LeishMANIAdb
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Serine/threonine-protein kinase PLK

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein kinase PLK
Gene product:
protein kinase, putative
Species:
Leishmania mexicana
UniProt:
E9AR40_LEIMU
TriTrypDb:
LmxM.17.0790
Length:
706

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000922 spindle pole 2 1
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0005813 centrosome 3 1
GO:0005815 microtubule organizing center 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AR40
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR40

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0000278 mitotic cell cycle 3 1
GO:0007049 cell cycle 2 1
GO:0010564 regulation of cell cycle process 5 1
GO:0032465 regulation of cytokinesis 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051302 regulation of cell division 4 1
GO:0051726 regulation of cell cycle 4 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0004674 protein serine/threonine kinase activity 4 10
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 482 486 PF00656 0.613
CLV_NRD_NRD_1 100 102 PF00675 0.352
CLV_NRD_NRD_1 139 141 PF00675 0.363
CLV_NRD_NRD_1 199 201 PF00675 0.274
CLV_NRD_NRD_1 345 347 PF00675 0.684
CLV_NRD_NRD_1 671 673 PF00675 0.286
CLV_PCSK_KEX2_1 100 102 PF00082 0.294
CLV_PCSK_KEX2_1 139 141 PF00082 0.365
CLV_PCSK_KEX2_1 201 203 PF00082 0.274
CLV_PCSK_KEX2_1 256 258 PF00082 0.294
CLV_PCSK_KEX2_1 345 347 PF00082 0.684
CLV_PCSK_KEX2_1 625 627 PF00082 0.342
CLV_PCSK_KEX2_1 670 672 PF00082 0.287
CLV_PCSK_PC1ET2_1 201 203 PF00082 0.274
CLV_PCSK_PC1ET2_1 256 258 PF00082 0.399
CLV_PCSK_PC1ET2_1 625 627 PF00082 0.342
CLV_PCSK_SKI1_1 100 104 PF00082 0.302
CLV_PCSK_SKI1_1 139 143 PF00082 0.347
CLV_PCSK_SKI1_1 168 172 PF00082 0.277
CLV_PCSK_SKI1_1 362 366 PF00082 0.676
CLV_PCSK_SKI1_1 371 375 PF00082 0.566
CLV_PCSK_SKI1_1 560 564 PF00082 0.268
CLV_PCSK_SKI1_1 574 578 PF00082 0.197
CLV_PCSK_SKI1_1 580 584 PF00082 0.294
CLV_PCSK_SKI1_1 660 664 PF00082 0.230
CLV_PCSK_SKI1_1 694 698 PF00082 0.400
CLV_Separin_Metazoa 372 376 PF03568 0.645
DEG_APCC_DBOX_1 287 295 PF00400 0.294
DEG_APCC_DBOX_1 370 378 PF00400 0.623
DEG_Nend_UBRbox_2 1 3 PF02207 0.701
DEG_SCF_FBW7_1 306 313 PF00400 0.569
DEG_SPOP_SBC_1 20 24 PF00917 0.672
DEG_SPOP_SBC_1 327 331 PF00917 0.726
DEG_SPOP_SBC_1 337 341 PF00917 0.648
DEG_SPOP_SBC_1 615 619 PF00917 0.595
DOC_CKS1_1 307 312 PF01111 0.601
DOC_CYCLIN_yCln2_LP_2 308 314 PF00134 0.609
DOC_MAPK_gen_1 100 110 PF00069 0.302
DOC_MAPK_gen_1 115 124 PF00069 0.294
DOC_MAPK_gen_1 168 177 PF00069 0.366
DOC_MAPK_gen_1 342 350 PF00069 0.478
DOC_MAPK_gen_1 625 636 PF00069 0.469
DOC_MAPK_gen_1 670 676 PF00069 0.519
DOC_MAPK_MEF2A_6 345 352 PF00069 0.635
DOC_PP1_RVXF_1 523 529 PF00149 0.519
