Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AR22_LEIMU

TriTrypDb:

LmxM.17.0530

Length:

1073

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	496	500	PF00656	0.753
CLV_C14_Caspase3-7	761	765	PF00656	0.376
CLV_NRD_NRD_1	448	450	PF00675	0.744
CLV_NRD_NRD_1	564	566	PF00675	0.760
CLV_NRD_NRD_1	60	62	PF00675	0.757
CLV_NRD_NRD_1	650	652	PF00675	0.505
CLV_NRD_NRD_1	849	851	PF00675	0.355
CLV_NRD_NRD_1	998	1000	PF00675	0.722
CLV_PCSK_FUR_1	446	450	PF00082	0.708
CLV_PCSK_KEX2_1	448	450	PF00082	0.744
CLV_PCSK_KEX2_1	564	566	PF00082	0.760
CLV_PCSK_KEX2_1	60	62	PF00082	0.757
CLV_PCSK_KEX2_1	650	652	PF00082	0.505
CLV_PCSK_KEX2_1	731	733	PF00082	0.539
CLV_PCSK_KEX2_1	997	999	PF00082	0.710
CLV_PCSK_PC1ET2_1	731	733	PF00082	0.539
CLV_PCSK_PC1ET2_1	997	999	PF00082	0.598
CLV_PCSK_SKI1_1	1055	1059	PF00082	0.412
CLV_PCSK_SKI1_1	156	160	PF00082	0.514
CLV_PCSK_SKI1_1	222	226	PF00082	0.544
CLV_PCSK_SKI1_1	517	521	PF00082	0.810
CLV_PCSK_SKI1_1	670	674	PF00082	0.484
CLV_PCSK_SKI1_1	749	753	PF00082	0.552
CLV_PCSK_SKI1_1	850	854	PF00082	0.543
CLV_PCSK_SKI1_1	896	900	PF00082	0.547
CLV_Separin_Metazoa	176	180	PF03568	0.352
DEG_APCC_DBOX_1	766	774	PF00400	0.525
DEG_APCC_DBOX_1	810	818	PF00400	0.554
DEG_SCF_FBW7_1	16	23	PF00400	0.699
DEG_SCF_FBW7_1	466	472	PF00400	0.728
DEG_SPOP_SBC_1	105	109	PF00917	0.548
DEG_SPOP_SBC_1	11	15	PF00917	0.733
DEG_SPOP_SBC_1	296	300	PF00917	0.574
DEG_SPOP_SBC_1	301	305	PF00917	0.577
DEG_SPOP_SBC_1	603	607	PF00917	0.701
DOC_CKS1_1	466	471	PF01111	0.729
DOC_CKS1_1	632	637	PF01111	0.598
DOC_CYCLIN_RxL_1	153	163	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	619	625	PF00134	0.467
DOC_MAPK_gen_1	486	495	PF00069	0.724
DOC_MAPK_MEF2A_6	222	229	PF00069	0.543
DOC_USP7_MATH_1	1035	1039	PF00917	0.597
DOC_USP7_MATH_1	1044	1048	PF00917	0.566
DOC_USP7_MATH_1	147	151	PF00917	0.597
DOC_USP7_MATH_1	20	24	PF00917	0.677
DOC_USP7_MATH_1	256	260	PF00917	0.748
DOC_USP7_MATH_1	273	277	PF00917	0.511
DOC_USP7_MATH_1	280	284	PF00917	0.718
DOC_USP7_MATH_1	286	290	PF00917	0.683
DOC_USP7_MATH_1	33	37	PF00917	0.587
DOC_USP7_MATH_1	461	465	PF00917	0.845
DOC_USP7_MATH_1	469	473	PF00917	0.712
DOC_USP7_MATH_1	481	485	PF00917	0.612
DOC_USP7_MATH_1	765	769	PF00917	0.540
DOC_USP7_MATH_1	778	782	PF00917	0.527
DOC_USP7_MATH_1	830	834	PF00917	0.401
DOC_USP7_MATH_1	855	859	PF00917	0.427
DOC_USP7_MATH_1	862	866	PF00917	0.397
DOC_USP7_MATH_1	9	13	PF00917	0.660
DOC_USP7_MATH_1	97	101	PF00917	0.602
DOC_USP7_MATH_1	978	982	PF00917	0.604
DOC_WW_Pin1_4	1023	1028	PF00397	0.720
DOC_WW_Pin1_4	1067	1072	PF00397	0.605
DOC_WW_Pin1_4	145	150	PF00397	0.632
DOC_WW_Pin1_4	16	21	PF00397	0.621
DOC_WW_Pin1_4	282	287	PF00397	0.795
DOC_WW_Pin1_4	309	314	PF00397	0.633
DOC_WW_Pin1_4	342	347	PF00397	0.716
DOC_WW_Pin1_4	352	357	PF00397	0.607
DOC_WW_Pin1_4	371	376	PF00397	0.529
DOC_WW_Pin1_4	378	383	PF00397	0.679
DOC_WW_Pin1_4	391	396	PF00397	0.570
DOC_WW_Pin1_4	407	412	PF00397	0.656
DOC_WW_Pin1_4	465	470	PF00397	0.790
DOC_WW_Pin1_4	528	533	PF00397	0.842
DOC_WW_Pin1_4	605	610	PF00397	0.721
DOC_WW_Pin1_4	618	623	PF00397	0.524
DOC_WW_Pin1_4	631	636	PF00397	0.588
DOC_WW_Pin1_4	68	73	PF00397	0.691
DOC_WW_Pin1_4	7	12	PF00397	0.658
DOC_WW_Pin1_4	75	80	PF00397	0.640
DOC_WW_Pin1_4	782	787	PF00397	0.681
LIG_14-3-3_CanoR_1	1002	1012	PF00244	0.721
LIG_14-3-3_CanoR_1	1067	1071	PF00244	0.638
LIG_14-3-3_CanoR_1	129	135	PF00244	0.618
LIG_14-3-3_CanoR_1	22	28	PF00244	0.696
LIG_14-3-3_CanoR_1	47	54	PF00244	0.688
LIG_14-3-3_CanoR_1	579	584	PF00244	0.523
LIG_14-3-3_CanoR_1	692	700	PF00244	0.518
LIG_14-3-3_CanoR_1	767	771	PF00244	0.516
LIG_14-3-3_CanoR_1	876	882	PF00244	0.354
LIG_14-3-3_CanoR_1	918	926	PF00244	0.507
LIG_Actin_WH2_2	803	820	PF00022	0.488
LIG_Actin_WH2_2	863	880	PF00022	0.540
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_Clathr_ClatBox_1	741	745	PF01394	0.542
LIG_EVH1_1	292	296	PF00568	0.726
LIG_FHA_1	1056	1062	PF00498	0.599
LIG_FHA_1	305	311	PF00498	0.758
LIG_FHA_1	466	472	PF00498	0.709
LIG_FHA_1	606	612	PF00498	0.692
LIG_FHA_1	658	664	PF00498	0.453
LIG_FHA_1	667	673	PF00498	0.509
LIG_FHA_1	897	903	PF00498	0.556
LIG_FHA_2	105	111	PF00498	0.690
LIG_FHA_2	418	424	PF00498	0.650
LIG_FHA_2	471	477	PF00498	0.738
LIG_FHA_2	503	509	PF00498	0.713
LIG_FHA_2	632	638	PF00498	0.591
LIG_FHA_2	753	759	PF00498	0.548
LIG_GBD_Chelix_1	806	814	PF00786	0.507
LIG_LIR_Apic_2	144	149	PF02991	0.613
LIG_LIR_Gen_1	157	167	PF02991	0.539
LIG_LIR_Gen_1	321	332	PF02991	0.698
LIG_LIR_Gen_1	344	352	PF02991	0.658
LIG_LIR_Gen_1	664	673	PF02991	0.520
LIG_LIR_Nem_3	157	162	PF02991	0.544
LIG_LIR_Nem_3	289	295	PF02991	0.729
LIG_LIR_Nem_3	321	327	PF02991	0.736
LIG_LIR_Nem_3	344	350	PF02991	0.658
LIG_LIR_Nem_3	664	668	PF02991	0.454
LIG_MYND_1	293	297	PF01753	0.725
LIG_PCNA_yPIPBox_3	715	727	PF02747	0.537
LIG_PTB_Apo_2	509	516	PF02174	0.718
LIG_PTB_Phospho_1	509	515	PF10480	0.719
