Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AR57_LEIMU

TriTrypDb:

LmxM.17.0840

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AR57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	370	374	PF00656	0.515
CLV_C14_Caspase3-7	386	390	PF00656	0.653
CLV_NRD_NRD_1	106	108	PF00675	0.558
CLV_NRD_NRD_1	18	20	PF00675	0.622
CLV_NRD_NRD_1	190	192	PF00675	0.536
CLV_NRD_NRD_1	193	195	PF00675	0.628
CLV_NRD_NRD_1	319	321	PF00675	0.411
CLV_NRD_NRD_1	342	344	PF00675	0.397
CLV_PCSK_FUR_1	191	195	PF00082	0.697
CLV_PCSK_KEX2_1	106	108	PF00082	0.578
CLV_PCSK_KEX2_1	18	20	PF00082	0.580
CLV_PCSK_KEX2_1	192	194	PF00082	0.625
CLV_PCSK_KEX2_1	3	5	PF00082	0.739
CLV_PCSK_KEX2_1	319	321	PF00082	0.411
CLV_PCSK_KEX2_1	342	344	PF00082	0.397
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.625
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.724
CLV_PCSK_SKI1_1	133	137	PF00082	0.631
CLV_PCSK_SKI1_1	138	142	PF00082	0.603
CLV_PCSK_SKI1_1	268	272	PF00082	0.595
CLV_PCSK_SKI1_1	427	431	PF00082	0.523
CLV_PCSK_SKI1_1	450	454	PF00082	0.522
CLV_PCSK_SKI1_1	504	508	PF00082	0.510
DEG_Nend_UBRbox_3	1	3	PF02207	0.515
DEG_SPOP_SBC_1	201	205	PF00917	0.679
DEG_SPOP_SBC_1	395	399	PF00917	0.700
DEG_SPOP_SBC_1	43	47	PF00917	0.777
DOC_CYCLIN_RxL_1	115	126	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	464	470	PF00134	0.554
DOC_MAPK_DCC_7	475	484	PF00069	0.512
DOC_MAPK_gen_1	115	124	PF00069	0.561
DOC_MAPK_gen_1	145	153	PF00069	0.549
DOC_MAPK_gen_1	319	326	PF00069	0.385
DOC_MAPK_gen_1	416	425	PF00069	0.435
DOC_MAPK_HePTP_8	472	484	PF00069	0.405
DOC_MAPK_MEF2A_6	475	484	PF00069	0.400
DOC_PP1_RVXF_1	118	125	PF00149	0.573
DOC_PP2B_LxvP_1	519	522	PF13499	0.617
DOC_PP4_FxxP_1	255	258	PF00568	0.556
DOC_PP4_FxxP_1	26	29	PF00568	0.726
DOC_PP4_FxxP_1	318	321	PF00568	0.397
DOC_USP7_MATH_1	116	120	PF00917	0.594
DOC_USP7_MATH_1	17	21	PF00917	0.664
DOC_USP7_MATH_1	201	205	PF00917	0.779
DOC_USP7_MATH_1	209	213	PF00917	0.733
DOC_USP7_MATH_1	264	268	PF00917	0.590
DOC_USP7_MATH_1	281	285	PF00917	0.422
DOC_USP7_MATH_1	294	298	PF00917	0.695
DOC_USP7_MATH_1	304	308	PF00917	0.385
DOC_USP7_MATH_1	367	371	PF00917	0.562
DOC_USP7_MATH_1	395	399	PF00917	0.700
DOC_USP7_MATH_1	44	48	PF00917	0.655
DOC_USP7_UBL2_3	109	113	PF12436	0.588
DOC_USP7_UBL2_3	53	57	PF12436	0.694
DOC_WW_Pin1_4	254	259	PF00397	0.544
DOC_WW_Pin1_4	275	280	PF00397	0.473
DOC_WW_Pin1_4	311	316	PF00397	0.475
DOC_WW_Pin1_4	355	360	PF00397	0.615
LIG_14-3-3_CanoR_1	191	197	PF00244	0.624
LIG_14-3-3_CanoR_1	200	209	PF00244	0.699
LIG_14-3-3_CanoR_1	394	404	PF00244	0.611
