Methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Methyltransferase

Gene product:

Putative methyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AR47_LEIMU

TriTrypDb:

LmxM.17.0700

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR47

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	368	370	PF00675	0.434
CLV_NRD_NRD_1	438	440	PF00675	0.783
CLV_NRD_NRD_1	472	474	PF00675	0.593
CLV_PCSK_FUR_1	436	440	PF00082	0.690
CLV_PCSK_KEX2_1	137	139	PF00082	0.369
CLV_PCSK_KEX2_1	368	370	PF00082	0.434
CLV_PCSK_KEX2_1	436	438	PF00082	0.728
CLV_PCSK_KEX2_1	471	473	PF00082	0.581
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.288
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.520
CLV_PCSK_PC7_1	133	139	PF00082	0.288
CLV_PCSK_SKI1_1	122	126	PF00082	0.400
CLV_PCSK_SKI1_1	196	200	PF00082	0.596
DEG_Nend_Nbox_1	1	3	PF02207	0.383
DEG_SPOP_SBC_1	233	237	PF00917	0.671
DEG_SPOP_SBC_1	422	426	PF00917	0.665
DEG_SPOP_SBC_1	74	78	PF00917	0.375
DOC_CKS1_1	247	252	PF01111	0.464
DOC_CYCLIN_yCln2_LP_2	247	253	PF00134	0.455
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.312
DOC_PP1_RVXF_1	394	400	PF00149	0.408
DOC_PP2B_LxvP_1	214	217	PF13499	0.384
DOC_PP2B_LxvP_1	83	86	PF13499	0.312
DOC_PP4_FxxP_1	429	432	PF00568	0.630
DOC_PP4_FxxP_1	71	74	PF00568	0.313
DOC_USP7_MATH_1	158	162	PF00917	0.444
DOC_USP7_MATH_1	227	231	PF00917	0.275
DOC_USP7_MATH_1	232	236	PF00917	0.624
DOC_USP7_MATH_1	34	38	PF00917	0.466
DOC_USP7_MATH_1	356	360	PF00917	0.529
DOC_USP7_MATH_1	422	426	PF00917	0.764
DOC_USP7_MATH_1	459	463	PF00917	0.774
DOC_USP7_MATH_1	75	79	PF00917	0.450
DOC_USP7_MATH_1	91	95	PF00917	0.179
DOC_USP7_UBL2_3	166	170	PF12436	0.415
DOC_WW_Pin1_4	242	247	PF00397	0.660
DOC_WW_Pin1_4	8	13	PF00397	0.405
LIG_14-3-3_CanoR_1	115	125	PF00244	0.284
LIG_14-3-3_CanoR_1	188	194	PF00244	0.625
LIG_14-3-3_CanoR_1	205	211	PF00244	0.363
LIG_14-3-3_CanoR_1	337	347	PF00244	0.548
LIG_14-3-3_CanoR_1	396	405	PF00244	0.408
LIG_14-3-3_CanoR_1	64	74	PF00244	0.366
LIG_BRCT_BRCA1_1	425	429	PF00533	0.673
LIG_eIF4E_1	272	278	PF01652	0.435
LIG_FHA_1	236	242	PF00498	0.552
LIG_FHA_1	327	333	PF00498	0.496
LIG_FHA_1	342	348	PF00498	0.399
LIG_FHA_1	376	382	PF00498	0.414
LIG_FHA_1	400	406	PF00498	0.384
LIG_FHA_2	271	277	PF00498	0.321
LIG_FHA_2	278	284	PF00498	0.349
LIG_FHA_2	398	404	PF00498	0.443
LIG_LIR_Apic_2	18	24	PF02991	0.458
LIG_LIR_Apic_2	258	264	PF02991	0.382
LIG_LIR_Apic_2	426	432	PF02991	0.626
LIG_LIR_Apic_2	68	74	PF02991	0.231
LIG_LIR_Gen_1	249	259	PF02991	0.390
LIG_LIR_Gen_1	299	308	PF02991	0.370
LIG_LIR_Gen_1	325	335	PF02991	0.449
LIG_LIR_Gen_1	362	371	PF02991	0.350
LIG_LIR_Nem_3	10	16	PF02991	0.347
LIG_LIR_Nem_3	249	254	PF02991	0.384
LIG_LIR_Nem_3	266	270	PF02991	0.246
LIG_LIR_Nem_3	299	305	PF02991	0.366
LIG_LIR_Nem_3	325	331	PF02991	0.458
LIG_LIR_Nem_3	362	366	PF02991	0.348
LIG_Pex14_2	152	156	PF04695	0.382
LIG_SH2_CRK	261	265	PF00017	0.432
LIG_SH2_PTP2	253	256	PF00017	0.423
LIG_SH2_PTP2	363	366	PF00017	0.429
LIG_SH2_STAT5	253	256	PF00017	0.366
LIG_SH2_STAT5	272	275	PF00017	0.193
LIG_SH2_STAT5	363	366	PF00017	0.394