LIG_RPA_C_Fungi	259	271	PF08784	0.609
LIG_SH2_CRK	1045	1049	PF00017	0.603
LIG_SH2_CRK	347	351	PF00017	0.728
LIG_SH2_CRK	361	365	PF00017	0.570
LIG_SH2_CRK	629	633	PF00017	0.625
LIG_SH2_CRK	665	669	PF00017	0.386
LIG_SH2_NCK_1	989	993	PF00017	0.513
LIG_SH2_SRC	201	204	PF00017	0.540
LIG_SH2_STAP1	933	937	PF00017	0.524
LIG_SH2_STAT3	627	630	PF00017	0.622
LIG_SH2_STAT5	242	245	PF00017	0.561
LIG_SH2_STAT5	309	312	PF00017	0.724
LIG_SH2_STAT5	347	350	PF00017	0.729
LIG_SH2_STAT5	627	630	PF00017	0.622
LIG_SH3_1	1009	1015	PF00018	0.539
LIG_SH3_1	629	635	PF00018	0.614
LIG_SH3_3	1009	1015	PF00018	0.552
LIG_SH3_3	290	296	PF00018	0.783
LIG_SH3_3	372	378	PF00018	0.826
LIG_SH3_3	482	488	PF00018	0.724
LIG_SH3_3	5	11	PF00018	0.686
LIG_SH3_3	629	635	PF00018	0.614
LIG_SUMO_SIM_par_1	740	745	PF11976	0.544
LIG_TRAF2_1	108	111	PF00917	0.614
LIG_TRAF2_1	180	183	PF00917	0.545
LIG_TRAF2_1	638	641	PF00917	0.568
LIG_TRAF2_1	890	893	PF00917	0.538
LIG_TRAF2_1	904	907	PF00917	0.408
LIG_TYR_ITIM	663	668	PF00017	0.457
LIG_WW_2	293	296	PF00397	0.725
LIG_WW_3	254	258	PF00397	0.642
MOD_CDC14_SPxK_1	15	18	PF00782	0.629
MOD_CDK_SPxK_1	12	18	PF00069	0.681
MOD_CDK_SPxK_1	75	81	PF00069	0.701
MOD_CK1_1	1001	1007	PF00069	0.578
MOD_CK1_1	118	124	PF00069	0.766
MOD_CK1_1	128	134	PF00069	0.601
MOD_CK1_1	23	29	PF00069	0.665
MOD_CK1_1	276	282	PF00069	0.672
MOD_CK1_1	326	332	PF00069	0.587
MOD_CK1_1	345	351	PF00069	0.690
MOD_CK1_1	381	387	PF00069	0.734
MOD_CK1_1	394	400	PF00069	0.615
MOD_CK1_1	470	476	PF00069	0.674
MOD_CK1_1	523	529	PF00069	0.742
MOD_CK1_1	530	536	PF00069	0.673
MOD_CK1_1	610	616	PF00069	0.714
MOD_CK1_1	621	627	PF00069	0.523
MOD_CK1_1	691	697	PF00069	0.515
MOD_CK1_1	7	13	PF00069	0.725
MOD_CK1_1	776	782	PF00069	0.607
MOD_CK1_1	85	91	PF00069	0.730
MOD_CK1_1	921	927	PF00069	0.528
MOD_CK2_1	1001	1007	PF00069	0.578
MOD_CK2_1	104	110	PF00069	0.689
MOD_CK2_1	145	151	PF00069	0.597
MOD_CK2_1	351	357	PF00069	0.675
MOD_CK2_1	502	508	PF00069	0.694
MOD_CK2_1	631	637	PF00069	0.601
MOD_CK2_1	752	758	PF00069	0.538
MOD_CK2_1	766	772	PF00069	0.415
MOD_CK2_1	901	907	PF00069	0.419
MOD_CK2_1	928	934	PF00069	0.535
MOD_Cter_Amidation	562	565	PF01082	0.702
MOD_DYRK1A_RPxSP_1	1067	1071	PF00069	0.599
MOD_DYRK1A_RPxSP_1	391	395	PF00069	0.679
MOD_GlcNHglycan	1015	1018	PF01048	0.679
MOD_GlcNHglycan	130	133	PF01048	0.673
MOD_GlcNHglycan	258	261	PF01048	0.707
MOD_GlcNHglycan	275	278	PF01048	0.498