LIG_14-3-3_CanoR_1	427	433	PF00244	0.434
LIG_APCC_ABBA_1	121	126	PF00400	0.592
LIG_APCC_ABBAyCdc20_2	120	126	PF00400	0.585
LIG_BRCT_BRCA1_1	240	244	PF00533	0.466
LIG_BRCT_BRCA1_1	306	310	PF00533	0.599
LIG_BRCT_BRCA1_1	455	459	PF00533	0.355
LIG_BRCT_BRCA1_1	76	80	PF00533	0.609
LIG_EH_1	77	81	PF12763	0.635
LIG_FHA_1	169	175	PF00498	0.649
LIG_FHA_1	226	232	PF00498	0.773
LIG_FHA_1	264	270	PF00498	0.516
LIG_FHA_1	469	475	PF00498	0.559
LIG_FHA_2	288	294	PF00498	0.740
LIG_FHA_2	384	390	PF00498	0.684
LIG_GBD_Chelix_1	490	498	PF00786	0.438
LIG_LIR_Apic_2	23	29	PF02991	0.725
LIG_LIR_Apic_2	316	321	PF02991	0.438
LIG_LIR_Gen_1	139	149	PF02991	0.533
LIG_LIR_Gen_1	307	318	PF02991	0.526
LIG_LIR_Gen_1	466	477	PF02991	0.569
LIG_LIR_Nem_3	139	144	PF02991	0.530
LIG_LIR_Nem_3	241	247	PF02991	0.456
LIG_LIR_Nem_3	307	313	PF02991	0.461
LIG_LIR_Nem_3	338	344	PF02991	0.377
LIG_LIR_Nem_3	466	472	PF02991	0.561
LIG_LIR_Nem_3	95	99	PF02991	0.656
LIG_MYND_1	351	355	PF01753	0.552
LIG_NRBOX	268	274	PF00104	0.592
LIG_Pex14_2	282	286	PF04695	0.658
LIG_SH2_CRK	469	473	PF00017	0.443
LIG_SH2_GRB2like	165	168	PF00017	0.533
LIG_SH2_NCK_1	99	103	PF00017	0.656
LIG_SH2_PTP2	356	359	PF00017	0.503
LIG_SH2_STAT5	146	149	PF00017	0.539
LIG_SH2_STAT5	165	168	PF00017	0.533
LIG_SH2_STAT5	285	288	PF00017	0.683
LIG_SH2_STAT5	356	359	PF00017	0.498
LIG_SH2_STAT5	424	427	PF00017	0.409
LIG_SH2_STAT5	477	480	PF00017	0.416
LIG_SH2_STAT5	518	521	PF00017	0.588
LIG_SH3_2	14	19	PF14604	0.724
LIG_SH3_3	11	17	PF00018	0.696
LIG_SH3_3	91	97	PF00018	0.696
LIG_SH3_CIN85_PxpxPR_1	13	18	PF14604	0.717
LIG_SUMO_SIM_par_1	401	408	PF11976	0.415
LIG_TRAF2_1	102	105	PF00917	0.593
LIG_TRAF2_1	290	293	PF00917	0.662
LIG_TRAF2_2	360	365	PF00917	0.434
LIG_UBA3_1	325	332	PF00899	0.546
MOD_CDK_SPK_2	254	259	PF00069	0.308
MOD_CK1_1	20	26	PF00069	0.665
MOD_CK1_1	202	208	PF00069	0.728
MOD_CK1_1	257	263	PF00069	0.537
MOD_CK1_1	369	375	PF00069	0.724
MOD_CK1_1	383	389	PF00069	0.657
MOD_CK1_1	398	404	PF00069	0.530
MOD_CK1_1	408	414	PF00069	0.355
MOD_CK1_1	433	439	PF00069	0.537
MOD_CK1_1	95	101	PF00069	0.619
MOD_CK2_1	287	293	PF00069	0.718
MOD_CK2_1	442	448	PF00069	0.430
MOD_CK2_1	82	88	PF00069	0.511
MOD_Cter_Amidation	50	53	PF01082	0.702
MOD_GlcNHglycan	19	22	PF01048	0.650
MOD_GlcNHglycan	194	197	PF01048	0.691
MOD_GlcNHglycan	211	214	PF01048	0.724
MOD_GlcNHglycan	215	218	PF01048	0.762
MOD_GlcNHglycan	241	244	PF01048	0.397
MOD_GlcNHglycan	261	264	PF01048	0.580
MOD_GlcNHglycan	296	299	PF01048	0.671
MOD_GlcNHglycan	369	372	PF01048	0.722
MOD_GlcNHglycan	382	385	PF01048	0.658