DOC_PP2B_LxvP_1 308 311 PF13499 0.536
DOC_PP2B_LxvP_1 319 322 PF13499 0.583
DOC_PP2B_LxvP_1 365 368 PF13499 0.647
DOC_PP4_FxxP_1 141 144 PF00568 0.161
DOC_PP4_FxxP_1 317 320 PF00568 0.678
DOC_SPAK_OSR1_1 140 144 PF12202 0.294
DOC_USP7_MATH_1 21 25 PF00917 0.679
DOC_USP7_MATH_1 33 37 PF00917 0.516
DOC_USP7_MATH_1 483 487 PF00917 0.548
DOC_USP7_MATH_1 615 619 PF00917 0.593
DOC_USP7_UBL2_3 87 91 PF12436 0.319
DOC_WW_Pin1_4 204 209 PF00397 0.280
DOC_WW_Pin1_4 281 286 PF00397 0.381
DOC_WW_Pin1_4 300 305 PF00397 0.344
DOC_WW_Pin1_4 306 311 PF00397 0.502
DOC_WW_Pin1_4 352 357 PF00397 0.560
DOC_WW_Pin1_4 387 392 PF00397 0.699
DOC_WW_Pin1_4 422 427 PF00397 0.669
DOC_WW_Pin1_4 442 447 PF00397 0.645
DOC_WW_Pin1_4 589 594 PF00397 0.574
DOC_WW_Pin1_4 599 604 PF00397 0.380
LIG_14-3-3_CanoR_1 139 144 PF00244 0.319
LIG_14-3-3_CanoR_1 295 300 PF00244 0.356
LIG_14-3-3_CanoR_1 392 398 PF00244 0.584
LIG_14-3-3_CanoR_1 440 446 PF00244 0.657
LIG_14-3-3_CanoR_1 469 475 PF00244 0.580
LIG_14-3-3_CanoR_1 560 566 PF00244 0.543
LIG_14-3-3_CanoR_1 588 593 PF00244 0.552
LIG_14-3-3_CanoR_1 611 615 PF00244 0.624
LIG_14-3-3_CanoR_1 660 665 PF00244 0.430
LIG_14-3-3_CanoR_1 670 675 PF00244 0.430
LIG_14-3-3_CanoR_1 691 697 PF00244 0.496
LIG_14-3-3_CanoR_1 80 84 PF00244 0.352
LIG_BRCT_BRCA1_1 617 621 PF00533 0.622
LIG_eIF4E_1 118 124 PF01652 0.399
LIG_EVH1_2 310 314 PF00568 0.600
LIG_FHA_1 144 150 PF00498 0.307
LIG_FHA_1 21 27 PF00498 0.638
LIG_FHA_1 227 233 PF00498 0.313
LIG_FHA_1 236 242 PF00498 0.233
LIG_FHA_1 276 282 PF00498 0.400
LIG_FHA_1 430 436 PF00498 0.761
LIG_FHA_1 522 528 PF00498 0.430
LIG_FHA_1 530 536 PF00498 0.430
LIG_FHA_1 640 646 PF00498 0.444
LIG_FHA_1 671 677 PF00498 0.435
LIG_FHA_1 691 697 PF00498 0.227
LIG_FHA_1 70 76 PF00498 0.378
LIG_FHA_2 111 117 PF00498 0.294
LIG_FHA_2 129 135 PF00498 0.294
LIG_FHA_2 140 146 PF00498 0.294
LIG_FHA_2 270 276 PF00498 0.344
LIG_FHA_2 288 294 PF00498 0.270
LIG_FHA_2 615 621 PF00498 0.571
LIG_FHA_2 679 685 PF00498 0.587
LIG_LIR_Apic_2 207 213 PF02991 0.280
LIG_LIR_Apic_2 316 320 PF02991 0.718
LIG_LIR_Gen_1 116 124 PF02991 0.352
LIG_LIR_Gen_1 145 156 PF02991 0.319
LIG_LIR_Gen_1 313 322 PF02991 0.640
LIG_LIR_Gen_1 536 546 PF02991 0.407
LIG_LIR_Gen_1 618 628 PF02991 0.494
LIG_LIR_Gen_1 695 706 PF02991 0.528
LIG_LIR_Nem_3 116 121 PF02991 0.306
LIG_LIR_Nem_3 145 151 PF02991 0.319
LIG_LIR_Nem_3 252 258 PF02991 0.281
LIG_LIR_Nem_3 313 317 PF02991 0.617
LIG_LIR_Nem_3 536 541 PF02991 0.407
LIG_LIR_Nem_3 579 585 PF02991 0.489
LIG_LIR_Nem_3 618 624 PF02991 0.495
LIG_LIR_Nem_3 656 662 PF02991 0.519
LIG_LIR_Nem_3 695 701 PF02991 0.501
LIG_MYND_1 306 310 PF01753 0.599
LIG_MYND_1 408 412 PF01753 0.491
LIG_NRBOX 131 137 PF00104 0.399
LIG_NRBOX 235 241 PF00104 0.274
LIG_Pex14_2 110 114 PF04695 0.294
LIG_SH2_CRK 237 241 PF00017 0.292
LIG_SH2_CRK 255 259 PF00017 0.197
