Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AR45_LEIMU

TriTrypDb:

LmxM.17.0680

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AR45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	198	204	PF00089	0.396
CLV_NRD_NRD_1	358	360	PF00675	0.454
CLV_NRD_NRD_1	367	369	PF00675	0.430
CLV_NRD_NRD_1	388	390	PF00675	0.587
CLV_NRD_NRD_1	431	433	PF00675	0.436
CLV_PCSK_FUR_1	365	369	PF00082	0.454
CLV_PCSK_KEX2_1	323	325	PF00082	0.430
CLV_PCSK_KEX2_1	358	360	PF00082	0.440
CLV_PCSK_KEX2_1	367	369	PF00082	0.441
CLV_PCSK_KEX2_1	387	389	PF00082	0.588
CLV_PCSK_KEX2_1	90	92	PF00082	0.446
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.469
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.443
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.423
CLV_PCSK_SKI1_1	266	270	PF00082	0.334
CLV_PCSK_SKI1_1	304	308	PF00082	0.447
CLV_PCSK_SKI1_1	323	327	PF00082	0.352
CLV_PCSK_SKI1_1	336	340	PF00082	0.355
CLV_PCSK_SKI1_1	367	371	PF00082	0.356
CLV_PCSK_SKI1_1	45	49	PF00082	0.259
DEG_APCC_DBOX_1	419	427	PF00400	0.518
DEG_Nend_Nbox_1	1	3	PF02207	0.630
DEG_SPOP_SBC_1	166	170	PF00917	0.338
DOC_CKS1_1	30	35	PF01111	0.402
DOC_CYCLIN_yCln2_LP_2	232	238	PF00134	0.427
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	47	53	PF00134	0.419
DOC_MAPK_gen_1	214	223	PF00069	0.548
DOC_MAPK_gen_1	333	343	PF00069	0.625
DOC_MAPK_MEF2A_6	214	223	PF00069	0.540
DOC_PP1_RVXF_1	199	205	PF00149	0.600
DOC_PP1_RVXF_1	302	308	PF00149	0.623
DOC_PP1_RVXF_1	82	89	PF00149	0.562
DOC_PP2B_LxvP_1	130	133	PF13499	0.399
DOC_PP2B_LxvP_1	240	243	PF13499	0.441
DOC_PP2B_LxvP_1	47	50	PF13499	0.380
DOC_PP4_FxxP_1	247	250	PF00568	0.372
DOC_PP4_FxxP_1	280	283	PF00568	0.632
DOC_USP7_MATH_1	227	231	PF00917	0.442
DOC_USP7_MATH_1	390	394	PF00917	0.729
DOC_USP7_UBL2_3	356	360	PF12436	0.693
DOC_WW_Pin1_4	148	153	PF00397	0.412
DOC_WW_Pin1_4	2	7	PF00397	0.623
DOC_WW_Pin1_4	29	34	PF00397	0.410
DOC_WW_Pin1_4	395	400	PF00397	0.612
LIG_14-3-3_CanoR_1	103	109	PF00244	0.554
LIG_14-3-3_CanoR_1	196	204	PF00244	0.547
LIG_14-3-3_CanoR_1	368	374	PF00244	0.738
LIG_14-3-3_CanoR_1	389	399	PF00244	0.608
LIG_14-3-3_CanoR_1	45	50	PF00244	0.238
LIG_APCC_ABBA_1	341	346	PF00400	0.655
LIG_APCC_ABBA_1	51	56	PF00400	0.422
LIG_Clathr_ClatBox_1	176	180	PF01394	0.427
LIG_FHA_1	108	114	PF00498	0.571
LIG_FHA_1	137	143	PF00498	0.344
LIG_FHA_1	180	186	PF00498	0.354
LIG_FHA_1	235	241	PF00498	0.399
LIG_FHA_1	260	266	PF00498	0.474
LIG_FHA_1	313	319	PF00498	0.688
LIG_FHA_1	368	374	PF00498	0.547
LIG_FHA_2	306	312	PF00498	0.629
LIG_FHA_2	370	376	PF00498	0.658
LIG_FHA_2	396	402	PF00498	0.707
LIG_LIR_Gen_1	190	198	PF02991	0.550
LIG_LIR_Gen_1	75	83	PF02991	0.614
LIG_LIR_Nem_3	102	108	PF02991	0.624
LIG_LIR_Nem_3	190	195	PF02991	0.483
LIG_LIR_Nem_3	48	54	PF02991	0.407
LIG_LIR_Nem_3	75	79	PF02991	0.529
LIG_MYND_1	250	254	PF01753	0.336
LIG_PCNA_yPIPBox_3	201	212	PF02747	0.558
