VID27 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

VID27 cytoplasmic protein, putative

Species:

Leishmania mexicana

UniProt:

E9AR41_LEIMU

TriTrypDb:

LmxM.17.0640

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AR41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	339	341	PF00675	0.357
CLV_NRD_NRD_1	372	374	PF00675	0.291
CLV_NRD_NRD_1	438	440	PF00675	0.441
CLV_PCSK_SKI1_1	341	345	PF00082	0.311
CLV_PCSK_SKI1_1	382	386	PF00082	0.307
DEG_SPOP_SBC_1	407	411	PF00917	0.355
DEG_SPOP_SBC_1	517	521	PF00917	0.489
DOC_CYCLIN_RxL_1	382	390	PF00134	0.338
DOC_MAPK_gen_1	439	446	PF00069	0.314
DOC_MAPK_JIP1_4	279	285	PF00069	0.355
DOC_MAPK_MEF2A_6	391	399	PF00069	0.308
DOC_PP1_RVXF_1	305	312	PF00149	0.357
DOC_PP4_FxxP_1	108	111	PF00568	0.484
DOC_PP4_FxxP_1	72	75	PF00568	0.448
DOC_USP7_MATH_1	192	196	PF00917	0.443
DOC_USP7_MATH_1	284	288	PF00917	0.355
DOC_USP7_MATH_1	295	299	PF00917	0.242
DOC_USP7_MATH_1	335	339	PF00917	0.365
DOC_USP7_MATH_1	495	499	PF00917	0.355
DOC_USP7_MATH_1	87	91	PF00917	0.501
DOC_WW_Pin1_4	446	451	PF00397	0.360
LIG_14-3-3_CanoR_1	107	111	PF00244	0.424
LIG_14-3-3_CanoR_1	133	139	PF00244	0.336
LIG_14-3-3_CanoR_1	524	531	PF00244	0.442
LIG_14-3-3_CanoR_1	550	555	PF00244	0.536
LIG_APCC_ABBA_1	413	418	PF00400	0.355
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BRCT_BRCA1_1	194	198	PF00533	0.380
LIG_BRCT_BRCA1_1	409	413	PF00533	0.355
LIG_BRCT_BRCA1_1	428	432	PF00533	0.160
LIG_CaM_NSCaTE_8	151	158	PF13499	0.501
LIG_Clathr_ClatBox_1	414	418	PF01394	0.355
LIG_FHA_1	117	123	PF00498	0.482
LIG_FHA_1	133	139	PF00498	0.291
LIG_FHA_1	158	164	PF00498	0.488
LIG_FHA_1	167	173	PF00498	0.482
LIG_FHA_1	199	205	PF00498	0.233
LIG_FHA_1	210	216	PF00498	0.270
LIG_FHA_1	241	247	PF00498	0.476
LIG_FHA_1	251	257	PF00498	0.410
LIG_FHA_1	3	9	PF00498	0.543
LIG_FHA_1	34	40	PF00498	0.363
LIG_FHA_1	409	415	PF00498	0.384
LIG_FHA_1	417	423	PF00498	0.335
LIG_FHA_1	473	479	PF00498	0.400
LIG_FHA_1	488	494	PF00498	0.209
LIG_FHA_1	86	92	PF00498	0.536
LIG_FHA_2	138	144	PF00498	0.392
LIG_FHA_2	157	163	PF00498	0.544
LIG_FHA_2	243	249	PF00498	0.432
LIG_FHA_2	384	390	PF00498	0.279
LIG_FHA_2	530	536	PF00498	0.341
LIG_GBD_Chelix_1	309	317	PF00786	0.410
LIG_HCF-1_HBM_1	24	27	PF13415	0.498
LIG_LIR_Apic_2	24	30	PF02991	0.481
LIG_LIR_Apic_2	332	337	PF02991	0.397
LIG_LIR_Apic_2	69	75	PF02991	0.460
LIG_LIR_Apic_2	83	87	PF02991	0.289
