Leucine_Rich_repeat

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Leucine_Rich_repeat

Gene product:

Component of motile flagella 44, putative

Species:

Leishmania mexicana

UniProt:

E9AR63_LEIMU

TriTrypDb:

LmxM.17.0900

Length:

671

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9AR63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.443
CLV_C14_Caspase3-7	343	347	PF00656	0.376
CLV_C14_Caspase3-7	502	506	PF00656	0.614
CLV_C14_Caspase3-7	525	529	PF00656	0.652
CLV_NRD_NRD_1	652	654	PF00675	0.639
CLV_NRD_NRD_1	657	659	PF00675	0.515
CLV_PCSK_FUR_1	7	11	PF00082	0.661
CLV_PCSK_KEX2_1	147	149	PF00082	0.405
CLV_PCSK_KEX2_1	652	654	PF00082	0.680
CLV_PCSK_KEX2_1	657	659	PF00082	0.511
CLV_PCSK_KEX2_1	9	11	PF00082	0.616
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.405
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.616
CLV_PCSK_PC7_1	653	659	PF00082	0.478
CLV_PCSK_SKI1_1	147	151	PF00082	0.377
CLV_PCSK_SKI1_1	652	656	PF00082	0.688
CLV_PCSK_SKI1_1	657	661	PF00082	0.544
CLV_Separin_Metazoa	626	630	PF03568	0.484
DEG_APCC_DBOX_1	123	131	PF00400	0.405
DEG_APCC_DBOX_1	147	155	PF00400	0.397
DEG_APCC_DBOX_1	309	317	PF00400	0.422
DEG_Nend_Nbox_1	1	3	PF02207	0.673
DEG_SCF_FBW7_2	619	624	PF00400	0.508
DEG_SPOP_SBC_1	329	333	PF00917	0.352
DEG_SPOP_SBC_1	493	497	PF00917	0.548
DOC_CYCLIN_RxL_1	332	343	PF00134	0.360
DOC_CYCLIN_RxL_1	447	458	PF00134	0.459
DOC_CYCLIN_yCln2_LP_2	175	178	PF00134	0.535
DOC_MAPK_gen_1	387	397	PF00069	0.306
DOC_MIT_MIM_1	611	619	PF04212	0.497
DOC_PP1_RVXF_1	266	272	PF00149	0.427
DOC_PP1_RVXF_1	333	340	PF00149	0.376
DOC_PP2B_LxvP_1	175	178	PF13499	0.535
DOC_PP2B_LxvP_1	309	312	PF13499	0.338
DOC_USP7_MATH_1	161	165	PF00917	0.542
DOC_USP7_MATH_1	211	215	PF00917	0.599
DOC_USP7_MATH_1	305	309	PF00917	0.420
DOC_USP7_MATH_1	469	473	PF00917	0.747
DOC_USP7_MATH_1	516	520	PF00917	0.714
DOC_USP7_MATH_1	527	531	PF00917	0.681
DOC_USP7_MATH_1	548	552	PF00917	0.705
DOC_USP7_MATH_1	568	572	PF00917	0.660
DOC_USP7_MATH_1	605	609	PF00917	0.464
DOC_WW_Pin1_4	464	469	PF00397	0.553
DOC_WW_Pin1_4	47	52	PF00397	0.549
DOC_WW_Pin1_4	583	588	PF00397	0.560
DOC_WW_Pin1_4	617	622	PF00397	0.493
LIG_14-3-3_CanoR_1	105	109	PF00244	0.381
LIG_14-3-3_CanoR_1	268	272	PF00244	0.419
LIG_14-3-3_CanoR_1	279	288	PF00244	0.536
LIG_14-3-3_CanoR_1	387	393	PF00244	0.360
LIG_14-3-3_CanoR_1	430	439	PF00244	0.418
LIG_14-3-3_CanoR_1	543	552	PF00244	0.676
LIG_BIR_III_4	404	408	PF00653	0.360
LIG_BIR_III_4	43	47	PF00653	0.409
LIG_Clathr_ClatBox_1	609	613	PF01394	0.459
LIG_deltaCOP1_diTrp_1	143	150	PF00928	0.445