LIG_RPA_C_Insects	86	101	PF08784	0.460
LIG_SH2_SRC	76	79	PF00017	0.449
LIG_SH2_STAP1	238	242	PF00017	0.525
LIG_SH2_STAP1	328	332	PF00017	0.489
LIG_SH2_STAT3	285	288	PF00017	0.508
LIG_SH2_STAT3	54	57	PF00017	0.468
LIG_SH2_STAT5	119	122	PF00017	0.369
LIG_SH2_STAT5	128	131	PF00017	0.360
LIG_SH2_STAT5	251	254	PF00017	0.342
LIG_SH2_STAT5	76	79	PF00017	0.521
LIG_SH3_3	280	286	PF00018	0.552
LIG_SH3_3	77	83	PF00018	0.458
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.514
LIG_TRAF2_1	398	401	PF00917	0.746
LIG_WRC_WIRS_1	105	110	PF05994	0.583
LIG_WRC_WIRS_1	137	142	PF05994	0.484
MOD_CDK_SPxxK_3	2	9	PF00069	0.522
MOD_CK1_1	107	113	PF00069	0.510
MOD_CK1_1	123	129	PF00069	0.282
MOD_CK1_1	164	170	PF00069	0.612
MOD_CK1_1	172	178	PF00069	0.390
MOD_CK1_1	260	266	PF00069	0.346
MOD_CK1_1	29	35	PF00069	0.514
MOD_CK1_1	379	385	PF00069	0.731
MOD_CK1_1	395	401	PF00069	0.812
MOD_CK1_1	406	412	PF00069	0.704
MOD_CK2_1	305	311	PF00069	0.461
MOD_CK2_1	391	397	PF00069	0.828
MOD_CK2_1	406	412	PF00069	0.614
MOD_GlcNHglycan	122	125	PF01048	0.439
MOD_GlcNHglycan	171	174	PF01048	0.645
MOD_GlcNHglycan	259	262	PF01048	0.436
MOD_GlcNHglycan	39	42	PF01048	0.430
MOD_GlcNHglycan	394	397	PF01048	0.767
MOD_GSK3_1	161	168	PF00069	0.599
MOD_GSK3_1	175	182	PF00069	0.360
MOD_GSK3_1	260	267	PF00069	0.334
MOD_GSK3_1	314	321	PF00069	0.616
MOD_GSK3_1	391	398	PF00069	0.728
MOD_GSK3_1	399	406	PF00069	0.680
MOD_GSK3_1	45	52	PF00069	0.234
MOD_N-GLC_1	270	275	PF02516	0.444
MOD_NEK2_1	12	17	PF00069	0.463
MOD_NEK2_1	153	158	PF00069	0.501
MOD_NEK2_1	165	170	PF00069	0.587
MOD_NEK2_1	257	262	PF00069	0.340
MOD_NEK2_1	305	310	PF00069	0.527
MOD_NEK2_1	37	42	PF00069	0.407
MOD_NEK2_1	391	396	PF00069	0.743
MOD_NEK2_2	187	192	PF00069	0.380
MOD_PIKK_1	196	202	PF00454	0.427
MOD_PIKK_1	318	324	PF00454	0.533
MOD_PIKK_1	379	385	PF00454	0.672
MOD_PKA_1	367	373	PF00069	0.626
MOD_PKA_2	367	373	PF00069	0.593
MOD_PKA_2	435	441	PF00069	0.382
MOD_PKB_1	365	373	PF00069	0.473
MOD_Plk_4	12	18	PF00069	0.380
MOD_Plk_4	123	129	PF00069	0.341
MOD_Plk_4	136	142	PF00069	0.485
MOD_Plk_4	172	178	PF00069	0.317
MOD_Plk_4	227	233	PF00069	0.333
MOD_Plk_4	264	270	PF00069	0.406
MOD_ProDKin_1	148	154	PF00069	0.511
MOD_ProDKin_1	2	8	PF00069	0.526
MOD_ProDKin_1	29	35	PF00069	0.508
MOD_ProDKin_1	395	401	PF00069	0.517
TRG_ENDOCYTIC_2	76	79	PF00928	0.395
TRG_ER_diArg_1	367	369	PF00400	0.603
TRG_ER_diArg_1	386	389	PF00400	0.757
TRG_ER_diArg_1	426	429	PF00400	0.579
TRG_NLS_MonoCore_2	357	362	PF00514	0.623
TRG_NLS_MonoExtN_4	356	363	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3N4	Leptomonas seymouri	60%	94%
A0A0S4KHH7	Bodo saltans	36%	90%
A0A1X0NTB3	Trypanosomatidae	48%	100%
A0A3S7WUI4	Leishmania donovani	93%	100%
A4H918	Leishmania braziliensis	82%	100%
A4HXF0	Leishmania infantum	93%	100%
C9ZP21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4QEB8	Leishmania major	92%	100%
V5BFE7	Trypanosoma cruzi	47%	100%