DBR1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AR56_LEIMU

TriTrypDb:

LmxM.17.0830

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AR56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR56

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006397	mRNA processing	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016071	mRNA metabolic process	6	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0008380	RNA splicing	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004521	RNA endonuclease activity	5	7
GO:0004540	RNA nuclease activity	4	7
GO:0008419	RNA lariat debranching enzyme activity	7	7
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	7
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	7
GO:0140098	catalytic activity, acting on RNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	601	605	PF00656	0.616
CLV_NRD_NRD_1	214	216	PF00675	0.367
CLV_NRD_NRD_1	288	290	PF00675	0.490
CLV_NRD_NRD_1	365	367	PF00675	0.349
CLV_NRD_NRD_1	402	404	PF00675	0.431
CLV_NRD_NRD_1	504	506	PF00675	0.637
CLV_NRD_NRD_1	72	74	PF00675	0.341
CLV_PCSK_FUR_1	363	367	PF00082	0.291
CLV_PCSK_FUR_1	400	404	PF00082	0.336
CLV_PCSK_KEX2_1	214	216	PF00082	0.404
CLV_PCSK_KEX2_1	288	290	PF00082	0.490
CLV_PCSK_KEX2_1	365	367	PF00082	0.376
CLV_PCSK_KEX2_1	402	404	PF00082	0.336
CLV_PCSK_KEX2_1	504	506	PF00082	0.710
CLV_PCSK_KEX2_1	77	79	PF00082	0.444
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.407
CLV_PCSK_PC7_1	73	79	PF00082	0.427
CLV_PCSK_SKI1_1	289	293	PF00082	0.476
CLV_PCSK_SKI1_1	348	352	PF00082	0.287
CLV_PCSK_SKI1_1	437	441	PF00082	0.466
CLV_PCSK_SKI1_1	447	451	PF00082	0.551
CLV_Separin_Metazoa	409	413	PF03568	0.391
DEG_ODPH_VHL_1	458	471	PF01847	0.428
DEG_SPOP_SBC_1	381	385	PF00917	0.177
DEG_SPOP_SBC_1	545	549	PF00917	0.630
DEG_SPOP_SBC_1	582	586	PF00917	0.647
DOC_MAPK_gen_1	348	358	PF00069	0.298
DOC_MAPK_gen_1	400	410	PF00069	0.391
DOC_MAPK_gen_1	73	83	PF00069	0.562
DOC_MAPK_gen_1	92	102	PF00069	0.343
DOC_MAPK_MEF2A_6	402	410	PF00069	0.352
DOC_MAPK_MEF2A_6	74	83	PF00069	0.240
DOC_PP2B_LxvP_1	457	460	PF13499	0.439
DOC_PP4_FxxP_1	157	160	PF00568	0.325
DOC_PP4_FxxP_1	186	189	PF00568	0.434
DOC_PP4_FxxP_1	19	22	PF00568	0.593
DOC_USP7_MATH_1	117	121	PF00917	0.503
DOC_USP7_MATH_1	150	154	PF00917	0.345
DOC_USP7_MATH_1	206	210	PF00917	0.460
DOC_USP7_MATH_1	304	308	PF00917	0.396