LIG_LIR_Gen_1	135	142	PF02991	0.387
LIG_LIR_Gen_1	149	158	PF02991	0.373
LIG_LIR_Gen_1	410	421	PF02991	0.327
LIG_LIR_Gen_1	466	473	PF02991	0.357
LIG_LIR_LC3C_4	201	204	PF02991	0.295
LIG_LIR_LC3C_4	231	235	PF02991	0.470
LIG_LIR_Nem_3	135	139	PF02991	0.354
LIG_LIR_Nem_3	140	145	PF02991	0.421
LIG_LIR_Nem_3	148	154	PF02991	0.349
LIG_LIR_Nem_3	410	416	PF02991	0.351
LIG_LIR_Nem_3	466	472	PF02991	0.297
LIG_LIR_Nem_3	90	96	PF02991	0.361
LIG_PCNA_yPIPBox_3	121	133	PF02747	0.393
LIG_SH2_CRK	136	140	PF00017	0.360
LIG_SH2_CRK	152	156	PF00017	0.381
LIG_SH2_CRK	28	32	PF00017	0.507
LIG_SH2_CRK	302	306	PF00017	0.297
LIG_SH2_CRK	334	338	PF00017	0.355
LIG_SH2_CRK	366	370	PF00017	0.279
LIG_SH2_CRK	84	88	PF00017	0.489
LIG_SH2_GRB2like	290	293	PF00017	0.410
LIG_SH2_NCK_1	142	146	PF00017	0.475
LIG_SH2_NCK_1	334	338	PF00017	0.306
LIG_SH2_NCK_1	84	88	PF00017	0.436
LIG_SH2_SRC	142	145	PF00017	0.545
LIG_SH2_SRC	16	19	PF00017	0.567
LIG_SH2_SRC	290	293	PF00017	0.410
LIG_SH2_SRC	421	424	PF00017	0.355
LIG_SH2_SRC	60	63	PF00017	0.468
LIG_SH2_STAT5	154	157	PF00017	0.382
LIG_SH2_STAT5	302	305	PF00017	0.279
LIG_SH2_STAT5	353	356	PF00017	0.331
LIG_SH2_STAT5	366	369	PF00017	0.246
LIG_SH2_STAT5	379	382	PF00017	0.297
LIG_SH2_STAT5	405	408	PF00017	0.283
LIG_SH2_STAT5	421	424	PF00017	0.283
LIG_SH2_STAT5	487	490	PF00017	0.361
LIG_SH2_STAT5	60	63	PF00017	0.453
LIG_SH3_3	88	94	PF00018	0.421
LIG_SUMO_SIM_anti_2	38	43	PF11976	0.409
LIG_SUMO_SIM_par_1	393	398	PF11976	0.297
LIG_SUMO_SIM_par_1	59	67	PF11976	0.492
LIG_TRAF2_1	19	22	PF00917	0.565
LIG_TRAF2_1	207	210	PF00917	0.464
LIG_TYR_ITSM	138	145	PF00017	0.457
LIG_UBA3_1	414	420	PF00899	0.355
LIG_WRC_WIRS_1	34	39	PF05994	0.407
MOD_CK1_1	137	143	PF00069	0.421
MOD_CK1_1	2	8	PF00069	0.483
MOD_CK1_1	242	248	PF00069	0.428
MOD_CK1_1	499	505	PF00069	0.355
MOD_CK1_1	53	59	PF00069	0.630
MOD_CK1_1	85	91	PF00069	0.402
MOD_CK2_1	156	162	PF00069	0.546
MOD_CK2_1	204	210	PF00069	0.517
MOD_CK2_1	242	248	PF00069	0.355
MOD_CK2_1	53	59	PF00069	0.562
MOD_GlcNHglycan	1	4	PF01048	0.602
MOD_GlcNHglycan	260	263	PF01048	0.407
MOD_GlcNHglycan	297	300	PF01048	0.351
MOD_GlcNHglycan	358	362	PF01048	0.334
MOD_GlcNHglycan	501	504	PF01048	0.612
MOD_GlcNHglycan	508	511	PF01048	0.405
MOD_GlcNHglycan	520	523	PF01048	0.249
MOD_GlcNHglycan	84	87	PF01048	0.448
MOD_GSK3_1	178	185	PF00069	0.537
MOD_GSK3_1	238	245	PF00069	0.429
MOD_GSK3_1	291	298	PF00069	0.373
MOD_GSK3_1	33	40	PF00069	0.312
