LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
RNA-binding protein, putative
Species:
Leishmania mexicana
UniProt:
E9AR53_LEIMU
TriTrypDb:
LmxM.17.0810
Length:
379

Annotations

LeishMANIAdb annotations

A Kinetoplastid-specific protein. Unlikely to be a membrane protein.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR53
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR53

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 3
GO:0005488 binding 1 3
GO:0097159 organic cyclic compound binding 2 3
GO:1901363 heterocyclic compound binding 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 17 21 PF00656 0.444
CLV_C14_Caspase3-7 188 192 PF00656 0.413
CLV_C14_Caspase3-7 262 266 PF00656 0.540
CLV_NRD_NRD_1 10 12 PF00675 0.422
CLV_NRD_NRD_1 182 184 PF00675 0.442
CLV_NRD_NRD_1 241 243 PF00675 0.364
CLV_NRD_NRD_1 277 279 PF00675 0.571
CLV_NRD_NRD_1 52 54 PF00675 0.602
CLV_PCSK_KEX2_1 10 12 PF00082 0.422
CLV_PCSK_KEX2_1 182 184 PF00082 0.577
CLV_PCSK_KEX2_1 241 243 PF00082 0.364
CLV_PCSK_KEX2_1 52 54 PF00082 0.602
CLV_PCSK_SKI1_1 183 187 PF00082 0.489
DEG_Nend_UBRbox_3 1 3 PF02207 0.476
DEG_SPOP_SBC_1 74 78 PF00917 0.476
DOC_MAPK_MEF2A_6 204 212 PF00069 0.474
DOC_USP7_MATH_1 112 116 PF00917 0.592
DOC_USP7_MATH_1 353 357 PF00917 0.397
DOC_USP7_MATH_1 371 375 PF00917 0.479
DOC_USP7_MATH_1 64 68 PF00917 0.640
DOC_USP7_MATH_1 86 90 PF00917 0.656
DOC_USP7_MATH_2 166 172 PF00917 0.480
DOC_USP7_UBL2_3 279 283 PF12436 0.588
DOC_WW_Pin1_4 166 171 PF00397 0.508
DOC_WW_Pin1_4 263 268 PF00397 0.722
DOC_WW_Pin1_4 283 288 PF00397 0.458
DOC_WW_Pin1_4 342 347 PF00397 0.478
DOC_WW_Pin1_4 84 89 PF00397 0.620
LIG_14-3-3_CanoR_1 173 177 PF00244 0.502
LIG_14-3-3_CanoR_1 197 205 PF00244 0.357
LIG_14-3-3_CanoR_1 41 47 PF00244 0.505
LIG_Actin_WH2_2 323 341 PF00022 0.480
LIG_BIR_III_2 269 273 PF00653 0.458
LIG_BIR_III_4 191 195 PF00653 0.470
LIG_CtBP_PxDLS_1 209 213 PF00389 0.489
LIG_FHA_1 132 138 PF00498 0.440
LIG_FHA_1 155 161 PF00498 0.439
LIG_FHA_1 311 317 PF00498 0.439
LIG_FHA_1 41 47 PF00498 0.525
LIG_FHA_1 7 13 PF00498 0.436
LIG_FHA_1 76 82 PF00498 0.495
LIG_FHA_2 186 192 PF00498 0.579
LIG_FHA_2 339 345 PF00498 0.462
LIG_Integrin_RGD_1 302 304 PF01839 0.605
LIG_PTB_Apo_2 331 338 PF02174 0.345
LIG_PTB_Phospho_1 331 337 PF10480 0.346
LIG_SH2_STAT5 275 278 PF00017 0.599
LIG_SH2_STAT5 337 340 PF00017 0.545
LIG_SH3_3 261 267 PF00018 0.626
LIG_SH3_3 281 287 PF00018 0.467
LIG_SH3_3 347 353 PF00018 0.379
LIG_SUMO_SIM_anti_2 315 322 PF11976 0.346
LIG_SUMO_SIM_anti_2 4 9 PF11976 0.438
LIG_SUMO_SIM_par_1 347 352 PF11976 0.369
LIG_SUMO_SIM_par_1 4 9 PF11976 0.472
LIG_WRC_WIRS_1 186 191 PF05994 0.573
LIG_WW_1 272 275 PF00397 0.534
LIG_WW_3 271 275 PF00397 0.532
MOD_CDK_SPxxK_3 166 173 PF00069 0.445
MOD_CK1_1 171 177 PF00069 0.438
MOD_CK1_1 282 288 PF00069 0.571
MOD_CK2_1 29 35 PF00069 0.370
MOD_CK2_1 338 344 PF00069 0.450
MOD_GlcNHglycan 115 118 PF01048 0.504
MOD_GlcNHglycan 152 155 PF01048 0.570
MOD_GlcNHglycan 290 293 PF01048 0.604
MOD_GlcNHglycan 321 324 PF01048 0.467
MOD_GlcNHglycan 355 358 PF01048 0.450
MOD_GlcNHglycan 66 69 PF01048 0.657
MOD_GlcNHglycan 88 91 PF01048 0.602
MOD_GSK3_1 150 157 PF00069 0.612
MOD_GSK3_1 168 175 PF00069 0.419
MOD_GSK3_1 193 200 PF00069 0.380
MOD_GSK3_1 279 286 PF00069 0.609
MOD_GSK3_1 338 345 PF00069 0.606
MOD_GSK3_1 371 378 PF00069 0.470
MOD_GSK3_1 58 65 PF00069 0.584
MOD_GSK3_1 75 82 PF00069 0.503
MOD_GSK3_1 84 91 PF00069 0.589
MOD_GSK3_1 99 106 PF00069 0.558
MOD_LATS_1 240 246 PF00433 0.368
MOD_NEK2_1 150 155 PF00069 0.631
MOD_NEK2_1 6 11 PF00069 0.447
MOD_PIKK_1 197 203 PF00454 0.342
MOD_PIKK_1 371 377 PF00454 0.449
MOD_PK_1 242 248 PF00069 0.474
MOD_PKA_2 172 178 PF00069 0.427
MOD_PKA_2 196 202 PF00069 0.403
MOD_PKA_2 338 344 PF00069 0.567
MOD_PKA_2 40 46 PF00069 0.525
MOD_Plk_4 160 166 PF00069 0.628
MOD_Plk_4 172 178 PF00069 0.476
MOD_ProDKin_1 166 172 PF00069 0.497
MOD_ProDKin_1 263 269 PF00069 0.724
MOD_ProDKin_1 283 289 PF00069 0.460
MOD_ProDKin_1 342 348 PF00069 0.467
MOD_ProDKin_1 84 90 PF00069 0.618
TRG_ER_diArg_1 10 12 PF00400 0.423
TRG_ER_diArg_1 182 184 PF00400 0.442
TRG_Pf-PMV_PEXEL_1 218 223 PF00026 0.452
TRG_Pf-PMV_PEXEL_1 31 35 PF00026 0.516

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKU0 Leptomonas seymouri 42% 73%
A0A1X0NT51 Trypanosomatidae 27% 76%
A0A3Q8ICU3 Leishmania donovani 92% 100%
A0A3R7JY32 Trypanosoma rangeli 29% 83%
A4H944 Leishmania braziliensis 79% 100%
C9ZP32 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 82%
Q4QEB0 Leishmania major 88% 100%
V5B6D3 Trypanosoma cruzi 29% 80%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS