Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AR55_LEIMU

TriTrypDb:

LmxM.17.0820

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.527
CLV_C14_Caspase3-7	347	351	PF00656	0.601
CLV_NRD_NRD_1	131	133	PF00675	0.647
CLV_NRD_NRD_1	436	438	PF00675	0.657
CLV_PCSK_KEX2_1	131	133	PF00082	0.647
CLV_PCSK_KEX2_1	436	438	PF00082	0.646
CLV_PCSK_SKI1_1	454	458	PF00082	0.644
DEG_ODPH_VHL_1	39	51	PF01847	0.497
DEG_SPOP_SBC_1	103	107	PF00917	0.618
DEG_SPOP_SBC_1	443	447	PF00917	0.662
DEG_SPOP_SBC_1	507	511	PF00917	0.627
DOC_MAPK_MEF2A_6	119	126	PF00069	0.620
DOC_USP7_MATH_1	113	117	PF00917	0.497
DOC_USP7_MATH_1	12	16	PF00917	0.611
DOC_USP7_MATH_1	176	180	PF00917	0.639
DOC_USP7_MATH_1	198	202	PF00917	0.612
DOC_USP7_MATH_1	208	212	PF00917	0.605
DOC_USP7_MATH_1	245	249	PF00917	0.714
DOC_USP7_MATH_1	283	287	PF00917	0.515
DOC_USP7_MATH_1	305	309	PF00917	0.594
DOC_USP7_MATH_1	426	430	PF00917	0.728
DOC_USP7_MATH_1	438	442	PF00917	0.660
DOC_USP7_MATH_1	458	462	PF00917	0.598
DOC_USP7_MATH_1	57	61	PF00917	0.592
DOC_WW_Pin1_4	118	123	PF00397	0.595
DOC_WW_Pin1_4	182	187	PF00397	0.641
DOC_WW_Pin1_4	192	197	PF00397	0.649
DOC_WW_Pin1_4	259	264	PF00397	0.626
DOC_WW_Pin1_4	268	273	PF00397	0.637
DOC_WW_Pin1_4	310	315	PF00397	0.621
DOC_WW_Pin1_4	69	74	PF00397	0.691
DOC_WW_Pin1_4	77	82	PF00397	0.613
LIG_14-3-3_CanoR_1	191	196	PF00244	0.649
LIG_14-3-3_CanoR_1	444	453	PF00244	0.668
LIG_14-3-3_CanoR_1	498	502	PF00244	0.625
LIG_BRCT_BRCA1_1	122	126	PF00533	0.616
LIG_BRCT_BRCA1_1	521	525	PF00533	0.622
LIG_FHA_1	178	184	PF00498	0.658
LIG_FHA_1	201	207	PF00498	0.504
LIG_FHA_1	224	230	PF00498	0.524
LIG_FHA_1	407	413	PF00498	0.485
LIG_FHA_1	83	89	PF00498	0.633
LIG_FHA_2	22	28	PF00498	0.685
LIG_Integrin_isoDGR_2	540	542	PF01839	0.728
LIG_LIR_Gen_1	47	57	PF02991	0.587
LIG_LIR_Gen_1	522	530	PF02991	0.621
LIG_LIR_LC3C_4	99	104	PF02991	0.676
LIG_LIR_Nem_3	364	369	PF02991	0.783
LIG_LIR_Nem_3	47	52	PF02991	0.588
LIG_LIR_Nem_3	522	528	PF02991	0.623
LIG_Pex14_1	240	244	PF04695	0.679
LIG_SH2_PTP2	260	263	PF00017	0.623
LIG_SH2_STAT5	260	263	PF00017	0.623
LIG_SH2_STAT5	327	330	PF00017	0.629
LIG_SH3_3	1	7	PF00018	0.634
LIG_SH3_3	17	23	PF00018	0.577
LIG_SH3_3	180	186	PF00018	0.639
LIG_SH3_3	258	264	PF00018	0.631
LIG_SH3_3	374	380	PF00018	0.611
LIG_SH3_3	413	419	PF00018	0.553
LIG_SH3_3	447	453	PF00018	0.643
LIG_SUMO_SIM_anti_2	219	226	PF11976	0.531
LIG_TRAF2_1	19	22	PF00917	0.699
LIG_TRAF2_1	40	43	PF00917	0.599
MOD_CDK_SPK_2	268	273	PF00069	0.637
MOD_CK1_1	143	149	PF00069	0.552
MOD_CK1_1	179	185	PF00069	0.697
MOD_CK1_1	202	208	PF00069	0.621
MOD_CK1_1	223	229	PF00069	0.602
MOD_CK1_1	253	259	PF00069	0.807
MOD_CK1_1	271	277	PF00069	0.525
MOD_CK1_1	281	287	PF00069	0.625
MOD_CK1_1	310	316	PF00069	0.727
MOD_CK1_1	388	394	PF00069	0.705
MOD_CK1_1	481	487	PF00069	0.635
MOD_CK1_1	496	502	PF00069	0.619
MOD_CK1_1	519	525	PF00069	0.620
MOD_CK1_1	82	88	PF00069	0.636
MOD_CK1_1	96	102	PF00069	0.600
MOD_CK2_1	487	493	PF00069	0.639
MOD_GlcNHglycan	110	113	PF01048	0.576
MOD_GlcNHglycan	142	145	PF01048	0.675
MOD_GlcNHglycan	160	163	PF01048	0.671
MOD_GlcNHglycan	172	175	PF01048	0.577
MOD_GlcNHglycan	210	213	PF01048	0.563
MOD_GlcNHglycan	273	276	PF01048	0.635
MOD_GlcNHglycan	285	288	PF01048	0.615
MOD_GlcNHglycan	300	303	PF01048	0.593
MOD_GlcNHglycan	387	390	PF01048	0.635
MOD_GlcNHglycan	438	441	PF01048	0.644
MOD_GlcNHglycan	446	449	PF01048	0.654
MOD_GlcNHglycan	483	486	PF01048	0.627
MOD_GlcNHglycan	488	492	PF01048	0.615
MOD_GlcNHglycan	510	513	PF01048	0.627
MOD_GlcNHglycan	60	63	PF01048	0.631
MOD_GlcNHglycan	81	84	PF01048	0.646
MOD_GlcNHglycan	99	102	PF01048	0.601
MOD_GSK3_1	104	111	PF00069	0.697
MOD_GSK3_1	172	179	PF00069	0.605
MOD_GSK3_1	198	205	PF00069	0.525
MOD_GSK3_1	283	290	PF00069	0.616
MOD_GSK3_1	322	329	PF00069	0.719
MOD_GSK3_1	339	346	PF00069	0.571
MOD_GSK3_1	428	435	PF00069	0.646
MOD_GSK3_1	438	445	PF00069	0.784
MOD_GSK3_1	487	494	PF00069	0.614
MOD_GSK3_1	508	515	PF00069	0.627
MOD_GSK3_1	516	523	PF00069	0.618
MOD_GSK3_1	69	76	PF00069	0.661
MOD_GSK3_1	93	100	PF00069	0.769
MOD_N-GLC_1	481	486	PF02516	0.625
MOD_N-GLC_1	512	517	PF02516	0.623
MOD_N-GLC_1	69	74	PF02516	0.707
MOD_NEK2_1	102	107	PF00069	0.706
MOD_NEK2_1	298	303	PF00069	0.653
MOD_NEK2_1	508	513	PF00069	0.628
MOD_NEK2_1	520	525	PF00069	0.622
MOD_PIKK_1	143	149	PF00454	0.552
MOD_PK_1	132	138	PF00069	0.628
MOD_PKA_1	436	442	PF00069	0.716
MOD_PKA_2	190	196	PF00069	0.648
MOD_PKA_2	340	346	PF00069	0.606
MOD_PKA_2	353	359	PF00069	0.602
MOD_PKA_2	436	442	PF00069	0.689
MOD_PKA_2	443	449	PF00069	0.629
MOD_PKA_2	497	503	PF00069	0.624
MOD_PKB_1	69	77	PF00069	0.726
MOD_Plk_1	220	226	PF00069	0.529
MOD_Plk_1	481	487	PF00069	0.653
MOD_Plk_1	516	522	PF00069	0.619
MOD_Plk_2-3	21	27	PF00069	0.648
MOD_Plk_4	120	126	PF00069	0.590
MOD_Plk_4	220	226	PF00069	0.529
MOD_Plk_4	293	299	PF00069	0.671
MOD_Plk_4	520	526	PF00069	0.623
MOD_ProDKin_1	118	124	PF00069	0.594
MOD_ProDKin_1	182	188	PF00069	0.640
MOD_ProDKin_1	192	198	PF00069	0.647
MOD_ProDKin_1	259	265	PF00069	0.626
MOD_ProDKin_1	268	274	PF00069	0.637
MOD_ProDKin_1	310	316	PF00069	0.622
MOD_ProDKin_1	69	75	PF00069	0.692
MOD_ProDKin_1	77	83	PF00069	0.612
MOD_SUMO_for_1	456	459	PF00179	0.718
TRG_DiLeu_BaEn_1	220	225	PF01217	0.530
TRG_DiLeu_BaEn_4	220	226	PF01217	0.529
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.527
TRG_ER_diArg_1	131	133	PF00400	0.647
TRG_ER_diArg_1	436	438	PF00400	0.722
TRG_ER_diArg_1	470	473	PF00400	0.628
TRG_ER_diArg_1	68	71	PF00400	0.730
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I516	Leptomonas seymouri	58%	98%
A0A3Q8IJG5	Leishmania donovani	96%	92%
A4H946	Leishmania braziliensis	85%	100%
A4HXG0	Leishmania infantum	96%	100%
Q4QEA8	Leishmania major	95%	100%