MOD_GlcNHglycan	389	393	PF01048	0.713
MOD_GlcNHglycan	410	413	PF01048	0.489
MOD_GlcNHglycan	437	440	PF01048	0.587
MOD_GlcNHglycan	494	497	PF01048	0.433
MOD_GlcNHglycan	59	63	PF01048	0.756
MOD_GSK3_1	199	206	PF00069	0.742
MOD_GSK3_1	209	216	PF00069	0.770
MOD_GSK3_1	259	266	PF00069	0.545
MOD_GSK3_1	271	278	PF00069	0.492
MOD_GSK3_1	281	288	PF00069	0.494
MOD_GSK3_1	294	301	PF00069	0.633
MOD_GSK3_1	304	311	PF00069	0.390
MOD_GSK3_1	363	370	PF00069	0.685
MOD_GSK3_1	394	401	PF00069	0.672
MOD_GSK3_1	428	435	PF00069	0.436
MOD_GSK3_1	455	462	PF00069	0.379
MOD_GSK3_1	82	89	PF00069	0.541
MOD_NEK2_1	238	243	PF00069	0.600
MOD_NEK2_1	309	314	PF00069	0.577
MOD_NEK2_1	423	428	PF00069	0.411
MOD_NEK2_1	432	437	PF00069	0.464
MOD_NEK2_1	453	458	PF00069	0.415
MOD_NEK2_1	459	464	PF00069	0.418
MOD_NEK2_1	468	473	PF00069	0.451
MOD_NEK2_1	58	63	PF00069	0.776
MOD_PIKK_1	324	330	PF00454	0.370
MOD_PIKK_1	332	338	PF00454	0.397
MOD_PIKK_1	430	436	PF00454	0.539
MOD_PIKK_1	459	465	PF00454	0.490
MOD_PKA_1	192	198	PF00069	0.715
MOD_PKA_2	17	23	PF00069	0.653
MOD_PKA_2	192	198	PF00069	0.715
MOD_PKA_2	199	205	PF00069	0.753
MOD_PKA_2	294	300	PF00069	0.712
MOD_PKB_1	198	206	PF00069	0.719
MOD_Plk_1	298	304	PF00069	0.406
MOD_Plk_2-3	442	448	PF00069	0.581
MOD_Plk_4	268	274	PF00069	0.535
MOD_Plk_4	281	287	PF00069	0.489
MOD_Plk_4	313	319	PF00069	0.534
MOD_Plk_4	373	379	PF00069	0.473
MOD_Plk_4	455	461	PF00069	0.353
MOD_Plk_4	506	512	PF00069	0.474
MOD_ProDKin_1	254	260	PF00069	0.540
MOD_ProDKin_1	275	281	PF00069	0.467
MOD_ProDKin_1	311	317	PF00069	0.473
MOD_ProDKin_1	355	361	PF00069	0.629
MOD_SUMO_for_1	114	117	PF00179	0.624
MOD_SUMO_rev_2	105	114	PF00179	0.550
MOD_SUMO_rev_2	168	177	PF00179	0.540
MOD_SUMO_rev_2	442	452	PF00179	0.590
MOD_SUMO_rev_2	500	506	PF00179	0.569
TRG_AP2beta_CARGO_1	139	148	PF09066	0.533
TRG_ENDOCYTIC_2	417	420	PF00928	0.429
TRG_ENDOCYTIC_2	469	472	PF00928	0.440
TRG_ER_diArg_1	17	19	PF00400	0.662
TRG_ER_diArg_1	191	194	PF00400	0.687
TRG_ER_diArg_1	197	200	PF00400	0.762
TRG_ER_diArg_1	318	320	PF00400	0.415
TRG_ER_diArg_1	341	343	PF00400	0.391
TRG_NLS_MonoCore_2	190	195	PF00514	0.674
TRG_NLS_MonoExtN_4	191	196	PF00514	0.705
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD84	Leptomonas seymouri	62%	100%
A0A1X0NST3	Trypanosomatidae	45%	98%
A0A3S5IR66	Trypanosoma rangeli	47%	99%
A0A3S7WUG6	Leishmania donovani	90%	100%
A4H948	Leishmania braziliensis	79%	100%
A4HXG2	Leishmania infantum	90%	100%
C9ZP42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	99%
Q4QEA6	Leishmania major	91%	100%
V5AQX9	Trypanosoma cruzi	47%	99%