Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AR24_LEIMU

TriTrypDb:

LmxM.17.0550

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR24

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.554
CLV_NRD_NRD_1	132	134	PF00675	0.562
CLV_NRD_NRD_1	148	150	PF00675	0.748
CLV_NRD_NRD_1	98	100	PF00675	0.672
CLV_PCSK_KEX2_1	132	134	PF00082	0.649
CLV_PCSK_KEX2_1	148	150	PF00082	0.587
CLV_PCSK_KEX2_1	95	97	PF00082	0.756
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.723
DEG_APCC_DBOX_1	253	261	PF00400	0.490
DEG_APCC_DBOX_1	61	69	PF00400	0.438
DOC_CYCLIN_yClb3_PxF_3	214	220	PF00134	0.537
DOC_MAPK_MEF2A_6	254	263	PF00069	0.502
DOC_MAPK_MEF2A_6	294	303	PF00069	0.455
DOC_PP2B_LxvP_1	182	185	PF13499	0.537
DOC_PP4_FxxP_1	188	191	PF00568	0.638
DOC_PP4_FxxP_1	195	198	PF00568	0.574
DOC_PP4_FxxP_1	263	266	PF00568	0.530
DOC_USP7_MATH_1	31	35	PF00917	0.434
DOC_USP7_MATH_1	89	93	PF00917	0.708
DOC_USP7_UBL2_3	38	42	PF12436	0.486
DOC_WW_Pin1_4	241	246	PF00397	0.371
DOC_WW_Pin1_4	78	83	PF00397	0.636
LIG_14-3-3_CanoR_1	12	19	PF00244	0.476
LIG_BIR_III_2	66	70	PF00653	0.520
LIG_EVH1_2	184	188	PF00568	0.529
LIG_EVH1_2	191	195	PF00568	0.498
LIG_FHA_1	290	296	PF00498	0.522
LIG_FHA_1	45	51	PF00498	0.440
LIG_FHA_1	73	79	PF00498	0.630
LIG_FHA_2	20	26	PF00498	0.463
LIG_FHA_2	49	55	PF00498	0.459
LIG_LIR_Apic_2	187	191	PF02991	0.504
LIG_LIR_Apic_2	194	198	PF02991	0.486
LIG_LIR_Apic_2	209	214	PF02991	0.517
LIG_LIR_Gen_1	114	121	PF02991	0.614
LIG_LIR_Gen_1	13	23	PF02991	0.413
LIG_LIR_Gen_1	46	57	PF02991	0.376
LIG_LIR_Nem_3	114	118	PF02991	0.612
LIG_LIR_Nem_3	13	19	PF02991	0.422
LIG_LIR_Nem_3	241	246	PF02991	0.448
LIG_LIR_Nem_3	25	29	PF02991	0.454
LIG_LIR_Nem_3	46	52	PF02991	0.361
LIG_MYND_1	215	219	PF01753	0.541
LIG_PTB_Apo_2	226	233	PF02174	0.465
LIG_SH2_CRK	211	215	PF00017	0.427
LIG_SH2_STAT3	121	124	PF00017	0.610
LIG_SH3_3	212	218	PF00018	0.508
LIG_SH3_3	290	296	PF00018	0.387
LIG_SUMO_SIM_anti_2	256	261	PF11976	0.502
LIG_SUMO_SIM_par_1	283	290	PF11976	0.525
LIG_TRAF2_1	82	85	PF00917	0.720
LIG_WRC_WIRS_1	32	37	PF05994	0.610
LIG_WRC_WIRS_1	49	54	PF05994	0.292
MOD_CDK_SPxxK_3	241	248	PF00069	0.385
MOD_CK1_1	10	16	PF00069	0.483
MOD_CK1_1	289	295	PF00069	0.507
MOD_CK1_1	94	100	PF00069	0.669
MOD_CK2_1	14	20	PF00069	0.560
MOD_CK2_1	31	37	PF00069	0.582
MOD_GlcNHglycan	16	19	PF01048	0.555
MOD_GlcNHglycan	177	180	PF01048	0.648
MOD_GlcNHglycan	289	292	PF01048	0.406
MOD_GlcNHglycan	78	81	PF01048	0.624
MOD_GlcNHglycan	89	92	PF01048	0.619
MOD_GSK3_1	103	110	PF00069	0.496
MOD_GSK3_1	128	135	PF00069	0.673
MOD_GSK3_1	157	164	PF00069	0.772
MOD_GSK3_1	44	51	PF00069	0.572
MOD_GSK3_1	6	13	PF00069	0.475
MOD_GSK3_1	72	79	PF00069	0.597
MOD_GSK3_1	87	94	PF00069	0.700
MOD_LATS_1	130	136	PF00433	0.551
MOD_N-GLC_1	161	166	PF02516	0.738
MOD_N-GLC_1	276	281	PF02516	0.302
MOD_NEK2_1	232	237	PF00069	0.530
MOD_NEK2_1	276	281	PF00069	0.523
MOD_NEK2_1	6	11	PF00069	0.449
MOD_NEK2_2	31	36	PF00069	0.440
MOD_PIKK_1	89	95	PF00454	0.552
MOD_PKA_1	132	138	PF00069	0.603
MOD_PKA_2	11	17	PF00069	0.474
MOD_PKA_2	126	132	PF00069	0.582
MOD_PKA_2	157	163	PF00069	0.598
MOD_Plk_1	19	25	PF00069	0.502
MOD_Plk_1	43	49	PF00069	0.444
MOD_Plk_4	44	50	PF00069	0.445
MOD_ProDKin_1	241	247	PF00069	0.371
MOD_ProDKin_1	78	84	PF00069	0.641
MOD_SUMO_rev_2	106	111	PF00179	0.570
TRG_ER_diArg_1	148	151	PF00400	0.658
TRG_ER_diArg_1	174	177	PF00400	0.737
TRG_NLS_MonoExtN_4	96	103	PF00514	0.673
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.267

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P0T6	Trypanosomatidae	35%	100%
A0A3Q8IAN2	Leishmania donovani	85%	100%
A0A3R7MFN4	Trypanosoma rangeli	35%	100%
A4H8Z8	Leishmania braziliensis	74%	100%
A4HXC9	Leishmania infantum	86%	100%
D0A4S0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QED9	Leishmania major	84%	98%
V5AZY6	Trypanosoma cruzi	36%	100%