Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

OSM3-like kinesin, putative

Species:

Leishmania mexicana

UniProt:

E9AR52_LEIMU

TriTrypDb:

LmxM.17.0800

Length:

938

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	7
GO:0099080	supramolecular complex	2	7
GO:0099081	supramolecular polymer	3	7
GO:0099512	supramolecular fiber	4	7
GO:0099513	polymeric cytoskeletal fiber	5	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0005929	cilium	4	1
GO:0032991	protein-containing complex	1	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AR52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR52

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	8
GO:0007018	microtubule-based movement	3	8
GO:0009987	cellular process	1	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003774	cytoskeletal motor activity	1	8
GO:0003777	microtubule motor activity	2	8
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0005524	ATP binding	5	8
GO:0008017	microtubule binding	5	8
GO:0008092	cytoskeletal protein binding	3	8
GO:0015631	tubulin binding	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140657	ATP-dependent activity	1	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	564	568	PF00656	0.614
CLV_C14_Caspase3-7	797	801	PF00656	0.593
CLV_NRD_NRD_1	203	205	PF00675	0.344
CLV_NRD_NRD_1	860	862	PF00675	0.575
CLV_NRD_NRD_1	876	878	PF00675	0.564
CLV_NRD_NRD_1	906	908	PF00675	0.542
CLV_NRD_NRD_1	925	927	PF00675	0.795
CLV_PCSK_KEX2_1	202	204	PF00082	0.345
CLV_PCSK_KEX2_1	555	557	PF00082	0.633
CLV_PCSK_KEX2_1	809	811	PF00082	0.596
CLV_PCSK_KEX2_1	876	878	PF00082	0.564
CLV_PCSK_KEX2_1	905	907	PF00082	0.541
CLV_PCSK_KEX2_1	925	927	PF00082	0.743
CLV_PCSK_PC1ET2_1	555	557	PF00082	0.633
CLV_PCSK_PC1ET2_1	809	811	PF00082	0.596
CLV_PCSK_SKI1_1	156	160	PF00082	0.403
CLV_PCSK_SKI1_1	339	343	PF00082	0.343
CLV_PCSK_SKI1_1	369	373	PF00082	0.578
CLV_PCSK_SKI1_1	495	499	PF00082	0.618
CLV_PCSK_SKI1_1	531	535	PF00082	0.677
CLV_PCSK_SKI1_1	640	644	PF00082	0.658
CLV_PCSK_SKI1_1	754	758	PF00082	0.527
CLV_PCSK_SKI1_1	830	834	PF00082	0.540
CLV_PCSK_SKI1_1	861	865	PF00082	0.578
CLV_PCSK_SKI1_1	918	922	PF00082	0.691
CLV_Separin_Metazoa	492	496	PF03568	0.685
DEG_APCC_DBOX_1	697	705	PF00400	0.584
DOC_CKS1_1	470	475	PF01111	0.668
DOC_CYCLIN_RxL_1	751	758	PF00134	0.532
DOC_MAPK_gen_1	779	788	PF00069	0.623
DOC_MAPK_gen_1	867	874	PF00069	0.574
DOC_MAPK_MEF2A_6	161	168	PF00069	0.343
DOC_MAPK_MEF2A_6	265	274	PF00069	0.343
