Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AR21_LEIMU

TriTrypDb:

LmxM.17.0520

Length:

794

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.773
CLV_C14_Caspase3-7	269	273	PF00656	0.581
CLV_C14_Caspase3-7	285	289	PF00656	0.748
CLV_C14_Caspase3-7	296	300	PF00656	0.600
CLV_C14_Caspase3-7	640	644	PF00656	0.696
CLV_NRD_NRD_1	145	147	PF00675	0.658
CLV_NRD_NRD_1	240	242	PF00675	0.658
CLV_NRD_NRD_1	51	53	PF00675	0.665
CLV_NRD_NRD_1	551	553	PF00675	0.683
CLV_NRD_NRD_1	9	11	PF00675	0.675
CLV_PCSK_KEX2_1	145	147	PF00082	0.658
CLV_PCSK_KEX2_1	239	241	PF00082	0.666
CLV_PCSK_KEX2_1	51	53	PF00082	0.665
CLV_PCSK_KEX2_1	788	790	PF00082	0.693
CLV_PCSK_KEX2_1	9	11	PF00082	0.662
CLV_PCSK_PC1ET2_1	788	790	PF00082	0.646
CLV_PCSK_SKI1_1	503	507	PF00082	0.521
CLV_PCSK_SKI1_1	548	552	PF00082	0.677
DEG_Kelch_Keap1_1	738	743	PF01344	0.634
DEG_Nend_UBRbox_1	1	4	PF02207	0.524
DEG_SCF_FBW7_2	334	341	PF00400	0.524
DEG_SPOP_SBC_1	37	41	PF00917	0.670
DEG_SPOP_SBC_1	495	499	PF00917	0.502
DOC_CKS1_1	335	340	PF01111	0.583
DOC_CKS1_1	363	368	PF01111	0.854
DOC_CKS1_1	46	51	PF01111	0.544
DOC_CKS1_1	709	714	PF01111	0.737
DOC_MAPK_gen_1	788	794	PF00069	0.658
DOC_MAPK_MEF2A_6	191	198	PF00069	0.523
DOC_MAPK_MEF2A_6	254	261	PF00069	0.531
DOC_MAPK_MEF2A_6	340	348	PF00069	0.727
DOC_PP1_RVXF_1	695	702	PF00149	0.574
DOC_PP1_SILK_1	548	553	PF00149	0.677
DOC_PP2B_LxvP_1	23	26	PF13499	0.641
DOC_PP2B_LxvP_1	747	750	PF13499	0.630
DOC_PP2B_LxvP_1	78	81	PF13499	0.630
DOC_USP7_MATH_1	108	112	PF00917	0.613
DOC_USP7_MATH_1	138	142	PF00917	0.680
DOC_USP7_MATH_1	185	189	PF00917	0.808
DOC_USP7_MATH_1	225	229	PF00917	0.758
DOC_USP7_MATH_1	244	248	PF00917	0.588
DOC_USP7_MATH_1	26	30	PF00917	0.636
DOC_USP7_MATH_1	295	299	PF00917	0.655
DOC_USP7_MATH_1	355	359	PF00917	0.707
DOC_USP7_MATH_1	36	40	PF00917	0.670
DOC_USP7_MATH_1	412	416	PF00917	0.572
DOC_USP7_MATH_1	463	467	PF00917	0.768
DOC_USP7_MATH_1	531	535	PF00917	0.615
DOC_USP7_MATH_1	60	64	PF00917	0.524
DOC_USP7_MATH_1	604	608	PF00917	0.685
DOC_USP7_MATH_1	690	694	PF00917	0.585
DOC_USP7_MATH_1	748	752	PF00917	0.495
DOC_WW_Pin1_4	200	205	PF00397	0.726
DOC_WW_Pin1_4	21	26	PF00397	0.601
DOC_WW_Pin1_4	249	254	PF00397	0.772
DOC_WW_Pin1_4	289	294	PF00397	0.567
DOC_WW_Pin1_4	334	339	PF00397	0.622
DOC_WW_Pin1_4	357	362	PF00397	0.785
DOC_WW_Pin1_4	38	43	PF00397	0.589
DOC_WW_Pin1_4	45	50	PF00397	0.629
DOC_WW_Pin1_4	472	477	PF00397	0.790
DOC_WW_Pin1_4	525	530	PF00397	0.714
DOC_WW_Pin1_4	579	584	PF00397	0.606
DOC_WW_Pin1_4	598	603	PF00397	0.764
DOC_WW_Pin1_4	620	625	PF00397	0.796
DOC_WW_Pin1_4	649	654	PF00397	0.707