LIG_SH2_CRK 263 267 PF00017 0.274
LIG_SH2_CRK 538 542 PF00017 0.406
LIG_SH2_CRK 698 702 PF00017 0.514
LIG_SH2_PTP2 148 151 PF00017 0.352
LIG_SH2_PTP2 210 213 PF00017 0.274
LIG_SH2_STAP1 237 241 PF00017 0.331
LIG_SH2_STAP1 73 77 PF00017 0.319
LIG_SH2_STAT5 119 122 PF00017 0.356
LIG_SH2_STAT5 148 151 PF00017 0.365
LIG_SH2_STAT5 210 213 PF00017 0.276
LIG_SH2_STAT5 237 240 PF00017 0.295
LIG_SH2_STAT5 581 584 PF00017 0.374
LIG_SH2_STAT5 585 588 PF00017 0.393
LIG_SH2_STAT5 623 626 PF00017 0.374
LIG_SH2_STAT5 664 667 PF00017 0.430
LIG_SH3_2 606 611 PF14604 0.654
LIG_SH3_3 14 20 PF00018 0.685
LIG_SH3_3 238 244 PF00018 0.274
LIG_SH3_3 301 307 PF00018 0.494
LIG_SH3_3 353 359 PF00018 0.692
LIG_SH3_3 370 376 PF00018 0.633
LIG_SH3_3 378 384 PF00018 0.606
LIG_SH3_3 385 391 PF00018 0.561
LIG_SH3_3 409 415 PF00018 0.734
LIG_SH3_3 524 530 PF00018 0.444
LIG_SH3_3 600 606 PF00018 0.612
LIG_SH3_4 28 35 PF00018 0.530
LIG_SH3_CIN85_PxpxPR_1 606 611 PF14604 0.651
LIG_TRAF2_2 245 250 PF00917 0.274
LIG_TYR_ITIM 235 240 PF00017 0.294
LIG_TYR_ITIM 696 701 PF00017 0.497
LIG_UBA3_1 132 137 PF00899 0.319
LIG_WRC_WIRS_1 111 116 PF05994 0.294
LIG_WRC_WIRS_1 314 319 PF05994 0.648
LIG_WW_3 608 612 PF00397 0.644
MOD_CDC14_SPxK_1 592 595 PF00782 0.596
MOD_CDK_SPK_2 387 392 PF00069 0.732
MOD_CDK_SPK_2 422 427 PF00069 0.673
MOD_CDK_SPxK_1 589 595 PF00069 0.603
MOD_CDK_SPxxK_3 281 288 PF00069 0.391
MOD_CK1_1 298 304 PF00069 0.613
MOD_CK1_1 313 319 PF00069 0.647
MOD_CK1_1 564 570 PF00069 0.552
MOD_CK1_1 639 645 PF00069 0.442
MOD_CK1_1 67 73 PF00069 0.405
MOD_CK1_1 675 681 PF00069 0.553
MOD_CK1_1 94 100 PF00069 0.352
MOD_CK2_1 139 145 PF00069 0.362
MOD_CK2_1 19 25 PF00069 0.708
MOD_CK2_1 33 39 PF00069 0.435
MOD_CK2_1 678 684 PF00069 0.616
MOD_Cter_Amidation 668 671 PF01082 0.319
MOD_DYRK1A_RPxSP_1 422 426 PF00069 0.669
MOD_GlcNHglycan 154 157 PF01048 0.396
MOD_GlcNHglycan 333 336 PF01048 0.742
MOD_GlcNHglycan 342 345 PF01048 0.612
MOD_GlcNHglycan 41 45 PF01048 0.572
MOD_GlcNHglycan 427 430 PF01048 0.731
MOD_GlcNHglycan 437 440 PF01048 0.588
MOD_GlcNHglycan 667 670 PF01048 0.286
MOD_GSK3_1 139 146 PF00069 0.321
MOD_GSK3_1 200 207 PF00069 0.280
MOD_GSK3_1 217 224 PF00069 0.280
MOD_GSK3_1 265 272 PF00069 0.157
MOD_GSK3_1 295 302 PF00069 0.354
MOD_GSK3_1 306 313 PF00069 0.468
MOD_GSK3_1 327 334 PF00069 0.694
MOD_GSK3_1 336 343 PF00069 0.570
MOD_GSK3_1 425 432 PF00069 0.724
MOD_GSK3_1 509 516 PF00069 0.519
MOD_GSK3_1 610 617 PF00069 0.608
MOD_GSK3_1 660 667 PF00069 0.375
MOD_N-GLC_1 520 525 PF02516 0.236
MOD_N-GLC_1 639 644 PF02516 0.244
MOD_NEK2_1 110 115 PF00069 0.294
MOD_NEK2_1 299 304 PF00069 0.592
MOD_NEK2_1 40 45 PF00069 0.608
MOD_NEK2_1 470 475 PF00069 0.440
MOD_NEK2_1 520 525 PF00069 0.436
MOD_NEK2_1 636 641 PF00069 0.430
MOD_NEK2_1 690 695 PF00069 0.488