DOC_MAPK_MEF2A_6	32	39	PF00069	0.343
DOC_MAPK_MEF2A_6	342	349	PF00069	0.462
DOC_MAPK_MEF2A_6	391	399	PF00069	0.557
DOC_PP1_RVXF_1	309	316	PF00149	0.343
DOC_PP2B_LxvP_1	628	631	PF13499	0.535
DOC_PP4_FxxP_1	470	473	PF00568	0.665
DOC_PP4_FxxP_1	75	78	PF00568	0.343
DOC_USP7_MATH_1	212	216	PF00917	0.334
DOC_USP7_MATH_1	238	242	PF00917	0.403
DOC_USP7_MATH_1	292	296	PF00917	0.361
DOC_USP7_MATH_1	402	406	PF00917	0.543
DOC_USP7_MATH_1	454	458	PF00917	0.598
DOC_USP7_MATH_1	477	481	PF00917	0.470
DOC_USP7_MATH_1	561	565	PF00917	0.685
DOC_USP7_MATH_1	665	669	PF00917	0.633
DOC_USP7_MATH_1	729	733	PF00917	0.557
DOC_USP7_UBL2_3	530	534	PF12436	0.715
DOC_USP7_UBL2_3	591	595	PF12436	0.527
DOC_USP7_UBL2_3	766	770	PF12436	0.515
DOC_USP7_UBL2_3	830	834	PF12436	0.545
DOC_WW_Pin1_4	133	138	PF00397	0.257
DOC_WW_Pin1_4	293	298	PF00397	0.361
DOC_WW_Pin1_4	469	474	PF00397	0.674
DOC_WW_Pin1_4	616	621	PF00397	0.618
LIG_14-3-3_CanoR_1	20	29	PF00244	0.461
LIG_14-3-3_CanoR_1	216	221	PF00244	0.403
LIG_14-3-3_CanoR_1	237	246	PF00244	0.420
LIG_14-3-3_CanoR_1	323	332	PF00244	0.403
LIG_14-3-3_CanoR_1	424	428	PF00244	0.555
LIG_14-3-3_CanoR_1	430	435	PF00244	0.540
LIG_14-3-3_CanoR_1	55	59	PF00244	0.343
LIG_14-3-3_CanoR_1	556	560	PF00244	0.628
LIG_14-3-3_CanoR_1	918	924	PF00244	0.707
LIG_14-3-3_CanoR_1	925	931	PF00244	0.686
LIG_Actin_WH2_2	481	497	PF00022	0.474
LIG_Actin_WH2_2	505	522	PF00022	0.614
LIG_Actin_WH2_2	847	863	PF00022	0.568
LIG_APCC_ABBAyCdc20_2	687	693	PF00400	0.669
LIG_Clathr_ClatBox_1	431	435	PF01394	0.656
LIG_Clathr_ClatBox_1	785	789	PF01394	0.564
LIG_deltaCOP1_diTrp_1	461	470	PF00928	0.667
LIG_deltaCOP1_diTrp_1	54	58	PF00928	0.403
LIG_FHA_1	173	179	PF00498	0.409
LIG_FHA_1	226	232	PF00498	0.431
LIG_FHA_1	234	240	PF00498	0.352
LIG_FHA_1	297	303	PF00498	0.343
LIG_FHA_1	358	364	PF00498	0.483
LIG_FHA_1	376	382	PF00498	0.546
LIG_FHA_1	41	47	PF00498	0.403
LIG_FHA_1	427	433	PF00498	0.545
LIG_FHA_1	485	491	PF00498	0.662
LIG_FHA_1	514	520	PF00498	0.745
LIG_FHA_1	616	622	PF00498	0.700
LIG_FHA_1	623	629	PF00498	0.756
LIG_FHA_1	71	77	PF00498	0.354
LIG_FHA_1	78	84	PF00498	0.351
LIG_FHA_1	780	786	PF00498	0.572
LIG_FHA_2	228	234	PF00498	0.403
LIG_FHA_2	261	267	PF00498	0.343
LIG_FHA_2	277	283	PF00498	0.343
LIG_FHA_2	470	476	PF00498	0.577
LIG_FHA_2	487	493	PF00498	0.488
LIG_FHA_2	527	533	PF00498	0.659
LIG_FHA_2	579	585	PF00498	0.670
LIG_FHA_2	700	706	PF00498	0.427
LIG_FHA_2	728	734	PF00498	0.679
LIG_FHA_2	753	759	PF00498	0.434
LIG_GBD_Chelix_1	362	370	PF00786	0.506
LIG_IRF3_LxIS_1	441	448	PF10401	0.670
LIG_LIR_Apic_2	73	78	PF02991	0.343
LIG_LIR_Gen_1	142	151	PF02991	0.395
LIG_LIR_Gen_1	219	225	PF02991	0.343
LIG_LIR_Gen_1	312	320	PF02991	0.343
LIG_LIR_Gen_1	464	473	PF02991	0.665
LIG_LIR_Gen_1	57	66	PF02991	0.349
LIG_LIR_Gen_1	688	696	PF02991	0.597
LIG_LIR_Gen_1	69	79	PF02991	0.343
LIG_LIR_LC3C_4	782	787	PF02991	0.380
LIG_LIR_Nem_3	142	147	PF02991	0.395
LIG_LIR_Nem_3	219	224	PF02991	0.343
LIG_LIR_Nem_3	312	318	PF02991	0.343
LIG_LIR_Nem_3	464	470	PF02991	0.724
LIG_LIR_Nem_3	57	61	PF02991	0.349
LIG_LIR_Nem_3	688	694	PF02991	0.717
LIG_LIR_Nem_3	69	75	PF02991	0.361
LIG_LIR_Nem_3	772	776	PF02991	0.645
LIG_PCNA_yPIPBox_3	111	120	PF02747	0.397
LIG_PCNA_yPIPBox_3	152	161	PF02747	0.343
LIG_Pex14_1	463	467	PF04695	0.662
LIG_Pex14_1	846	850	PF04695	0.569
LIG_PTB_Apo_2	60	67	PF02174	0.343
LIG_Rb_LxCxE_1	222	240	PF01857	0.403
LIG_REV1ctd_RIR_1	174	183	PF16727	0.397
LIG_SH2_STAP1	722	726	PF00017	0.549
LIG_SH2_STAT3	373	376	PF00017	0.406
LIG_SH2_STAT3	580	583	PF00017	0.625
LIG_SH2_STAT5	144	147	PF00017	0.343
LIG_SH2_STAT5	469	472	PF00017	0.550
LIG_SH2_STAT5	580	583	PF00017	0.690
LIG_SH2_STAT5	773	776	PF00017	0.528
LIG_SH3_3	183	189	PF00018	0.359
LIG_SUMO_SIM_anti_2	782	789	PF11976	0.385
LIG_SUMO_SIM_par_1	42	48	PF11976	0.411
LIG_SUMO_SIM_par_1	486	492	PF11976	0.446
LIG_SUMO_SIM_par_1	648	657	PF11976	0.644
LIG_SUMO_SIM_par_1	782	789	PF11976	0.560
LIG_TRAF2_1	489	492	PF00917	0.625
LIG_TRAF2_1	581	584	PF00917	0.629
LIG_TRAF2_1	863	866	PF00917	0.506
LIG_TRAF2_1	901	904	PF00917	0.586
LIG_TRFH_1	469	473	PF08558	0.671
LIG_UBA3_1	586	595	PF00899	0.707
LIG_WRC_WIRS_1	144	149	PF05994	0.343
MOD_CDK_SPxxK_3	469	476	PF00069	0.671
MOD_CK1_1	136	142	PF00069	0.244
MOD_CK1_1	214	220	PF00069	0.357
MOD_CK1_1	260	266	PF00069	0.403
MOD_CK1_1	296	302	PF00069	0.361
MOD_CK1_1	416	422	PF00069	0.481
MOD_CK1_1	654	660	PF00069	0.620
MOD_CK1_1	686	692	PF00069	0.720
MOD_CK1_1	82	88	PF00069	0.286
MOD_CK1_1	919	925	PF00069	0.739
MOD_CK1_1	99	105	PF00069	0.332
MOD_CK2_1	109	115	PF00069	0.397
MOD_CK2_1	143	149	PF00069	0.343
MOD_CK2_1	20	26	PF00069	0.403
MOD_CK2_1	260	266	PF00069	0.343
MOD_CK2_1	469	475	PF00069	0.582
MOD_CK2_1	486	492	PF00069	0.490
MOD_CK2_1	519	525	PF00069	0.651
MOD_CK2_1	526	532	PF00069	0.589
MOD_CK2_1	578	584	PF00069	0.678
MOD_CK2_1	699	705	PF00069	0.524
MOD_CK2_1	727	733	PF00069	0.592
MOD_CK2_1	752	758	PF00069	0.435
MOD_CK2_1	774	780	PF00069	0.555
MOD_CK2_1	841	847	PF00069	0.623
MOD_CK2_1	878	884	PF00069	0.609
