Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AR46_LEIMU

TriTrypDb:

LmxM.17.0690

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR46

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.462
CLV_NRD_NRD_1	273	275	PF00675	0.561
CLV_NRD_NRD_1	42	44	PF00675	0.480
CLV_NRD_NRD_1	437	439	PF00675	0.565
CLV_NRD_NRD_1	85	87	PF00675	0.507
CLV_PCSK_KEX2_1	151	153	PF00082	0.433
CLV_PCSK_KEX2_1	273	275	PF00082	0.561
CLV_PCSK_KEX2_1	42	44	PF00082	0.525
CLV_PCSK_KEX2_1	437	439	PF00082	0.565
CLV_PCSK_SKI1_1	61	65	PF00082	0.501
CLV_PCSK_SKI1_1	93	97	PF00082	0.517
DEG_APCC_DBOX_1	150	158	PF00400	0.373
DEG_APCC_DBOX_1	42	50	PF00400	0.485
DEG_SCF_FBW7_1	344	351	PF00400	0.623
DEG_SPOP_SBC_1	105	109	PF00917	0.492
DEG_SPOP_SBC_1	310	314	PF00917	0.593
DEG_SPOP_SBC_1	462	466	PF00917	0.695
DOC_CDC14_PxL_1	337	345	PF14671	0.670
DOC_CKS1_1	220	225	PF01111	0.665
DOC_CKS1_1	255	260	PF01111	0.708
DOC_PP1_RVXF_1	435	442	PF00149	0.527
DOC_PP4_FxxP_1	20	23	PF00568	0.490
DOC_USP7_MATH_1	103	107	PF00917	0.529
DOC_USP7_MATH_1	119	123	PF00917	0.580
DOC_USP7_MATH_1	128	132	PF00917	0.538
DOC_USP7_MATH_1	210	214	PF00917	0.670
DOC_USP7_MATH_1	258	262	PF00917	0.564
DOC_USP7_MATH_1	276	280	PF00917	0.651
DOC_USP7_MATH_1	305	309	PF00917	0.630
DOC_USP7_MATH_1	310	314	PF00917	0.572
DOC_USP7_MATH_1	318	322	PF00917	0.630
DOC_USP7_MATH_1	331	335	PF00917	0.634
DOC_USP7_MATH_1	348	352	PF00917	0.508
DOC_USP7_MATH_1	370	374	PF00917	0.760
DOC_USP7_MATH_1	391	395	PF00917	0.662
DOC_USP7_MATH_1	486	490	PF00917	0.735
DOC_USP7_MATH_1	97	101	PF00917	0.508
DOC_USP7_MATH_2	419	425	PF00917	0.464
DOC_USP7_UBL2_3	141	145	PF12436	0.481
DOC_WW_Pin1_4	219	224	PF00397	0.621
DOC_WW_Pin1_4	254	259	PF00397	0.681
DOC_WW_Pin1_4	260	265	PF00397	0.627
DOC_WW_Pin1_4	272	277	PF00397	0.507
DOC_WW_Pin1_4	314	319	PF00397	0.721
DOC_WW_Pin1_4	344	349	PF00397	0.601
DOC_WW_Pin1_4	402	407	PF00397	0.671
DOC_WW_Pin1_4	464	469	PF00397	0.632
LIG_14-3-3_CanoR_1	162	168	PF00244	0.581
LIG_14-3-3_CanoR_1	173	180	PF00244	0.445
LIG_14-3-3_CanoR_1	240	248	PF00244	0.620
LIG_14-3-3_CanoR_1	316	324	PF00244	0.531
LIG_14-3-3_CanoR_1	93	102	PF00244	0.630
LIG_BRCT_BRCA1_1	184	188	PF00533	0.638
LIG_BRCT_BRCA1_1	488	492	PF00533	0.608
LIG_EVH1_1	340	344	PF00568	0.602
LIG_FHA_1	344	350	PF00498	0.504
LIG_FHA_1	402	408	PF00498	0.645
LIG_FHA_1	412	418	PF00498	0.551
LIG_FHA_1	67	73	PF00498	0.402
LIG_FHA_2	133	139	PF00498	0.414
LIG_FHA_2	193	199	PF00498	0.674
LIG_LIR_Apic_2	17	23	PF02991	0.481
LIG_LIR_Gen_1	169	179	PF02991	0.496
LIG_LIR_Gen_1	233	241	PF02991	0.556
LIG_LIR_Gen_1	489	498	PF02991	0.600
LIG_LIR_Nem_3	169	174	PF02991	0.488
LIG_LIR_Nem_3	233	238	PF02991	0.559
LIG_LIR_Nem_3	489	495	PF02991	0.604
LIG_NRBOX	34	40	PF00104	0.440
LIG_NRBOX	454	460	PF00104	0.614
LIG_Pex14_2	20	24	PF04695	0.490
LIG_PTB_Apo_2	73	80	PF02174	0.460
LIG_PTB_Phospho_1	73	79	PF10480	0.458
LIG_SH2_STAP1	235	239	PF00017	0.612
LIG_SH2_STAT3	392	395	PF00017	0.685
LIG_SH3_3	224	230	PF00018	0.603
LIG_SH3_3	338	344	PF00018	0.667
LIG_SH3_3	413	419	PF00018	0.500
LIG_SUMO_SIM_anti_2	282	287	PF11976	0.542
LIG_TRAF2_1	431	434	PF00917	0.537
LIG_UBA3_1	38	45	PF00899	0.420
LIG_WW_2	341	344	PF00397	0.599