MOD_GSK3_1	341	348	PF00069	0.293
MOD_GSK3_1	383	390	PF00069	0.297
MOD_GSK3_1	427	434	PF00069	0.371
MOD_GSK3_1	44	51	PF00069	0.651
MOD_GSK3_1	446	453	PF00069	0.243
MOD_GSK3_1	495	502	PF00069	0.355
MOD_GSK3_1	513	520	PF00069	0.335
MOD_GSK3_1	546	553	PF00069	0.507
MOD_GSK3_1	7	14	PF00069	0.371
MOD_N-GLC_1	198	203	PF02516	0.333
MOD_N-GLC_1	291	296	PF02516	0.410
MOD_N-GLC_1	53	58	PF02516	0.628
MOD_N-GLC_2	132	134	PF02516	0.322
MOD_N-GLC_2	189	191	PF02516	0.363
MOD_NEK2_1	106	111	PF00069	0.418
MOD_NEK2_1	198	203	PF00069	0.242
MOD_NEK2_1	257	262	PF00069	0.197
MOD_NEK2_1	37	42	PF00069	0.442
MOD_NEK2_1	387	392	PF00069	0.336
MOD_NEK2_1	416	421	PF00069	0.299
MOD_NEK2_1	478	483	PF00069	0.402
MOD_NEK2_1	489	494	PF00069	0.435
MOD_NEK2_1	518	523	PF00069	0.425
MOD_NEK2_1	80	85	PF00069	0.381
MOD_NEK2_2	192	197	PF00069	0.262
MOD_NEK2_2	450	455	PF00069	0.355
MOD_NEK2_2	87	92	PF00069	0.421
MOD_OFUCOSY	479	484	PF10250	0.355
MOD_PIKK_1	175	181	PF00454	0.418
MOD_PIKK_1	346	352	PF00454	0.355
MOD_PIKK_1	496	502	PF00454	0.444
MOD_PKA_2	106	112	PF00069	0.433
MOD_PKA_2	132	138	PF00069	0.343
MOD_PKA_2	523	529	PF00069	0.453
MOD_Plk_1	198	204	PF00069	0.480
MOD_Plk_1	209	215	PF00069	0.461
MOD_Plk_1	250	256	PF00069	0.395
MOD_Plk_1	450	456	PF00069	0.355
MOD_Plk_1	53	59	PF00069	0.669
MOD_Plk_2-3	209	215	PF00069	0.475
MOD_Plk_4	11	17	PF00069	0.390
MOD_Plk_4	134	140	PF00069	0.428
MOD_Plk_4	242	248	PF00069	0.410
MOD_Plk_4	250	256	PF00069	0.410
MOD_Plk_4	270	276	PF00069	0.150
MOD_Plk_4	383	389	PF00069	0.279
MOD_Plk_4	409	415	PF00069	0.440
MOD_Plk_4	457	463	PF00069	0.294
MOD_Plk_4	513	519	PF00069	0.552
MOD_ProDKin_1	446	452	PF00069	0.360
MOD_SUMO_for_1	544	547	PF00179	0.449
MOD_SUMO_rev_2	321	331	PF00179	0.428
MOD_SUMO_rev_2	412	422	PF00179	0.355
TRG_ENDOCYTIC_2	136	139	PF00928	0.337
TRG_ENDOCYTIC_2	142	145	PF00928	0.399
TRG_ENDOCYTIC_2	152	155	PF00928	0.366
TRG_ENDOCYTIC_2	28	31	PF00928	0.421
TRG_ENDOCYTIC_2	302	305	PF00928	0.279
TRG_ENDOCYTIC_2	353	356	PF00928	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUK8	Leptomonas seymouri	63%	100%
A0A1X0NPH3	Trypanosomatidae	40%	100%
A0A3R7NJV3	Trypanosoma rangeli	42%	100%
A0A3S7WUG9	Leishmania donovani	97%	100%
A4H914	Leishmania braziliensis	88%	100%
A4HXE6	Leishmania infantum	97%	100%
C9ZUK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4QEC2	Leishmania major	96%	100%
V5BNW8	Trypanosoma cruzi	44%	100%