DOC_WW_Pin1_4	656	661	PF00397	0.799
DOC_WW_Pin1_4	686	691	PF00397	0.741
DOC_WW_Pin1_4	705	710	PF00397	0.754
DOC_WW_Pin1_4	782	787	PF00397	0.601
LIG_14-3-3_CanoR_1	239	248	PF00244	0.664
LIG_14-3-3_CanoR_1	375	379	PF00244	0.709
LIG_14-3-3_CanoR_1	541	547	PF00244	0.593
LIG_14-3-3_CanoR_1	617	625	PF00244	0.691
LIG_BIR_III_2	290	294	PF00653	0.534
LIG_BIR_III_2	655	659	PF00653	0.682
LIG_BIR_III_2	85	89	PF00653	0.655
LIG_BRCT_BRCA1_1	533	537	PF00533	0.621
LIG_BRCT_BRCA1_1	697	701	PF00533	0.661
LIG_FHA_1	116	122	PF00498	0.587
LIG_FHA_1	156	162	PF00498	0.663
LIG_FHA_1	309	315	PF00498	0.662
LIG_FHA_1	343	349	PF00498	0.677
LIG_FHA_1	380	386	PF00498	0.769
LIG_FHA_1	479	485	PF00498	0.723
LIG_FHA_1	630	636	PF00498	0.560
LIG_FHA_1	64	70	PF00498	0.736
LIG_FHA_1	742	748	PF00498	0.647
LIG_FHA_1	93	99	PF00498	0.655
LIG_FHA_2	14	20	PF00498	0.667
LIG_FHA_2	530	536	PF00498	0.673
LIG_FHA_2	638	644	PF00498	0.695
LIG_FHA_2	650	656	PF00498	0.606
LIG_FHA_2	663	669	PF00498	0.730
LIG_FHA_2	770	776	PF00498	0.676
LIG_LIR_Nem_3	534	540	PF02991	0.612
LIG_LIR_Nem_3	632	637	PF02991	0.684
LIG_LIR_Nem_3	711	717	PF02991	0.534
LIG_LYPXL_yS_3	714	717	PF13949	0.541
LIG_NRBOX	756	762	PF00104	0.493
LIG_PDZ_Class_2	789	794	PF00595	0.659
LIG_SH2_CRK	425	429	PF00017	0.538
LIG_SH2_GRB2like	425	428	PF00017	0.672
LIG_SH2_NCK_1	425	429	PF00017	0.538
LIG_SH2_SRC	100	103	PF00017	0.652
LIG_SH2_STAP1	117	121	PF00017	0.590
LIG_SH2_STAT5	100	103	PF00017	0.652
LIG_SH2_STAT5	117	120	PF00017	0.531
LIG_SH2_STAT5	546	549	PF00017	0.491
LIG_SH3_2	335	340	PF14604	0.592
LIG_SH3_3	191	197	PF00018	0.703
LIG_SH3_3	262	268	PF00018	0.539
LIG_SH3_3	332	338	PF00018	0.616
LIG_SH3_3	396	402	PF00018	0.687
LIG_SH3_3	433	439	PF00018	0.736
LIG_SH3_3	577	583	PF00018	0.657
LIG_SH3_3	706	712	PF00018	0.713
LIG_SH3_3	780	786	PF00018	0.597
LIG_SUMO_SIM_anti_2	345	352	PF11976	0.674
LIG_SUMO_SIM_anti_2	779	785	PF11976	0.498
LIG_UBA3_1	501	506	PF00899	0.592
MOD_CDC14_SPxK_1	785	788	PF00782	0.529
MOD_CDK_SPK_2	249	254	PF00069	0.516
MOD_CDK_SPK_2	598	603	PF00069	0.735
MOD_CDK_SPxK_1	334	340	PF00069	0.595
MOD_CDK_SPxK_1	45	51	PF00069	0.545
MOD_CDK_SPxK_1	782	788	PF00069	0.656
MOD_CDK_SPxxK_3	357	364	PF00069	0.822
MOD_CDK_SPxxK_3	45	52	PF00069	0.546
MOD_CDK_SPxxK_3	782	789	PF00069	0.598
MOD_CK1_1	111	117	PF00069	0.677
MOD_CK1_1	155	161	PF00069	0.754
MOD_CK1_1	186	192	PF00069	0.762
MOD_CK1_1	212	218	PF00069	0.724
MOD_CK1_1	228	234	PF00069	0.626
MOD_CK1_1	362	368	PF00069	0.734
MOD_CK1_1	373	379	PF00069	0.656
MOD_CK1_1	390	396	PF00069	0.608
MOD_CK1_1	41	47	PF00069	0.579