MOD_CDK_SPxK_1	344	350	PF00069	0.604
MOD_CDK_SPxxK_3	402	409	PF00069	0.671
MOD_CK1_1	104	110	PF00069	0.579
MOD_CK1_1	112	118	PF00069	0.702
MOD_CK1_1	186	192	PF00069	0.492
MOD_CK1_1	233	239	PF00069	0.558
MOD_CK1_1	308	314	PF00069	0.551
MOD_CK1_1	317	323	PF00069	0.633
MOD_CK1_1	360	366	PF00069	0.668
MOD_CK1_1	461	467	PF00069	0.654
MOD_CK1_1	476	482	PF00069	0.694
MOD_CK1_1	493	499	PF00069	0.481
MOD_CK2_1	132	138	PF00069	0.440
MOD_CK2_1	276	282	PF00069	0.549
MOD_CK2_1	322	328	PF00069	0.629
MOD_CK2_1	467	473	PF00069	0.626
MOD_GlcNHglycan	103	106	PF01048	0.536
MOD_GlcNHglycan	111	114	PF01048	0.674
MOD_GlcNHglycan	163	166	PF01048	0.545
MOD_GlcNHglycan	207	210	PF01048	0.673
MOD_GlcNHglycan	212	215	PF01048	0.647
MOD_GlcNHglycan	260	263	PF01048	0.670
MOD_GlcNHglycan	324	327	PF01048	0.686
MOD_GlcNHglycan	337	340	PF01048	0.675
MOD_GlcNHglycan	359	362	PF01048	0.659
MOD_GlcNHglycan	372	375	PF01048	0.542
MOD_GlcNHglycan	383	386	PF01048	0.558
MOD_GlcNHglycan	395	398	PF01048	0.642
MOD_GlcNHglycan	423	426	PF01048	0.491
MOD_GlcNHglycan	460	463	PF01048	0.512
MOD_GlcNHglycan	478	481	PF01048	0.669
MOD_GlcNHglycan	488	491	PF01048	0.580
MOD_GlcNHglycan	495	498	PF01048	0.500
MOD_GSK3_1	101	108	PF00069	0.535
MOD_GSK3_1	124	131	PF00069	0.593
MOD_GSK3_1	182	189	PF00069	0.635
MOD_GSK3_1	254	261	PF00069	0.806
MOD_GSK3_1	272	279	PF00069	0.496
MOD_GSK3_1	305	312	PF00069	0.518
MOD_GSK3_1	314	321	PF00069	0.622
MOD_GSK3_1	331	338	PF00069	0.773
MOD_GSK3_1	344	351	PF00069	0.604
MOD_GSK3_1	355	362	PF00069	0.576
MOD_GSK3_1	37	44	PF00069	0.336
MOD_GSK3_1	458	465	PF00069	0.567
MOD_GSK3_1	486	493	PF00069	0.735
MOD_GSK3_1	93	100	PF00069	0.461
MOD_N-GLC_1	182	187	PF02516	0.581
MOD_NEK2_1	132	137	PF00069	0.517
MOD_NEK2_1	309	314	PF00069	0.561
MOD_NEK2_1	355	360	PF00069	0.528
MOD_NEK2_1	41	46	PF00069	0.395
MOD_NEK2_1	451	456	PF00069	0.564
MOD_NEK2_1	458	463	PF00069	0.529
MOD_NEK2_2	97	102	PF00069	0.472
MOD_PIKK_1	119	125	PF00454	0.600
MOD_PIKK_1	132	138	PF00454	0.457
MOD_PIKK_1	391	397	PF00454	0.641
MOD_PIKK_1	432	438	PF00454	0.402
MOD_PKA_2	161	167	PF00069	0.429
MOD_PKA_2	205	211	PF00069	0.690
MOD_PKA_2	239	245	PF00069	0.608
MOD_PKA_2	41	47	PF00069	0.395
MOD_PKA_2	473	479	PF00069	0.697
MOD_Plk_1	16	22	PF00069	0.429
MOD_Plk_1	31	37	PF00069	0.498
MOD_Plk_1	411	417	PF00069	0.657
MOD_Plk_2-3	473	479	PF00069	0.653
MOD_Plk_4	31	37	PF00069	0.442
MOD_ProDKin_1	219	225	PF00069	0.619
MOD_ProDKin_1	254	260	PF00069	0.681
MOD_ProDKin_1	272	278	PF00069	0.501
MOD_ProDKin_1	314	320	PF00069	0.721
MOD_ProDKin_1	344	350	PF00069	0.604
MOD_ProDKin_1	402	408	PF00069	0.670
MOD_ProDKin_1	464	470	PF00069	0.633
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.467
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.480
TRG_ENDOCYTIC_2	235	238	PF00928	0.615
TRG_ER_diArg_1	150	152	PF00400	0.470
TRG_ER_diArg_1	297	300	PF00400	0.490
TRG_ER_diArg_1	41	43	PF00400	0.481
TRG_ER_diArg_1	437	439	PF00400	0.505
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW8	Leptomonas seymouri	41%	96%
A0A3S5H709	Leishmania donovani	91%	100%
A4H919	Leishmania braziliensis	68%	100%
A4HXF1	Leishmania infantum	91%	100%
Q4QEB7	Leishmania major	89%	100%