META domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AR60_LEIMU

TriTrypDb:

LmxM.17.0870

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AR60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR60

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006979	response to oxidative stress	3	1
GO:0009266	response to temperature stimulus	3	1
GO:0009408	response to heat	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034599	cellular response to oxidative stress	4	1
GO:0034605	cellular response to heat	4	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0062197	cellular response to chemical stress	4	1
GO:0070887	cellular response to chemical stimulus	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	398	402	PF00656	0.474
CLV_PCSK_SKI1_1	328	332	PF00082	0.512
CLV_PCSK_SKI1_1	353	357	PF00082	0.418
CLV_PCSK_SKI1_1	373	377	PF00082	0.205
DOC_MAPK_MEF2A_6	243	250	PF00069	0.510
DOC_MAPK_MEF2A_6	412	419	PF00069	0.469
DOC_USP7_MATH_1	101	105	PF00917	0.332
DOC_USP7_MATH_1	178	182	PF00917	0.451
DOC_USP7_MATH_1	284	288	PF00917	0.457
DOC_USP7_MATH_1	71	75	PF00917	0.515
DOC_WW_Pin1_4	126	131	PF00397	0.315
DOC_WW_Pin1_4	136	141	PF00397	0.394
DOC_WW_Pin1_4	18	23	PF00397	0.237
DOC_WW_Pin1_4	66	71	PF00397	0.412
LIG_14-3-3_CanoR_1	10	20	PF00244	0.418
LIG_14-3-3_CanoR_1	219	226	PF00244	0.607
LIG_14-3-3_CanoR_1	386	392	PF00244	0.461
LIG_Actin_WH2_2	83	101	PF00022	0.469
LIG_AP2alpha_1	83	87	PF02296	0.469
LIG_BIR_III_2	440	444	PF00653	0.523
LIG_BRCT_BRCA1_1	103	107	PF00533	0.491
LIG_BRCT_BRCA1_1	189	193	PF00533	0.475
LIG_BRCT_BRCA1_1	246	250	PF00533	0.380
LIG_BRCT_BRCA1_1	79	83	PF00533	0.475
LIG_deltaCOP1_diTrp_1	371	376	PF00928	0.358
LIG_FHA_1	147	153	PF00498	0.407
LIG_FHA_1	24	30	PF00498	0.436
LIG_FHA_1	253	259	PF00498	0.419
LIG_FHA_1	269	275	PF00498	0.360
LIG_FHA_1	286	292	PF00498	0.277
LIG_FHA_1	378	384	PF00498	0.494
LIG_FHA_2	1	7	PF00498	0.588
LIG_FHA_2	291	297	PF00498	0.519
LIG_FHA_2	62	68	PF00498	0.510
LIG_GBD_Chelix_1	89	97	PF00786	0.396
LIG_Integrin_RGD_1	168	170	PF01839	0.412
LIG_LIR_Gen_1	326	337	PF02991	0.545
LIG_LIR_Gen_1	85	93	PF02991	0.469
LIG_LIR_Nem_3	247	253	PF02991	0.538
LIG_LIR_Nem_3	326	332	PF02991	0.526
LIG_LIR_Nem_3	371	377	PF02991	0.383
LIG_LIR_Nem_3	85	90	PF02991	0.469
LIG_LRP6_Inhibitor_1	263	269	PF00058	0.412
LIG_Pex14_2	107	111	PF04695	0.237
LIG_Pex14_2	193	197	PF04695	0.475
LIG_Pex14_2	303	307	PF04695	0.372
LIG_Pex14_2	83	87	PF04695	0.401
LIG_SH2_GRB2like	52	55	PF00017	0.475
LIG_SH2_STAP1	413	417	PF00017	0.237
LIG_SH2_STAT3	439	442	PF00017	0.451
LIG_SH2_STAT5	11	14	PF00017	0.469
LIG_SH2_STAT5	230	233	PF00017	0.416
LIG_SH3_3	246	252	PF00018	0.332
LIG_SUMO_SIM_anti_2	259	264	PF11976	0.548
LIG_SUMO_SIM_par_1	121	127	PF11976	0.504
LIG_TRAF2_1	130	133	PF00917	0.515
LIG_TRAF2_1	280	283	PF00917	0.475
LIG_TRAF2_1	293	296	PF00917	0.300
LIG_TRAF2_1	70	73	PF00917	0.475
LIG_WRC_WIRS_1	232	237	PF05994	0.469
MOD_CDK_SPxK_1	18	24	PF00069	0.237
MOD_CK1_1	146	152	PF00069	0.513
MOD_CK1_1	60	66	PF00069	0.544
MOD_CK2_1	221	227	PF00069	0.451
MOD_CK2_1	277	283	PF00069	0.431
MOD_CK2_1	290	296	PF00069	0.315
MOD_CK2_1	392	398	PF00069	0.395
MOD_CK2_1	61	67	PF00069	0.494
MOD_GlcNHglycan	203	206	PF01048	0.451
MOD_GSK3_1	107	114	PF00069	0.342
MOD_GSK3_1	132	139	PF00069	0.527
MOD_GSK3_1	290	297	PF00069	0.395
MOD_GSK3_1	34	41	PF00069	0.460
MOD_GSK3_1	342	349	PF00069	0.468
MOD_GSK3_1	57	64	PF00069	0.415
MOD_N-GLC_1	101	106	PF02516	0.526
MOD_N-GLC_1	201	206	PF02516	0.469
MOD_N-GLC_1	377	382	PF02516	0.357
MOD_N-GLC_2	352	354	PF02516	0.412
MOD_NEK2_1	107	112	PF00069	0.482
MOD_NEK2_1	134	139	PF00069	0.397
MOD_NEK2_1	171	176	PF00069	0.446
MOD_NEK2_1	285	290	PF00069	0.398
MOD_NEK2_1	46	51	PF00069	0.446
MOD_NEK2_1	61	66	PF00069	0.294
MOD_NEK2_2	25	30	PF00069	0.469
MOD_PIKK_1	171	177	PF00454	0.475
MOD_PIKK_1	219	225	PF00454	0.467
MOD_PIKK_1	294	300	PF00454	0.412
MOD_PKA_2	268	274	PF00069	0.433
MOD_PKA_2	46	52	PF00069	0.438
MOD_PKA_2	9	15	PF00069	0.397
MOD_Plk_1	101	107	PF00069	0.482
MOD_Plk_1	132	138	PF00069	0.434
MOD_Plk_1	178	184	PF00069	0.475
MOD_Plk_1	258	264	PF00069	0.466
MOD_Plk_1	294	300	PF00069	0.451
MOD_Plk_1	318	324	PF00069	0.369
MOD_Plk_1	415	421	PF00069	0.406
MOD_Plk_4	101	107	PF00069	0.379
MOD_Plk_4	143	149	PF00069	0.355
MOD_Plk_4	244	250	PF00069	0.380
MOD_ProDKin_1	126	132	PF00069	0.315
MOD_ProDKin_1	136	142	PF00069	0.394
MOD_ProDKin_1	18	24	PF00069	0.237
MOD_ProDKin_1	66	72	PF00069	0.412
MOD_SUMO_for_1	355	358	PF00179	0.469
MOD_SUMO_rev_2	14	21	PF00179	0.374
MOD_SUMO_rev_2	369	375	PF00179	0.420
TRG_DiLeu_BaEn_1	358	363	PF01217	0.469
TRG_DiLeu_BaEn_4	294	300	PF01217	0.475
TRG_ER_diArg_1	383	386	PF00400	0.494
TRG_NES_CRM1_1	77	92	PF08389	0.469
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L4	Leptomonas seymouri	62%	100%
A0A1X0NSU0	Trypanosomatidae	36%	100%
A0A3Q8IAQ3	Leishmania donovani	93%	100%
A0A422NH16	Trypanosoma rangeli	34%	100%
A4H951	Leishmania braziliensis	80%	100%
A4HXG5	Leishmania infantum	93%	100%
C9ZP52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4QEA3	Leishmania major	93%	100%