Isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Isomerase

Gene product:

Phenazine biosynthesis-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9AR17_LEIMU

TriTrypDb:

LmxM.17.0480

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AR17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR17

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016853	isomerase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.704
CLV_NRD_NRD_1	226	228	PF00675	0.702
CLV_NRD_NRD_1	229	231	PF00675	0.581
CLV_NRD_NRD_1	305	307	PF00675	0.389
CLV_NRD_NRD_1	399	401	PF00675	0.536
CLV_NRD_NRD_1	505	507	PF00675	0.411
CLV_NRD_NRD_1	61	63	PF00675	0.730
CLV_PCSK_FUR_1	227	231	PF00082	0.628
CLV_PCSK_KEX2_1	140	142	PF00082	0.628
CLV_PCSK_KEX2_1	226	228	PF00082	0.702
CLV_PCSK_KEX2_1	229	231	PF00082	0.581
CLV_PCSK_KEX2_1	305	307	PF00082	0.389
CLV_PCSK_KEX2_1	399	401	PF00082	0.541
CLV_PCSK_KEX2_1	494	496	PF00082	0.369
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.411
CLV_PCSK_SKI1_1	239	243	PF00082	0.362
CLV_PCSK_SKI1_1	399	403	PF00082	0.494
CLV_PCSK_SKI1_1	510	514	PF00082	0.411
CLV_PCSK_SKI1_1	62	66	PF00082	0.780
CLV_PCSK_SKI1_1	80	84	PF00082	0.432
DEG_APCC_DBOX_1	160	168	PF00400	0.538
DEG_APCC_KENBOX_2	411	415	PF00400	0.335
DEG_Nend_UBRbox_2	1	3	PF02207	0.632
DEG_SPOP_SBC_1	17	21	PF00917	0.285
DEG_SPOP_SBC_1	401	405	PF00917	0.510
DOC_CKS1_1	240	245	PF01111	0.411
DOC_CKS1_1	382	387	PF01111	0.442
DOC_CKS1_1	8	13	PF01111	0.538
DOC_MAPK_gen_1	480	489	PF00069	0.338
DOC_MAPK_gen_1	506	513	PF00069	0.411
DOC_PP4_FxxP_1	284	287	PF00568	0.411
DOC_PP4_FxxP_1	448	451	PF00568	0.411
DOC_SPAK_OSR1_1	480	484	PF12202	0.338
DOC_USP7_MATH_1	176	180	PF00917	0.714
DOC_USP7_MATH_1	196	200	PF00917	0.690
DOC_USP7_MATH_1	214	218	PF00917	0.649
DOC_USP7_MATH_1	401	405	PF00917	0.510
DOC_USP7_MATH_1	44	48	PF00917	0.637
DOC_USP7_UBL2_3	63	67	PF12436	0.761
DOC_WW_Pin1_4	188	193	PF00397	0.707
DOC_WW_Pin1_4	239	244	PF00397	0.411
DOC_WW_Pin1_4	322	327	PF00397	0.602
DOC_WW_Pin1_4	381	386	PF00397	0.382
DOC_WW_Pin1_4	402	407	PF00397	0.376
DOC_WW_Pin1_4	7	12	PF00397	0.472
LIG_14-3-3_CanoR_1	161	170	PF00244	0.750
LIG_14-3-3_CanoR_1	213	219	PF00244	0.629
LIG_14-3-3_CanoR_1	229	238	PF00244	0.389
LIG_14-3-3_CanoR_1	266	276	PF00244	0.411
LIG_14-3-3_CanoR_1	381	385	PF00244	0.446
LIG_14-3-3_CanoR_1	399	408	PF00244	0.460
LIG_14-3-3_CanoR_1	522	528	PF00244	0.634
LIG_BRCT_BRCA1_1	196	200	PF00533	0.690
LIG_BRCT_BRCA1_1	403	407	PF00533	0.441
LIG_BRCT_BRCA1_1	445	449	PF00533	0.411
