Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AR18_LEIMU

TriTrypDb:

LmxM.17.0490

Length:

915

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AR18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR18

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.782
CLV_C14_Caspase3-7	221	225	PF00656	0.485
CLV_C14_Caspase3-7	64	68	PF00656	0.725
CLV_C14_Caspase3-7	95	99	PF00656	0.670
CLV_MEL_PAP_1	286	292	PF00089	0.463
CLV_NRD_NRD_1	209	211	PF00675	0.765
CLV_NRD_NRD_1	213	215	PF00675	0.793
CLV_NRD_NRD_1	218	220	PF00675	0.532
CLV_NRD_NRD_1	280	282	PF00675	0.463
CLV_NRD_NRD_1	292	294	PF00675	0.413
CLV_NRD_NRD_1	451	453	PF00675	0.531
CLV_NRD_NRD_1	604	606	PF00675	0.402
CLV_NRD_NRD_1	698	700	PF00675	0.275
CLV_NRD_NRD_1	74	76	PF00675	0.698
CLV_NRD_NRD_1	85	87	PF00675	0.619
CLV_NRD_NRD_1	879	881	PF00675	0.409
CLV_NRD_NRD_1	92	94	PF00675	0.679
CLV_PCSK_FUR_1	213	217	PF00082	0.701
CLV_PCSK_FUR_1	83	87	PF00082	0.502
CLV_PCSK_KEX2_1	209	211	PF00082	0.772
CLV_PCSK_KEX2_1	213	215	PF00082	0.797
CLV_PCSK_KEX2_1	280	282	PF00082	0.462
CLV_PCSK_KEX2_1	451	453	PF00082	0.530
CLV_PCSK_KEX2_1	604	606	PF00082	0.402
CLV_PCSK_KEX2_1	698	700	PF00082	0.275
CLV_PCSK_KEX2_1	74	76	PF00082	0.712
CLV_PCSK_KEX2_1	759	761	PF00082	0.269
CLV_PCSK_KEX2_1	85	87	PF00082	0.619
CLV_PCSK_KEX2_1	878	880	PF00082	0.351
CLV_PCSK_KEX2_1	92	94	PF00082	0.661
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.557
CLV_PCSK_PC1ET2_1	759	761	PF00082	0.269
CLV_PCSK_PC1ET2_1	878	880	PF00082	0.351
CLV_PCSK_PC7_1	209	215	PF00082	0.489
CLV_PCSK_PC7_1	276	282	PF00082	0.594
CLV_PCSK_PC7_1	875	881	PF00082	0.324
CLV_PCSK_SKI1_1	101	105	PF00082	0.501
CLV_PCSK_SKI1_1	268	272	PF00082	0.476
CLV_PCSK_SKI1_1	281	285	PF00082	0.440
CLV_PCSK_SKI1_1	293	297	PF00082	0.599
CLV_PCSK_SKI1_1	533	537	PF00082	0.571
CLV_PCSK_SKI1_1	647	651	PF00082	0.376
CLV_PCSK_SKI1_1	657	661	PF00082	0.260
CLV_PCSK_SKI1_1	700	704	PF00082	0.407
CLV_PCSK_SKI1_1	718	722	PF00082	0.234
CLV_PCSK_SKI1_1	735	739	PF00082	0.416
CLV_PCSK_SKI1_1	79	83	PF00082	0.790
CLV_PCSK_SKI1_1	838	842	PF00082	0.290
CLV_PCSK_SKI1_1	879	883	PF00082	0.293
CLV_Separin_Metazoa	803	807	PF03568	0.383
DEG_APCC_DBOX_1	717	725	PF00400	0.312
DEG_COP1_1	52	63	PF00400	0.501
DEG_SCF_FBW7_1	24	30	PF00400	0.523
DEG_SPOP_SBC_1	192	196	PF00917	0.647
DOC_CKS1_1	24	29	PF01111	0.524
DOC_CYCLIN_RxL_1	530	540	PF00134	0.546
DOC_MAPK_gen_1	258	267	PF00069	0.605
DOC_MAPK_gen_1	647	655	PF00069	0.331
DOC_MAPK_gen_1	703	712	PF00069	0.287
DOC_MAPK_gen_1	735	744	PF00069	0.317
DOC_MAPK_gen_1	878	886	PF00069	0.183
DOC_MAPK_MEF2A_6	261	269	PF00069	0.556
DOC_MAPK_MEF2A_6	859	868	PF00069	0.304
DOC_PP2B_LxvP_1	351	354	PF13499	0.501
DOC_PP4_FxxP_1	799	802	PF00568	0.256
DOC_USP7_MATH_1	108	112	PF00917	0.609
DOC_USP7_MATH_1	188	192	PF00917	0.664
DOC_USP7_MATH_1	233	237	PF00917	0.743
DOC_USP7_MATH_1	27	31	PF00917	0.647
DOC_USP7_MATH_1	360	364	PF00917	0.707
DOC_USP7_MATH_1	37	41	PF00917	0.608
DOC_USP7_MATH_1	552	556	PF00917	0.715
DOC_USP7_MATH_1	570	574	PF00917	0.626
DOC_USP7_MATH_1	775	779	PF00917	0.314
DOC_USP7_MATH_1	84	88	PF00917	0.637
DOC_WW_Pin1_4	12	17	PF00397	0.751
DOC_WW_Pin1_4	222	227	PF00397	0.490
DOC_WW_Pin1_4	23	28	PF00397	0.732
DOC_WW_Pin1_4	342	347	PF00397	0.743
DOC_WW_Pin1_4	405	410	PF00397	0.687
DOC_WW_Pin1_4	47	52	PF00397	0.605
DOC_WW_Pin1_4	502	507	PF00397	0.765
DOC_WW_Pin1_4	514	519	PF00397	0.521
DOC_WW_Pin1_4	520	525	PF00397	0.654
DOC_WW_Pin1_4	526	531	PF00397	0.729
DOC_WW_Pin1_4	793	798	PF00397	0.195
DOC_WW_Pin1_4	902	907	PF00397	0.499
DOC_WW_Pin1_4	909	914	PF00397	0.555
LIG_14-3-3_CanoR_1	209	213	PF00244	0.665
LIG_14-3-3_CanoR_1	219	226	PF00244	0.517
LIG_14-3-3_CanoR_1	293	301	PF00244	0.574
LIG_14-3-3_CanoR_1	385	390	PF00244	0.625
LIG_14-3-3_CanoR_1	604	609	PF00244	0.469
LIG_14-3-3_CanoR_1	879	887	PF00244	0.260
LIG_APCC_ABBA_1	682	687	PF00400	0.269
LIG_BRCT_BRCA1_1	577	581	PF00533	0.574
LIG_BRCT_BRCA1_1	795	799	PF00533	0.390
LIG_CtBP_PxDLS_1	348	352	PF00389	0.530
LIG_DLG_GKlike_1	385	393	PF00625	0.599
LIG_FHA_1	41	47	PF00498	0.606
LIG_FHA_1	538	544	PF00498	0.699
LIG_FHA_1	590	596	PF00498	0.588
LIG_FHA_1	670	676	PF00498	0.343
LIG_FHA_1	715	721	PF00498	0.402
LIG_FHA_2	131	137	PF00498	0.596
LIG_FHA_2	178	184	PF00498	0.619
LIG_FHA_2	294	300	PF00498	0.547
LIG_FHA_2	312	318	PF00498	0.501
LIG_FHA_2	614	620	PF00498	0.402
LIG_FHA_2	86	92	PF00498	0.757
LIG_FHA_2	891	897	PF00498	0.374
LIG_LIR_Apic_2	796	802	PF02991	0.309
LIG_LIR_Gen_1	315	325	PF02991	0.596
LIG_LIR_Nem_3	296	301	PF02991	0.427
LIG_LIR_Nem_3	315	321	PF02991	0.475
LIG_LIR_Nem_3	613	617	PF02991	0.335
LIG_LIR_Nem_3	683	688	PF02991	0.402
LIG_LRP6_Inhibitor_1	19	25	PF00058	0.618
LIG_MLH1_MIPbox_1	795	799	PF16413	0.390
LIG_Pex14_1	278	282	PF04695	0.331
LIG_Pex14_2	841	845	PF04695	0.390
LIG_Pex14_2	869	873	PF04695	0.249
LIG_PTAP_UEV_1	16	21	PF05743	0.497
LIG_PTB_Apo_2	441	448	PF02174	0.600
LIG_PTB_Phospho_1	441	447	PF10480	0.597
LIG_REV1ctd_RIR_1	866	875	PF16727	0.250
LIG_SH2_GRB2like	442	445	PF00017	0.591
LIG_SH2_NCK_1	442	446	PF00017	0.519
LIG_SH2_SRC	726	729	PF00017	0.317
LIG_SH2_STAP1	400	404	PF00017	0.461
LIG_SH2_STAP1	442	446	PF00017	0.590
LIG_SH2_STAP1	716	720	PF00017	0.336
LIG_SH2_STAT3	668	671	PF00017	0.269
LIG_SH2_STAT3	716	719	PF00017	0.269
LIG_SH2_STAT5	282	285	PF00017	0.553
LIG_SH2_STAT5	301	304	PF00017	0.455
LIG_SH2_STAT5	439	442	PF00017	0.447
LIG_SH2_STAT5	447	450	PF00017	0.491
LIG_SH2_STAT5	716	719	PF00017	0.327
LIG_SH2_STAT5	726	729	PF00017	0.308
LIG_SH2_STAT5	811	814	PF00017	0.390
LIG_SH3_1	14	20	PF00018	0.613
LIG_SH3_3	14	20	PF00018	0.615
LIG_SH3_3	343	349	PF00018	0.721
LIG_SH3_3	43	49	PF00018	0.671
LIG_SH3_3	524	530	PF00018	0.769
LIG_SH3_3	791	797	PF00018	0.256
LIG_SH3_3	900	906	PF00018	0.560
LIG_SUMO_SIM_anti_2	709	715	PF11976	0.287
LIG_SUMO_SIM_par_1	269	275	PF11976	0.370
LIG_SUMO_SIM_par_1	42	50	PF11976	0.600
LIG_TRAF2_1	145	148	PF00917	0.711
LIG_TRAF2_1	163	166	PF00917	0.619
LIG_TRAF2_1	778	781	PF00917	0.290
LIG_TRAF2_1	898	901	PF00917	0.561
LIG_TRFH_1	405	409	PF08558	0.599
LIG_TYR_ITSM	614	621	PF00017	0.402
LIG_UBA3_1	655	662	PF00899	0.269
LIG_UBA3_1	743	751	PF00899	0.287
LIG_UBA3_1	840	849	PF00899	0.310
MOD_CDK_SPK_2	405	410	PF00069	0.560
MOD_CDK_SPxxK_3	47	54	PF00069	0.606
MOD_CDK_SPxxK_3	502	509	PF00069	0.611
MOD_CDK_SPxxK_3	526	533	PF00069	0.537
MOD_CK1_1	15	21	PF00069	0.606
MOD_CK1_1	191	197	PF00069	0.792
MOD_CK1_1	236	242	PF00069	0.761
MOD_CK1_1	30	36	PF00069	0.573
MOD_CK1_1	326	332	PF00069	0.633
MOD_CK1_1	363	369	PF00069	0.749
MOD_CK1_1	39	45	PF00069	0.622
MOD_CK1_1	417	423	PF00069	0.665
MOD_CK1_1	431	437	PF00069	0.417
MOD_CK1_1	489	495	PF00069	0.543
MOD_CK1_1	502	508	PF00069	0.673
MOD_CK1_1	517	523	PF00069	0.576
MOD_CK1_1	542	548	PF00069	0.765
MOD_CK1_1	573	579	PF00069	0.535
MOD_CK1_1	613	619	PF00069	0.347
MOD_CK1_1	693	699	PF00069	0.402
MOD_CK1_1	848	854	PF00069	0.181
MOD_CK1_1	905	911	PF00069	0.553
MOD_CK2_1	130	136	PF00069	0.786
MOD_CK2_1	142	148	PF00069	0.776
MOD_CK2_1	160	166	PF00069	0.736
MOD_CK2_1	420	426	PF00069	0.621
MOD_CK2_1	552	558	PF00069	0.655
MOD_CK2_1	613	619	PF00069	0.347
MOD_CK2_1	775	781	PF00069	0.460
MOD_CK2_1	85	91	PF00069	0.507
MOD_CK2_1	905	911	PF00069	0.698
MOD_Cter_Amidation	207	210	PF01082	0.575
MOD_Cter_Amidation	217	220	PF01082	0.777
MOD_GlcNHglycan	17	20	PF01048	0.596
MOD_GlcNHglycan	185	191	PF01048	0.583
MOD_GlcNHglycan	196	199	PF01048	0.587
MOD_GlcNHglycan	236	239	PF01048	0.819
MOD_GlcNHglycan	249	252	PF01048	0.539
MOD_GlcNHglycan	29	32	PF01048	0.644
MOD_GlcNHglycan	339	342	PF01048	0.575
MOD_GlcNHglycan	363	366	PF01048	0.675
MOD_GlcNHglycan	378	381	PF01048	0.600
MOD_GlcNHglycan	389	392	PF01048	0.612
MOD_GlcNHglycan	431	434	PF01048	0.576
MOD_GlcNHglycan	544	547	PF01048	0.785
MOD_GlcNHglycan	56	59	PF01048	0.764
MOD_GlcNHglycan	572	575	PF01048	0.740
MOD_GlcNHglycan	744	747	PF01048	0.345
MOD_GlcNHglycan	854	857	PF01048	0.192
MOD_GSK3_1	173	180	PF00069	0.769
MOD_GSK3_1	186	193	PF00069	0.806
MOD_GSK3_1	194	201	PF00069	0.746
MOD_GSK3_1	218	225	PF00069	0.780
MOD_GSK3_1	229	236	PF00069	0.779
MOD_GSK3_1	23	30	PF00069	0.735
MOD_GSK3_1	32	39	PF00069	0.598
MOD_GSK3_1	332	339	PF00069	0.679
MOD_GSK3_1	385	392	PF00069	0.588
MOD_GSK3_1	411	418	PF00069	0.710
MOD_GSK3_1	482	489	PF00069	0.612
MOD_GSK3_1	54	61	PF00069	0.736
MOD_GSK3_1	708	715	PF00069	0.272
MOD_GSK3_1	789	796	PF00069	0.256
MOD_GSK3_1	848	855	PF00069	0.187
MOD_GSK3_1	905	912	PF00069	0.730
MOD_LATS_1	383	389	PF00433	0.526
MOD_N-GLC_1	360	365	PF02516	0.624
MOD_N-GLC_1	393	398	PF02516	0.602
MOD_N-GLC_1	458	463	PF02516	0.580
MOD_N-GLC_1	581	586	PF02516	0.518
MOD_NEK2_1	229	234	PF00069	0.656
MOD_NEK2_1	3	8	PF00069	0.755
MOD_NEK2_1	336	341	PF00069	0.708
MOD_NEK2_1	36	41	PF00069	0.482
MOD_NEK2_1	376	381	PF00069	0.691
MOD_NEK2_1	387	392	PF00069	0.716
MOD_NEK2_1	411	416	PF00069	0.677
MOD_NEK2_1	458	463	PF00069	0.617
MOD_NEK2_1	483	488	PF00069	0.604
MOD_NEK2_1	531	536	PF00069	0.693
MOD_NEK2_1	581	586	PF00069	0.456
MOD_NEK2_1	589	594	PF00069	0.461
MOD_NEK2_1	655	660	PF00069	0.253
MOD_NEK2_1	708	713	PF00069	0.320
MOD_NEK2_1	755	760	PF00069	0.356
MOD_NEK2_1	789	794	PF00069	0.426
MOD_PIKK_1	119	125	PF00454	0.660
MOD_PIKK_1	219	225	PF00454	0.599
MOD_PIKK_1	389	395	PF00454	0.590
MOD_PIKK_1	619	625	PF00454	0.331
MOD_PIKK_1	776	782	PF00454	0.178
MOD_PIKK_1	905	911	PF00454	0.698
MOD_PK_1	604	610	PF00069	0.402
MOD_PKA_1	219	225	PF00069	0.777
MOD_PKA_1	293	299	PF00069	0.558
MOD_PKA_1	604	610	PF00069	0.402
MOD_PKA_1	85	91	PF00069	0.507
MOD_PKA_1	879	885	PF00069	0.349
MOD_PKA_2	208	214	PF00069	0.775
MOD_PKA_2	218	224	PF00069	0.675
MOD_PKA_2	429	435	PF00069	0.535
MOD_PKA_2	440	446	PF00069	0.475
MOD_PKA_2	604	610	PF00069	0.421
MOD_PKA_2	84	90	PF00069	0.709
MOD_PKA_2	845	851	PF00069	0.304
MOD_PKA_2	874	880	PF00069	0.320
MOD_PKB_1	83	91	PF00069	0.503
MOD_Plk_1	411	417	PF00069	0.723
MOD_Plk_1	458	464	PF00069	0.584
MOD_Plk_1	581	587	PF00069	0.504
MOD_Plk_1	633	639	PF00069	0.386
MOD_Plk_2-3	132	138	PF00069	0.625
MOD_Plk_2-3	142	148	PF00069	0.740
MOD_Plk_2-3	311	317	PF00069	0.445
MOD_Plk_4	332	338	PF00069	0.696
MOD_Plk_4	420	426	PF00069	0.646
MOD_Plk_4	431	437	PF00069	0.464
MOD_Plk_4	486	492	PF00069	0.550
MOD_Plk_4	604	610	PF00069	0.399
MOD_Plk_4	613	619	PF00069	0.317
MOD_Plk_4	663	669	PF00069	0.346
MOD_Plk_4	789	795	PF00069	0.253
MOD_ProDKin_1	12	18	PF00069	0.753
MOD_ProDKin_1	222	228	PF00069	0.493
MOD_ProDKin_1	23	29	PF00069	0.729
MOD_ProDKin_1	342	348	PF00069	0.740
MOD_ProDKin_1	405	411	PF00069	0.686
MOD_ProDKin_1	47	53	PF00069	0.604
MOD_ProDKin_1	502	508	PF00069	0.761
MOD_ProDKin_1	514	520	PF00069	0.521
MOD_ProDKin_1	526	532	PF00069	0.722
MOD_ProDKin_1	793	799	PF00069	0.195
MOD_ProDKin_1	902	908	PF00069	0.510
MOD_ProDKin_1	909	915	PF00069	0.559
MOD_SUMO_for_1	649	652	PF00179	0.331
MOD_SUMO_rev_2	47	55	PF00179	0.650
MOD_SUMO_rev_2	619	628	PF00179	0.269
MOD_SUMO_rev_2	745	753	PF00179	0.269
TRG_ENDOCYTIC_2	618	621	PF00928	0.309
TRG_ER_diArg_1	212	214	PF00400	0.701
TRG_ER_diArg_1	273	276	PF00400	0.542
TRG_ER_diArg_1	279	281	PF00400	0.471
TRG_ER_diArg_1	603	605	PF00400	0.517
TRG_ER_diArg_1	697	699	PF00400	0.275
TRG_ER_diArg_1	83	86	PF00400	0.564
TRG_NES_CRM1_1	583	599	PF08389	0.573
TRG_NES_CRM1_1	816	826	PF08389	0.333
TRG_NLS_MonoExtN_4	213	218	PF00514	0.487
TRG_NLS_MonoExtN_4	875	882	PF00514	0.415
TRG_Pf-PMV_PEXEL_1	897	901	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H5	Leptomonas seymouri	50%	70%
A0A1X0NSX9	Trypanosomatidae	43%	97%
A0A3R7M724	Trypanosoma rangeli	43%	100%
A0A3S5H705	Leishmania donovani	84%	100%
A4HXC3	Leishmania infantum	83%	100%
C9ZU16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AI55	Leishmania braziliensis	62%	100%
Q4QEE5	Leishmania major	83%	98%
V5B639	Trypanosoma cruzi	42%	100%