DOC_USP7_MATH_1	337	341	PF00917	0.569
DOC_USP7_MATH_1	34	38	PF00917	0.684
DOC_USP7_MATH_1	381	385	PF00917	0.465
DOC_USP7_MATH_1	40	44	PF00917	0.684
DOC_USP7_MATH_1	545	549	PF00917	0.684
DOC_USP7_MATH_1	609	613	PF00917	0.566
DOC_USP7_UBL2_3	280	284	PF12436	0.356
DOC_WW_Pin1_4	18	23	PF00397	0.708
DOC_WW_Pin1_4	244	249	PF00397	0.684
DOC_WW_Pin1_4	36	41	PF00397	0.436
DOC_WW_Pin1_4	469	474	PF00397	0.447
DOC_WW_Pin1_4	483	488	PF00397	0.624
DOC_WW_Pin1_4	495	500	PF00397	0.770
DOC_WW_Pin1_4	546	551	PF00397	0.636
DOC_WW_Pin1_4	592	597	PF00397	0.562
LIG_14-3-3_CanoR_1	412	418	PF00244	0.489
LIG_14-3-3_CanoR_1	513	519	PF00244	0.660
LIG_14-3-3_CanoR_1	536	540	PF00244	0.743
LIG_14-3-3_CanoR_1	6	12	PF00244	0.421
LIG_APCC_ABBA_1	568	573	PF00400	0.645
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BRCT_BRCA1_1	182	186	PF00533	0.333
LIG_BRCT_BRCA1_1	306	310	PF00533	0.377
LIG_BRCT_BRCA1_1	339	343	PF00533	0.336
LIG_BRCT_BRCA1_1	413	417	PF00533	0.336
LIG_BRCT_BRCA1_1	594	598	PF00533	0.596
LIG_FHA_1	134	140	PF00498	0.353
LIG_FHA_1	226	232	PF00498	0.425
LIG_FHA_1	295	301	PF00498	0.385
LIG_FHA_1	339	345	PF00498	0.335
LIG_FHA_1	390	396	PF00498	0.421
LIG_FHA_1	460	466	PF00498	0.394
LIG_FHA_1	514	520	PF00498	0.564
LIG_FHA_1	535	541	PF00498	0.750
LIG_FHA_1	555	561	PF00498	0.605
LIG_FHA_1	563	569	PF00498	0.618
LIG_FHA_1	589	595	PF00498	0.565
LIG_FHA_2	170	176	PF00498	0.341
LIG_FHA_2	355	361	PF00498	0.376
LIG_FHA_2	501	507	PF00498	0.713
LIG_FHA_2	599	605	PF00498	0.615
LIG_FHA_2	91	97	PF00498	0.475
LIG_GBD_Chelix_1	3	11	PF00786	0.572
LIG_LIR_Apic_2	16	22	PF02991	0.587
LIG_LIR_Apic_2	183	189	PF02991	0.454
LIG_LIR_Apic_2	190	194	PF02991	0.295
LIG_LIR_Gen_1	340	350	PF02991	0.278
LIG_LIR_Gen_1	357	364	PF02991	0.245
LIG_LIR_Gen_1	404	413	PF02991	0.376
LIG_LIR_Gen_1	87	94	PF02991	0.316
LIG_LIR_Nem_3	104	109	PF02991	0.447
LIG_LIR_Nem_3	111	115	PF02991	0.387
LIG_LIR_Nem_3	152	157	PF02991	0.305
LIG_LIR_Nem_3	340	346	PF02991	0.278
LIG_LIR_Nem_3	357	361	PF02991	0.245
LIG_LIR_Nem_3	404	410	PF02991	0.408
LIG_LIR_Nem_3	46	51	PF02991	0.384
LIG_LIR_Nem_3	87	91	PF02991	0.312
LIG_Pex14_1	44	48	PF04695	0.552
LIG_Pex14_2	279	283	PF04695	0.471
LIG_SH2_CRK	106	110	PF00017	0.463
LIG_SH2_CRK	191	195	PF00017	0.399
LIG_SH2_CRK	222	226	PF00017	0.261
LIG_SH2_NCK_1	116	120	PF00017	0.420
LIG_SH2_NCK_1	191	195	PF00017	0.399
LIG_SH2_SRC	116	119	PF00017	0.407
