ACB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acyl CoA binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AR30_LEIMU

TriTrypDb:

LmxM.17.0610

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR30

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	7
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0008289	lipid binding	2	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0033218	amide binding	2	7
GO:0036094	small molecule binding	2	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0120227	acyl-CoA binding	3	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:1901567	fatty acid derivative binding	3	7
GO:1901681	sulfur compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.648
CLV_C14_Caspase3-7	41	45	PF00656	0.436
CLV_NRD_NRD_1	100	102	PF00675	0.411
CLV_NRD_NRD_1	123	125	PF00675	0.514
CLV_NRD_NRD_1	326	328	PF00675	0.752
CLV_NRD_NRD_1	338	340	PF00675	0.745
CLV_NRD_NRD_1	47	49	PF00675	0.513
CLV_NRD_NRD_1	481	483	PF00675	0.537
CLV_NRD_NRD_1	8	10	PF00675	0.585
CLV_PCSK_FUR_1	327	331	PF00082	0.753
CLV_PCSK_KEX2_1	193	195	PF00082	0.222
CLV_PCSK_KEX2_1	227	229	PF00082	0.411
CLV_PCSK_KEX2_1	268	270	PF00082	0.759
CLV_PCSK_KEX2_1	329	331	PF00082	0.661
CLV_PCSK_KEX2_1	338	340	PF00082	0.699
CLV_PCSK_KEX2_1	481	483	PF00082	0.664
CLV_PCSK_KEX2_1	8	10	PF00082	0.590
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.222
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.411
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.759
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.663
CLV_PCSK_SKI1_1	104	108	PF00082	0.513
CLV_PCSK_SKI1_1	173	177	PF00082	0.389
CLV_PCSK_SKI1_1	201	205	PF00082	0.298
CLV_PCSK_SKI1_1	232	236	PF00082	0.499
CLV_PCSK_SKI1_1	264	268	PF00082	0.661
CLV_PCSK_SKI1_1	481	485	PF00082	0.680
CLV_PCSK_SKI1_1	71	75	PF00082	0.387
DEG_Nend_Nbox_1	1	3	PF02207	0.742
DOC_CKS1_1	184	189	PF01111	0.513
DOC_MAPK_gen_1	108	116	PF00069	0.389
DOC_MAPK_MEF2A_6	110	118	PF00069	0.401
DOC_PP1_RVXF_1	61	67	PF00149	0.411
DOC_PP4_FxxP_1	29	32	PF00568	0.580
DOC_USP7_MATH_1	359	363	PF00917	0.678
DOC_USP7_MATH_1	450	454	PF00917	0.787
DOC_USP7_MATH_1	477	481	PF00917	0.653
DOC_USP7_UBL2_3	232	236	PF12436	0.601
DOC_USP7_UBL2_3	264	268	PF12436	0.763
DOC_USP7_UBL2_3	329	333	PF12436	0.714
DOC_USP7_UBL2_3	484	488	PF12436	0.685
DOC_USP7_UBL2_3	79	83	PF12436	0.222
DOC_WW_Pin1_4	183	188	PF00397	0.513
DOC_WW_Pin1_4	433	438	PF00397	0.738
LIG_14-3-3_CanoR_1	124	130	PF00244	0.675
LIG_14-3-3_CanoR_1	303	307	PF00244	0.654
LIG_BIR_III_4	292	296	PF00653	0.662
LIG_BIR_III_4	375	379	PF00653	0.546
LIG_BRCT_BRCA1_1	21	25	PF00533	0.660
LIG_deltaCOP1_diTrp_1	137	143	PF00928	0.564
LIG_deltaCOP1_diTrp_1	90	95	PF00928	0.411
LIG_FHA_2	177	183	PF00498	0.255
LIG_FHA_2	284	290	PF00498	0.611
LIG_FHA_2	308	314	PF00498	0.655
LIG_FHA_2	364	370	PF00498	0.817
LIG_FHA_2	387	393	PF00498	0.697
LIG_FHA_2	72	78	PF00498	0.411
LIG_KLC1_Yacidic_2	113	117	PF13176	0.347
LIG_LIR_Apic_2	128	134	PF02991	0.703
LIG_LIR_Apic_2	28	32	PF02991	0.589
LIG_LIR_Gen_1	113	123	PF02991	0.411
LIG_LIR_Gen_1	137	147	PF02991	0.411
LIG_LIR_Gen_1	213	221	PF02991	0.411
LIG_LIR_Nem_3	11	17	PF02991	0.685
