VASt domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GRAM domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AR38_LEIMU

TriTrypDb:

LmxM.17.0730

Length:

658

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0005886	plasma membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0044232	organelle membrane contact site	2	1
GO:0140268	endoplasmic reticulum-plasma membrane contact site	3	1

Expansion

Sequence features

E9AR38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR38

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006869	lipid transport	5	1
GO:0009987	cellular process	1	1
GO:0015850	organic hydroxy compound transport	5	1
GO:0015918	sterol transport	6	1
GO:0032365	intracellular lipid transport	4	1
GO:0032366	intracellular sterol transport	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071702	organic substance transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005319	lipid transporter activity	2	1
GO:0005488	binding	1	1
GO:0005496	steroid binding	3	1
GO:0008289	lipid binding	2	1
GO:0015248	sterol transporter activity	3	1
GO:0032934	sterol binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:0120013	lipid transfer activity	3	1
GO:0120015	sterol transfer activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.552
CLV_C14_Caspase3-7	217	221	PF00656	0.317
CLV_C14_Caspase3-7	292	296	PF00656	0.269
CLV_C14_Caspase3-7	525	529	PF00656	0.387
CLV_NRD_NRD_1	185	187	PF00675	0.748
CLV_NRD_NRD_1	206	208	PF00675	0.517
CLV_NRD_NRD_1	30	32	PF00675	0.574
CLV_NRD_NRD_1	402	404	PF00675	0.481
CLV_NRD_NRD_1	559	561	PF00675	0.750
CLV_PCSK_KEX2_1	206	208	PF00082	0.517
CLV_PCSK_SKI1_1	206	210	PF00082	0.546
CLV_PCSK_SKI1_1	269	273	PF00082	0.559
CLV_PCSK_SKI1_1	379	383	PF00082	0.506
CLV_PCSK_SKI1_1	426	430	PF00082	0.516
CLV_PCSK_SKI1_1	449	453	PF00082	0.481
CLV_PCSK_SKI1_1	625	629	PF00082	0.455
DEG_APCC_DBOX_1	448	456	PF00400	0.388
DEG_APCC_DBOX_1	624	632	PF00400	0.608
DEG_Nend_Nbox_1	1	3	PF02207	0.326
DEG_SCF_FBW7_1	100	106	PF00400	0.394
DEG_SPOP_SBC_1	129	133	PF00917	0.419
DOC_ANK_TNKS_1	113	120	PF00023	0.420
DOC_CKS1_1	100	105	PF01111	0.394
DOC_CKS1_1	162	167	PF01111	0.494
DOC_CKS1_1	2	7	PF01111	0.380
DOC_CKS1_1	369	374	PF01111	0.435
DOC_CYCLIN_yCln2_LP_2	369	375	PF00134	0.301
DOC_CYCLIN_yCln2_LP_2	631	637	PF00134	0.517
DOC_MAPK_DCC_7	367	375	PF00069	0.327
DOC_MAPK_gen_1	263	273	PF00069	0.317
DOC_MAPK_MEF2A_6	454	463	PF00069	0.319
DOC_MAPK_MEF2A_6	575	582	PF00069	0.446
DOC_PP1_RVXF_1	5	11	PF00149	0.332
DOC_PP4_FxxP_1	245	248	PF00568	0.317
DOC_USP7_MATH_1	103	107	PF00917	0.481
DOC_USP7_MATH_1	129	133	PF00917	0.547
DOC_USP7_MATH_1	153	157	PF00917	0.463
DOC_USP7_MATH_1	191	195	PF00917	0.559
DOC_USP7_MATH_1	284	288	PF00917	0.186
DOC_USP7_MATH_1	316	320	PF00917	0.532
DOC_USP7_MATH_1	567	571	PF00917	0.567
DOC_USP7_MATH_1	654	658	PF00917	0.484
DOC_USP7_MATH_1	93	97	PF00917	0.494
DOC_USP7_UBL2_3	309	313	PF12436	0.411
DOC_WW_Pin1_4	1	6	PF00397	0.413
DOC_WW_Pin1_4	161	166	PF00397	0.615
DOC_WW_Pin1_4	244	249	PF00397	0.317
DOC_WW_Pin1_4	368	373	PF00397	0.431
DOC_WW_Pin1_4	568	573	PF00397	0.504
DOC_WW_Pin1_4	614	619	PF00397	0.548
DOC_WW_Pin1_4	630	635	PF00397	0.638
DOC_WW_Pin1_4	99	104	PF00397	0.495
LIG_14-3-3_CanoR_1	152	158	PF00244	0.528
LIG_14-3-3_CanoR_1	180	184	PF00244	0.528
LIG_14-3-3_CanoR_1	426	434	PF00244	0.306
LIG_14-3-3_CanoR_1	516	526	PF00244	0.340
LIG_14-3-3_CanoR_1	7	15	PF00244	0.379
LIG_14-3-3_CanoR_1	81	86	PF00244	0.463
LIG_Actin_WH2_2	266	283	PF00022	0.317
LIG_AP2alpha_1	474	478	PF02296	0.306
LIG_BRCT_BRCA1_1	284	288	PF00533	0.317
LIG_BRCT_BRCA1_1	606	610	PF00533	0.397
LIG_BRCT_BRCA1_1	95	99	PF00533	0.455
LIG_Clathr_ClatBox_1	270	274	PF01394	0.317
LIG_deltaCOP1_diTrp_1	407	413	PF00928	0.324
LIG_eIF4E_1	447	453	PF01652	0.388
LIG_FHA_1	152	158	PF00498	0.538
LIG_FHA_1	162	168	PF00498	0.574
LIG_FHA_1	171	177	PF00498	0.431
LIG_FHA_1	213	219	PF00498	0.317
LIG_FHA_1	31	37	PF00498	0.374
LIG_FHA_1	391	397	PF00498	0.388
LIG_FHA_1	429	435	PF00498	0.281
LIG_FHA_1	458	464	PF00498	0.277
LIG_FHA_1	630	636	PF00498	0.635
LIG_FHA_1	638	644	PF00498	0.292
LIG_FHA_2	146	152	PF00498	0.516
LIG_FHA_2	199	205	PF00498	0.474
LIG_FHA_2	215	221	PF00498	0.382
LIG_FHA_2	290	296	PF00498	0.269
LIG_FHA_2	313	319	PF00498	0.505
LIG_FHA_2	328	334	PF00498	0.445
LIG_GBD_Chelix_1	533	541	PF00786	0.524
LIG_LIR_Apic_2	83	89	PF02991	0.446
LIG_LIR_Gen_1	239	250	PF02991	0.258
LIG_LIR_Gen_1	255	264	PF02991	0.258
LIG_LIR_Gen_1	274	284	PF02991	0.195
LIG_LIR_Gen_1	285	296	PF02991	0.237
LIG_LIR_Gen_1	346	355	PF02991	0.345
LIG_LIR_Gen_1	360	370	PF02991	0.321
LIG_LIR_Gen_1	49	60	PF02991	0.463
LIG_LIR_Gen_1	61	70	PF02991	0.279
LIG_LIR_Nem_3	204	208	PF02991	0.292
LIG_LIR_Nem_3	239	245	PF02991	0.258
LIG_LIR_Nem_3	255	261	PF02991	0.258
LIG_LIR_Nem_3	274	280	PF02991	0.189
LIG_LIR_Nem_3	285	291	PF02991	0.216
LIG_LIR_Nem_3	346	351	PF02991	0.366
LIG_LIR_Nem_3	360	365	PF02991	0.323
LIG_LIR_Nem_3	446	450	PF02991	0.286
LIG_LIR_Nem_3	49	55	PF02991	0.340
LIG_LIR_Nem_3	528	533	PF02991	0.354
LIG_LIR_Nem_3	607	612	PF02991	0.368
LIG_LIR_Nem_3	61	67	PF02991	0.310
LIG_LIR_Nem_3	613	619	PF02991	0.533
LIG_MLH1_MIPbox_1	606	610	PF16413	0.397
LIG_PDZ_Class_2	653	658	PF00595	0.594
LIG_Pex14_2	10	14	PF04695	0.349
LIG_Pex14_2	205	209	PF04695	0.317
LIG_Pex14_2	385	389	PF04695	0.281
LIG_Pex14_2	474	478	PF04695	0.306
LIG_Pex14_2	52	56	PF04695	0.378
LIG_Pex14_2	605	609	PF04695	0.312
LIG_SH2_CRK	530	534	PF00017	0.304
LIG_SH2_CRK	64	68	PF00017	0.369
LIG_SH2_PTP2	2	5	PF00017	0.380
LIG_SH2_PTP2	277	280	PF00017	0.317
LIG_SH2_PTP2	577	580	PF00017	0.467
LIG_SH2_SRC	442	445	PF00017	0.340
LIG_SH2_SRC	577	580	PF00017	0.431
LIG_SH2_STAT5	2	5	PF00017	0.380
LIG_SH2_STAT5	277	280	PF00017	0.317
LIG_SH2_STAT5	444	447	PF00017	0.383
LIG_SH2_STAT5	504	507	PF00017	0.345
LIG_SH2_STAT5	577	580	PF00017	0.556
LIG_SH3_1	207	213	PF00018	0.317
LIG_SH3_1	409	415	PF00018	0.282
LIG_SH3_2	412	417	PF14604	0.317
LIG_SH3_3	159	165	PF00018	0.530
LIG_SH3_3	207	213	PF00018	0.272
LIG_SH3_3	318	324	PF00018	0.495
LIG_SH3_3	409	415	PF00018	0.282
LIG_SH3_3	566	572	PF00018	0.526
LIG_SH3_3	573	579	PF00018	0.472
LIG_SH3_3	97	103	PF00018	0.463
LIG_SUMO_SIM_anti_2	16	24	PF11976	0.336
LIG_SUMO_SIM_anti_2	38	44	PF11976	0.348
LIG_SUMO_SIM_par_1	16	24	PF11976	0.401
LIG_SUMO_SIM_par_1	25	30	PF11976	0.345
LIG_SUMO_SIM_par_1	269	274	PF11976	0.282
LIG_SUMO_SIM_par_1	38	44	PF11976	0.363
LIG_SUMO_SIM_par_1	595	600	PF11976	0.384
LIG_WRC_WIRS_1	483	488	PF05994	0.317
LIG_WRC_WIRS_1	645	650	PF05994	0.379
MOD_CDK_SPxK_1	1	7	PF00069	0.378
MOD_CDK_SPxK_1	368	374	PF00069	0.434
MOD_CDK_SPxxK_3	568	575	PF00069	0.514
MOD_CK1_1	101	107	PF00069	0.458
MOD_CK1_1	124	130	PF00069	0.529
MOD_CK1_1	174	180	PF00069	0.494
MOD_CK1_1	282	288	PF00069	0.271
MOD_CK1_1	289	295	PF00069	0.242
MOD_CK1_1	319	325	PF00069	0.479
MOD_CK1_1	357	363	PF00069	0.349
MOD_CK1_1	491	497	PF00069	0.388
MOD_CK1_1	543	549	PF00069	0.434
MOD_CK1_1	630	636	PF00069	0.686
MOD_CK1_1	91	97	PF00069	0.508
MOD_CK2_1	10	16	PF00069	0.387
MOD_CK2_1	198	204	PF00069	0.493
MOD_CK2_1	249	255	PF00069	0.359
MOD_CK2_1	327	333	PF00069	0.419
MOD_CK2_1	346	352	PF00069	0.242
MOD_CK2_1	543	549	PF00069	0.368
MOD_CK2_1	567	573	PF00069	0.574
MOD_CK2_1	69	75	PF00069	0.382
MOD_CMANNOS	410	413	PF00535	0.481
MOD_Cter_Amidation	558	561	PF01082	0.621
MOD_GlcNHglycan	109	112	PF01048	0.689
MOD_GlcNHglycan	157	160	PF01048	0.780
MOD_GlcNHglycan	173	176	PF01048	0.651
MOD_GlcNHglycan	281	284	PF01048	0.527
MOD_GlcNHglycan	321	324	PF01048	0.701
MOD_GlcNHglycan	356	359	PF01048	0.655
MOD_GlcNHglycan	455	458	PF01048	0.529
MOD_GlcNHglycan	490	493	PF01048	0.544
MOD_GlcNHglycan	545	548	PF01048	0.716
MOD_GlcNHglycan	599	602	PF01048	0.403
MOD_GSK3_1	124	131	PF00069	0.552
MOD_GSK3_1	141	148	PF00069	0.504
MOD_GSK3_1	151	158	PF00069	0.491
MOD_GSK3_1	170	177	PF00069	0.404
MOD_GSK3_1	208	215	PF00069	0.359
MOD_GSK3_1	282	289	PF00069	0.262
MOD_GSK3_1	301	308	PF00069	0.214
MOD_GSK3_1	312	319	PF00069	0.442
MOD_GSK3_1	346	353	PF00069	0.357
MOD_GSK3_1	453	460	PF00069	0.391
MOD_GSK3_1	482	489	PF00069	0.346
MOD_GSK3_1	491	498	PF00069	0.343
MOD_GSK3_1	50	57	PF00069	0.366
MOD_GSK3_1	517	524	PF00069	0.387
MOD_GSK3_1	610	617	PF00069	0.437
MOD_GSK3_1	629	636	PF00069	0.639
MOD_GSK3_1	88	95	PF00069	0.498
MOD_GSK3_1	98	105	PF00069	0.467
MOD_N-GLC_1	121	126	PF02516	0.667
MOD_N-GLC_1	289	294	PF02516	0.479
MOD_N-GLC_1	592	597	PF02516	0.470
MOD_NEK2_1	10	15	PF00069	0.384
MOD_NEK2_1	130	135	PF00069	0.506
MOD_NEK2_1	157	162	PF00069	0.614
MOD_NEK2_1	228	233	PF00069	0.286
MOD_NEK2_1	236	241	PF00069	0.315
MOD_NEK2_1	249	254	PF00069	0.239
MOD_NEK2_1	286	291	PF00069	0.399
MOD_NEK2_1	305	310	PF00069	0.255
MOD_NEK2_1	327	332	PF00069	0.455
MOD_NEK2_1	428	433	PF00069	0.297
MOD_NEK2_1	453	458	PF00069	0.388
MOD_NEK2_1	486	491	PF00069	0.196
MOD_NEK2_1	507	512	PF00069	0.317
MOD_NEK2_1	55	60	PF00069	0.376
MOD_NEK2_1	597	602	PF00069	0.450
MOD_NEK2_1	604	609	PF00069	0.319
MOD_NEK2_1	610	615	PF00069	0.279
MOD_NEK2_1	66	71	PF00069	0.298
MOD_NEK2_2	495	500	PF00069	0.319
MOD_PIKK_1	121	127	PF00454	0.540
MOD_PIKK_1	174	180	PF00454	0.599
MOD_PIKK_1	236	242	PF00454	0.317
MOD_PIKK_1	346	352	PF00454	0.453
MOD_PIKK_1	464	470	PF00454	0.388
MOD_PIKK_1	484	490	PF00454	0.162
MOD_PIKK_1	58	64	PF00454	0.377
MOD_PIKK_1	620	626	PF00454	0.627
MOD_PKA_1	403	409	PF00069	0.281
MOD_PKA_2	106	112	PF00069	0.536
MOD_PKA_2	151	157	PF00069	0.518
MOD_PKA_2	179	185	PF00069	0.552
MOD_PKA_2	30	36	PF00069	0.374
MOD_PKA_2	413	419	PF00069	0.351
MOD_PKA_2	80	86	PF00069	0.372
MOD_Plk_1	178	184	PF00069	0.555
MOD_Plk_1	301	307	PF00069	0.269
MOD_Plk_1	316	322	PF00069	0.364
MOD_Plk_1	360	366	PF00069	0.361
MOD_Plk_1	495	501	PF00069	0.388
MOD_Plk_1	50	56	PF00069	0.393
MOD_Plk_1	592	598	PF00069	0.470
MOD_Plk_2-3	145	151	PF00069	0.539
MOD_Plk_4	10	16	PF00069	0.413
MOD_Plk_4	316	322	PF00069	0.372
MOD_Plk_4	36	42	PF00069	0.356
MOD_Plk_4	429	435	PF00069	0.306
MOD_Plk_4	507	513	PF00069	0.317
MOD_Plk_4	592	598	PF00069	0.475
MOD_Plk_4	604	610	PF00069	0.379
MOD_Plk_4	66	72	PF00069	0.334
MOD_Plk_4	81	87	PF00069	0.419
MOD_ProDKin_1	1	7	PF00069	0.412
MOD_ProDKin_1	161	167	PF00069	0.616
MOD_ProDKin_1	244	250	PF00069	0.317
MOD_ProDKin_1	368	374	PF00069	0.434
MOD_ProDKin_1	568	574	PF00069	0.503
MOD_ProDKin_1	614	620	PF00069	0.549
MOD_ProDKin_1	630	636	PF00069	0.635
MOD_ProDKin_1	99	105	PF00069	0.497
MOD_SUMO_rev_2	24	33	PF00179	0.371
MOD_SUMO_rev_2	251	258	PF00179	0.291
MOD_SUMO_rev_2	262	271	PF00179	0.258
MOD_SUMO_rev_2	332	340	PF00179	0.470
MOD_SUMO_rev_2	397	406	PF00179	0.306
MOD_SUMO_rev_2	570	576	PF00179	0.467
MOD_SUMO_rev_2	84	91	PF00179	0.398
TRG_DiLeu_BaEn_3	16	22	PF01217	0.375
TRG_ENDOCYTIC_2	277	280	PF00928	0.317
TRG_ENDOCYTIC_2	442	445	PF00928	0.312
TRG_ENDOCYTIC_2	450	453	PF00928	0.250
TRG_ENDOCYTIC_2	504	507	PF00928	0.345
TRG_ENDOCYTIC_2	530	533	PF00928	0.324
TRG_ENDOCYTIC_2	577	580	PF00928	0.467
TRG_ENDOCYTIC_2	64	67	PF00928	0.365
TRG_ER_diArg_1	205	207	PF00400	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NSV7	Trypanosomatidae	41%	92%
A0A3R7LZ26	Trypanosoma rangeli	41%	100%
A0A3S7WUF7	Leishmania donovani	91%	100%
A4H911	Leishmania braziliensis	80%	100%
A4HXE3	Leishmania infantum	91%	100%
Q4QEC5	Leishmania major	89%	100%
V5B9G2	Trypanosoma cruzi	40%	92%