N6-adenine methyltransferase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Probable N6-adenine methyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AR11_LEIMU

TriTrypDb:

LmxM.17.0420

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AR11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR11

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	9
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016278	lysine N-methyltransferase activity	6	12
GO:0016279	protein-lysine N-methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.498
CLV_C14_Caspase3-7	358	362	PF00656	0.536
CLV_NRD_NRD_1	246	248	PF00675	0.604
CLV_NRD_NRD_1	532	534	PF00675	0.452
CLV_NRD_NRD_1	77	79	PF00675	0.362
CLV_NRD_NRD_1	93	95	PF00675	0.325
CLV_PCSK_KEX2_1	248	250	PF00082	0.648
CLV_PCSK_KEX2_1	532	534	PF00082	0.522
CLV_PCSK_KEX2_1	77	79	PF00082	0.362
CLV_PCSK_KEX2_1	93	95	PF00082	0.325
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.680
CLV_PCSK_SKI1_1	153	157	PF00082	0.274
CLV_PCSK_SKI1_1	161	165	PF00082	0.254
CLV_PCSK_SKI1_1	180	184	PF00082	0.195
CLV_PCSK_SKI1_1	26	30	PF00082	0.386
CLV_PCSK_SKI1_1	382	386	PF00082	0.600
CLV_PCSK_SKI1_1	532	536	PF00082	0.495
CLV_PCSK_SKI1_1	543	547	PF00082	0.377
CLV_PCSK_SKI1_1	550	554	PF00082	0.339
DEG_SPOP_SBC_1	410	414	PF00917	0.367
DOC_CKS1_1	65	70	PF01111	0.487
DOC_CYCLIN_RxL_1	147	158	PF00134	0.561
DOC_CYCLIN_RxL_1	377	389	PF00134	0.319
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.501
DOC_MAPK_FxFP_2	534	537	PF00069	0.561
DOC_MAPK_gen_1	372	380	PF00069	0.571
DOC_MAPK_gen_1	435	444	PF00069	0.594
DOC_MAPK_RevD_3	63	78	PF00069	0.562
DOC_PIKK_1	169	177	PF02985	0.562
DOC_PP1_RVXF_1	159	165	PF00149	0.487
DOC_PP4_FxxP_1	116	119	PF00568	0.487
DOC_PP4_FxxP_1	466	469	PF00568	0.469
DOC_PP4_FxxP_1	534	537	PF00568	0.535
DOC_USP7_MATH_1	19	23	PF00917	0.599
DOC_USP7_MATH_1	24	28	PF00917	0.554
DOC_USP7_MATH_1	321	325	PF00917	0.727
DOC_USP7_MATH_1	335	339	PF00917	0.589
DOC_USP7_MATH_1	409	413	PF00917	0.594
DOC_USP7_MATH_1	484	488	PF00917	0.766
DOC_USP7_UBL2_3	153	157	PF12436	0.521
DOC_WW_Pin1_4	400	405	PF00397	0.713
DOC_WW_Pin1_4	461	466	PF00397	0.605
DOC_WW_Pin1_4	64	69	PF00397	0.487
LIG_14-3-3_CanoR_1	234	242	PF00244	0.594
LIG_14-3-3_CanoR_1	93	101	PF00244	0.520
LIG_Actin_WH2_2	220	236	PF00022	0.507
LIG_APCC_ABBA_1	302	307	PF00400	0.697
LIG_BIR_II_1	1	5	PF00653	0.483
LIG_BIR_III_2	401	405	PF00653	0.476
LIG_BRCT_BRCA1_1	337	341	PF00533	0.523
LIG_BRCT_BRCA1_1	68	72	PF00533	0.476
LIG_BRCT_BRCA1_1	95	99	PF00533	0.476
LIG_FHA_1	13	19	PF00498	0.584
LIG_FHA_1	139	145	PF00498	0.476
LIG_FHA_1	149	155	PF00498	0.476
LIG_FHA_1	163	169	PF00498	0.451
LIG_FHA_1	222	228	PF00498	0.585
LIG_FHA_1	285	291	PF00498	0.708
LIG_FHA_1	412	418	PF00498	0.520
LIG_FHA_1	423	429	PF00498	0.487
LIG_FHA_1	65	71	PF00498	0.493
LIG_FHA_2	164	170	PF00498	0.487
LIG_FHA_2	321	327	PF00498	0.781
LIG_Integrin_RGD_1	78	80	PF01839	0.351
LIG_LIR_Apic_2	115	119	PF02991	0.476
LIG_LIR_Apic_2	464	469	PF02991	0.460
LIG_LIR_Apic_2	531	537	PF02991	0.439
LIG_LIR_Gen_1	195	206	PF02991	0.476
LIG_LIR_Nem_3	108	114	PF02991	0.474
LIG_LIR_Nem_3	143	148	PF02991	0.486
LIG_LIR_Nem_3	195	201	PF02991	0.449
LIG_LIR_Nem_3	294	298	PF02991	0.697
LIG_LIR_Nem_3	36	41	PF02991	0.487
LIG_LIR_Nem_3	69	74	PF02991	0.466
