Putative P-type ATPase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

P-type ATPase, putative

Species:

Leishmania mexicana

UniProt:

E9AR29_LEIMU

TriTrypDb:

LmxM.17.0600

Length:

1135

Annotations

LeishMANIAdb annotations

Homologous to other eukaryotic P-type Ca2+ ATPases.. For some reason, this group has heavily expanded in Kinetoplastida.. Localization: Endosomal (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	11
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

E9AR29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR29

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005215	transporter activity	1	4
GO:0005388	P-type calcium transporter activity	4	4
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	4
GO:0015075	monoatomic ion transmembrane transporter activity	3	4
GO:0015085	calcium ion transmembrane transporter activity	6	4
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	4

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1102	1106	PF00656	0.490
CLV_C14_Caspase3-7	412	416	PF00656	0.537
CLV_NRD_NRD_1	1067	1069	PF00675	0.271
CLV_NRD_NRD_1	332	334	PF00675	0.299
CLV_NRD_NRD_1	427	429	PF00675	0.377
CLV_NRD_NRD_1	473	475	PF00675	0.360
CLV_NRD_NRD_1	581	583	PF00675	0.266
CLV_NRD_NRD_1	642	644	PF00675	0.341
CLV_NRD_NRD_1	716	718	PF00675	0.290
CLV_NRD_NRD_1	771	773	PF00675	0.320

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y1	Leptomonas seymouri	30%	100%
A0A0N1HWG6	Leptomonas seymouri	74%	100%
A0A0N1PFH3	Leptomonas seymouri	28%	93%
A0A0S4J1M1	Bodo saltans	29%	100%
A0A0S4J5A1	Bodo saltans	28%	100%
A0A0S4J6U4	Bodo saltans	43%	100%
A0A0S4JA92	Bodo saltans	53%	100%
A0A0S4JRV4	Bodo saltans	37%	100%
A0A0S4KIG5	Bodo saltans	29%	100%
A0A0S4KNQ6	Bodo saltans	38%	100%

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