Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AR61_LEIMU

TriTrypDb:

LmxM.17.0880

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AR61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.445
CLV_C14_Caspase3-7	252	256	PF00656	0.523
CLV_C14_Caspase3-7	293	297	PF00656	0.408
CLV_NRD_NRD_1	493	495	PF00675	0.713
CLV_NRD_NRD_1	508	510	PF00675	0.607
CLV_NRD_NRD_1	89	91	PF00675	0.623
CLV_PCSK_KEX2_1	155	157	PF00082	0.663
CLV_PCSK_KEX2_1	493	495	PF00082	0.742
CLV_PCSK_KEX2_1	508	510	PF00082	0.637
CLV_PCSK_KEX2_1	89	91	PF00082	0.623
CLV_PCSK_KEX2_1	95	97	PF00082	0.614
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.574
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.644
CLV_PCSK_SKI1_1	32	36	PF00082	0.612
CLV_PCSK_SKI1_1	323	327	PF00082	0.619
CLV_PCSK_SKI1_1	415	419	PF00082	0.661
CLV_PCSK_SKI1_1	493	497	PF00082	0.683
CLV_PCSK_SKI1_1	501	505	PF00082	0.695
DOC_ANK_TNKS_1	88	95	PF00023	0.361
DOC_MAPK_gen_1	315	322	PF00069	0.462
DOC_MAPK_gen_1	508	520	PF00069	0.469
DOC_PP4_FxxP_1	310	313	PF00568	0.493
DOC_USP7_MATH_1	188	192	PF00917	0.570
DOC_USP7_MATH_1	227	231	PF00917	0.572
DOC_USP7_MATH_1	249	253	PF00917	0.477
DOC_USP7_MATH_1	460	464	PF00917	0.514
DOC_USP7_MATH_1	481	485	PF00917	0.431
DOC_USP7_MATH_1	526	530	PF00917	0.503
DOC_WW_Pin1_4	134	139	PF00397	0.451
DOC_WW_Pin1_4	183	188	PF00397	0.405
DOC_WW_Pin1_4	234	239	PF00397	0.458
DOC_WW_Pin1_4	422	427	PF00397	0.423
LIG_14-3-3_CanoR_1	330	334	PF00244	0.557
LIG_14-3-3_CanoR_1	366	375	PF00244	0.408
LIG_14-3-3_CanoR_1	464	473	PF00244	0.489
LIG_14-3-3_CanoR_1	67	75	PF00244	0.443
LIG_14-3-3_CterR_2	558	560	PF00244	0.636
LIG_APCC_ABBAyCdc20_2	50	56	PF00400	0.361
LIG_BRCT_BRCA1_1	471	475	PF00533	0.491
LIG_deltaCOP1_diTrp_1	159	164	PF00928	0.450
LIG_deltaCOP1_diTrp_1	303	310	PF00928	0.526
LIG_FHA_1	111	117	PF00498	0.528
LIG_FHA_1	201	207	PF00498	0.475
LIG_FHA_1	260	266	PF00498	0.439
LIG_FHA_1	399	405	PF00498	0.475
LIG_FHA_1	44	50	PF00498	0.330
LIG_FHA_2	106	112	PF00498	0.578
LIG_FHA_2	171	177	PF00498	0.425
LIG_FHA_2	266	272	PF00498	0.454
LIG_FHA_2	291	297	PF00498	0.443
LIG_FHA_2	433	439	PF00498	0.409
LIG_LIR_Apic_2	307	313	PF02991	0.495
LIG_LIR_Apic_2	527	533	PF02991	0.461
LIG_LIR_Gen_1	172	183	PF02991	0.475
LIG_LIR_Gen_1	193	204	PF02991	0.491
LIG_LIR_Gen_1	255	266	PF02991	0.467
LIG_LIR_Gen_1	303	313	PF02991	0.497
LIG_LIR_Gen_1	373	382	PF02991	0.406
LIG_LIR_Gen_1	435	442	PF02991	0.480
LIG_LIR_Gen_1	468	477	PF02991	0.370
LIG_LIR_Nem_3	193	199	PF02991	0.516
LIG_LIR_Nem_3	230	234	PF02991	0.380
LIG_LIR_Nem_3	255	261	PF02991	0.459
LIG_LIR_Nem_3	303	308	PF02991	0.509
LIG_LIR_Nem_3	373	379	PF02991	0.423
LIG_LIR_Nem_3	435	439	PF02991	0.406
LIG_LIR_Nem_3	468	474	PF02991	0.520
LIG_LIR_Nem_3	80	86	PF02991	0.457
LIG_PCNA_yPIPBox_3	18	32	PF02747	0.322
LIG_REV1ctd_RIR_1	323	332	PF16727	0.448
LIG_SH2_CRK	471	475	PF00017	0.500
LIG_SH2_CRK	488	492	PF00017	0.424
LIG_SH2_CRK	530	534	PF00017	0.492
LIG_SH2_NCK_1	248	252	PF00017	0.397
LIG_SH2_NCK_1	488	492	PF00017	0.473
LIG_SH2_NCK_1	530	534	PF00017	0.456
LIG_SH2_NCK_1	58	62	PF00017	0.329
LIG_SH2_STAP1	171	175	PF00017	0.438
LIG_SH2_STAP1	471	475	PF00017	0.373
LIG_SH2_STAT5	196	199	PF00017	0.477
LIG_SH2_STAT5	257	260	PF00017	0.400
LIG_SH2_STAT5	86	89	PF00017	0.411
LIG_SH3_1	530	536	PF00018	0.370
LIG_SH3_3	383	389	PF00018	0.430
LIG_SH3_3	401	407	PF00018	0.523
LIG_SH3_3	420	426	PF00018	0.419
LIG_SH3_3	515	521	PF00018	0.501
LIG_SH3_3	530	536	PF00018	0.387
LIG_SUMO_SIM_anti_2	210	217	PF11976	0.500
LIG_TRAF2_1	467	470	PF00917	0.483
LIG_WRC_WIRS_1	49	54	PF05994	0.446
MOD_CK1_1	100	106	PF00069	0.502
MOD_CK1_1	110	116	PF00069	0.503
MOD_CK1_1	290	296	PF00069	0.434
MOD_CK1_1	463	469	PF00069	0.467
MOD_CK1_1	531	537	PF00069	0.480
MOD_CK2_1	16	22	PF00069	0.402
MOD_CK2_1	265	271	PF00069	0.474
MOD_CK2_1	329	335	PF00069	0.462
MOD_CK2_1	352	358	PF00069	0.433
MOD_CK2_1	374	380	PF00069	0.349
MOD_CK2_1	463	469	PF00069	0.602
MOD_CMANNOS	161	164	PF00535	0.675
MOD_Cter_Amidation	93	96	PF01082	0.548
MOD_GlcNHglycan	167	170	PF01048	0.692
MOD_GlcNHglycan	18	21	PF01048	0.705
MOD_GlcNHglycan	190	193	PF01048	0.642
MOD_GlcNHglycan	262	265	PF01048	0.662
MOD_GlcNHglycan	530	533	PF01048	0.648
MOD_GlcNHglycan	68	71	PF01048	0.541
MOD_GlcNHglycan	99	102	PF01048	0.655
MOD_GSK3_1	116	123	PF00069	0.520
MOD_GSK3_1	12	19	PF00069	0.512
MOD_GSK3_1	186	193	PF00069	0.532
MOD_GSK3_1	249	256	PF00069	0.494
MOD_GSK3_1	290	297	PF00069	0.577
MOD_GSK3_1	366	373	PF00069	0.455
MOD_GSK3_1	460	467	PF00069	0.518
MOD_GSK3_1	66	73	PF00069	0.565
MOD_LATS_1	273	279	PF00433	0.426
MOD_N-GLC_1	119	124	PF02516	0.641
MOD_N-GLC_1	200	205	PF02516	0.607
MOD_N-GLC_1	70	75	PF02516	0.660
MOD_NEK2_1	219	224	PF00069	0.455
MOD_NEK2_1	368	373	PF00069	0.434
MOD_NEK2_1	475	480	PF00069	0.491
MOD_NEK2_1	66	71	PF00069	0.530
MOD_NEK2_2	190	195	PF00069	0.407
MOD_PIKK_1	221	227	PF00454	0.425
MOD_PIKK_1	366	372	PF00454	0.507
MOD_PIKK_1	450	456	PF00454	0.542
MOD_PKA_2	298	304	PF00069	0.458
MOD_PKA_2	329	335	PF00069	0.526
MOD_PKA_2	463	469	PF00069	0.564
MOD_PKA_2	475	481	PF00069	0.408
MOD_PKA_2	66	72	PF00069	0.494
MOD_Plk_1	105	111	PF00069	0.518
MOD_Plk_1	219	225	PF00069	0.462
MOD_Plk_1	469	475	PF00069	0.489
MOD_Plk_1	526	532	PF00069	0.386
MOD_Plk_2-3	74	80	PF00069	0.453
MOD_Plk_4	249	255	PF00069	0.444
MOD_Plk_4	275	281	PF00069	0.471
MOD_Plk_4	329	335	PF00069	0.536
MOD_Plk_4	352	358	PF00069	0.430
MOD_Plk_4	371	377	PF00069	0.369
MOD_Plk_4	432	438	PF00069	0.480
MOD_Plk_4	469	475	PF00069	0.489
MOD_ProDKin_1	134	140	PF00069	0.449
MOD_ProDKin_1	183	189	PF00069	0.404
MOD_ProDKin_1	234	240	PF00069	0.457
MOD_ProDKin_1	422	428	PF00069	0.425
MOD_SUMO_for_1	132	135	PF00179	0.422
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.369
TRG_DiLeu_BaLyEn_6	494	499	PF01217	0.483
TRG_ENDOCYTIC_2	196	199	PF00928	0.551
TRG_ENDOCYTIC_2	376	379	PF00928	0.458
TRG_ENDOCYTIC_2	471	474	PF00928	0.446
TRG_ENDOCYTIC_2	488	491	PF00928	0.444
TRG_ER_diArg_1	493	495	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	501	506	PF00026	0.674
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P605	Leptomonas seymouri	35%	100%
A0A1X0NTG4	Trypanosomatidae	25%	100%
A0A3S7WUI7	Leishmania donovani	89%	100%
A4H941	Leishmania braziliensis	71%	100%
A4HXG6	Leishmania infantum	89%	100%
C9ZP51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
Q4QEA2	Leishmania major	88%	100%