MOD_Cter_Amidation	1	4	PF01082	0.639
MOD_GlcNHglycan	259	262	PF01048	0.391
MOD_GlcNHglycan	26	29	PF01048	0.222
MOD_GlcNHglycan	274	277	PF01048	0.318
MOD_GlcNHglycan	449	452	PF01048	0.652
MOD_GlcNHglycan	634	637	PF01048	0.676
MOD_GlcNHglycan	645	648	PF01048	0.640
MOD_GlcNHglycan	656	659	PF01048	0.562
MOD_GlcNHglycan	818	821	PF01048	0.587
MOD_GlcNHglycan	84	87	PF01048	0.411
MOD_GlcNHglycan	918	921	PF01048	0.720
MOD_GlcNHglycan	96	99	PF01048	0.338
MOD_GSK3_1	133	140	PF00069	0.332
MOD_GSK3_1	20	27	PF00069	0.257
MOD_GSK3_1	212	219	PF00069	0.355
MOD_GSK3_1	233	240	PF00069	0.355
MOD_GSK3_1	272	279	PF00069	0.343
MOD_GSK3_1	292	299	PF00069	0.350
MOD_GSK3_1	323	330	PF00069	0.354
MOD_GSK3_1	426	433	PF00069	0.635
MOD_GSK3_1	632	639	PF00069	0.803
MOD_GSK3_1	699	706	PF00069	0.424
MOD_GSK3_1	812	819	PF00069	0.569
MOD_GSK3_1	925	932	PF00069	0.679
MOD_GSK3_1	99	106	PF00069	0.359
MOD_N-GLC_1	110	115	PF02516	0.397
MOD_N-GLC_1	133	138	PF02516	0.222
MOD_N-GLC_1	270	275	PF02516	0.343
MOD_N-GLC_1	323	328	PF02516	0.357
MOD_N-GLC_1	400	405	PF02516	0.554
MOD_N-GLC_1	62	67	PF02516	0.341
MOD_N-GLC_1	640	645	PF02516	0.767
MOD_N-GLC_1	87	92	PF02516	0.343
MOD_NEK2_1	109	114	PF00069	0.461
MOD_NEK2_1	143	148	PF00069	0.348
MOD_NEK2_1	272	277	PF00069	0.374
MOD_NEK2_1	302	307	PF00069	0.344
MOD_NEK2_1	325	330	PF00069	0.314
MOD_NEK2_1	484	489	PF00069	0.757
MOD_NEK2_1	519	524	PF00069	0.697
MOD_NEK2_1	533	538	PF00069	0.461
MOD_NEK2_1	652	657	PF00069	0.655
MOD_NEK2_1	704	709	PF00069	0.521
MOD_NEK2_1	774	779	PF00069	0.581
MOD_NEK2_1	79	84	PF00069	0.343
MOD_NEK2_1	87	92	PF00069	0.343
MOD_NEK2_2	505	510	PF00069	0.465
MOD_PIKK_1	372	378	PF00454	0.437
MOD_PIKK_1	454	460	PF00454	0.516
MOD_PIKK_1	461	467	PF00454	0.535
MOD_PIKK_1	519	525	PF00454	0.698
MOD_PIKK_1	64	70	PF00454	0.343
MOD_PK_1	216	222	PF00069	0.343
MOD_PK_1	555	561	PF00069	0.629
MOD_PKA_1	555	561	PF00069	0.645
MOD_PKA_1	925	931	PF00069	0.695
MOD_PKA_2	423	429	PF00069	0.611
MOD_PKA_2	526	532	PF00069	0.556
MOD_PKA_2	54	60	PF00069	0.343
MOD_PKA_2	555	561	PF00069	0.738
MOD_PKA_2	686	692	PF00069	0.605
MOD_PKA_2	925	931	PF00069	0.747
MOD_PKB_1	18	26	PF00069	0.403
MOD_PKB_1	202	210	PF00069	0.343
MOD_PKB_1	742	750	PF00069	0.603
MOD_Plk_1	110	116	PF00069	0.397
MOD_Plk_1	172	178	PF00069	0.403
MOD_Plk_1	270	276	PF00069	0.343
MOD_Plk_1	505	511	PF00069	0.628
MOD_Plk_1	578	584	PF00069	0.765
MOD_Plk_1	62	68	PF00069	0.320
MOD_Plk_1	704	710	PF00069	0.583
MOD_Plk_1	823	829	PF00069	0.587
MOD_Plk_1	87	93	PF00069	0.354
