Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AR49_LEIMU

TriTrypDb:

LmxM.17.0720

Length:

792

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AR49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.677
CLV_NRD_NRD_1	134	136	PF00675	0.457
CLV_NRD_NRD_1	540	542	PF00675	0.577
CLV_NRD_NRD_1	589	591	PF00675	0.572
CLV_NRD_NRD_1	598	600	PF00675	0.525
CLV_NRD_NRD_1	729	731	PF00675	0.554
CLV_PCSK_KEX2_1	34	36	PF00082	0.431
CLV_PCSK_KEX2_1	540	542	PF00082	0.577
CLV_PCSK_KEX2_1	729	731	PF00082	0.544
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.390
CLV_PCSK_SKI1_1	328	332	PF00082	0.271
CLV_PCSK_SKI1_1	34	38	PF00082	0.391
CLV_PCSK_SKI1_1	405	409	PF00082	0.360
CLV_PCSK_SKI1_1	446	450	PF00082	0.776
CLV_PCSK_SKI1_1	540	544	PF00082	0.535
CLV_PCSK_SKI1_1	552	556	PF00082	0.501
CLV_PCSK_SKI1_1	757	761	PF00082	0.508
CLV_Separin_Metazoa	409	413	PF03568	0.438
DEG_APCC_DBOX_1	728	736	PF00400	0.414
DEG_SPOP_SBC_1	121	125	PF00917	0.765
DEG_SPOP_SBC_1	250	254	PF00917	0.552
DEG_SPOP_SBC_1	574	578	PF00917	0.608
DOC_CKS1_1	215	220	PF01111	0.571
DOC_CKS1_1	397	402	PF01111	0.589
DOC_CKS1_1	447	452	PF01111	0.464
DOC_CKS1_1	553	558	PF01111	0.507
DOC_CYCLIN_RxL_1	150	159	PF00134	0.412
DOC_CYCLIN_yClb3_PxF_3	127	135	PF00134	0.335
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.458
DOC_MAPK_gen_1	135	142	PF00069	0.385
DOC_MAPK_gen_1	271	280	PF00069	0.455
DOC_MAPK_gen_1	310	320	PF00069	0.450
DOC_MAPK_gen_1	540	546	PF00069	0.541
DOC_MAPK_gen_1	599	606	PF00069	0.497
DOC_MAPK_MEF2A_6	135	142	PF00069	0.385
DOC_MAPK_MEF2A_6	19	26	PF00069	0.436
DOC_MAPK_MEF2A_6	286	293	PF00069	0.369
DOC_MAPK_MEF2A_6	313	322	PF00069	0.453
DOC_MAPK_NFAT4_5	19	27	PF00069	0.441
DOC_PP1_RVXF_1	151	158	PF00149	0.430
DOC_PP1_RVXF_1	383	390	PF00149	0.491
DOC_PP2B_LxvP_1	160	163	PF13499	0.394
DOC_PP2B_LxvP_1	265	268	PF13499	0.227
DOC_PP2B_LxvP_1	775	778	PF13499	0.433
DOC_PP4_FxxP_1	293	296	PF00568	0.331
DOC_PP4_FxxP_1	408	411	PF00568	0.421
DOC_USP7_MATH_1	122	126	PF00917	0.756
DOC_USP7_MATH_1	164	168	PF00917	0.567
DOC_USP7_MATH_1	251	255	PF00917	0.638
DOC_USP7_MATH_1	305	309	PF00917	0.578
DOC_USP7_MATH_1	343	347	PF00917	0.543
DOC_USP7_MATH_1	348	352	PF00917	0.499
DOC_USP7_MATH_1	456	460	PF00917	0.609
DOC_USP7_MATH_1	574	578	PF00917	0.698
DOC_USP7_MATH_1	627	631	PF00917	0.550
DOC_USP7_MATH_1	635	639	PF00917	0.553
DOC_USP7_MATH_1	669	673	PF00917	0.391
DOC_USP7_MATH_1	68	72	PF00917	0.464
DOC_WW_Pin1_4	2	7	PF00397	0.634