MOD_NEK2_2 33 38 PF00069 0.513
MOD_PIKK_1 143 149 PF00454 0.294
MOD_PIKK_1 275 281 PF00454 0.399
MOD_PIKK_1 493 499 PF00454 0.488
MOD_PKA_1 139 145 PF00069 0.406
MOD_PKA_1 200 206 PF00069 0.274
MOD_PKA_1 574 580 PF00069 0.488
MOD_PKA_1 670 676 PF00069 0.519
MOD_PKA_2 139 145 PF00069 0.297
MOD_PKA_2 287 293 PF00069 0.280
MOD_PKA_2 509 515 PF00069 0.444
MOD_PKA_2 610 616 PF00069 0.618
MOD_PKA_2 636 642 PF00069 0.430
MOD_PKA_2 670 676 PF00069 0.430
MOD_PKA_2 690 696 PF00069 0.228
MOD_PKA_2 79 85 PF00069 0.352
MOD_PKB_1 670 678 PF00069 0.346
MOD_Plk_1 251 257 PF00069 0.399
MOD_Plk_1 639 645 PF00069 0.444
MOD_Plk_1 94 100 PF00069 0.352
MOD_Plk_2-3 128 134 PF00069 0.399
MOD_Plk_4 128 134 PF00069 0.294
MOD_Plk_4 235 241 PF00069 0.294
MOD_Plk_4 287 293 PF00069 0.285
MOD_Plk_4 295 301 PF00069 0.292
MOD_Plk_4 33 39 PF00069 0.432
MOD_Plk_4 581 587 PF00069 0.406
MOD_Plk_4 692 698 PF00069 0.438
MOD_ProDKin_1 204 210 PF00069 0.280
MOD_ProDKin_1 281 287 PF00069 0.381
MOD_ProDKin_1 300 306 PF00069 0.351
MOD_ProDKin_1 352 358 PF00069 0.560
MOD_ProDKin_1 387 393 PF00069 0.700
MOD_ProDKin_1 422 428 PF00069 0.667
MOD_ProDKin_1 442 448 PF00069 0.642
MOD_ProDKin_1 589 595 PF00069 0.567
MOD_ProDKin_1 599 605 PF00069 0.390
MOD_SUMO_for_1 541 544 PF00179 0.519
MOD_SUMO_for_1 556 559 PF00179 0.519
MOD_SUMO_rev_2 163 172 PF00179 0.405
MOD_SUMO_rev_2 193 203 PF00179 0.279
MOD_SUMO_rev_2 214 220 PF00179 0.399
MOD_SUMO_rev_2 567 577 PF00179 0.517
TRG_ENDOCYTIC_2 119 122 PF00928 0.301
TRG_ENDOCYTIC_2 148 151 PF00928 0.352
TRG_ENDOCYTIC_2 237 240 PF00928 0.292
TRG_ENDOCYTIC_2 255 258 PF00928 0.197
TRG_ENDOCYTIC_2 538 541 PF00928 0.406
TRG_ENDOCYTIC_2 698 701 PF00928 0.505
TRG_ER_diArg_1 100 102 PF00400 0.352
TRG_ER_diArg_1 138 140 PF00400 0.307
TRG_ER_diArg_1 670 672 PF00400 0.514
TRG_NES_CRM1_1 134 145 PF08389 0.399
TRG_NES_CRM1_1 180 193 PF08389 0.320
TRG_Pf-PMV_PEXEL_1 274 279 PF00026 0.399
TRG_Pf-PMV_PEXEL_1 346 351 PF00026 0.489
TRG_Pf-PMV_PEXEL_1 626 631 PF00026 0.484

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I191 Leptomonas seymouri 73% 95%
A0A0S4JMY6 Bodo saltans 47% 92%
A0A1X0NTN5 Trypanosomatidae 50% 93%
A0A3Q8IAR8 Leishmania donovani 94% 100%
A0A422N3U8 Trypanosoma rangeli 48% 98%
A4H913 Leishmania braziliensis 90% 99%
A4HXE5 Leishmania infantum 94% 100%
C9ZTW0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
P0C8M8 Zea mays 38% 100%
P32562 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 100%
P34331 Caenorhabditis elegans 31% 100%
P50528 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
P53351 Mus musculus 30% 100%
Q4FZD7 Mus musculus 29% 100%
Q4QEC3 Leishmania major 94% 99%
Q5R4L1 Pongo abelii 31% 100%
Q60806 Mus musculus 31% 100%
Q9NYY3 Homo sapiens 30% 100%
Q9R012 Rattus norvegicus 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS