AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania mexicana

UniProt:

E9AR35_LEIMU

TriTrypDb:

LmxM.17.0760

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AR35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR35

PDB structure(s): 7aih_Ak , 7ane_Ak

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.449
CLV_NRD_NRD_1	241	243	PF00675	0.459
CLV_NRD_NRD_1	283	285	PF00675	0.542
CLV_PCSK_KEX2_1	241	243	PF00082	0.437
CLV_PCSK_KEX2_1	282	284	PF00082	0.469
CLV_PCSK_KEX2_1	43	45	PF00082	0.370
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.428
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.370
CLV_PCSK_SKI1_1	164	168	PF00082	0.507
CLV_PCSK_SKI1_1	235	239	PF00082	0.405
CLV_PCSK_SKI1_1	287	291	PF00082	0.467
DEG_SCF_FBW7_1	122	129	PF00400	0.323
DOC_CKS1_1	123	128	PF01111	0.336
DOC_CKS1_1	167	172	PF01111	0.264
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.459
DOC_CYCLIN_yCln2_LP_2	186	192	PF00134	0.367
DOC_CYCLIN_yCln2_LP_2	220	226	PF00134	0.372
DOC_MAPK_gen_1	144	151	PF00069	0.558
DOC_MAPK_gen_1	287	295	PF00069	0.347
DOC_MAPK_MEF2A_6	274	281	PF00069	0.445
DOC_PP2B_LxvP_1	220	223	PF13499	0.323
DOC_USP7_MATH_1	159	163	PF00917	0.414
DOC_USP7_MATH_1	177	181	PF00917	0.485
DOC_USP7_UBL2_3	312	316	PF12436	0.611
DOC_USP7_UBL2_3	317	321	PF12436	0.696
DOC_WW_Pin1_4	122	127	PF00397	0.334
DOC_WW_Pin1_4	166	171	PF00397	0.349
DOC_WW_Pin1_4	185	190	PF00397	0.252
LIG_14-3-3_CanoR_1	106	114	PF00244	0.421
LIG_APCC_ABBA_1	231	236	PF00400	0.460
LIG_Clathr_ClatBox_1	120	124	PF01394	0.356
LIG_Clathr_ClatBox_1	17	21	PF01394	0.321
LIG_DLG_GKlike_1	116	123	PF00625	0.449
LIG_EH1_1	114	122	PF00400	0.411
LIG_FHA_1	1	7	PF00498	0.512
LIG_FHA_1	123	129	PF00498	0.310
LIG_FHA_1	297	303	PF00498	0.481
LIG_FHA_1	30	36	PF00498	0.477
LIG_HCF-1_HBM_1	202	205	PF13415	0.507
LIG_HP1_1	16	20	PF01393	0.375
LIG_LIR_Gen_1	88	99	PF02991	0.344
LIG_LIR_Nem_3	202	208	PF02991	0.356
LIG_LIR_Nem_3	236	240	PF02991	0.383
LIG_LIR_Nem_3	88	94	PF02991	0.347
LIG_LIR_Nem_3	98	102	PF02991	0.237
LIG_Pex14_1	271	275	PF04695	0.351
LIG_REV1ctd_RIR_1	235	242	PF16727	0.406
LIG_SH2_CRK	99	103	PF00017	0.305
LIG_SH2_PTP2	205	208	PF00017	0.358
LIG_SH2_SRC	182	185	PF00017	0.419
LIG_SH2_SRC	205	208	PF00017	0.377
LIG_SH2_STAP1	182	186	PF00017	0.402
LIG_SH2_STAP1	45	49	PF00017	0.393
LIG_SH2_STAT5	205	208	PF00017	0.343
LIG_SH3_3	146	152	PF00018	0.464
LIG_SH3_3	211	217	PF00018	0.410
LIG_SH3_3	221	227	PF00018	0.381
LIG_SH3_3	56	62	PF00018	0.318
LIG_SH3_4	313	320	PF00018	0.502
LIG_SUMO_SIM_anti_2	119	125	PF11976	0.391
LIG_SUMO_SIM_par_1	119	125	PF11976	0.393
LIG_SUMO_SIM_par_1	15	21	PF11976	0.313
LIG_TRAF2_1	37	40	PF00917	0.445
MOD_CK1_1	162	168	PF00069	0.433
MOD_CK1_1	188	194	PF00069	0.562
MOD_CK1_1	298	304	PF00069	0.565
MOD_CK2_1	162	168	PF00069	0.354
MOD_CK2_1	177	183	PF00069	0.466
MOD_CK2_1	298	304	PF00069	0.536
MOD_CK2_1	63	69	PF00069	0.510
MOD_GlcNHglycan	164	167	PF01048	0.575
MOD_GlcNHglycan	256	259	PF01048	0.443
MOD_GlcNHglycan	28	32	PF01048	0.584
MOD_GSK3_1	122	129	PF00069	0.322
MOD_GSK3_1	162	169	PF00069	0.416
MOD_GSK3_1	241	248	PF00069	0.512
MOD_NEK2_1	107	112	PF00069	0.470
MOD_NEK2_1	20	25	PF00069	0.340
MOD_NEK2_1	27	32	PF00069	0.458
MOD_NEK2_1	295	300	PF00069	0.443
MOD_NEK2_1	48	53	PF00069	0.474
MOD_NEK2_1	63	68	PF00069	0.229
MOD_NEK2_1	73	78	PF00069	0.312
MOD_NEK2_1	95	100	PF00069	0.288
MOD_NEK2_2	159	164	PF00069	0.497
MOD_NEK2_2	177	182	PF00069	0.223
MOD_PKA_1	241	247	PF00069	0.377
MOD_PKA_2	133	139	PF00069	0.515
MOD_PKA_2	241	247	PF00069	0.503
MOD_Plk_1	154	160	PF00069	0.430
MOD_Plk_1	177	183	PF00069	0.367
MOD_Plk_1	20	26	PF00069	0.486
MOD_Plk_4	1	7	PF00069	0.478
MOD_Plk_4	116	122	PF00069	0.321
MOD_Plk_4	177	183	PF00069	0.476
MOD_Plk_4	188	194	PF00069	0.437
MOD_Plk_4	241	247	PF00069	0.447
MOD_ProDKin_1	122	128	PF00069	0.335
MOD_ProDKin_1	166	172	PF00069	0.351
MOD_ProDKin_1	185	191	PF00069	0.251
TRG_DiLeu_BaEn_1	291	296	PF01217	0.434
TRG_ENDOCYTIC_2	205	208	PF00928	0.343
TRG_ENDOCYTIC_2	45	48	PF00928	0.364
TRG_ENDOCYTIC_2	99	102	PF00928	0.305
TRG_ER_diArg_1	240	242	PF00400	0.413
TRG_ER_diArg_1	283	285	PF00400	0.542
TRG_ER_diLys_1	319	324	PF00400	0.629
TRG_NLS_MonoExtN_4	317	324	PF00514	0.757
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBS7	Leptomonas seymouri	75%	78%
A0A0S4J8H7	Bodo saltans	40%	78%
A0A1X0NUK7	Trypanosomatidae	53%	81%
A0A3S7WUH0	Leishmania donovani	95%	100%
A0A422N4J3	Trypanosoma rangeli	55%	85%
A4H908	Leishmania braziliensis	86%	100%
A4HXE0	Leishmania infantum	95%	100%
C9ZU35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	86%
Q4QEC8	Leishmania major	95%	100%
V5API2	Trypanosoma cruzi	55%	86%