Str_synth domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AR32_LEIMU

TriTrypDb:

LmxM.17.0630

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR32

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	234	236	PF00675	0.637
CLV_NRD_NRD_1	25	27	PF00675	0.307
CLV_PCSK_KEX2_1	234	236	PF00082	0.635
CLV_PCSK_KEX2_1	99	101	PF00082	0.433
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.433
CLV_PCSK_SKI1_1	138	142	PF00082	0.416
CLV_PCSK_SKI1_1	28	32	PF00082	0.486
CLV_PCSK_SKI1_1	313	317	PF00082	0.425
DEG_APCC_DBOX_1	233	241	PF00400	0.635
DOC_CYCLIN_RxL_1	25	33	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	226	232	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	264	270	PF00134	0.439
DOC_MAPK_gen_1	194	203	PF00069	0.456
DOC_MAPK_MEF2A_6	194	203	PF00069	0.456
DOC_PP1_RVXF_1	136	143	PF00149	0.418
DOC_PP2B_LxvP_1	226	229	PF13499	0.465
DOC_PP4_FxxP_1	116	119	PF00568	0.652
DOC_SPAK_OSR1_1	196	200	PF12202	0.456
DOC_USP7_MATH_1	181	185	PF00917	0.536
DOC_USP7_MATH_1	243	247	PF00917	0.579
DOC_USP7_UBL2_3	215	219	PF12436	0.483
DOC_USP7_UBL2_3	363	367	PF12436	0.490
LIG_14-3-3_CanoR_1	26	31	PF00244	0.285
LIG_14-3-3_CanoR_1	296	302	PF00244	0.495
LIG_APCC_ABBA_1	6	11	PF00400	0.430
LIG_BIR_II_1	1	5	PF00653	0.504
LIG_BIR_III_4	287	291	PF00653	0.470
LIG_BIR_III_4	81	85	PF00653	0.488
LIG_deltaCOP1_diTrp_1	78	85	PF00928	0.503
LIG_FHA_1	155	161	PF00498	0.499
LIG_FHA_1	31	37	PF00498	0.424
LIG_FHA_1	364	370	PF00498	0.478
LIG_FHA_2	175	181	PF00498	0.498
LIG_FHA_2	200	206	PF00498	0.412
LIG_FHA_2	257	263	PF00498	0.486
LIG_Integrin_isoDGR_2	136	138	PF01839	0.449
LIG_Integrin_RGD_1	21	23	PF01839	0.499
LIG_Integrin_RGD_1	284	286	PF01839	0.498
LIG_LIR_Apic_2	113	119	PF02991	0.649
LIG_LIR_Gen_1	334	340	PF02991	0.332
LIG_LIR_Nem_3	334	338	PF02991	0.324
LIG_REV1ctd_RIR_1	139	149	PF16727	0.453
LIG_REV1ctd_RIR_1	209	216	PF16727	0.456
LIG_SH2_PTP2	335	338	PF00017	0.355
LIG_SH2_STAT3	230	233	PF00017	0.509
LIG_SH2_STAT5	278	281	PF00017	0.458
LIG_SH2_STAT5	335	338	PF00017	0.365
LIG_SH2_STAT5	350	353	PF00017	0.447
LIG_SH3_3	248	254	PF00018	0.538
LIG_SH3_3	84	90	PF00018	0.454
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.482
LIG_SUMO_SIM_anti_2	266	276	PF11976	0.338
LIG_SUMO_SIM_par_1	256	262	PF11976	0.482
LIG_TRAF2_1	177	180	PF00917	0.563
LIG_TYR_ITIM	333	338	PF00017	0.319
LIG_UBA3_1	124	129	PF00899	0.373
LIG_UBA3_1	210	219	PF00899	0.422
MOD_CK1_1	238	244	PF00069	0.418
MOD_CK2_1	174	180	PF00069	0.549
MOD_CK2_1	181	187	PF00069	0.493
MOD_CK2_1	199	205	PF00069	0.240
MOD_CK2_1	243	249	PF00069	0.578
MOD_GlcNHglycan	245	248	PF01048	0.401
MOD_GlcNHglycan	304	307	PF01048	0.493
MOD_GlcNHglycan	44	48	PF01048	0.475
MOD_GSK3_1	101	108	PF00069	0.501
MOD_GSK3_1	22	29	PF00069	0.509
MOD_GSK3_1	238	245	PF00069	0.590
MOD_N-GLC_1	243	248	PF02516	0.508
MOD_NEK2_1	124	129	PF00069	0.403
MOD_NEK2_1	13	18	PF00069	0.429
MOD_NEK2_1	30	35	PF00069	0.314
MOD_NEK2_1	43	48	PF00069	0.321
MOD_PKA_1	26	32	PF00069	0.287
MOD_PKA_2	110	116	PF00069	0.598
MOD_Plk_1	13	19	PF00069	0.466
MOD_Plk_1	43	49	PF00069	0.478
MOD_Plk_2-3	174	180	PF00069	0.519
MOD_Plk_2-3	187	193	PF00069	0.393
MOD_Plk_4	105	111	PF00069	0.444
MOD_Plk_4	181	187	PF00069	0.528
MOD_Plk_4	253	259	PF00069	0.468
MOD_Plk_4	26	32	PF00069	0.497
MOD_SUMO_rev_2	248	257	PF00179	0.485
MOD_SUMO_rev_2	334	344	PF00179	0.494
MOD_SUMO_rev_2	44	54	PF00179	0.390
TRG_DiLeu_BaEn_1	266	271	PF01217	0.439
TRG_DiLeu_BaEn_1	312	317	PF01217	0.437
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.482
TRG_DiLeu_LyEn_5	159	164	PF01217	0.476
TRG_ENDOCYTIC_2	335	338	PF00928	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICT3	Leishmania donovani	93%	100%
A0A3Q8IJF2	Leishmania donovani	94%	100%
A4H906	Leishmania braziliensis	75%	100%
A4HXD7	Leishmania infantum	93%	100%
N4WEA4	Cochliobolus heterostrophus (strain C4 / ATCC 48331 / race T)	30%	82%
Q4QED1	Leishmania major	91%	100%