LIG_SH3_2	432	437	PF14604	0.626
LIG_SH3_3	172	178	PF00018	0.375
LIG_SH3_3	428	434	PF00018	0.812
LIG_SH3_3	6	12	PF00018	0.351
LIG_SH3_3	83	89	PF00018	0.312
LIG_TRFH_1	71	75	PF08558	0.300
LIG_TYR_ITIM	361	366	PF00017	0.440
LIG_UBA3_1	1	7	PF00899	0.311
LIG_WW_3	433	437	PF00397	0.626
MOD_CDK_SPxK_1	242	248	PF00069	0.480
MOD_CK1_1	189	195	PF00069	0.622
MOD_CK1_1	209	215	PF00069	0.371
MOD_CK1_1	235	241	PF00069	0.707
MOD_CK1_1	341	347	PF00069	0.481
MOD_CK1_1	359	365	PF00069	0.425
MOD_CK1_1	76	82	PF00069	0.414
MOD_CK2_1	270	276	PF00069	0.321
MOD_CK2_1	342	348	PF00069	0.476
MOD_CK2_1	397	403	PF00069	0.414
MOD_CK2_1	441	447	PF00069	0.548
MOD_CK2_1	91	97	PF00069	0.254
MOD_Cter_Amidation	310	313	PF01082	0.339
MOD_GlcNHglycan	193	196	PF01048	0.497
MOD_GlcNHglycan	217	220	PF01048	0.503
MOD_GlcNHglycan	344	347	PF01048	0.594
MOD_GlcNHglycan	414	417	PF01048	0.727
MOD_GlcNHglycan	425	428	PF01048	0.687
MOD_GlcNHglycan	449	452	PF01048	0.605
MOD_GlcNHglycan	45	48	PF01048	0.400
MOD_GlcNHglycan	59	62	PF01048	0.312
MOD_GlcNHglycan	79	82	PF01048	0.262
MOD_GSK3_1	205	212	PF00069	0.454
MOD_GSK3_1	232	239	PF00069	0.656
MOD_GSK3_1	242	249	PF00069	0.459
MOD_GSK3_1	338	345	PF00069	0.462
MOD_GSK3_1	408	415	PF00069	0.595
MOD_GSK3_1	437	444	PF00069	0.531
MOD_GSK3_1	447	454	PF00069	0.684
MOD_GSK3_1	73	80	PF00069	0.437
MOD_N-GLC_1	189	194	PF02516	0.559
MOD_N-GLC_1	35	40	PF02516	0.360
MOD_N-GLC_1	447	452	PF02516	0.563
MOD_N-GLC_2	289	291	PF02516	0.323
MOD_NEK2_1	197	202	PF00069	0.454
MOD_NEK2_1	210	215	PF00069	0.307
MOD_NEK2_1	270	275	PF00069	0.324
MOD_NEK2_1	277	282	PF00069	0.334
MOD_NEK2_1	35	40	PF00069	0.426
MOD_NEK2_1	55	60	PF00069	0.284
MOD_PIKK_1	408	414	PF00454	0.481
MOD_PK_1	441	447	PF00069	0.508
MOD_PKA_1	437	443	PF00069	0.643
MOD_PKA_2	392	398	PF00069	0.347
MOD_PKA_2	437	443	PF00069	0.785
MOD_PKB_1	439	447	PF00069	0.508
MOD_Plk_1	189	195	PF00069	0.457
MOD_Plk_1	35	41	PF00069	0.404
MOD_Plk_1	441	447	PF00069	0.508
MOD_Plk_4	159	165	PF00069	0.438
MOD_Plk_4	206	212	PF00069	0.459
MOD_Plk_4	356	362	PF00069	0.427
MOD_Plk_4	91	97	PF00069	0.179
MOD_ProDKin_1	242	248	PF00069	0.652
MOD_ProDKin_1	8	14	PF00069	0.404
MOD_SUMO_for_1	222	225	PF00179	0.375
MOD_SUMO_for_1	405	408	PF00179	0.587
TRG_DiLeu_LyEn_5	123	128	PF01217	0.179
TRG_ENDOCYTIC_2	13	16	PF00928	0.367
TRG_ENDOCYTIC_2	253	256	PF00928	0.371
TRG_ENDOCYTIC_2	363	366	PF00928	0.429
TRG_ENDOCYTIC_2	372	375	PF00928	0.463
TRG_ER_diArg_1	396	399	PF00400	0.447
TRG_ER_diArg_1	435	438	PF00400	0.798
TRG_NES_CRM1_1	123	136	PF08389	0.422
TRG_NES_CRM1_1	167	179	PF08389	0.456
TRG_NLS_MonoCore_2	468	473	PF00514	0.580
TRG_NLS_MonoExtC_3	468	473	PF00514	0.746
TRG_NLS_MonoExtN_4	469	475	PF00514	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWR5	Leptomonas seymouri	58%	100%
A0A1X0NSU1	Trypanosomatidae	39%	100%
A0A3S7WUF8	Leishmania donovani	91%	100%
A0A422N4P6	Trypanosoma rangeli	40%	100%
A4H920	Leishmania braziliensis	77%	98%
A4HXF2	Leishmania infantum	91%	100%
C9ZP24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4QEB6	Leishmania major	90%	100%