MOD_GlcNHglycan	282	285	PF01048	0.657
MOD_GlcNHglycan	288	291	PF01048	0.659
MOD_GlcNHglycan	328	331	PF01048	0.692
MOD_GlcNHglycan	350	353	PF01048	0.637
MOD_GlcNHglycan	386	389	PF01048	0.780
MOD_GlcNHglycan	391	394	PF01048	0.710
MOD_GlcNHglycan	396	399	PF01048	0.617
MOD_GlcNHglycan	50	53	PF01048	0.717
MOD_GlcNHglycan	525	528	PF01048	0.788
MOD_GlcNHglycan	544	547	PF01048	0.565
MOD_GlcNHglycan	554	557	PF01048	0.811
MOD_GlcNHglycan	693	696	PF01048	0.512
MOD_GlcNHglycan	780	783	PF01048	0.664
MOD_GlcNHglycan	826	831	PF01048	0.531
MOD_GlcNHglycan	832	835	PF01048	0.472
MOD_GlcNHglycan	87	90	PF01048	0.704
MOD_GlcNHglycan	920	923	PF01048	0.528
MOD_GlcNHglycan	982	985	PF01048	0.637
MOD_GSK3_1	1013	1020	PF00069	0.679
MOD_GSK3_1	1030	1037	PF00069	0.537
MOD_GSK3_1	1051	1058	PF00069	0.596
MOD_GSK3_1	106	113	PF00069	0.653
MOD_GSK3_1	124	131	PF00069	0.570
MOD_GSK3_1	141	148	PF00069	0.568
MOD_GSK3_1	16	23	PF00069	0.672
MOD_GSK3_1	256	263	PF00069	0.701
MOD_GSK3_1	276	283	PF00069	0.602
MOD_GSK3_1	284	291	PF00069	0.727
MOD_GSK3_1	295	302	PF00069	0.559
MOD_GSK3_1	341	348	PF00069	0.730
MOD_GSK3_1	380	387	PF00069	0.791
MOD_GSK3_1	461	468	PF00069	0.788
MOD_GSK3_1	517	524	PF00069	0.757
MOD_GSK3_1	526	533	PF00069	0.700
MOD_GSK3_1	552	559	PF00069	0.706
MOD_GSK3_1	589	596	PF00069	0.700
MOD_GSK3_1	597	604	PF00069	0.644
MOD_GSK3_1	607	614	PF00069	0.529
MOD_GSK3_1	617	624	PF00069	0.513
MOD_GSK3_1	7	14	PF00069	0.707
MOD_GSK3_1	773	780	PF00069	0.594
MOD_GSK3_1	826	833	PF00069	0.405
MOD_GSK3_1	876	883	PF00069	0.434
MOD_GSK3_1	896	903	PF00069	0.385
MOD_GSK3_1	921	928	PF00069	0.537
MOD_N-GLC_1	503	508	PF02516	0.733
MOD_N-GLC_2	675	677	PF02516	0.478
MOD_NEK2_1	1051	1056	PF00069	0.595
MOD_NEK2_1	1061	1066	PF00069	0.506
MOD_NEK2_1	341	346	PF00069	0.573
MOD_NEK2_1	350	355	PF00069	0.604
MOD_NEK2_1	389	394	PF00069	0.651
MOD_NEK2_1	4	9	PF00069	0.682
MOD_NEK2_1	412	417	PF00069	0.710
MOD_NEK2_1	444	449	PF00069	0.568
MOD_NEK2_1	522	527	PF00069	0.732
MOD_NEK2_1	744	749	PF00069	0.537
MOD_NEK2_1	766	771	PF00069	0.536
MOD_NEK2_1	777	782	PF00069	0.548
MOD_NEK2_1	846	851	PF00069	0.450
MOD_NEK2_1	877	882	PF00069	0.355
MOD_NEK2_2	481	486	PF00069	0.551
MOD_PIKK_1	734	740	PF00454	0.544
MOD_PIKK_1	901	907	PF00454	0.519
MOD_PIKK_1	925	931	PF00454	0.535
MOD_PK_1	579	585	PF00069	0.523
MOD_PKA_1	998	1004	PF00069	0.684
MOD_PKA_2	1051	1057	PF00069	0.596
MOD_PKA_2	1066	1072	PF00069	0.485
MOD_PKA_2	128	134	PF00069	0.648
