_3	447	453	PF00018	0.590
LIG_SUMO_SIM_anti_2	249	254	PF11976	0.385
LIG_SUMO_SIM_par_1	263	269	PF11976	0.389
LIG_TRAF2_1	261	264	PF00917	0.339
LIG_TRAF2_1	321	324	PF00917	0.575
LIG_TYR_ITIM	177	182	PF00017	0.339
LIG_TYR_ITIM	79	84	PF00017	0.469
LIG_UBA3_1	152	161	PF00899	0.547
LIG_UBA3_1	327	333	PF00899	0.371
LIG_WRC_WIRS_1	140	145	PF05994	0.510
LIG_WRC_WIRS_1	22	27	PF05994	0.148
MOD_CDK_SPK_2	216	221	PF00069	0.339
MOD_CDK_SPxxK_3	273	280	PF00069	0.431
MOD_CK2_1	20	26	PF00069	0.387
MOD_CK2_1	258	264	PF00069	0.339
MOD_CK2_1	273	279	PF00069	0.430
MOD_Cter_Amidation	466	469	PF01082	0.284
MOD_GlcNHglycan	420	423	PF01048	0.395
MOD_GSK3_1	266	273	PF00069	0.426
MOD_N-GLC_1	200	205	PF02516	0.185
MOD_NEK2_1	146	151	PF00069	0.532
MOD_NEK2_1	15	20	PF00069	0.272
MOD_NEK2_1	180	185	PF00069	0.475
MOD_NEK2_1	284	289	PF00069	0.630
MOD_NEK2_1	298	303	PF00069	0.561
MOD_NEK2_1	33	38	PF00069	0.371
MOD_NEK2_1	340	345	PF00069	0.479
MOD_NEK2_1	395	400	PF00069	0.296
MOD_NEK2_1	5	10	PF00069	0.525
MOD_NEK2_1	59	64	PF00069	0.336
MOD_NEK2_2	96	101	PF00069	0.580
MOD_PIKK_1	223	229	PF00454	0.522
MOD_PKA_2	244	250	PF00069	0.441
MOD_PKA_2	49	55	PF00069	0.364
MOD_PKA_2	5	11	PF00069	0.339
MOD_Plk_1	266	272	PF00069	0.406
MOD_Plk_1	282	288	PF00069	0.601
MOD_Plk_1	374	380	PF00069	0.522
MOD_Plk_1	453	459	PF00069	0.583
MOD_Plk_4	139	145	PF00069	0.510
MOD_Plk_4	395	401	PF00069	0.324
MOD_Plk_4	44	50	PF00069	0.223
MOD_Plk_4	442	448	PF00069	0.524
MOD_Plk_4	453	459	PF00069	0.523
MOD_Plk_4	79	85	PF00069	0.474
MOD_ProDKin_1	203	209	PF00069	0.522
MOD_ProDKin_1	216	222	PF00069	0.522
MOD_ProDKin_1	273	279	PF00069	0.579
MOD_ProDKin_1	405	411	PF00069	0.285
TRG_DiLeu_BaEn_1	323	328	PF01217	0.392
TRG_DiLeu_BaEn_1	337	342	PF01217	0.541
TRG_DiLeu_BaEn_4	263	269	PF01217	0.476
TRG_ENDOCYTIC_2	110	113	PF00928	0.595
TRG_ENDOCYTIC_2	141	144	PF00928	0.522
TRG_ENDOCYTIC_2	179	182	PF00928	0.437
TRG_ENDOCYTIC_2	390	393	PF00928	0.572
TRG_ENDOCYTIC_2	411	414	PF00928	0.287
TRG_ENDOCYTIC_2	447	450	PF00928	0.575
TRG_ENDOCYTIC_2	81	84	PF00928	0.484
TRG_ER_diArg_1	386	388	PF00400	0.571
TRG_ER_diArg_1	460	463	PF00400	0.604
TRG_ER_diArg_1	468	471	PF00400	0.649
TRG_ER_diLys_1	472	477	PF00400	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKC7	Leptomonas seymouri	57%	100%
A0A0S4J7G6	Bodo saltans	30%	100%
A0A1X0NU94	Trypanosomatidae	38%	100%
A0A3Q8IE09	Leishmania donovani	83%	100%
A0A422NH08	Trypanosoma rangeli	42%	100%
A4H937	Leishmania braziliensis	75%	100%
A4HXG9	Leishmania infantum	83%	100%
C9ZP55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QE99	Leishmania major	82%	100%
Q5F3X0	Gallus gallus	28%	100%
V5BF39	Trypanosoma cruzi	39%	100%