RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AR09_LEIMU

TriTrypDb:

LmxM.17.0400

Length:

1055

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR09

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.550
CLV_C14_Caspase3-7	362	366	PF00656	0.489
CLV_C14_Caspase3-7	507	511	PF00656	0.639
CLV_C14_Caspase3-7	606	610	PF00656	0.678
CLV_C14_Caspase3-7	64	68	PF00656	0.587
CLV_C14_Caspase3-7	864	868	PF00656	0.497
CLV_C14_Caspase3-7	94	98	PF00656	0.675
CLV_C14_Caspase3-7	964	968	PF00656	0.526
CLV_NRD_NRD_1	191	193	PF00675	0.706
CLV_NRD_NRD_1	203	205	PF00675	0.592
CLV_NRD_NRD_1	287	289	PF00675	0.521
CLV_NRD_NRD_1	486	488	PF00675	0.708
CLV_NRD_NRD_1	49	51	PF00675	0.521
CLV_NRD_NRD_1	52	54	PF00675	0.549
CLV_NRD_NRD_1	604	606	PF00675	0.670
CLV_NRD_NRD_1	711	713	PF00675	0.558
CLV_NRD_NRD_1	955	957	PF00675	0.373
CLV_PCSK_FUR_1	287	291	PF00082	0.592
CLV_PCSK_FUR_1	50	54	PF00082	0.428
CLV_PCSK_KEX2_1	191	193	PF00082	0.709
CLV_PCSK_KEX2_1	202	204	PF00082	0.604
CLV_PCSK_KEX2_1	237	239	PF00082	0.646
CLV_PCSK_KEX2_1	287	289	PF00082	0.517
CLV_PCSK_KEX2_1	379	381	PF00082	0.511
CLV_PCSK_KEX2_1	45	47	PF00082	0.550
CLV_PCSK_KEX2_1	486	488	PF00082	0.706
CLV_PCSK_KEX2_1	49	51	PF00082	0.517
CLV_PCSK_KEX2_1	52	54	PF00082	0.530
CLV_PCSK_KEX2_1	604	606	PF00082	0.670
CLV_PCSK_KEX2_1	711	713	PF00082	0.558
CLV_PCSK_KEX2_1	955	957	PF00082	0.373
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.646
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.583
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.587
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.551
CLV_PCSK_SKI1_1	1038	1042	PF00082	0.534
CLV_PCSK_SKI1_1	29	33	PF00082	0.606
CLV_PCSK_SKI1_1	376	380	PF00082	0.679
CLV_PCSK_SKI1_1	431	435	PF00082	0.452
CLV_PCSK_SKI1_1	456	460	PF00082	0.553
CLV_PCSK_SKI1_1	52	56	PF00082	0.482
CLV_PCSK_SKI1_1	976	980	PF00082	0.430
CLV_Separin_Metazoa	425	429	PF03568	0.543
DEG_APCC_DBOX_1	28	36	PF00400	0.607
DEG_APCC_DBOX_1	51	59	PF00400	0.479
DEG_Nend_UBRbox_3	1	3	PF02207	0.640
DEG_ODPH_VHL_1	614	625	PF01847	0.629
DEG_SCF_TRCP1_1	720	725	PF00400	0.554
DEG_SPOP_SBC_1	108	112	PF00917	0.511
DEG_SPOP_SBC_1	496	500	PF00917	0.532
DEG_SPOP_SBC_1	502	506	PF00917	0.515
DOC_ANK_TNKS_1	122	129	PF00023	0.539
DOC_ANK_TNKS_1	486	493	PF00023	0.532
DOC_CKS1_1	114	119	PF01111	0.662
DOC_CYCLIN_RxL_1	237	248	PF00134	0.648
DOC_CYCLIN_RxL_1	26	34	PF00134	0.557
DOC_CYCLIN_RxL_1	46	57	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	690	696	PF00134	0.567
DOC_CYCLIN_yCln2_LP_2	765	771	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	910	916	PF00134	0.285
DOC_MAPK_gen_1	237	246	PF00069	0.648
DOC_MAPK_gen_1	376	386	PF00069	0.525
DOC_MAPK_MEF2A_6	379	386	PF00069	0.512
DOC_MAPK_MEF2A_6	672	680	PF00069	0.429
DOC_MAPK_RevD_3	30	45	PF00069	0.544
DOC_MAPK_RevD_3	696	712	PF00069	0.562
DOC_PP1_RVXF_1	709	716	PF00149	0.473
DOC_PP2B_LxvP_1	765	768	PF13499	0.460
DOC_PP2B_LxvP_1	843	846	PF13499	0.407
DOC_PP2B_LxvP_1	979	982	PF13499	0.461
DOC_PP4_FxxP_1	114	117	PF00568	0.661
DOC_PP4_FxxP_1	158	161	PF00568	0.629
DOC_PP4_FxxP_1	551	554	PF00568	0.679
DOC_PP4_MxPP_1	475	478	PF00568	0.583
DOC_USP7_MATH_1	108	112	PF00917	0.793
DOC_USP7_MATH_1	118	122	PF00917	0.711