LIG_SH2_STAT5	134	137	PF00017	0.330
LIG_SH2_STAT5	164	167	PF00017	0.323
LIG_SH2_STAT5	224	227	PF00017	0.421
LIG_SH2_STAT5	282	285	PF00017	0.383
LIG_SH2_STAT5	317	320	PF00017	0.391
LIG_SH2_STAT5	553	556	PF00017	0.664
LIG_SH3_1	191	197	PF00018	0.386
LIG_SH3_2	487	492	PF14604	0.659
LIG_SH3_3	19	25	PF00018	0.727
LIG_SH3_3	191	197	PF00018	0.386
LIG_SH3_3	319	325	PF00018	0.420
LIG_SH3_3	470	476	PF00018	0.454
LIG_SH3_3	484	490	PF00018	0.580
LIG_SH3_3	522	528	PF00018	0.671
LIG_SH3_4	280	287	PF00018	0.356
LIG_SUMO_SIM_par_1	168	175	PF11976	0.364
LIG_UBA3_1	7	12	PF00899	0.636
LIG_WRC_WIRS_1	355	360	PF05994	0.360
LIG_WRPW_2	279	282	PF00400	0.389
LIG_WW_3	195	199	PF00397	0.493
LIG_WW_3	607	611	PF00397	0.657
MOD_CDC14_SPxK_1	489	492	PF00782	0.617
MOD_CDK_SPxK_1	486	492	PF00069	0.613
MOD_CK1_1	120	126	PF00069	0.541
MOD_CK1_1	169	175	PF00069	0.457
MOD_CK1_1	233	239	PF00069	0.562
MOD_CK1_1	244	250	PF00069	0.588
MOD_CK1_1	369	375	PF00069	0.365
MOD_CK1_1	384	390	PF00069	0.360
MOD_CK1_1	486	492	PF00069	0.654
MOD_CK1_1	538	544	PF00069	0.674
MOD_CK1_1	581	587	PF00069	0.720
MOD_CK1_1	612	618	PF00069	0.594
MOD_CK2_1	232	238	PF00069	0.518
MOD_CK2_1	380	386	PF00069	0.274
MOD_CK2_1	40	46	PF00069	0.684
MOD_CK2_1	615	621	PF00069	0.666
MOD_CK2_1	64	70	PF00069	0.479
MOD_Cter_Amidation	75	78	PF01082	0.439
MOD_GlcNHglycan	118	122	PF01048	0.531
MOD_GlcNHglycan	13	16	PF01048	0.650
MOD_GlcNHglycan	182	185	PF01048	0.405
MOD_GlcNHglycan	208	211	PF01048	0.397
MOD_GlcNHglycan	243	246	PF01048	0.599
MOD_GlcNHglycan	325	328	PF01048	0.600
MOD_GlcNHglycan	36	39	PF01048	0.614
MOD_GlcNHglycan	368	371	PF01048	0.350
MOD_GlcNHglycan	374	377	PF01048	0.362
MOD_GlcNHglycan	40	43	PF01048	0.577
MOD_GlcNHglycan	452	455	PF01048	0.532
MOD_GlcNHglycan	500	503	PF01048	0.697
MOD_GlcNHglycan	565	568	PF01048	0.784
MOD_GlcNHglycan	580	583	PF01048	0.578
MOD_GlcNHglycan	586	589	PF01048	0.709
MOD_GSK3_1	117	124	PF00069	0.521
MOD_GSK3_1	165	172	PF00069	0.389
MOD_GSK3_1	23	30	PF00069	0.504
MOD_GSK3_1	232	239	PF00069	0.603
MOD_GSK3_1	240	247	PF00069	0.717
MOD_GSK3_1	32	39	PF00069	0.665
MOD_GSK3_1	323	330	PF00069	0.493
MOD_GSK3_1	365	372	PF00069	0.317
MOD_GSK3_1	380	387	PF00069	0.324
MOD_GSK3_1	534	541	PF00069	0.705
MOD_GSK3_1	574	581	PF00069	0.713
MOD_GSK3_1	584	591	PF00069	0.653
MOD_GSK3_1	594	601	PF00069	0.464
MOD_GSK3_1	609	616	PF00069	0.534
MOD_GSK3_1	7	14	PF00069	0.586
MOD_LATS_1	527	533	PF00433	0.722
MOD_N-GLC_1	420	425	PF02516	0.333
MOD_N-GLC_1	513	518	PF02516	0.617
MOD_NEK2_1	165	170	PF00069	0.324
MOD_NEK2_1	225	230	PF00069	0.455
MOD_NEK2_1	380	385	PF00069	0.209
MOD_NEK2_1	396	401	PF00069	0.431
MOD_NEK2_1	411	416	PF00069	0.211
MOD_NEK2_1	535	540	PF00069	0.581
MOD_NEK2_1	620	625	PF00069	0.692
MOD_NEK2_2	133	138	PF00069	0.315
MOD_PIKK_1	225	231	PF00454	0.398
MOD_PIKK_1	554	560	PF00454	0.648
MOD_PKA_1	365	371	PF00069	0.234
MOD_PKA_2	225	231	PF00069	0.398
MOD_PKA_2	365	371	PF00069	0.321
MOD_PKA_2	411	417	PF00069	0.326
MOD_PKA_2	450	456	PF00069	0.489
MOD_PKA_2	512	518	PF00069	0.759
MOD_PKA_2	535	541	PF00069	0.649
MOD_PKA_2	609	615	PF00069	0.604
MOD_PKA_2	72	78	PF00069	0.487
MOD_PKB_1	363	371	PF00069	0.326
MOD_Plk_1	318	324	PF00069	0.411
MOD_Plk_1	505	511	PF00069	0.627
MOD_Plk_2-3	66	72	PF00069	0.378
MOD_Plk_4	133	139	PF00069	0.325
MOD_Plk_4	166	172	PF00069	0.415
MOD_Plk_4	304	310	PF00069	0.210
MOD_Plk_4	354	360	PF00069	0.333
MOD_Plk_4	375	381	PF00069	0.226
MOD_Plk_4	391	397	PF00069	0.409
MOD_Plk_4	461	467	PF00069	0.450
MOD_Plk_4	505	511	PF00069	0.705
MOD_Plk_4	535	541	PF00069	0.532
MOD_Plk_4	615	621	PF00069	0.666
MOD_ProDKin_1	18	24	PF00069	0.709
MOD_ProDKin_1	244	250	PF00069	0.677
MOD_ProDKin_1	36	42	PF00069	0.426
MOD_ProDKin_1	469	475	PF00069	0.452
MOD_ProDKin_1	483	489	PF00069	0.627
MOD_ProDKin_1	495	501	PF00069	0.770
MOD_ProDKin_1	546	552	PF00069	0.639
MOD_ProDKin_1	592	598	PF00069	0.566
MOD_SUMO_rev_2	66	75	PF00179	0.271
TRG_DiLeu_BaEn_1	144	149	PF01217	0.374
TRG_DiLeu_BaLyEn_6	296	301	PF01217	0.458
TRG_ENDOCYTIC_2	106	109	PF00928	0.380
TRG_ENDOCYTIC_2	116	119	PF00928	0.357
TRG_ENDOCYTIC_2	134	137	PF00928	0.210
TRG_ENDOCYTIC_2	154	157	PF00928	0.176
TRG_ENDOCYTIC_2	222	225	PF00928	0.256
TRG_ER_diArg_1	213	215	PF00400	0.366
TRG_ER_diArg_1	287	289	PF00400	0.464
TRG_ER_diArg_1	362	365	PF00400	0.391
TRG_ER_diArg_1	400	403	PF00400	0.336
TRG_ER_diArg_1	528	531	PF00400	0.761
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYD2	Leptomonas seymouri	52%	100%
A0A0S4ITU3	Bodo saltans	41%	100%
A0A3R7KE78	Trypanosoma rangeli	52%	100%
A0A3S5H711	Leishmania donovani	92%	100%
A4H947	Leishmania braziliensis	82%	100%
A4HXG1	Leishmania infantum	92%	100%
C9ZP39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4QEA7	Leishmania major	92%	99%