DOC_WW_Pin1_4	214	219	PF00397	0.566
DOC_WW_Pin1_4	255	260	PF00397	0.548
DOC_WW_Pin1_4	339	344	PF00397	0.481
DOC_WW_Pin1_4	389	394	PF00397	0.402
DOC_WW_Pin1_4	396	401	PF00397	0.602
DOC_WW_Pin1_4	43	48	PF00397	0.423
DOC_WW_Pin1_4	446	451	PF00397	0.585
DOC_WW_Pin1_4	552	557	PF00397	0.519
DOC_WW_Pin1_4	640	645	PF00397	0.518
DOC_WW_Pin1_4	746	751	PF00397	0.468
LIG_14-3-3_CanoR_1	153	158	PF00244	0.371
LIG_14-3-3_CanoR_1	227	235	PF00244	0.636
LIG_14-3-3_CanoR_1	356	361	PF00244	0.404
LIG_14-3-3_CanoR_1	385	390	PF00244	0.492
LIG_14-3-3_CanoR_1	412	416	PF00244	0.447
LIG_14-3-3_CanoR_1	637	642	PF00244	0.487
LIG_14-3-3_CanoR_1	684	690	PF00244	0.504
LIG_Actin_WH2_2	403	418	PF00022	0.450
LIG_Actin_WH2_2	547	562	PF00022	0.538
LIG_Actin_WH2_2	600	618	PF00022	0.542
LIG_BIR_III_4	438	442	PF00653	0.536
LIG_BIR_III_4	455	459	PF00653	0.474
LIG_BRCT_BRCA1_1	305	309	PF00533	0.534
LIG_BRCT_BRCA1_1	351	355	PF00533	0.457
LIG_deltaCOP1_diTrp_1	93	100	PF00928	0.475
LIG_DLG_GKlike_1	153	160	PF00625	0.354
LIG_DLG_GKlike_1	356	363	PF00625	0.399
LIG_EVH1_2	218	222	PF00568	0.529
LIG_FHA_1	142	148	PF00498	0.335
LIG_FHA_1	215	221	PF00498	0.733
LIG_FHA_1	256	262	PF00498	0.448
LIG_FHA_2	11	17	PF00498	0.462
LIG_FHA_2	181	187	PF00498	0.582
LIG_FHA_2	397	403	PF00498	0.568
LIG_FHA_2	553	559	PF00498	0.515
LIG_FHA_2	612	618	PF00498	0.591
LIG_GBD_Chelix_1	473	481	PF00786	0.343
LIG_LIR_Apic_2	290	296	PF02991	0.327
LIG_LIR_Apic_2	394	400	PF02991	0.546
LIG_LIR_Apic_2	550	556	PF02991	0.506
LIG_LIR_Apic_2	655	659	PF02991	0.462
LIG_LIR_Gen_1	13	22	PF02991	0.443
LIG_LIR_Gen_1	156	164	PF02991	0.471
LIG_LIR_Gen_1	29	37	PF02991	0.407
LIG_LIR_Gen_1	494	503	PF02991	0.401
LIG_LIR_Gen_1	688	697	PF02991	0.408
LIG_LIR_Nem_3	13	18	PF02991	0.450
LIG_LIR_Nem_3	156	160	PF02991	0.418
LIG_LIR_Nem_3	210	216	PF02991	0.577
LIG_LIR_Nem_3	29	33	PF02991	0.379
LIG_LIR_Nem_3	306	312	PF02991	0.451
LIG_LIR_Nem_3	359	363	PF02991	0.371
LIG_LIR_Nem_3	382	387	PF02991	0.590
LIG_LIR_Nem_3	494	498	PF02991	0.405
LIG_LIR_Nem_3	699	703	PF02991	0.338
LIG_LIR_Nem_3	93	99	PF02991	0.494
LIG_MYND_1	368	372	PF01753	0.488
LIG_Pex14_1	380	384	PF04695	0.514
LIG_SH2_CRK	134	138	PF00017	0.391
LIG_SH2_CRK	15	19	PF00017	0.426
LIG_SH2_CRK	213	217	PF00017	0.619
LIG_SH2_CRK	30	34	PF00017	0.388
LIG_SH2_CRK	384	388	PF00017	0.601
LIG_SH2_NCK_1	397	401	PF00017	0.528
LIG_SH2_PTP2	495	498	PF00017	0.328
LIG_SH2_SRC	15	18	PF00017	0.482
LIG_SH2_STAP1	506	510	PF00017	0.437
