HTH myb-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Myb-like DNA-binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AR48_LEIMU

TriTrypDb:

LmxM.17.0710

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000974	Prp19 complex	2	1
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AR48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR48

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.709
CLV_C14_Caspase3-7	313	317	PF00656	0.589
CLV_C14_Caspase3-7	397	401	PF00656	0.491
CLV_C14_Caspase3-7	450	454	PF00656	0.716
CLV_C14_Caspase3-7	537	541	PF00656	0.622
CLV_C14_Caspase3-7	547	551	PF00656	0.616
CLV_NRD_NRD_1	151	153	PF00675	0.469
CLV_NRD_NRD_1	154	156	PF00675	0.499
CLV_NRD_NRD_1	194	196	PF00675	0.484
CLV_NRD_NRD_1	228	230	PF00675	0.514
CLV_NRD_NRD_1	502	504	PF00675	0.579
CLV_NRD_NRD_1	570	572	PF00675	0.693
CLV_NRD_NRD_1	777	779	PF00675	0.515
CLV_NRD_NRD_1	92	94	PF00675	0.277
CLV_PCSK_FUR_1	148	152	PF00082	0.455
CLV_PCSK_FUR_1	802	806	PF00082	0.392
CLV_PCSK_KEX2_1	148	150	PF00082	0.452
CLV_PCSK_KEX2_1	151	153	PF00082	0.469
CLV_PCSK_KEX2_1	435	437	PF00082	0.639
CLV_PCSK_KEX2_1	483	485	PF00082	0.651
CLV_PCSK_KEX2_1	570	572	PF00082	0.584
CLV_PCSK_KEX2_1	777	779	PF00082	0.515
CLV_PCSK_KEX2_1	804	806	PF00082	0.392
CLV_PCSK_KEX2_1	92	94	PF00082	0.277
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.636
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.577
CLV_PCSK_PC1ET2_1	804	806	PF00082	0.392
CLV_PCSK_SKI1_1	20	24	PF00082	0.277
CLV_PCSK_SKI1_1	229	233	PF00082	0.517
CLV_PCSK_SKI1_1	297	301	PF00082	0.476
CLV_PCSK_SKI1_1	334	338	PF00082	0.691
CLV_PCSK_SKI1_1	346	350	PF00082	0.541
CLV_PCSK_SKI1_1	368	372	PF00082	0.644
CLV_PCSK_SKI1_1	375	379	PF00082	0.566
CLV_PCSK_SKI1_1	41	45	PF00082	0.281
CLV_PCSK_SKI1_1	438	442	PF00082	0.639
CLV_PCSK_SKI1_1	631	635	PF00082	0.542
CLV_PCSK_SKI1_1	707	711	PF00082	0.576
CLV_PCSK_SKI1_1	771	775	PF00082	0.568
DEG_APCC_DBOX_1	333	341	PF00400	0.606
DEG_APCC_DBOX_1	437	445	PF00400	0.636
DEG_APCC_DBOX_1	776	784	PF00400	0.519
DEG_SPOP_SBC_1	323	327	PF00917	0.533
DEG_SPOP_SBC_1	473	477	PF00917	0.696
DEG_SPOP_SBC_1	542	546	PF00917	0.771
DEG_SPOP_SBC_1	584	588	PF00917	0.569
DOC_CKS1_1	594	599	PF01111	0.647
DOC_MAPK_DCC_7	436	446	PF00069	0.717
DOC_PP1_RVXF_1	1	7	PF00149	0.540
DOC_PP2B_LxvP_1	429	432	PF13499	0.648
DOC_PP2B_LxvP_1	497	500	PF13499	0.651
DOC_PP2B_LxvP_1	738	741	PF13499	0.658
DOC_PP4_MxPP_1	425	428	PF00568	0.651
DOC_USP7_MATH_1	261	265	PF00917	0.728
DOC_USP7_MATH_1	323	327	PF00917	0.716
DOC_USP7_MATH_1	355	359	PF00917	0.656
DOC_USP7_MATH_1	472	476	PF00917	0.664
DOC_USP7_MATH_1	522	526	PF00917	0.705
DOC_USP7_MATH_1	536	540	PF00917	0.595
DOC_USP7_MATH_1	584	588	PF00917	0.707
DOC_USP7_MATH_1	602	606	PF00917	0.609
DOC_USP7_MATH_1	648	652	PF00917	0.672
DOC_USP7_MATH_2	135	141	PF00917	0.417
DOC_USP7_UBL2_3	192	196	PF12436	0.485
DOC_USP7_UBL2_3	392	396	PF12436	0.612
DOC_WW_Pin1_4	353	358	PF00397	0.695
DOC_WW_Pin1_4	417	422	PF00397	0.642
DOC_WW_Pin1_4	586	591	PF00397	0.697
DOC_WW_Pin1_4	593	598	PF00397	0.654
DOC_WW_Pin1_4	614	619	PF00397	0.521
DOC_WW_Pin1_4	700	705	PF00397	0.613
DOC_WW_Pin1_4	720	725	PF00397	0.682
DOC_WW_Pin1_4	91	96	PF00397	0.477
LIG_14-3-3_CanoR_1	33	38	PF00244	0.477
LIG_14-3-3_CanoR_1	346	352	PF00244	0.709
LIG_14-3-3_CanoR_1	368	377	PF00244	0.675
LIG_14-3-3_CanoR_1	647	653	PF00244	0.632
LIG_APCC_ABBA_1	277	282	PF00400	0.539
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_BIR_III_4	129	133	PF00653	0.599
LIG_BIR_III_4	316	320	PF00653	0.628
LIG_BRCT_BRCA1_1	361	365	PF00533	0.643
LIG_EVH1_1	429	433	PF00568	0.649
LIG_FHA_1	180	186	PF00498	0.453
LIG_FHA_1	220	226	PF00498	0.501
LIG_FHA_1	365	371	PF00498	0.642
LIG_FHA_1	494	500	PF00498	0.594
LIG_FHA_1	511	517	PF00498	0.599
LIG_FHA_1	763	769	PF00498	0.499
LIG_FHA_2	10	16	PF00498	0.477
LIG_FHA_2	155	161	PF00498	0.472
LIG_FHA_2	445	451	PF00498	0.748
LIG_FHA_2	476	482	PF00498	0.537
LIG_FHA_2	554	560	PF00498	0.606
LIG_FHA_2	586	592	PF00498	0.703
LIG_FHA_2	594	600	PF00498	0.692
LIG_FHA_2	615	621	PF00498	0.667
LIG_FHA_2	794	800	PF00498	0.480
LIG_LIR_Apic_2	51	56	PF02991	0.477
LIG_LIR_Gen_1	106	115	PF02991	0.382
LIG_LIR_Gen_1	271	280	PF02991	0.593
LIG_LIR_Gen_1	30	38	PF02991	0.477
LIG_LIR_Gen_1	400	410	PF02991	0.554
LIG_LIR_Gen_1	492	502	PF02991	0.576
LIG_LIR_Gen_1	692	701	PF02991	0.519
LIG_LIR_Nem_3	106	112	PF02991	0.380
LIG_LIR_Nem_3	271	277	PF02991	0.610
LIG_LIR_Nem_3	30	34	PF02991	0.477
LIG_LIR_Nem_3	400	406	PF02991	0.534
LIG_LIR_Nem_3	48	53	PF02991	0.477
LIG_LIR_Nem_3	492	497	PF02991	0.592
LIG_LIR_Nem_3	692	696	PF02991	0.510
LIG_Pex14_2	79	83	PF04695	0.474
LIG_SH2_PTP2	98	101	PF00017	0.410
LIG_SH2_SRC	53	56	PF00017	0.541
LIG_SH2_STAT3	119	122	PF00017	0.433
LIG_SH2_STAT3	280	283	PF00017	0.519
LIG_SH2_STAT5	109	112	PF00017	0.370
LIG_SH2_STAT5	119	122	PF00017	0.454
LIG_SH2_STAT5	53	56	PF00017	0.541
LIG_SH2_STAT5	713	716	PF00017	0.560
LIG_SH2_STAT5	746	749	PF00017	0.575
LIG_SH2_STAT5	98	101	PF00017	0.410
LIG_SH3_2	430	435	PF14604	0.651
LIG_SH3_2	466	471	PF14604	0.667
LIG_SH3_3	424	430	PF00018	0.642
LIG_SH3_3	463	469	PF00018	0.767
LIG_SUMO_SIM_par_1	442	447	PF11976	0.719
LIG_TRAF2_1	157	160	PF00917	0.461
LIG_TRAF2_1	234	237	PF00917	0.496
LIG_TRAF2_1	391	394	PF00917	0.614
LIG_TRAF2_1	447	450	PF00917	0.716
LIG_TRAF2_1	65	68	PF00917	0.477
LIG_WRC_WIRS_1	141	146	PF05994	0.521
LIG_WW_2	427	430	PF00397	0.692
MOD_CDK_SPxxK_3	700	707	PF00069	0.562
MOD_CK1_1	140	146	PF00069	0.527
MOD_CK1_1	327	333	PF00069	0.666
MOD_CK1_1	350	356	PF00069	0.773
MOD_CK1_1	36	42	PF00069	0.315
MOD_CK1_1	455	461	PF00069	0.598
MOD_CK1_1	475	481	PF00069	0.655
MOD_CK1_1	762	768	PF00069	0.474
MOD_CK2_1	154	160	PF00069	0.478
MOD_CK2_1	210	216	PF00069	0.461
MOD_CK2_1	355	361	PF00069	0.646
MOD_CK2_1	444	450	PF00069	0.720
MOD_CK2_1	475	481	PF00069	0.668
MOD_CK2_1	553	559	PF00069	0.612
MOD_CK2_1	585	591	PF00069	0.720
MOD_CK2_1	593	599	PF00069	0.681
MOD_CK2_1	602	608	PF00069	0.597
MOD_CK2_1	62	68	PF00069	0.315
MOD_CK2_1	9	15	PF00069	0.315
MOD_GlcNHglycan	168	171	PF01048	0.514
MOD_GlcNHglycan	219	222	PF01048	0.499
MOD_GlcNHglycan	257	260	PF01048	0.635
MOD_GlcNHglycan	312	315	PF01048	0.720
MOD_GlcNHglycan	327	330	PF01048	0.576
MOD_GlcNHglycan	349	352	PF01048	0.719
MOD_GlcNHglycan	407	410	PF01048	0.782
MOD_GlcNHglycan	421	424	PF01048	0.517
MOD_GlcNHglycan	546	549	PF01048	0.674
MOD_GlcNHglycan	612	615	PF01048	0.729
MOD_GlcNHglycan	697	700	PF01048	0.446
MOD_GlcNHglycan	710	713	PF01048	0.479
MOD_GlcNHglycan	728	731	PF01048	0.686
MOD_GSK3_1	160	167	PF00069	0.555
MOD_GSK3_1	217	224	PF00069	0.483
MOD_GSK3_1	321	328	PF00069	0.661
MOD_GSK3_1	346	353	PF00069	0.751
MOD_GSK3_1	355	362	PF00069	0.673
MOD_GSK3_1	364	371	PF00069	0.724
MOD_GSK3_1	375	382	PF00069	0.456
MOD_GSK3_1	472	479	PF00069	0.645
MOD_GSK3_1	579	586	PF00069	0.488
MOD_GSK3_1	610	617	PF00069	0.721
MOD_GSK3_1	627	634	PF00069	0.574
MOD_GSK3_1	789	796	PF00069	0.542
MOD_GSK3_1	84	91	PF00069	0.345
MOD_NEK2_1	180	185	PF00069	0.448
MOD_NEK2_1	225	230	PF00069	0.507
MOD_NEK2_1	359	364	PF00069	0.675
MOD_NEK2_1	402	407	PF00069	0.593
MOD_NEK2_1	493	498	PF00069	0.694
MOD_NEK2_1	636	641	PF00069	0.621
MOD_NEK2_2	221	226	PF00069	0.504
MOD_PIKK_1	41	47	PF00454	0.320
MOD_PIKK_1	631	637	PF00454	0.692
MOD_PIKK_1	669	675	PF00454	0.599
MOD_PKA_2	154	160	PF00069	0.478
MOD_PKA_2	225	231	PF00069	0.506
MOD_PKA_2	261	267	PF00069	0.706
MOD_PKA_2	578	584	PF00069	0.613
MOD_PKA_2	762	768	PF00069	0.537
MOD_PKB_1	757	765	PF00069	0.520
MOD_Plk_1	452	458	PF00069	0.723
MOD_Plk_1	793	799	PF00069	0.503
MOD_Plk_2-3	137	143	PF00069	0.579
MOD_Plk_2-3	62	68	PF00069	0.315
MOD_Plk_4	140	146	PF00069	0.527
MOD_Plk_4	33	39	PF00069	0.315
MOD_Plk_4	355	361	PF00069	0.646
MOD_Plk_4	602	608	PF00069	0.548
MOD_ProDKin_1	353	359	PF00069	0.696
MOD_ProDKin_1	417	423	PF00069	0.640
MOD_ProDKin_1	586	592	PF00069	0.698
MOD_ProDKin_1	593	599	PF00069	0.651
MOD_ProDKin_1	614	620	PF00069	0.524
MOD_ProDKin_1	700	706	PF00069	0.613
MOD_ProDKin_1	720	726	PF00069	0.688
MOD_ProDKin_1	91	97	PF00069	0.315
MOD_SUMO_for_1	112	115	PF00179	0.384
MOD_SUMO_for_1	209	212	PF00179	0.459
MOD_SUMO_for_1	391	394	PF00179	0.614
MOD_SUMO_rev_2	278	286	PF00179	0.557
MOD_SUMO_rev_2	390	398	PF00179	0.529
MOD_SUMO_rev_2	475	485	PF00179	0.534
MOD_SUMO_rev_2	65	73	PF00179	0.315
TRG_DiLeu_BaEn_1	301	306	PF01217	0.439
TRG_DiLeu_BaEn_1	68	73	PF01217	0.315
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.315
TRG_DiLeu_LyEn_5	301	306	PF01217	0.439
TRG_ENDOCYTIC_2	109	112	PF00928	0.370
TRG_ER_diArg_1	148	151	PF00400	0.460
TRG_ER_diArg_1	570	572	PF00400	0.584
TRG_ER_diArg_1	757	760	PF00400	0.693
TRG_ER_diArg_1	776	778	PF00400	0.396
TRG_NES_CRM1_1	666	681	PF08389	0.411
TRG_NLS_MonoExtC_3	228	233	PF00514	0.503
TRG_NLS_MonoExtN_4	226	233	PF00514	0.504
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	293	298	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	778	782	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	795	799	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKC2	Leptomonas seymouri	53%	100%
A0A3S7WUG8	Leishmania donovani	92%	100%
A4H921	Leishmania braziliensis	83%	100%
A4HXF3	Leishmania infantum	92%	100%
Q4QEB5	Leishmania major	90%	100%