GMP reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

GMP reductase

Gene product:

GMP reductase

Species:

Leishmania mexicana

UniProt:

E9AR50_LEIMU

TriTrypDb:

LmxM.17.0725

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	12
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0032991	protein-containing complex	1	8
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1

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Expansion

Sequence features

E9AR50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR50

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006144	purine nucleobase metabolic process	5	8
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006164	purine nucleotide biosynthetic process	6	12
GO:0006177	GMP biosynthetic process	8	11
GO:0006183	GTP biosynthetic process	8	1
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003920	GMP reductase activity	5	8
GO:0003938	IMP dehydrogenase activity	5	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	12
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	12
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	3	8
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.549
CLV_NRD_NRD_1	123	125	PF00675	0.253
CLV_NRD_NRD_1	140	142	PF00675	0.205
CLV_NRD_NRD_1	30	32	PF00675	0.244
CLV_NRD_NRD_1	89	91	PF00675	0.305
CLV_PCSK_FUR_1	188	192	PF00082	0.322
CLV_PCSK_FUR_1	414	418	PF00082	0.319
CLV_PCSK_KEX2_1	140	142	PF00082	0.330
CLV_PCSK_KEX2_1	190	192	PF00082	0.307
CLV_PCSK_KEX2_1	244	246	PF00082	0.332

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0B5L585	Penicillium brevicompactum	35%	90%
A0A0N0P602	Leptomonas seymouri	87%	100%
A0A0N1I2L9	Leptomonas seymouri	36%	96%
A0A0S4ISB5	Bodo saltans	36%	96%
A0A0S4KKC7	Bodo saltans	73%	90%
A0A1X0NTH3	Trypanosomatidae	76%	100%
A0A1X0P5Z8	Trypanosomatidae	36%	96%
A0A3Q8IBE3	Leishmania donovani	35%	96%
A0A3R7MPJ5	Trypanosoma rangeli	39%	96%
A0A3S7WUI0	Leishmania donovani	97%	100%

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