LIG_CSL_BTD_1	187	190	PF09270	0.640
LIG_deltaCOP1_diTrp_1	394	402	PF00928	0.509
LIG_EH1_1	261	269	PF00400	0.513
LIG_EVH1_2	346	350	PF00568	0.292
LIG_FHA_1	288	294	PF00498	0.448
LIG_FHA_1	326	332	PF00498	0.496
LIG_FHA_1	334	340	PF00498	0.415
LIG_FHA_1	459	465	PF00498	0.411
LIG_FHA_1	498	504	PF00498	0.411
LIG_FHA_1	524	530	PF00498	0.580
LIG_FHA_1	98	104	PF00498	0.423
LIG_FHA_2	111	117	PF00498	0.655
LIG_FHA_2	146	152	PF00498	0.684
LIG_FHA_2	218	224	PF00498	0.732
LIG_FHA_2	63	69	PF00498	0.652
LIG_Integrin_isoDGR_2	478	480	PF01839	0.338
LIG_LIR_Apic_2	283	287	PF02991	0.411
LIG_LIR_Apic_2	446	451	PF02991	0.411
LIG_LIR_Gen_1	205	214	PF02991	0.387
LIG_LIR_Gen_1	368	379	PF02991	0.472
LIG_LIR_Gen_1	394	402	PF02991	0.509
LIG_LIR_Gen_1	41	50	PF02991	0.629
LIG_LIR_Nem_3	205	210	PF02991	0.367
LIG_LIR_Nem_3	233	238	PF02991	0.389
LIG_LIR_Nem_3	348	353	PF02991	0.443
LIG_LIR_Nem_3	368	374	PF02991	0.476
LIG_LIR_Nem_3	394	398	PF02991	0.511
LIG_LIR_Nem_3	41	45	PF02991	0.617
LIG_MLH1_MIPbox_1	445	449	PF16413	0.411
LIG_MYND_1	192	196	PF01753	0.644
LIG_Pex14_1	207	211	PF04695	0.373
LIG_Pex14_2	236	240	PF04695	0.411
LIG_Pex14_2	448	452	PF04695	0.353
LIG_PTB_Apo_2	475	482	PF02174	0.338
LIG_SH2_CRK	104	108	PF00017	0.520
LIG_SH2_CRK	371	375	PF00017	0.495
LIG_SH2_NCK_1	211	215	PF00017	0.706
LIG_SH2_STAP1	129	133	PF00017	0.601
LIG_SH2_STAP1	329	333	PF00017	0.425
LIG_SH2_STAT5	211	214	PF00017	0.628
LIG_SH2_STAT5	322	325	PF00017	0.616
LIG_SH2_STAT5	378	381	PF00017	0.431
LIG_SH2_STAT5	38	41	PF00017	0.551
LIG_SH3_3	151	157	PF00018	0.737
LIG_SH3_3	177	183	PF00018	0.608
LIG_SH3_3	186	192	PF00018	0.650
LIG_SH3_3	328	334	PF00018	0.422
LIG_SH3_3	5	11	PF00018	0.559
LIG_SUMO_SIM_anti_2	509	516	PF11976	0.411
LIG_SUMO_SIM_par_1	4	10	PF11976	0.352
LIG_TYR_ITIM	369	374	PF00017	0.479
MOD_CDK_SPxK_1	239	245	PF00069	0.411
MOD_CK1_1	198	204	PF00069	0.650
MOD_CK1_1	205	211	PF00069	0.559
MOD_CK1_1	217	223	PF00069	0.607
MOD_CK1_1	270	276	PF00069	0.411
MOD_CK1_1	308	314	PF00069	0.305
MOD_CK1_1	325	331	PF00069	0.550
MOD_CK1_1	372	378	PF00069	0.565
MOD_CK1_1	43	49	PF00069	0.640
MOD_CK1_1	463	469	PF00069	0.521
MOD_CK1_1	516	522	PF00069	0.272
MOD_CK2_1	110	116	PF00069	0.652
MOD_CK2_1	217	223	PF00069	0.727
MOD_CK2_1	337	343	PF00069	0.472
MOD_CK2_1	43	49	PF00069	0.640
MOD_Cter_Amidation	224	227	PF01082	0.738
MOD_Cter_Amidation	504	507	PF01082	0.411
MOD_GlcNHglycan	143	146	PF01048	0.667
MOD_GlcNHglycan	164	167	PF01048	0.603
MOD_GlcNHglycan	204	207	PF01048	0.652
