G-patch domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

G-patch domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AR54_LEIMU

TriTrypDb:

LmxM.17.0815

Length:

207

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AR54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR54

Function

Biological processes
Term	Name	Level	Count
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0090069	regulation of ribosome biogenesis	5	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.594
CLV_C14_Caspase3-7	155	159	PF00656	0.697
CLV_NRD_NRD_1	139	141	PF00675	0.660
CLV_NRD_NRD_1	35	37	PF00675	0.369
CLV_NRD_NRD_1	75	77	PF00675	0.639
CLV_PCSK_FUR_1	137	141	PF00082	0.658
CLV_PCSK_KEX2_1	136	138	PF00082	0.730
CLV_PCSK_KEX2_1	139	141	PF00082	0.732
CLV_PCSK_KEX2_1	160	162	PF00082	0.720
CLV_PCSK_KEX2_1	201	203	PF00082	0.543
CLV_PCSK_KEX2_1	35	37	PF00082	0.344
CLV_PCSK_KEX2_1	77	79	PF00082	0.602
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.730
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.720
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.642
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.615
CLV_PCSK_PC7_1	132	138	PF00082	0.767
CLV_PCSK_PC7_1	156	162	PF00082	0.677
CLV_PCSK_SKI1_1	132	136	PF00082	0.524
CLV_PCSK_SKI1_1	176	180	PF00082	0.541
DEG_SPOP_SBC_1	113	117	PF00917	0.669
DOC_MAPK_MEF2A_6	122	131	PF00069	0.480
DOC_USP7_MATH_1	113	117	PF00917	0.779
DOC_USP7_UBL2_3	122	126	PF12436	0.724
DOC_USP7_UBL2_3	28	32	PF12436	0.397
DOC_USP7_UBL2_3	7	11	PF12436	0.444
DOC_USP7_UBL2_3	73	77	PF12436	0.571
DOC_WW_Pin1_4	141	146	PF00397	0.727
LIG_14-3-3_CanoR_1	139	145	PF00244	0.690
LIG_14-3-3_CanoR_1	172	179	PF00244	0.548
LIG_BIR_II_1	1	5	PF00653	0.549
LIG_FHA_1	57	63	PF00498	0.637
LIG_FHA_2	32	38	PF00498	0.369
LIG_LIR_Gen_1	29	38	PF02991	0.344
LIG_LIR_Nem_3	29	33	PF02991	0.344
LIG_LIR_Nem_3	65	71	PF02991	0.555
LIG_SH2_CRK	68	72	PF00017	0.587
LIG_SH2_PTP2	30	33	PF00017	0.369
LIG_SH2_STAT5	166	169	PF00017	0.422
LIG_SH2_STAT5	30	33	PF00017	0.369
MOD_CK1_1	104	110	PF00069	0.678
MOD_CK1_1	111	117	PF00069	0.650
MOD_CK1_1	118	124	PF00069	0.601
MOD_CK1_1	143	149	PF00069	0.672
MOD_CK1_1	159	165	PF00069	0.666
MOD_CK1_1	55	61	PF00069	0.611
MOD_CK2_1	118	124	PF00069	0.691
MOD_CK2_1	159	165	PF00069	0.653
MOD_CK2_1	171	177	PF00069	0.595
MOD_CK2_1	90	96	PF00069	0.736
MOD_GlcNHglycan	1	4	PF01048	0.532
MOD_GlcNHglycan	110	113	PF01048	0.686
MOD_GlcNHglycan	117	120	PF01048	0.636
MOD_GlcNHglycan	23	27	PF01048	0.448
MOD_GSK3_1	101	108	PF00069	0.669
MOD_GSK3_1	111	118	PF00069	0.607
MOD_GSK3_1	139	146	PF00069	0.631
MOD_GSK3_1	22	29	PF00069	0.401
MOD_GSK3_1	52	59	PF00069	0.708
MOD_N-GLC_1	90	95	PF02516	0.529
MOD_NEK2_1	56	61	PF00069	0.635
MOD_PKA_1	139	145	PF00069	0.487
MOD_PKA_2	139	145	PF00069	0.534
MOD_PKA_2	171	177	PF00069	0.601
MOD_PKA_2	79	85	PF00069	0.647
MOD_PKB_1	137	145	PF00069	0.485
MOD_Plk_1	168	174	PF00069	0.558
MOD_Plk_4	26	32	PF00069	0.369
MOD_ProDKin_1	141	147	PF00069	0.729
MOD_SUMO_rev_2	114	123	PF00179	0.715
MOD_SUMO_rev_2	152	162	PF00179	0.766
TRG_ENDOCYTIC_2	30	33	PF00928	0.369
TRG_ENDOCYTIC_2	68	71	PF00928	0.551
TRG_ER_diArg_1	137	140	PF00400	0.661
TRG_ER_diArg_1	192	195	PF00400	0.587
TRG_NLS_MonoExtC_3	135	140	PF00514	0.706
TRG_NLS_MonoExtC_3	159	165	PF00514	0.713
TRG_NLS_MonoExtC_3	75	80	PF00514	0.662
TRG_NLS_MonoExtN_4	73	80	PF00514	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6K7	Leptomonas seymouri	56%	99%
A0A0S4J7Y3	Bodo saltans	31%	100%
A0A3S5H710	Leishmania donovani	90%	100%
A4H945	Leishmania braziliensis	73%	100%
A4HXF9	Leishmania infantum	90%	100%
C9ZP33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4QEA9	Leishmania major	93%	100%
V5AQX6	Trypanosoma cruzi	40%	78%