MOD_CK1_1	415	421	PF00069	0.653
MOD_CK1_1	466	472	PF00069	0.725
MOD_CK1_1	488	494	PF00069	0.638
MOD_CK1_1	496	502	PF00069	0.556
MOD_CK1_1	504	510	PF00069	0.576
MOD_CK1_1	554	560	PF00069	0.628
MOD_CK1_1	607	613	PF00069	0.624
MOD_CK1_1	61	67	PF00069	0.503
MOD_CK1_1	619	625	PF00069	0.702
MOD_CK1_1	708	714	PF00069	0.748
MOD_CK2_1	333	339	PF00069	0.692
MOD_CK2_1	529	535	PF00069	0.681
MOD_CK2_1	62	68	PF00069	0.501
MOD_CK2_1	662	668	PF00069	0.549
MOD_CK2_1	737	743	PF00069	0.660
MOD_CK2_1	769	775	PF00069	0.682
MOD_GlcNHglycan	126	129	PF01048	0.736
MOD_GlcNHglycan	131	134	PF01048	0.708
MOD_GlcNHglycan	225	228	PF01048	0.750
MOD_GlcNHglycan	230	233	PF01048	0.717
MOD_GlcNHglycan	242	245	PF01048	0.590
MOD_GlcNHglycan	305	308	PF01048	0.828
MOD_GlcNHglycan	376	379	PF01048	0.692
MOD_GlcNHglycan	417	420	PF01048	0.680
MOD_GlcNHglycan	445	448	PF01048	0.776
MOD_GlcNHglycan	511	514	PF01048	0.665
MOD_GlcNHglycan	553	556	PF01048	0.645
MOD_GlcNHglycan	607	610	PF01048	0.789
MOD_GlcNHglycan	618	621	PF01048	0.720
MOD_GlcNHglycan	649	652	PF01048	0.683
MOD_GlcNHglycan	665	668	PF01048	0.606
MOD_GlcNHglycan	692	695	PF01048	0.562
MOD_GlcNHglycan	725	728	PF01048	0.741
MOD_GlcNHglycan	754	757	PF01048	0.534
MOD_GSK3_1	111	118	PF00069	0.605
MOD_GSK3_1	129	136	PF00069	0.636
MOD_GSK3_1	163	170	PF00069	0.701
MOD_GSK3_1	171	178	PF00069	0.632
MOD_GSK3_1	183	190	PF00069	0.602
MOD_GSK3_1	205	212	PF00069	0.716
MOD_GSK3_1	240	247	PF00069	0.771
MOD_GSK3_1	27	34	PF00069	0.540
MOD_GSK3_1	271	278	PF00069	0.617
MOD_GSK3_1	329	336	PF00069	0.804
MOD_GSK3_1	355	362	PF00069	0.811
MOD_GSK3_1	369	376	PF00069	0.592
MOD_GSK3_1	37	44	PF00069	0.682
MOD_GSK3_1	462	469	PF00069	0.693
MOD_GSK3_1	470	477	PF00069	0.647
MOD_GSK3_1	501	508	PF00069	0.602
MOD_GSK3_1	521	528	PF00069	0.756
MOD_GSK3_1	542	549	PF00069	0.633
MOD_GSK3_1	551	558	PF00069	0.582
MOD_GSK3_1	575	582	PF00069	0.609
MOD_GSK3_1	58	65	PF00069	0.556
MOD_GSK3_1	593	600	PF00069	0.707
MOD_GSK3_1	615	622	PF00069	0.741
MOD_GSK3_1	685	692	PF00069	0.659
MOD_GSK3_1	703	710	PF00069	0.667
MOD_GSK3_1	713	720	PF00069	0.703
MOD_GSK3_1	737	744	PF00069	0.724
MOD_GSK3_1	748	755	PF00069	0.635
MOD_GSK3_1	88	95	PF00069	0.647
MOD_GSK3_1	9	16	PF00069	0.756
MOD_LATS_1	438	444	PF00433	0.535
MOD_N-GLC_1	413	418	PF02516	0.513
MOD_N-GLC_1	575	580	PF02516	0.659
MOD_N-GLC_1	647	652	PF02516	0.682
MOD_N-GLC_1	685	690	PF02516	0.537
MOD_NEK2_1	115	120	PF00069	0.546
MOD_NEK2_1	129	134	PF00069	0.515
MOD_NEK2_1	183	188	PF00069	0.634
MOD_NEK2_1	230	235	PF00069	0.681
MOD_NEK2_1	271	276	PF00069	0.733
MOD_NEK2_1	374	379	PF00069	0.553
