J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AR15_LEIMU

TriTrypDb:

LmxM.17.0460

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0031207	Sec62/Sec63 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

E9AR15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR15

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006613	cotranslational protein targeting to membrane	6	1
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	1
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0008320	protein transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022884	macromolecule transmembrane transporter activity	3	1
GO:0140318	protein transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.532
CLV_NRD_NRD_1	205	207	PF00675	0.448
CLV_NRD_NRD_1	320	322	PF00675	0.380
CLV_NRD_NRD_1	83	85	PF00675	0.480
CLV_PCSK_KEX2_1	119	121	PF00082	0.501
CLV_PCSK_KEX2_1	205	207	PF00082	0.416
CLV_PCSK_KEX2_1	320	322	PF00082	0.366
CLV_PCSK_KEX2_1	83	85	PF00082	0.479
CLV_PCSK_PC7_1	116	122	PF00082	0.492
CLV_PCSK_SKI1_1	24	28	PF00082	0.520
CLV_PCSK_SKI1_1	316	320	PF00082	0.355
CLV_PCSK_SKI1_1	61	65	PF00082	0.513
CLV_Separin_Metazoa	232	236	PF03568	0.563
DEG_Nend_Nbox_1	1	3	PF02207	0.703
DEG_SPOP_SBC_1	46	50	PF00917	0.723
DOC_CKS1_1	242	247	PF01111	0.567
DOC_USP7_MATH_1	154	158	PF00917	0.475
DOC_USP7_MATH_1	303	307	PF00917	0.616
DOC_USP7_MATH_1	46	50	PF00917	0.723
DOC_USP7_MATH_1	53	57	PF00917	0.750
DOC_WW_Pin1_4	197	202	PF00397	0.575
DOC_WW_Pin1_4	241	246	PF00397	0.558
DOC_WW_Pin1_4	311	316	PF00397	0.561
DOC_WW_Pin1_4	38	43	PF00397	0.727
DOC_WW_Pin1_4	99	104	PF00397	0.673
LIG_14-3-3_CanoR_1	208	218	PF00244	0.577
LIG_14-3-3_CanoR_1	235	240	PF00244	0.555
LIG_14-3-3_CanoR_1	4	11	PF00244	0.688
LIG_14-3-3_CanoR_1	61	66	PF00244	0.745
LIG_14-3-3_CanoR_1	83	93	PF00244	0.714
LIG_BRCT_BRCA1_1	271	275	PF00533	0.356
LIG_deltaCOP1_diTrp_1	308	318	PF00928	0.563
LIG_FHA_1	156	162	PF00498	0.476
LIG_FHA_1	25	31	PF00498	0.779
LIG_FHA_1	52	58	PF00498	0.729
LIG_FHA_2	108	114	PF00498	0.710
LIG_FHA_2	126	132	PF00498	0.727
LIG_LIR_Gen_1	246	254	PF02991	0.429
LIG_LIR_Gen_1	272	283	PF02991	0.362
LIG_LIR_Nem_3	204	210	PF02991	0.600
LIG_LIR_Nem_3	213	219	PF02991	0.584
LIG_LIR_Nem_3	246	251	PF02991	0.450
LIG_LIR_Nem_3	272	278	PF02991	0.358
LIG_MLH1_MIPbox_1	271	275	PF16413	0.396
LIG_NRBOX	279	285	PF00104	0.350
LIG_Pex14_2	217	221	PF04695	0.577
LIG_Pex14_2	263	267	PF04695	0.324
LIG_SH2_CRK	207	211	PF00017	0.589
LIG_SH2_CRK	219	223	PF00017	0.553
LIG_SH2_CRK	93	97	PF00017	0.665
LIG_SH2_NCK_1	194	198	PF00017	0.460