LIG_SH2_STAP1	703	707	PF00017	0.393
LIG_SH2_STAT5	406	409	PF00017	0.357
LIG_SH2_STAT5	43	46	PF00017	0.419
LIG_SH2_STAT5	495	498	PF00017	0.349
LIG_SH2_STAT5	656	659	PF00017	0.462
LIG_SH3_1	3	9	PF00018	0.489
LIG_SH3_3	124	130	PF00018	0.551
LIG_SH3_3	212	218	PF00018	0.557
LIG_SH3_3	256	262	PF00018	0.487
LIG_SH3_3	293	299	PF00018	0.356
LIG_SH3_3	3	9	PF00018	0.568
LIG_SH3_3	362	368	PF00018	0.484
LIG_SH3_3	390	396	PF00018	0.473
LIG_SH3_3	444	450	PF00018	0.458
LIG_SH3_3	744	750	PF00018	0.621
LIG_SH3_5	696	700	PF00018	0.377
LIG_SUMO_SIM_anti_2	315	322	PF11976	0.412
LIG_SUMO_SIM_anti_2	494	501	PF11976	0.392
LIG_SUMO_SIM_anti_2	779	786	PF11976	0.436
LIG_SUMO_SIM_par_1	57	63	PF11976	0.406
LIG_SUMO_SIM_par_1	779	786	PF11976	0.436
LIG_TRAF2_1	207	210	PF00917	0.642
LIG_TRAF2_1	336	339	PF00917	0.438
LIG_TRAF2_1	399	402	PF00917	0.610
LIG_TRAF2_1	429	432	PF00917	0.488
LIG_TRAF2_1	47	50	PF00917	0.417
LIG_TRAF2_1	555	558	PF00917	0.511
LIG_TYR_ITIM	493	498	PF00017	0.386
LIG_TYR_ITSM	11	18	PF00017	0.444
LIG_WRC_WIRS_1	357	362	PF05994	0.449
MOD_CDK_SPK_2	7	12	PF00069	0.570
MOD_CDK_SPxxK_3	640	647	PF00069	0.528
MOD_CK1_1	10	16	PF00069	0.484
MOD_CK1_1	125	131	PF00069	0.478
MOD_CK1_1	174	180	PF00069	0.627
MOD_CK1_1	253	259	PF00069	0.536
MOD_CK1_1	342	348	PF00069	0.611
MOD_CK1_1	349	355	PF00069	0.499
MOD_CK1_1	640	646	PF00069	0.458
MOD_CK1_1	69	75	PF00069	0.776
MOD_CK2_1	180	186	PF00069	0.550
MOD_CK2_1	396	402	PF00069	0.548
MOD_CK2_1	494	500	PF00069	0.409
MOD_CK2_1	544	550	PF00069	0.574
MOD_CK2_1	552	558	PF00069	0.522
MOD_CK2_1	560	566	PF00069	0.654
MOD_CK2_1	586	592	PF00069	0.749
MOD_CK2_1	780	786	PF00069	0.367
MOD_CMANNOS	97	100	PF00535	0.597
MOD_Cter_Amidation	538	541	PF01082	0.584
MOD_GlcNHglycan	124	127	PF01048	0.698
MOD_GlcNHglycan	173	176	PF01048	0.744
MOD_GlcNHglycan	191	195	PF01048	0.593
MOD_GlcNHglycan	281	284	PF01048	0.369
MOD_GlcNHglycan	305	308	PF01048	0.542
MOD_GlcNHglycan	348	351	PF01048	0.583
MOD_GlcNHglycan	427	430	PF01048	0.479
MOD_GlcNHglycan	537	540	PF01048	0.650
MOD_GlcNHglycan	620	623	PF01048	0.637
MOD_GlcNHglycan	633	636	PF01048	0.468
MOD_GlcNHglycan	672	675	PF01048	0.480
MOD_GlcNHglycan	677	680	PF01048	0.405
MOD_GlcNHglycan	80	83	PF01048	0.635
MOD_GSK3_1	121	128	PF00069	0.516
MOD_GSK3_1	186	193	PF00069	0.495
MOD_GSK3_1	249	256	PF00069	0.602
MOD_GSK3_1	294	301	PF00069	0.400
MOD_GSK3_1	339	346	PF00069	0.470
MOD_GSK3_1	366	373	PF00069	0.469
MOD_GSK3_1	385	392	PF00069	0.483