MOD_GlcNHglycan	298	301	PF01048	0.389
MOD_GlcNHglycan	41	45	PF01048	0.613
MOD_GlcNHglycan	413	417	PF01048	0.583
MOD_GlcNHglycan	515	518	PF01048	0.424
MOD_GSK3_1	106	113	PF00069	0.522
MOD_GSK3_1	141	148	PF00069	0.636
MOD_GSK3_1	162	169	PF00069	0.825
MOD_GSK3_1	194	201	PF00069	0.690
MOD_GSK3_1	205	212	PF00069	0.667
MOD_GSK3_1	214	221	PF00069	0.621
MOD_GSK3_1	296	303	PF00069	0.352
MOD_GSK3_1	318	325	PF00069	0.622
MOD_GSK3_1	333	340	PF00069	0.413
MOD_GSK3_1	40	47	PF00069	0.581
MOD_N-GLC_1	523	528	PF02516	0.633
MOD_N-GLC_1	95	100	PF02516	0.504
MOD_NEK2_1	170	175	PF00069	0.648
MOD_NEK2_1	18	23	PF00069	0.355
MOD_NEK2_1	202	207	PF00069	0.633
MOD_NEK2_1	209	214	PF00069	0.508
MOD_NEK2_1	262	267	PF00069	0.507
MOD_NEK2_1	318	323	PF00069	0.663
MOD_NEK2_1	40	45	PF00069	0.613
MOD_NEK2_1	424	429	PF00069	0.467
MOD_NEK2_1	48	53	PF00069	0.664
MOD_NEK2_1	513	518	PF00069	0.458
MOD_NEK2_1	97	102	PF00069	0.481
MOD_NEK2_2	176	181	PF00069	0.534
MOD_NEK2_2	300	305	PF00069	0.411
MOD_OFUCOSY	15	22	PF10250	0.278
MOD_PIKK_1	170	176	PF00454	0.742
MOD_PIKK_1	230	236	PF00454	0.389
MOD_PKA_1	141	147	PF00069	0.634
MOD_PKA_1	305	311	PF00069	0.389
MOD_PKA_1	62	68	PF00069	0.686
MOD_PKA_2	141	147	PF00069	0.634
MOD_PKA_2	212	218	PF00069	0.639
MOD_PKA_2	305	311	PF00069	0.389
MOD_PKA_2	380	386	PF00069	0.457
MOD_PKB_1	60	68	PF00069	0.483
MOD_Plk_1	262	268	PF00069	0.411
MOD_Plk_1	40	46	PF00069	0.565
MOD_Plk_1	412	418	PF00069	0.551
MOD_Plk_1	48	54	PF00069	0.618
MOD_Plk_1	523	529	PF00069	0.635
MOD_Plk_2-3	337	343	PF00069	0.472
MOD_Plk_2-3	74	80	PF00069	0.613
MOD_Plk_4	214	220	PF00069	0.669
MOD_Plk_4	313	319	PF00069	0.346
MOD_Plk_4	33	39	PF00069	0.457
MOD_Plk_4	516	522	PF00069	0.384
MOD_ProDKin_1	188	194	PF00069	0.708
MOD_ProDKin_1	239	245	PF00069	0.411
MOD_ProDKin_1	322	328	PF00069	0.588
MOD_ProDKin_1	381	387	PF00069	0.381
MOD_ProDKin_1	402	408	PF00069	0.378
MOD_ProDKin_1	7	13	PF00069	0.464
MOD_SUMO_rev_2	124	133	PF00179	0.568
MOD_SUMO_rev_2	56	65	PF00179	0.795
TRG_DiLeu_BaEn_1	263	268	PF01217	0.513
TRG_DiLeu_BaEn_1	509	514	PF01217	0.411
TRG_ENDOCYTIC_2	371	374	PF00928	0.495
TRG_ER_diArg_1	140	142	PF00400	0.647
TRG_ER_diArg_1	226	229	PF00400	0.676
TRG_ER_diArg_1	304	306	PF00400	0.389
TRG_ER_diArg_1	398	400	PF00400	0.593
TRG_NES_CRM1_1	348	362	PF08389	0.288
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCR2	Leptomonas seymouri	67%	100%
A0A3Q8IJD5	Leishmania donovani	94%	100%
A4H8Z1	Leishmania braziliensis	77%	100%
A4HXC2	Leishmania infantum	93%	100%
Q4QEE6	Leishmania major	91%	100%