LIG_LIR_Nem_3	113	118	PF02991	0.411
LIG_LIR_Nem_3	137	143	PF02991	0.564
LIG_LIR_Nem_3	192	198	PF02991	0.413
LIG_LIR_Nem_3	213	218	PF02991	0.411
LIG_LIR_Nem_3	90	94	PF02991	0.411
LIG_MYND_3	440	444	PF01753	0.650
LIG_Pex14_2	2	6	PF04695	0.542
LIG_Pex14_2	25	29	PF04695	0.618
LIG_Pex14_2	66	70	PF04695	0.513
LIG_REV1ctd_RIR_1	3	11	PF16727	0.636
LIG_SH2_NCK_1	36	40	PF00017	0.513
LIG_SH2_PTP2	115	118	PF00017	0.383
LIG_SH2_SRC	36	39	PF00017	0.358
LIG_SH2_STAP1	212	216	PF00017	0.411
LIG_SH2_STAP1	36	40	PF00017	0.513
LIG_SH2_STAT5	115	118	PF00017	0.411
LIG_SH2_STAT5	159	162	PF00017	0.329
LIG_SH2_STAT5	230	233	PF00017	0.411
LIG_SH2_STAT5	243	246	PF00017	0.586
LIG_SH2_STAT5	46	49	PF00017	0.411
LIG_SH3_3	14	20	PF00018	0.716
LIG_SH3_3	241	247	PF00018	0.585
LIG_SH3_3	29	35	PF00018	0.509
LIG_SH3_3	79	85	PF00018	0.415
LIG_SH3_CIN85_PxpxPR_1	437	442	PF14604	0.523
LIG_TRAF2_1	286	289	PF00917	0.715
LIG_TRAF2_1	320	323	PF00917	0.668
LIG_TRAF2_1	39	42	PF00917	0.436
LIG_UBA3_1	118	125	PF00899	0.472
LIG_UBA3_1	149	155	PF00899	0.472
LIG_ULM_U2AF65_1	193	198	PF00076	0.338
LIG_WRC_WIRS_1	2	7	PF05994	0.594
LIG_WRC_WIRS_1	306	311	PF05994	0.725
MOD_CK1_1	262	268	PF00069	0.735
MOD_CK2_1	15	21	PF00069	0.489
MOD_CK2_1	283	289	PF00069	0.703
MOD_CK2_1	296	302	PF00069	0.481
MOD_CK2_1	307	313	PF00069	0.592
MOD_CK2_1	363	369	PF00069	0.829
MOD_Cter_Amidation	325	328	PF01082	0.661
MOD_Cter_Amidation	6	9	PF01082	0.740
MOD_GlcNHglycan	134	137	PF01048	0.679
MOD_GlcNHglycan	236	239	PF01048	0.548
MOD_GlcNHglycan	261	264	PF01048	0.641
MOD_GlcNHglycan	408	411	PF01048	0.654
MOD_GlcNHglycan	419	422	PF01048	0.723
MOD_GlcNHglycan	433	436	PF01048	0.680
MOD_GlcNHglycan	444	448	PF01048	0.762
MOD_GlcNHglycan	467	470	PF01048	0.572
MOD_GSK3_1	15	22	PF00069	0.447
MOD_GSK3_1	258	265	PF00069	0.658
MOD_GSK3_1	359	366	PF00069	0.772
MOD_N-GLC_1	450	455	PF02516	0.528
MOD_N-GLC_2	398	400	PF02516	0.731
MOD_NEK2_1	1	6	PF00069	0.587
MOD_NEK2_1	176	181	PF00069	0.222
MOD_NEK2_1	352	357	PF00069	0.543
MOD_NEK2_1	399	404	PF00069	0.719
MOD_NEK2_1	428	433	PF00069	0.581
MOD_NEK2_1	443	448	PF00069	0.730
MOD_PIKK_1	71	77	PF00454	0.222
MOD_PKA_2	302	308	PF00069	0.601
MOD_Plk_1	363	369	PF00069	0.774
MOD_Plk_1	428	434	PF00069	0.647
MOD_Plk_4	1	7	PF00069	0.610
MOD_Plk_4	125	131	PF00069	0.583
MOD_Plk_4	19	25	PF00069	0.599
MOD_Plk_4	296	302	PF00069	0.716
MOD_Plk_4	399	405	PF00069	0.506
MOD_Plk_4	65	71	PF00069	0.390
MOD_Plk_4	83	89	PF00069	0.411
MOD_ProDKin_1	183	189	PF00069	0.513
MOD_ProDKin_1	433	439	PF00069	0.736
MOD_SUMO_for_1	357	360	PF00179	0.745
MOD_SUMO_rev_2	11	17	PF00179	0.644
MOD_SUMO_rev_2	77	85	PF00179	0.406
TRG_ENDOCYTIC_2	115	118	PF00928	0.411
TRG_ENDOCYTIC_2	195	198	PF00928	0.411
TRG_ENDOCYTIC_2	67	70	PF00928	0.472
TRG_ENDOCYTIC_2	94	97	PF00928	0.513
TRG_ER_diArg_1	198	201	PF00400	0.393
TRG_NES_CRM1_1	289	302	PF08389	0.646
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	382	387	PF00026	0.753

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F7	Leptomonas seymouri	56%	100%
A0A3Q8IDY9	Leishmania donovani	86%	99%
A4H904	Leishmania braziliensis	67%	98%
A4HXD5	Leishmania infantum	86%	99%
Q4QED3	Leishmania major	87%	100%