MOD_NEK2_1	461	466	PF00069	0.561
MOD_NEK2_1	494	499	PF00069	0.773
MOD_NEK2_1	501	506	PF00069	0.640
MOD_NEK2_1	515	520	PF00069	0.604
MOD_NEK2_1	551	556	PF00069	0.628
MOD_NEK2_1	605	610	PF00069	0.603
MOD_NEK2_1	637	642	PF00069	0.793
MOD_NEK2_1	717	722	PF00069	0.623
MOD_NEK2_1	752	757	PF00069	0.533
MOD_NEK2_1	781	786	PF00069	0.493
MOD_PIKK_1	175	181	PF00454	0.670
MOD_PIKK_1	205	211	PF00454	0.619
MOD_PIKK_1	42	48	PF00454	0.699
MOD_PIKK_1	474	480	PF00454	0.655
MOD_PIKK_1	717	723	PF00454	0.670
MOD_PKA_1	145	151	PF00069	0.528
MOD_PKA_1	240	246	PF00069	0.531
MOD_PKA_1	9	15	PF00069	0.661
MOD_PKA_2	145	151	PF00069	0.528
MOD_PKA_2	228	234	PF00069	0.749
MOD_PKA_2	240	246	PF00069	0.570
MOD_PKA_2	301	307	PF00069	0.687
MOD_PKA_2	374	380	PF00069	0.624
MOD_PKA_2	449	455	PF00069	0.682
MOD_PKA_2	479	485	PF00069	0.678
MOD_PKA_2	551	557	PF00069	0.643
MOD_PKA_2	616	622	PF00069	0.685
MOD_PKA_2	637	643	PF00069	0.753
MOD_PKA_2	663	669	PF00069	0.597
MOD_PKA_2	703	709	PF00069	0.620
MOD_PKA_2	723	729	PF00069	0.713
MOD_PKA_2	9	15	PF00069	0.719
MOD_Plk_1	101	107	PF00069	0.642
MOD_Plk_1	575	581	PF00069	0.660
MOD_Plk_4	152	158	PF00069	0.707
MOD_Plk_4	209	215	PF00069	0.562
MOD_Plk_4	329	335	PF00069	0.671
MOD_Plk_4	406	412	PF00069	0.518
MOD_Plk_4	496	502	PF00069	0.640
MOD_Plk_4	542	548	PF00069	0.630
MOD_Plk_4	562	568	PF00069	0.538
MOD_Plk_4	748	754	PF00069	0.525
MOD_ProDKin_1	200	206	PF00069	0.726
MOD_ProDKin_1	21	27	PF00069	0.602
MOD_ProDKin_1	249	255	PF00069	0.772
MOD_ProDKin_1	289	295	PF00069	0.566
MOD_ProDKin_1	334	340	PF00069	0.622
MOD_ProDKin_1	357	363	PF00069	0.787
MOD_ProDKin_1	38	44	PF00069	0.592
MOD_ProDKin_1	45	51	PF00069	0.627
MOD_ProDKin_1	472	478	PF00069	0.791
MOD_ProDKin_1	525	531	PF00069	0.709
MOD_ProDKin_1	579	585	PF00069	0.603
MOD_ProDKin_1	598	604	PF00069	0.763
MOD_ProDKin_1	620	626	PF00069	0.793
MOD_ProDKin_1	649	655	PF00069	0.708
MOD_ProDKin_1	656	662	PF00069	0.798
MOD_ProDKin_1	686	692	PF00069	0.740
MOD_ProDKin_1	705	711	PF00069	0.755
MOD_ProDKin_1	782	788	PF00069	0.599
MOD_SUMO_for_1	1	4	PF00179	0.524
MOD_SUMO_rev_2	252	260	PF00179	0.656
TRG_ENDOCYTIC_2	425	428	PF00928	0.672
TRG_ENDOCYTIC_2	714	717	PF00928	0.541
TRG_ER_diArg_1	144	146	PF00400	0.661
TRG_ER_diArg_1	239	241	PF00400	0.527
TRG_ER_diArg_1	789	792	PF00400	0.636
TRG_ER_diArg_1	8	10	PF00400	0.663
TRG_NLS_MonoExtN_4	786	792	PF00514	0.595
TRG_Pf-PMV_PEXEL_1	538	542	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUD2	Leishmania donovani	75%	94%
A4H8Z5	Leishmania braziliensis	44%	100%
A4HXC6	Leishmania infantum	74%	94%
Q4QEE2	Leishmania major	73%	100%