MOD_Plk_2-3	54	60	PF00069	0.343
MOD_Plk_4	139	145	PF00069	0.374
MOD_Plk_4	172	178	PF00069	0.345
MOD_Plk_4	216	222	PF00069	0.343
MOD_Plk_4	276	282	PF00069	0.343
MOD_Plk_4	296	302	PF00069	0.343
MOD_Plk_4	309	315	PF00069	0.343
MOD_Plk_4	45	51	PF00069	0.420
MOD_Plk_4	686	692	PF00069	0.605
MOD_Plk_4	79	85	PF00069	0.346
MOD_Plk_4	87	93	PF00069	0.343
MOD_Plk_4	919	925	PF00069	0.671
MOD_ProDKin_1	133	139	PF00069	0.257
MOD_ProDKin_1	293	299	PF00069	0.361
MOD_ProDKin_1	469	475	PF00069	0.672
MOD_ProDKin_1	616	622	PF00069	0.615
MOD_SUMO_for_1	132	135	PF00179	0.314
MOD_SUMO_for_1	371	374	PF00179	0.561
MOD_SUMO_for_1	547	550	PF00179	0.609
MOD_SUMO_for_1	678	681	PF00179	0.579
MOD_SUMO_for_1	901	904	PF00179	0.586
MOD_SUMO_rev_2	350	357	PF00179	0.486
MOD_SUMO_rev_2	514	522	PF00179	0.645
MOD_SUMO_rev_2	549	557	PF00179	0.682
MOD_SUMO_rev_2	672	678	PF00179	0.595
MOD_SUMO_rev_2	717	727	PF00179	0.544
MOD_SUMO_rev_2	794	801	PF00179	0.590
MOD_SUMO_rev_2	847	854	PF00179	0.521
MOD_SUMO_rev_2	859	869	PF00179	0.543
TRG_DiLeu_BaEn_1	870	875	PF01217	0.568
TRG_DiLeu_BaEn_4	383	389	PF01217	0.533
TRG_DiLeu_BaEn_4	605	611	PF01217	0.666
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.663
TRG_DiLeu_LyEn_5	870	875	PF01217	0.568
TRG_ENDOCYTIC_2	144	147	PF00928	0.343
TRG_ENDOCYTIC_2	467	470	PF00928	0.679
TRG_ENDOCYTIC_2	691	694	PF00928	0.594
TRG_ENDOCYTIC_2	773	776	PF00928	0.646
TRG_ER_diArg_1	17	20	PF00400	0.344
TRG_ER_diArg_1	202	204	PF00400	0.344
TRG_ER_diArg_1	875	877	PF00400	0.547
TRG_ER_diArg_1	905	907	PF00400	0.685
TRG_ER_diArg_1	924	926	PF00400	0.590
TRG_NES_CRM1_1	387	400	PF08389	0.487
TRG_NES_CRM1_1	436	449	PF08389	0.585
TRG_NES_CRM1_1	479	492	PF08389	0.449
TRG_NLS_MonoExtC_3	829	834	PF00514	0.533
TRG_NLS_MonoExtN_4	828	834	PF00514	0.536
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	430	435	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	542	546	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	601	605	PF00026	0.708
TRG_Pf-PMV_PEXEL_1	713	717	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	754	758	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	862	866	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L3	Leptomonas seymouri	68%	100%
A0A1X0P0C2	Trypanosomatidae	29%	100%
A0A3Q8I9R7	Leishmania donovani	94%	100%
A4H925	Leishmania braziliensis	83%	99%
A4HXF7	Leishmania infantum	94%	100%
Q4QEB1	Leishmania major	94%	100%
Q5W7C6	Oryza sativa subsp. japonica	30%	89%
V5BFF1	Trypanosoma cruzi	57%	85%