MOD_PKA_2	21	27	PF00069	0.702
MOD_PKA_2	256	262	PF00069	0.652
MOD_PKA_2	46	52	PF00069	0.687
MOD_PKA_2	691	697	PF00069	0.519
MOD_PKA_2	709	715	PF00069	0.388
MOD_PKA_2	766	772	PF00069	0.521
MOD_PKA_2	877	883	PF00069	0.358
MOD_PKA_2	998	1004	PF00069	0.723
MOD_PKB_1	139	147	PF00069	0.606
MOD_PKB_1	894	902	PF00069	0.555
MOD_Plk_1	614	620	PF00069	0.509
MOD_Plk_1	826	832	PF00069	0.531
MOD_Plk_1	910	916	PF00069	0.534
MOD_Plk_4	345	351	PF00069	0.659
MOD_Plk_4	461	467	PF00069	0.752
MOD_Plk_4	877	883	PF00069	0.358
MOD_ProDKin_1	1023	1029	PF00069	0.720
MOD_ProDKin_1	1067	1073	PF00069	0.615
MOD_ProDKin_1	145	151	PF00069	0.627
MOD_ProDKin_1	16	22	PF00069	0.623
MOD_ProDKin_1	282	288	PF00069	0.796
MOD_ProDKin_1	309	315	PF00069	0.627
MOD_ProDKin_1	342	348	PF00069	0.718
MOD_ProDKin_1	352	358	PF00069	0.608
MOD_ProDKin_1	371	377	PF00069	0.526
MOD_ProDKin_1	378	384	PF00069	0.680
MOD_ProDKin_1	391	397	PF00069	0.568
MOD_ProDKin_1	407	413	PF00069	0.660
MOD_ProDKin_1	465	471	PF00069	0.791
MOD_ProDKin_1	528	534	PF00069	0.838
MOD_ProDKin_1	605	611	PF00069	0.722
MOD_ProDKin_1	618	624	PF00069	0.519
MOD_ProDKin_1	631	637	PF00069	0.584
MOD_ProDKin_1	68	74	PF00069	0.693
MOD_ProDKin_1	7	13	PF00069	0.659
MOD_ProDKin_1	75	81	PF00069	0.642
MOD_ProDKin_1	782	788	PF00069	0.679
MOD_SUMO_for_1	173	176	PF00179	0.499
MOD_SUMO_rev_2	317	324	PF00179	0.656
MOD_SUMO_rev_2	707	717	PF00179	0.538
TRG_DiLeu_BaEn_1	220	225	PF01217	0.547
TRG_DiLeu_BaEn_1	954	959	PF01217	0.547
TRG_DiLeu_BaEn_4	220	226	PF01217	0.547
TRG_DiLeu_BaEn_4	641	647	PF01217	0.564
TRG_DiLeu_BaEn_4	654	660	PF01217	0.404
TRG_DiLeu_BaEn_4	892	898	PF01217	0.508
TRG_ENDOCYTIC_2	1045	1048	PF00928	0.606
TRG_ENDOCYTIC_2	347	350	PF00928	0.781
TRG_ENDOCYTIC_2	665	668	PF00928	0.518
TRG_ENDOCYTIC_2	962	965	PF00928	0.489
TRG_ER_diArg_1	446	449	PF00400	0.711
TRG_ER_diArg_1	492	495	PF00400	0.693
TRG_ER_diArg_1	59	61	PF00400	0.761
TRG_ER_diArg_1	649	651	PF00400	0.513
TRG_ER_diArg_1	839	842	PF00400	0.550
TRG_ER_diArg_1	894	897	PF00400	0.550
TRG_NES_CRM1_1	657	671	PF08389	0.502
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	650	654	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	703	708	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	918	923	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUD7	Leishmania donovani	89%	100%
A4H8Z6	Leishmania braziliensis	69%	98%
A4HXC7	Leishmania infantum	89%	100%
Q4QEE1	Leishmania major	88%	99%