MOD_GSK3_1	611	618	PF00069	0.599
MOD_GSK3_1	627	634	PF00069	0.552
MOD_GSK3_1	746	753	PF00069	0.507
MOD_GSK3_1	776	783	PF00069	0.446
MOD_N-GLC_1	164	169	PF02516	0.492
MOD_N-GLC_1	475	480	PF02516	0.452
MOD_NEK2_1	387	392	PF00069	0.469
MOD_NEK2_1	41	46	PF00069	0.409
MOD_NEK2_1	423	428	PF00069	0.461
MOD_NEK2_1	58	63	PF00069	0.305
MOD_NEK2_1	586	591	PF00069	0.600
MOD_NEK2_1	615	620	PF00069	0.681
MOD_NEK2_1	670	675	PF00069	0.501
MOD_NEK2_2	305	310	PF00069	0.534
MOD_NEK2_2	411	416	PF00069	0.559
MOD_PIKK_1	475	481	PF00454	0.345
MOD_PIKK_1	594	600	PF00454	0.685
MOD_PIKK_1	66	72	PF00454	0.461
MOD_PKA_2	226	232	PF00069	0.636
MOD_PKA_2	270	276	PF00069	0.566
MOD_PKA_2	411	417	PF00069	0.399
MOD_PKA_2	615	621	PF00069	0.600
MOD_PKA_2	652	658	PF00069	0.500
MOD_Plk_1	467	473	PF00069	0.404
MOD_Plk_1	611	617	PF00069	0.660
MOD_Plk_1	771	777	PF00069	0.460
MOD_Plk_2-3	467	473	PF00069	0.442
MOD_Plk_2-3	494	500	PF00069	0.386
MOD_Plk_2-3	780	786	PF00069	0.426
MOD_Plk_4	494	500	PF00069	0.374
MOD_Plk_4	652	658	PF00069	0.471
MOD_Plk_4	712	718	PF00069	0.434
MOD_Plk_4	780	786	PF00069	0.426
MOD_ProDKin_1	2	8	PF00069	0.629
MOD_ProDKin_1	214	220	PF00069	0.567
MOD_ProDKin_1	255	261	PF00069	0.535
MOD_ProDKin_1	339	345	PF00069	0.485
MOD_ProDKin_1	389	395	PF00069	0.413
MOD_ProDKin_1	396	402	PF00069	0.594
MOD_ProDKin_1	43	49	PF00069	0.424
MOD_ProDKin_1	446	452	PF00069	0.585
MOD_ProDKin_1	552	558	PF00069	0.519
MOD_ProDKin_1	640	646	PF00069	0.514
MOD_ProDKin_1	746	752	PF00069	0.468
MOD_SUMO_rev_2	557	562	PF00179	0.536
TRG_DiLeu_BaEn_1	494	499	PF01217	0.384
TRG_DiLeu_BaEn_4	382	388	PF01217	0.394
TRG_ENDOCYTIC_2	134	137	PF00928	0.346
TRG_ENDOCYTIC_2	15	18	PF00928	0.418
TRG_ENDOCYTIC_2	213	216	PF00928	0.618
TRG_ENDOCYTIC_2	30	33	PF00928	0.407
TRG_ENDOCYTIC_2	384	387	PF00928	0.612
TRG_ENDOCYTIC_2	495	498	PF00928	0.384
TRG_ENDOCYTIC_2	506	509	PF00928	0.412
TRG_ENDOCYTIC_2	689	692	PF00928	0.531
TRG_ER_diArg_1	100	103	PF00400	0.675
TRG_ER_diArg_1	540	542	PF00400	0.577
TRG_ER_diArg_1	728	730	PF00400	0.570
TRG_NES_CRM1_1	701	714	PF08389	0.338
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	508	513	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	723	727	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L1	Leptomonas seymouri	50%	100%
A0A1X0NSU7	Trypanosomatidae	29%	100%
A0A3S7WUG5	Leishmania donovani	85%	99%
A4H922	Leishmania braziliensis	73%	99%
A4HXF4	Leishmania infantum	84%	100%
Q4QEB4	Leishmania major	84%	100%