LIG_eIF4E_1	144	150	PF01652	0.439
LIG_FHA_1	239	245	PF00498	0.423
LIG_FHA_1	268	274	PF00498	0.391
LIG_FHA_1	281	287	PF00498	0.477
LIG_FHA_1	331	337	PF00498	0.364
LIG_FHA_1	389	395	PF00498	0.300
LIG_FHA_1	478	484	PF00498	0.520
LIG_FHA_1	485	491	PF00498	0.777
LIG_FHA_1	494	500	PF00498	0.632
LIG_FHA_1	575	581	PF00498	0.767
LIG_FHA_1	605	611	PF00498	0.355
LIG_FHA_2	205	211	PF00498	0.614
LIG_FHA_2	418	424	PF00498	0.395
LIG_FHA_2	618	624	PF00498	0.496
LIG_FHA_2	94	100	PF00498	0.456
LIG_FXI_DFP_1	39	43	PF00024	0.553
LIG_LIR_Gen_1	22	30	PF02991	0.511
LIG_LIR_Gen_1	255	265	PF02991	0.453
LIG_LIR_Gen_1	85	95	PF02991	0.477
LIG_LIR_Nem_3	143	149	PF02991	0.512
LIG_LIR_Nem_3	255	261	PF02991	0.450
LIG_LIR_Nem_3	613	619	PF02991	0.483
LIG_LIR_Nem_3	85	90	PF02991	0.484
LIG_NRBOX	150	156	PF00104	0.230
LIG_PCNA_yPIPBox_3	80	90	PF02747	0.504
LIG_Pex14_1	146	150	PF04695	0.343
LIG_Pex14_2	267	271	PF04695	0.422
LIG_SH2_CRK	87	91	PF00017	0.489
LIG_SH2_STAP1	254	258	PF00017	0.379
LIG_SH2_STAP1	494	498	PF00017	0.611
LIG_SH2_STAP1	87	91	PF00017	0.430
LIG_SH2_STAT3	636	639	PF00017	0.523
LIG_SH2_STAT5	238	241	PF00017	0.363
LIG_SH2_STAT5	368	371	PF00017	0.353
LIG_SH2_STAT5	53	56	PF00017	0.499
LIG_SH3_3	12	18	PF00018	0.633
LIG_SH3_3	239	245	PF00018	0.439
LIG_SH3_3	357	363	PF00018	0.425
LIG_SH3_3	462	468	PF00018	0.485
LIG_SH3_3	92	98	PF00018	0.455
LIG_SUMO_SIM_anti_2	351	357	PF11976	0.426
LIG_SUMO_SIM_par_1	479	484	PF11976	0.521
LIG_SUMO_SIM_par_1	495	502	PF11976	0.613
LIG_SUMO_SIM_par_1	607	613	PF11976	0.469
LIG_TRAF2_1	363	366	PF00917	0.340
LIG_TRAF2_1	57	60	PF00917	0.508
LIG_TRAF2_1	621	624	PF00917	0.501
LIG_WRC_WIRS_1	264	269	PF05994	0.416
LIG_WRPW_2	251	254	PF00400	0.474
LIG_WW_2	468	471	PF00397	0.494
MOD_CK1_1	131	137	PF00069	0.491
MOD_CK1_1	198	204	PF00069	0.643
MOD_CK1_1	330	336	PF00069	0.352
MOD_CK1_1	340	346	PF00069	0.298
MOD_CK1_1	455	461	PF00069	0.505
MOD_CK1_1	486	492	PF00069	0.659
MOD_CK1_1	551	557	PF00069	0.666
MOD_CK1_1	8	14	PF00069	0.487
MOD_CK2_1	431	437	PF00069	0.418
MOD_CK2_1	503	509	PF00069	0.684
MOD_CK2_1	54	60	PF00069	0.508
MOD_CK2_1	605	611	PF00069	0.472
MOD_CK2_1	617	623	PF00069	0.489
MOD_CK2_1	66	72	PF00069	0.507
MOD_GlcNHglycan	10	13	PF01048	0.532
MOD_GlcNHglycan	163	166	PF01048	0.522
MOD_GlcNHglycan	200	203	PF01048	0.635
MOD_GlcNHglycan	454	457	PF01048	0.461
MOD_GSK3_1	198	205	PF00069	0.590
MOD_GSK3_1	263	270	PF00069	0.423
MOD_GSK3_1	477	484	PF00069	0.748
MOD_GSK3_1	485	492	PF00069	0.779
MOD_GSK3_1	499	506	PF00069	0.684
MOD_GSK3_1	512	519	PF00069	0.558
MOD_GSK3_1	529	536	PF00069	0.682
MOD_GSK3_1	544	551	PF00069	0.609
MOD_GSK3_1	66	73	PF00069	0.485
MOD_GSK3_1	93	100	PF00069	0.469
MOD_N-GLC_1	171	176	PF02516	0.578
MOD_N-GLC_1	388	393	PF02516	0.300
MOD_N-GLC_1	605	610	PF02516	0.466
MOD_NEK2_1	104	109	PF00069	0.369
MOD_NEK2_1	189	194	PF00069	0.641
MOD_NEK2_1	267	272	PF00069	0.413
MOD_NEK2_1	328	333	PF00069	0.330
MOD_NEK2_1	337	342	PF00069	0.273
MOD_NEK2_1	374	379	PF00069	0.321
MOD_NEK2_1	388	393	PF00069	0.283
MOD_NEK2_1	42	47	PF00069	0.597
MOD_NEK2_1	431	436	PF00069	0.313
MOD_NEK2_1	452	457	PF00069	0.458
MOD_NEK2_1	483	488	PF00069	0.500
MOD_NEK2_1	499	504	PF00069	0.650
MOD_NEK2_1	54	59	PF00069	0.500
MOD_NEK2_1	544	549	PF00069	0.780
MOD_NEK2_1	590	595	PF00069	0.530
MOD_NEK2_1	640	645	PF00069	0.549
MOD_NEK2_1	66	71	PF00069	0.477
MOD_NEK2_2	263	268	PF00069	0.422
MOD_NEK2_2	305	310	PF00069	0.422
MOD_PIKK_1	189	195	PF00454	0.641
MOD_PIKK_1	337	343	PF00454	0.360
MOD_PIKK_1	444	450	PF00454	0.475
MOD_PIKK_1	455	461	PF00454	0.368
MOD_PIKK_1	575	581	PF00454	0.707
MOD_PIKK_1	93	99	PF00454	0.457
MOD_PKA_2	104	110	PF00069	0.419
MOD_PKA_2	131	137	PF00069	0.464
MOD_PKA_2	267	273	PF00069	0.367
MOD_PKA_2	542	548	PF00069	0.681
MOD_PKA_2	568	574	PF00069	0.660
MOD_PKA_2	664	670	PF00069	0.578
MOD_Plk_1	211	217	PF00069	0.592
MOD_Plk_1	388	394	PF00069	0.300
MOD_Plk_1	527	533	PF00069	0.703
MOD_Plk_1	558	564	PF00069	0.652
MOD_Plk_1	605	611	PF00069	0.472
MOD_Plk_1	640	646	PF00069	0.685
MOD_Plk_4	171	177	PF00069	0.631
MOD_Plk_4	179	185	PF00069	0.535
MOD_Plk_4	351	357	PF00069	0.403
MOD_Plk_4	489	495	PF00069	0.708
MOD_Plk_4	49	55	PF00069	0.513
MOD_Plk_4	605	611	PF00069	0.472
MOD_Plk_4	97	103	PF00069	0.498
MOD_ProDKin_1	464	470	PF00069	0.557
MOD_ProDKin_1	47	53	PF00069	0.550
MOD_ProDKin_1	583	589	PF00069	0.556
MOD_ProDKin_1	617	623	PF00069	0.489
TRG_DiLeu_BaEn_1	291	296	PF01217	0.446
TRG_DiLeu_BaEn_1	351	356	PF01217	0.422
TRG_DiLeu_BaEn_4	81	87	PF01217	0.502
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.444
TRG_DiLeu_BaLyEn_6	594	599	PF01217	0.454
TRG_ENDOCYTIC_2	254	257	PF00928	0.384
TRG_ENDOCYTIC_2	303	306	PF00928	0.363
TRG_ENDOCYTIC_2	87	90	PF00928	0.438
TRG_NES_CRM1_1	64	77	PF08389	0.350
TRG_NLS_MonoExtN_4	569	576	PF00514	0.573
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	393	398	PF00026	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWS3	Leptomonas seymouri	56%	100%
A0A3R7LWJ9	Trypanosoma rangeli	40%	100%
A0A3S7WUQ4	Leishmania donovani	92%	100%
A4H936	Leishmania braziliensis	78%	100%
A4HXG8	Leishmania infantum	92%	100%
Q4QEA0	Leishmania major	91%	100%