LeishMANIAdb
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META domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
META domain-containing protein
Gene product:
META domain containing protein, putative
Species:
Leishmania mexicana
UniProt:
E9AR62_LEIMU
TriTrypDb:
LmxM.17.0890
Length:
112

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR62
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR62

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 55 57 PF00675 0.350
DEG_Nend_UBRbox_2 1 3 PF02207 0.513
DOC_USP7_UBL2_3 97 101 PF12436 0.226
LIG_14-3-3_CanoR_1 11 16 PF00244 0.216
LIG_Actin_WH2_2 36 54 PF00022 0.300
LIG_BRCT_BRCA1_1 80 84 PF00533 0.415
LIG_Clathr_ClatBox_1 73 77 PF01394 0.431
LIG_FHA_1 102 108 PF00498 0.414
LIG_FHA_1 63 69 PF00498 0.352
LIG_FHA_2 89 95 PF00498 0.388
LIG_Integrin_isoDGR_2 16 18 PF01839 0.288
LIG_MAD2 11 19 PF02301 0.350
LIG_PDZ_Class_2 107 112 PF00595 0.485
LIG_SH2_CRK 10 14 PF00017 0.213
LIG_SH2_STAT5 90 93 PF00017 0.475
MOD_GlcNHglycan 32 36 PF01048 0.455
MOD_GlcNHglycan 58 61 PF01048 0.458
MOD_GSK3_1 58 65 PF00069 0.440
MOD_GSK3_1 99 106 PF00069 0.394
MOD_NEK2_1 58 63 PF00069 0.318
MOD_NEK2_1 88 93 PF00069 0.506
MOD_NEK2_2 96 101 PF00069 0.213
MOD_PIKK_1 78 84 PF00454 0.463
MOD_PK_1 11 17 PF00069 0.275
MOD_PKA_1 56 62 PF00069 0.350
MOD_Plk_4 2 8 PF00069 0.366
MOD_Plk_4 58 64 PF00069 0.362
TRG_DiLeu_BaEn_1 2 7 PF01217 0.455
TRG_ENDOCYTIC_2 10 13 PF00928 0.300

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5L5 Leptomonas seymouri 44% 100%
A0A0N1PC21 Leptomonas seymouri 35% 97%
A0A1X0NST7 Trypanosomatidae 45% 100%
A0A1X0NT42 Trypanosomatidae 37% 92%
A0A3S5H712 Leishmania donovani 81% 100%
A0A422NGZ1 Trypanosoma rangeli 33% 93%
A4H942 Leishmania braziliensis 55% 100%
A4HXG7 Leishmania infantum 82% 100%
C9ZP48 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 84%
C9ZP50 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 84%
C9ZP53 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 84%
Q25307 Leishmania major 79% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS