Thioredoxin-like fold

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AR39_LEIMU

TriTrypDb:

LmxM.17.0733

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.776
CLV_C14_Caspase3-7	36	40	PF00656	0.708
CLV_NRD_NRD_1	138	140	PF00675	0.755
CLV_NRD_NRD_1	277	279	PF00675	0.723
CLV_NRD_NRD_1	59	61	PF00675	0.671
CLV_PCSK_KEX2_1	406	408	PF00082	0.597
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.597
CLV_PCSK_SKI1_1	143	147	PF00082	0.731
CLV_PCSK_SKI1_1	294	298	PF00082	0.511
DEG_APCC_DBOX_1	309	317	PF00400	0.564
DEG_COP1_1	94	102	PF00400	0.520
DOC_CKS1_1	135	140	PF01111	0.754
DOC_CKS1_1	269	274	PF01111	0.537
DOC_CKS1_1	388	393	PF01111	0.580
DOC_CYCLIN_yClb5_NLxxxL_5	370	379	PF00134	0.507
DOC_MAPK_gen_1	294	303	PF00069	0.464
DOC_MAPK_gen_1	350	358	PF00069	0.597
DOC_MAPK_MEF2A_6	294	303	PF00069	0.464
DOC_USP7_MATH_1	277	281	PF00917	0.639
DOC_USP7_MATH_1	93	97	PF00917	0.704
DOC_WW_Pin1_4	124	129	PF00397	0.765
DOC_WW_Pin1_4	131	136	PF00397	0.682
DOC_WW_Pin1_4	151	156	PF00397	0.640
DOC_WW_Pin1_4	179	184	PF00397	0.682
DOC_WW_Pin1_4	19	24	PF00397	0.516
DOC_WW_Pin1_4	190	195	PF00397	0.641
DOC_WW_Pin1_4	232	237	PF00397	0.591
DOC_WW_Pin1_4	240	245	PF00397	0.577
DOC_WW_Pin1_4	268	273	PF00397	0.546
DOC_WW_Pin1_4	387	392	PF00397	0.563
DOC_WW_Pin1_4	40	45	PF00397	0.705
DOC_WW_Pin1_4	82	87	PF00397	0.733
LIG_14-3-3_CanoR_1	278	285	PF00244	0.699
LIG_14-3-3_CanoR_1	310	314	PF00244	0.593
LIG_14-3-3_CanoR_1	319	327	PF00244	0.429
LIG_14-3-3_CanoR_1	330	335	PF00244	0.483
LIG_BIR_II_1	1	5	PF00653	0.708
LIG_BIR_III_2	149	153	PF00653	0.699
LIG_CSL_BTD_1	233	236	PF09270	0.614
LIG_CtBP_PxDLS_1	155	159	PF00389	0.747
LIG_FHA_1	187	193	PF00498	0.595
LIG_FHA_1	23	29	PF00498	0.740
LIG_FHA_1	241	247	PF00498	0.757
LIG_FHA_1	375	381	PF00498	0.576
LIG_FHA_1	45	51	PF00498	0.769
LIG_FHA_2	220	226	PF00498	0.735
LIG_FHA_2	41	47	PF00498	0.608
LIG_FHA_2	69	75	PF00498	0.725
LIG_LIR_Apic_2	228	233	PF02991	0.689
LIG_LIR_Apic_2	386	391	PF02991	0.475
LIG_LIR_Gen_1	258	264	PF02991	0.481
LIG_LIR_Nem_3	315	320	PF02991	0.618
LIG_PAM2_1	144	156	PF00658	0.650
LIG_PAM2_1	225	237	PF00658	0.630
LIG_Pex14_2	285	289	PF04695	0.621
LIG_PTAP_UEV_1	193	198	PF05743	0.682
LIG_SH2_CRK	317	321	PF00017	0.628
LIG_SH2_PTP2	205	208	PF00017	0.696
LIG_SH2_STAP1	366	370	PF00017	0.441
LIG_SH2_STAP1	427	431	PF00017	0.485
LIG_SH2_STAT5	205	208	PF00017	0.696
LIG_SH2_STAT5	306	309	PF00017	0.330
LIG_SH2_STAT5	382	385	PF00017	0.303
LIG_SH2_STAT5	408	411	PF00017	0.454
LIG_SH2_STAT5	412	415	PF00017	0.433
LIG_SH3_1	205	211	PF00018	0.692
LIG_SH3_1	230	236	PF00018	0.661
LIG_SH3_2	135	140	PF14604	0.825
LIG_SH3_2	274	279	PF14604	0.601
LIG_SH3_3	132	138	PF00018	0.729
LIG_SH3_3	149	155	PF00018	0.639
LIG_SH3_3	191	197	PF00018	0.617
LIG_SH3_3	205	211	PF00018	0.723
LIG_SH3_3	230	236	PF00018	0.591
LIG_SH3_3	266	272	PF00018	0.572
LIG_SH3_3	331	337	PF00018	0.597
LIG_SH3_3	418	424	PF00018	0.560
LIG_SH3_3	47	53	PF00018	0.652
LIG_SUMO_SIM_anti_2	428	433	PF11976	0.513
LIG_SUMO_SIM_par_1	154	160	PF11976	0.745
