Bis(5'-nucleosyl)-tetraphosphatase,symmetrical-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bis(5'-nucleosyl)-tetraphosphatase, symmetrical-like protein

Species:

Leishmania mexicana

UniProt:

E9AR27_LEIMU

TriTrypDb:

LmxM.17.0580

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AR27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR27

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006797	polyphosphate metabolic process	4	1
GO:0006798	polyphosphate catabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	6
GO:0000298	endopolyphosphatase activity	6	1
GO:0016462	pyrophosphatase activity	5	2
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	6	1
GO:0008803	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	192	194	PF00675	0.438
CLV_NRD_NRD_1	246	248	PF00675	0.520
CLV_NRD_NRD_1	265	267	PF00675	0.302
CLV_PCSK_KEX2_1	245	247	PF00082	0.693
CLV_PCSK_KEX2_1	264	266	PF00082	0.290
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.437
CLV_Separin_Metazoa	190	194	PF03568	0.360
DEG_Nend_UBRbox_4	1	3	PF02207	0.562
DEG_SCF_TRCP1_1	227	233	PF00400	0.503
DOC_MAPK_gen_1	71	78	PF00069	0.367
DOC_USP7_MATH_1	16	20	PF00917	0.588
DOC_USP7_MATH_1	204	208	PF00917	0.573
DOC_USP7_MATH_1	225	229	PF00917	0.613
DOC_USP7_UBL2_3	232	236	PF12436	0.639
DOC_WW_Pin1_4	14	19	PF00397	0.646
DOC_WW_Pin1_4	230	235	PF00397	0.504
DOC_WW_Pin1_4	302	307	PF00397	0.590
LIG_14-3-3_CterR_2	308	312	PF00244	0.466
LIG_Actin_WH2_2	295	310	PF00022	0.359
LIG_APCC_ABBAyCdc20_2	245	251	PF00400	0.517
LIG_BRCT_BRCA1_1	168	172	PF00533	0.543
LIG_FHA_1	285	291	PF00498	0.416
LIG_FHA_2	77	83	PF00498	0.321
LIG_LIR_Gen_1	169	180	PF02991	0.542
LIG_LIR_Gen_1	185	195	PF02991	0.448
LIG_LIR_Gen_1	96	106	PF02991	0.321
LIG_LIR_Nem_3	169	175	PF02991	0.509
LIG_LIR_Nem_3	185	191	PF02991	0.538
LIG_LIR_Nem_3	251	255	PF02991	0.446
LIG_LIR_Nem_3	41	46	PF02991	0.263
LIG_SH2_CRK	114	118	PF00017	0.425
LIG_SH2_CRK	43	47	PF00017	0.292
LIG_SH2_SRC	272	275	PF00017	0.409
LIG_SH2_STAT3	149	152	PF00017	0.298
LIG_SH3_3	100	106	PF00018	0.255
LIG_SH3_3	293	299	PF00018	0.440
LIG_TRAF2_1	200	203	PF00917	0.541
LIG_TRAF2_1	79	82	PF00917	0.213
LIG_UBA3_1	65	71	PF00899	0.263
MOD_CDC14_SPxK_1	305	308	PF00782	0.552
MOD_CDK_SPK_2	230	235	PF00069	0.504
MOD_CDK_SPxK_1	230	236	PF00069	0.500
MOD_CDK_SPxK_1	302	308	PF00069	0.522
MOD_CK1_1	130	136	PF00069	0.171
MOD_CK1_1	182	188	PF00069	0.374
MOD_CK1_1	205	211	PF00069	0.625
MOD_CK1_1	216	222	PF00069	0.606
MOD_CK1_1	228	234	PF00069	0.515
MOD_CK2_1	76	82	PF00069	0.364
MOD_GlcNHglycan	14	17	PF01048	0.679
MOD_GlcNHglycan	168	171	PF01048	0.684
MOD_GlcNHglycan	18	21	PF01048	0.633
MOD_GlcNHglycan	215	218	PF01048	0.623
MOD_GlcNHglycan	226	230	PF01048	0.555
MOD_GlcNHglycan	277	280	PF01048	0.518
MOD_GSK3_1	12	19	PF00069	0.606
MOD_GSK3_1	123	130	PF00069	0.171
MOD_GSK3_1	151	158	PF00069	0.578
MOD_GSK3_1	182	189	PF00069	0.411
MOD_GSK3_1	202	209	PF00069	0.503
MOD_GSK3_1	290	297	PF00069	0.530
MOD_GSK3_1	76	83	PF00069	0.303
MOD_N-GLC_1	182	187	PF02516	0.373
MOD_N-GLC_1	205	210	PF02516	0.486
MOD_NEK2_1	101	106	PF00069	0.352
MOD_NEK2_1	12	17	PF00069	0.604
MOD_NEK2_1	166	171	PF00069	0.646
MOD_NEK2_1	195	200	PF00069	0.629
MOD_NEK2_1	307	312	PF00069	0.583
MOD_PKB_1	177	185	PF00069	0.387
MOD_PKB_1	211	219	PF00069	0.598
MOD_Plk_1	182	188	PF00069	0.374
MOD_Plk_4	291	297	PF00069	0.429
MOD_Plk_4	83	89	PF00069	0.348
MOD_ProDKin_1	14	20	PF00069	0.641
MOD_ProDKin_1	230	236	PF00069	0.500
MOD_ProDKin_1	302	308	PF00069	0.599
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.388
TRG_ENDOCYTIC_2	114	117	PF00928	0.425
TRG_ENDOCYTIC_2	252	255	PF00928	0.449
TRG_ENDOCYTIC_2	43	46	PF00928	0.292
TRG_ER_diArg_1	177	180	PF00400	0.539
TRG_ER_diArg_1	244	247	PF00400	0.555
TRG_ER_diArg_1	265	267	PF00400	0.436
TRG_NES_CRM1_1	67	82	PF08389	0.283
TRG_NLS_Bipartite_1	246	268	PF00514	0.411
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD44	Leptomonas seymouri	53%	72%
A0A3S7WUL2	Leishmania donovani	85%	98%
A4H901	Leishmania braziliensis	72%	100%
A4HXD2	Leishmania infantum	85%	98%
C9ZWV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q3JBF6	Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107)	28%	100%
Q4QED6	Leishmania major	86%	100%