LIG_SH2_STAP1	299	303	PF00017	0.355
LIG_SH2_STAP1	307	311	PF00017	0.538
LIG_SH2_STAT5	216	219	PF00017	0.571
LIG_SH2_STAT5	258	261	PF00017	0.383
LIG_SUMO_SIM_anti_2	54	61	PF11976	0.662
LIG_TRAF2_1	109	112	PF00917	0.638
LIG_TYR_ITAM	191	210	PF00017	0.575
LIG_TYR_ITIM	163	168	PF00017	0.460
LIG_Vh1_VBS_1	269	287	PF01044	0.343
MOD_CDK_SPK_2	311	316	PF00069	0.560
MOD_CDK_SPK_2	99	104	PF00069	0.716
MOD_CK1_1	157	163	PF00069	0.492
MOD_CK1_1	33	39	PF00069	0.666
MOD_CK1_1	41	47	PF00069	0.613
MOD_CK2_1	107	113	PF00069	0.711
MOD_CMANNOS	239	242	PF00535	0.356
MOD_GlcNHglycan	12	15	PF01048	0.536
MOD_GlcNHglycan	141	144	PF01048	0.542
MOD_GlcNHglycan	245	248	PF01048	0.342
MOD_GlcNHglycan	43	46	PF01048	0.463
MOD_GlcNHglycan	76	79	PF01048	0.497
MOD_GlcNHglycan	87	90	PF01048	0.433
MOD_GlcNHglycan	96	99	PF01048	0.468
MOD_GSK3_1	135	142	PF00069	0.701
MOD_GSK3_1	195	202	PF00069	0.467
MOD_GSK3_1	24	31	PF00069	0.752
MOD_GSK3_1	3	10	PF00069	0.725
MOD_GSK3_1	41	48	PF00069	0.658
MOD_GSK3_1	68	75	PF00069	0.701
MOD_N-GLC_1	72	77	PF02516	0.532
MOD_NEK2_1	269	274	PF00069	0.331
MOD_NEK2_1	283	288	PF00069	0.271
MOD_NEK2_1	297	302	PF00069	0.330
MOD_NEK2_1	3	8	PF00069	0.719
MOD_NEK2_1	47	52	PF00069	0.729
MOD_NEK2_1	68	73	PF00069	0.661
MOD_PIKK_1	155	161	PF00454	0.516
MOD_PIKK_1	211	217	PF00454	0.573
MOD_PKA_1	119	125	PF00069	0.735
MOD_PKA_2	119	125	PF00069	0.736
MOD_PKA_2	3	9	PF00069	0.737
MOD_Plk_4	269	275	PF00069	0.348
MOD_Plk_4	283	289	PF00069	0.280
MOD_Plk_4	297	303	PF00069	0.360
MOD_ProDKin_1	197	203	PF00069	0.580
MOD_ProDKin_1	241	247	PF00069	0.555
MOD_ProDKin_1	311	317	PF00069	0.557
MOD_ProDKin_1	38	44	PF00069	0.729
MOD_ProDKin_1	99	105	PF00069	0.674
TRG_ENDOCYTIC_2	165	168	PF00928	0.460
TRG_ENDOCYTIC_2	194	197	PF00928	0.460
TRG_ENDOCYTIC_2	207	210	PF00928	0.596
TRG_ENDOCYTIC_2	218	221	PF00928	0.566
TRG_ENDOCYTIC_2	264	267	PF00928	0.328
TRG_ENDOCYTIC_2	299	302	PF00928	0.325
TRG_ENDOCYTIC_2	93	96	PF00928	0.666
TRG_ER_diArg_1	119	121	PF00400	0.733
TRG_ER_diArg_1	161	164	PF00400	0.460
TRG_ER_diArg_1	205	207	PF00400	0.648
TRG_ER_diArg_1	319	321	PF00400	0.577
TRG_ER_diArg_1	83	85	PF00400	0.678
TRG_Pf-PMV_PEXEL_1	208	213	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK95	Leptomonas seymouri	78%	100%
A0A0S4J1V7	Bodo saltans	58%	100%
A0A1X0NSX2	Trypanosomatidae	62%	100%
A0A3Q8ICS4	Leishmania donovani	94%	91%
A0A3R7MRU2	Trypanosoma rangeli	67%	100%
A4H8Y9	Leishmania braziliensis	88%	100%
A4HXB9	Leishmania infantum	94%	100%
C9ZU12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
Q4QEE8	Leishmania major	97%	100%