LIG_LYPXL_S_1	187	191	PF13949	0.362
LIG_LYPXL_yS_3	188	191	PF13949	0.562
LIG_MLH1_MIPbox_1	68	72	PF16413	0.476
LIG_NRBOX	173	179	PF00104	0.501
LIG_NRP_CendR_1	553	556	PF00754	0.659
LIG_Pex14_2	183	187	PF04695	0.487
LIG_Pex14_2	38	42	PF04695	0.487
LIG_SH2_CRK	196	200	PF00017	0.487
LIG_SH2_CRK	498	502	PF00017	0.374
LIG_SH2_NCK_1	498	502	PF00017	0.456
LIG_SH2_SRC	196	199	PF00017	0.476
LIG_SH2_STAP1	101	105	PF00017	0.562
LIG_SH2_STAP1	148	152	PF00017	0.547
LIG_SH2_STAP1	343	347	PF00017	0.422
LIG_SH2_STAP1	502	506	PF00017	0.510
LIG_SH2_STAT3	101	104	PF00017	0.537
LIG_SH2_STAT5	111	114	PF00017	0.585
LIG_SH2_STAT5	132	135	PF00017	0.499
LIG_SH2_STAT5	198	201	PF00017	0.476
LIG_SH3_3	131	137	PF00018	0.517
LIG_SH3_3	401	407	PF00018	0.469
LIG_SUMO_SIM_anti_2	383	389	PF11976	0.448
LIG_TRAF2_1	522	525	PF00917	0.573
LIG_TYR_ITIM	194	199	PF00017	0.487
LIG_UBA3_1	538	543	PF00899	0.419
LIG_UBA3_1	545	553	PF00899	0.438
LIG_WRC_WIRS_1	353	358	PF05994	0.354
MOD_CK1_1	22	28	PF00069	0.613
MOD_CK1_1	324	330	PF00069	0.678
MOD_CK1_1	412	418	PF00069	0.586
MOD_CK1_1	44	50	PF00069	0.468
MOD_CK1_1	464	470	PF00069	0.726
MOD_CK1_1	66	72	PF00069	0.475
MOD_CK2_1	163	169	PF00069	0.476
MOD_CK2_1	233	239	PF00069	0.486
MOD_CK2_1	412	418	PF00069	0.563
MOD_GlcNHglycan	10	13	PF01048	0.727
MOD_GlcNHglycan	21	24	PF01048	0.607
MOD_GlcNHglycan	26	29	PF01048	0.454
MOD_GlcNHglycan	323	326	PF01048	0.712
MOD_GlcNHglycan	414	417	PF01048	0.504
MOD_GlcNHglycan	486	489	PF01048	0.749
MOD_GlcNHglycan	492	495	PF01048	0.729
MOD_GSK3_1	200	207	PF00069	0.537
MOD_GSK3_1	316	323	PF00069	0.636
MOD_GSK3_1	352	359	PF00069	0.430
MOD_GSK3_1	378	385	PF00069	0.550
MOD_GSK3_1	461	468	PF00069	0.625
MOD_GSK3_1	484	491	PF00069	0.753
MOD_GSK3_1	8	15	PF00069	0.678
MOD_N-GLC_1	169	174	PF02516	0.287
MOD_N-GLC_1	394	399	PF02516	0.441
MOD_NEK2_1	1	6	PF00069	0.636
MOD_NEK2_1	162	167	PF00069	0.468
MOD_NEK2_1	92	97	PF00069	0.520
MOD_PIKK_1	1	7	PF00454	0.651
MOD_PIKK_1	87	93	PF00454	0.525
MOD_PKA_1	93	99	PF00069	0.553
MOD_PKA_2	233	239	PF00069	0.461
MOD_PKA_2	44	50	PF00069	0.581
MOD_PKA_2	87	93	PF00069	0.536
MOD_Plk_1	169	175	PF00069	0.487
MOD_Plk_1	382	388	PF00069	0.619
MOD_Plk_2-3	169	175	PF00069	0.479
MOD_Plk_4	163	169	PF00069	0.471
MOD_Plk_4	300	306	PF00069	0.622
MOD_Plk_4	382	388	PF00069	0.522
MOD_Plk_4	66	72	PF00069	0.486
MOD_ProDKin_1	400	406	PF00069	0.710
MOD_ProDKin_1	461	467	PF00069	0.611
MOD_ProDKin_1	64	70	PF00069	0.487
MOD_SUMO_for_1	34	37	PF00179	0.550
MOD_SUMO_rev_2	215	224	PF00179	0.486
TRG_DiLeu_BaEn_1	158	163	PF01217	0.562
TRG_ENDOCYTIC_2	188	191	PF00928	0.507
TRG_ENDOCYTIC_2	196	199	PF00928	0.442
TRG_ENDOCYTIC_2	513	516	PF00928	0.420
TRG_ER_diArg_1	347	350	PF00400	0.540
TRG_ER_diArg_1	532	534	PF00400	0.561
TRG_ER_diArg_1	92	94	PF00400	0.528
TRG_NES_CRM1_1	361	376	PF08389	0.547
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR6	Leptomonas seymouri	64%	100%
A0A0S4KEA9	Bodo saltans	39%	100%
A0A1X0NT88	Trypanosomatidae	42%	100%
A0A3Q8IDX6	Leishmania donovani	87%	100%
A0A422NXL8	Trypanosoma rangeli	43%	100%
A4H8Y5	Leishmania braziliensis	80%	100%
A4HXB5	Leishmania infantum	87%	100%
C9ZU02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4QEF2	Leishmania major	88%	100%
V5BAJ7	Trypanosoma cruzi	41%	89%