LIG_SUMO_SIM_par_1	430	436	PF11976	0.515
LIG_SUMO_SIM_par_1	78	85	PF11976	0.632
LIG_TRAF2_1	53	56	PF00917	0.759
LIG_TRAF2_1	64	67	PF00917	0.739
LIG_TRAF2_1	72	75	PF00917	0.633
LIG_UBA3_1	344	352	PF00899	0.497
MOD_CDK_SPK_2	124	129	PF00069	0.783
MOD_CDK_SPK_2	134	139	PF00069	0.702
MOD_CDK_SPK_2	82	87	PF00069	0.600
MOD_CDK_SPxK_1	134	140	PF00069	0.828
MOD_CK1_1	127	133	PF00069	0.745
MOD_CK1_1	134	140	PF00069	0.705
MOD_CK1_1	154	160	PF00069	0.626
MOD_CK2_1	245	251	PF00069	0.412
MOD_CK2_1	26	32	PF00069	0.660
MOD_CK2_1	40	46	PF00069	0.541
MOD_CK2_1	68	74	PF00069	0.697
MOD_Cter_Amidation	404	407	PF01082	0.521
MOD_GlcNHglycan	118	121	PF01048	0.744
MOD_GlcNHglycan	16	19	PF01048	0.820
MOD_GlcNHglycan	227	230	PF01048	0.736
MOD_GlcNHglycan	28	31	PF01048	0.754
MOD_GlcNHglycan	3	6	PF01048	0.702
MOD_GlcNHglycan	383	386	PF01048	0.452
MOD_GlcNHglycan	94	98	PF01048	0.675
MOD_GSK3_1	127	134	PF00069	0.759
MOD_GSK3_1	186	193	PF00069	0.563
MOD_GSK3_1	219	226	PF00069	0.730
MOD_GSK3_1	22	29	PF00069	0.755
MOD_GSK3_1	35	42	PF00069	0.604
MOD_GSK3_1	383	390	PF00069	0.464
MOD_N-GLC_1	330	335	PF02516	0.608
MOD_N-GLC_1	358	363	PF02516	0.633
MOD_N-GLC_1	373	378	PF02516	0.336
MOD_NEK2_1	1	6	PF00069	0.722
MOD_NEK2_1	163	168	PF00069	0.756
MOD_NEK2_1	285	290	PF00069	0.504
MOD_NEK2_1	304	309	PF00069	0.445
MOD_NEK2_1	416	421	PF00069	0.493
MOD_NEK2_2	309	314	PF00069	0.555
MOD_NEK2_2	325	330	PF00069	0.251
MOD_PIKK_1	374	380	PF00454	0.572
MOD_PK_1	114	120	PF00069	0.517
MOD_PK_1	330	336	PF00069	0.600
MOD_PKA_1	217	223	PF00069	0.683
MOD_PKA_1	278	284	PF00069	0.704
MOD_PKA_2	277	283	PF00069	0.704
MOD_PKA_2	309	315	PF00069	0.597
MOD_PKA_2	318	324	PF00069	0.464
MOD_PKA_2	416	422	PF00069	0.626
MOD_Plk_1	114	120	PF00069	0.732
MOD_Plk_1	238	244	PF00069	0.675
MOD_Plk_1	325	331	PF00069	0.515
MOD_Plk_1	45	51	PF00069	0.675
MOD_Plk_4	163	169	PF00069	0.687
MOD_Plk_4	383	389	PF00069	0.495
MOD_Plk_4	45	51	PF00069	0.667
MOD_ProDKin_1	124	130	PF00069	0.767
MOD_ProDKin_1	131	137	PF00069	0.680
MOD_ProDKin_1	151	157	PF00069	0.637
MOD_ProDKin_1	179	185	PF00069	0.682
MOD_ProDKin_1	19	25	PF00069	0.517
MOD_ProDKin_1	190	196	PF00069	0.638
MOD_ProDKin_1	232	238	PF00069	0.591
MOD_ProDKin_1	240	246	PF00069	0.578
MOD_ProDKin_1	268	274	PF00069	0.554
MOD_ProDKin_1	387	393	PF00069	0.574
MOD_ProDKin_1	40	46	PF00069	0.709
MOD_ProDKin_1	82	88	PF00069	0.733
MOD_SUMO_for_1	128	131	PF00179	0.800
MOD_SUMO_for_1	216	219	PF00179	0.800
MOD_SUMO_for_1	33	36	PF00179	0.583
MOD_SUMO_for_1	76	79	PF00179	0.810
MOD_SUMO_rev_2	35	43	PF00179	0.536
MOD_SUMO_rev_2	414	422	PF00179	0.627
MOD_SUMO_rev_2	54	63	PF00179	0.637
TRG_DiLeu_BaEn_3	78	84	PF01217	0.730
TRG_ENDOCYTIC_2	317	320	PF00928	0.586
TRG_ENDOCYTIC_2	396	399	PF00928	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C3	Leptomonas seymouri	66%	95%
A0A3S7WUF4	Leishmania donovani	86%	100%
A4H912	Leishmania braziliensis	73%	100%
A4HXE4	Leishmania infantum	86%	100%
C9ZU38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QEC4	Leishmania major	87%	100%