DUF4101 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AR25_LEIMU

TriTrypDb:

LmxM.17.0560

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.514
CLV_NRD_NRD_1	10	12	PF00675	0.702
CLV_NRD_NRD_1	58	60	PF00675	0.700
CLV_PCSK_KEX2_1	10	12	PF00082	0.702
CLV_PCSK_KEX2_1	58	60	PF00082	0.696
CLV_PCSK_SKI1_1	132	136	PF00082	0.530
DEG_COP1_1	191	201	PF00400	0.396
DOC_MAPK_gen_1	58	64	PF00069	0.638
DOC_PP2B_LxvP_1	6	9	PF13499	0.817
DOC_USP7_MATH_1	47	51	PF00917	0.588
DOC_USP7_MATH_1	86	90	PF00917	0.624
DOC_WW_Pin1_4	1	6	PF00397	0.763
DOC_WW_Pin1_4	75	80	PF00397	0.691
LIG_14-3-3_CanoR_1	10	20	PF00244	0.722
LIG_14-3-3_CanoR_1	139	148	PF00244	0.482
LIG_14-3-3_CanoR_1	178	187	PF00244	0.515
LIG_14-3-3_CanoR_1	192	199	PF00244	0.343
LIG_14-3-3_CanoR_1	85	95	PF00244	0.621
LIG_Actin_WH2_2	24	40	PF00022	0.661
LIG_APCC_ABBAyCdc20_2	132	138	PF00400	0.345
LIG_BIR_III_2	125	129	PF00653	0.541
LIG_BRCT_BRCA1_1	141	145	PF00533	0.476
LIG_BRCT_BRCA1_1	193	197	PF00533	0.523
LIG_deltaCOP1_diTrp_1	191	197	PF00928	0.440
LIG_FHA_1	64	70	PF00498	0.613
LIG_GBD_Chelix_1	140	148	PF00786	0.579
LIG_LIR_Gen_1	174	183	PF02991	0.502
LIG_LIR_Nem_3	142	148	PF02991	0.461
LIG_LIR_Nem_3	170	176	PF02991	0.577
LIG_MYND_3	198	202	PF01753	0.587
LIG_NRBOX	15	21	PF00104	0.639
LIG_PCNA_PIPBox_1	137	146	PF02747	0.595
LIG_PCNA_yPIPBox_3	10	20	PF02747	0.662
LIG_Pex14_1	193	197	PF04695	0.430
LIG_Rb_pABgroove_1	139	147	PF01858	0.486
LIG_SH2_CRK	124	128	PF00017	0.534
LIG_SH2_STAP1	176	180	PF00017	0.500
LIG_SH2_STAT5	27	30	PF00017	0.539
LIG_SH3_3	20	26	PF00018	0.610
LIG_TRAF2_1	128	131	PF00917	0.644
LIG_TRAF2_1	165	168	PF00917	0.543
MOD_CK1_1	4	10	PF00069	0.751
MOD_CK2_1	162	168	PF00069	0.565
MOD_CK2_1	171	177	PF00069	0.474
MOD_CK2_1	86	92	PF00069	0.620
MOD_GlcNHglycan	118	121	PF01048	0.535
MOD_GlcNHglycan	151	154	PF01048	0.484
MOD_GlcNHglycan	180	183	PF01048	0.558
MOD_GlcNHglycan	193	196	PF01048	0.385
MOD_GlcNHglycan	49	52	PF01048	0.678
MOD_GlcNHglycan	89	92	PF01048	0.633
MOD_N-GLC_1	106	111	PF02516	0.628
MOD_NEK2_2	171	176	PF00069	0.568
MOD_PIKK_1	80	86	PF00454	0.779
MOD_PIKK_1	9	15	PF00454	0.529
MOD_PKA_2	191	197	PF00069	0.491
MOD_PKA_2	87	93	PF00069	0.517
MOD_PKA_2	9	15	PF00069	0.529
MOD_Plk_1	130	136	PF00069	0.575
MOD_ProDKin_1	1	7	PF00069	0.762
MOD_ProDKin_1	75	81	PF00069	0.692
MOD_SUMO_rev_2	125	134	PF00179	0.465
TRG_DiLeu_BaEn_4	130	136	PF01217	0.541
TRG_ENDOCYTIC_2	124	127	PF00928	0.552
TRG_ENDOCYTIC_2	176	179	PF00928	0.572
TRG_ER_diArg_1	57	59	PF00400	0.676
TRG_ER_diArg_1	9	11	PF00400	0.807
TRG_NES_CRM1_1	146	161	PF08389	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6A6	Leptomonas seymouri	69%	79%
A0A3S5H706	Leishmania donovani	92%	100%
A4H8Z9	Leishmania braziliensis	81%	100%
A4HXD0	Leishmania infantum	91%	100%
Q4QED8	Leishmania major	91%	100%