DOC_USP7_MATH_1	129	133	PF00917	0.593
DOC_USP7_MATH_1	225	229	PF00917	0.555
DOC_USP7_MATH_1	342	346	PF00917	0.596
DOC_USP7_MATH_1	502	506	PF00917	0.580
DOC_USP7_MATH_1	82	86	PF00917	0.664
DOC_USP7_MATH_1	880	884	PF00917	0.508
DOC_USP7_UBL2_3	641	645	PF12436	0.515
DOC_USP7_UBL2_3	658	662	PF12436	0.585
DOC_WW_Pin1_4	1048	1053	PF00397	0.650
DOC_WW_Pin1_4	113	118	PF00397	0.641
DOC_WW_Pin1_4	134	139	PF00397	0.667
DOC_WW_Pin1_4	157	162	PF00397	0.629
DOC_WW_Pin1_4	568	573	PF00397	0.519
DOC_WW_Pin1_4	574	579	PF00397	0.513
DOC_WW_Pin1_4	663	668	PF00397	0.540
DOC_WW_Pin1_4	800	805	PF00397	0.367
DOC_WW_Pin1_4	909	914	PF00397	0.285
LIG_14-3-3_CanoR_1	113	117	PF00244	0.528
LIG_14-3-3_CanoR_1	202	210	PF00244	0.518
LIG_14-3-3_CanoR_1	275	281	PF00244	0.514
LIG_14-3-3_CanoR_1	320	325	PF00244	0.588
LIG_14-3-3_CanoR_1	431	437	PF00244	0.517
LIG_14-3-3_CanoR_1	503	509	PF00244	0.580
LIG_14-3-3_CanoR_1	604	608	PF00244	0.675
LIG_14-3-3_CanoR_1	711	716	PF00244	0.470
LIG_14-3-3_CanoR_1	778	783	PF00244	0.331
LIG_14-3-3_CanoR_1	853	857	PF00244	0.356
LIG_14-3-3_CanoR_1	955	963	PF00244	0.462
LIG_Actin_WH2_2	379	396	PF00022	0.581
LIG_AP2alpha_1	607	611	PF02296	0.676
LIG_BIR_III_4	180	184	PF00653	0.596
LIG_BIR_III_4	9	13	PF00653	0.551
LIG_BRCT_BRCA1_1	110	114	PF00533	0.625
LIG_CtBP_PxDLS_1	440	444	PF00389	0.626
LIG_deltaCOP1_diTrp_1	253	258	PF00928	0.462
LIG_EH1_1	468	476	PF00400	0.539
LIG_eIF4E_1	16	22	PF01652	0.617
LIG_EVH1_1	843	847	PF00568	0.488
LIG_FHA_1	305	311	PF00498	0.536
LIG_FHA_1	675	681	PF00498	0.599
LIG_FHA_1	793	799	PF00498	0.445
LIG_FHA_1	834	840	PF00498	0.552
LIG_FHA_2	1039	1045	PF00498	0.501
LIG_FHA_2	15	21	PF00498	0.596
LIG_FHA_2	195	201	PF00498	0.621
LIG_FHA_2	554	560	PF00498	0.567
LIG_FHA_2	604	610	PF00498	0.603
LIG_FHA_2	862	868	PF00498	0.475
LIG_FHA_2	92	98	PF00498	0.620
LIG_FHA_2	962	968	PF00498	0.527
LIG_LIR_Apic_2	111	117	PF02991	0.653
LIG_LIR_Apic_2	156	161	PF02991	0.633
LIG_LIR_Apic_2	957	962	PF02991	0.530
LIG_LIR_Gen_1	403	410	PF02991	0.499
LIG_LIR_Gen_1	563	574	PF02991	0.409
LIG_LIR_Gen_1	609	618	PF02991	0.586
LIG_LIR_Gen_1	714	723	PF02991	0.463
LIG_LIR_Nem_3	1025	1030	PF02991	0.377
LIG_LIR_Nem_3	271	277	PF02991	0.631
LIG_LIR_Nem_3	403	408	PF02991	0.489
LIG_LIR_Nem_3	435	439	PF02991	0.601
LIG_LIR_Nem_3	563	569	PF02991	0.399
LIG_LIR_Nem_3	609	614	PF02991	0.600
LIG_LIR_Nem_3	714	718	PF02991	0.439
LIG_LIR_Nem_3	744	748	PF02991	0.437
LIG_LIR_Nem_3	972	978	PF02991	0.319
LIG_Pex14_1	254	258	PF04695	0.473
LIG_Pex14_2	3	7	PF04695	0.617
LIG_Pex14_2	458	462	PF04695	0.480
LIG_Pex14_2	607	611	PF04695	0.676
LIG_PTB_Apo_2	396	403	PF02174	0.469
LIG_SH2_CRK	283	287	PF00017	0.646
LIG_SH2_CRK	405	409	PF00017	0.539
LIG_SH2_CRK	959	963	PF00017	0.517
LIG_SH2_CRK	975	979	PF00017	0.275
LIG_SH2_GRB2like	1015	1018	PF00017	0.397
LIG_SH2_NCK_1	247	251	PF00017	0.509
LIG_SH2_STAP1	405	409	PF00017	0.539
LIG_SH2_STAP1	737	741	PF00017	0.488
LIG_SH2_STAT5	16	19	PF00017	0.588
LIG_SH2_STAT5	273	276	PF00017	0.495
LIG_SH2_STAT5	297	300	PF00017	0.618
LIG_SH2_STAT5	324	327	PF00017	0.620
LIG_SH2_STAT5	373	376	PF00017	0.590
LIG_SH3_3	1049	1055	PF00018	0.545
LIG_SH3_3	381	387	PF00018	0.593
LIG_SH3_3	434	440	PF00018	0.523
LIG_SH3_3	475	481	PF00018	0.651
LIG_SH3_3	566	572	PF00018	0.479
LIG_SH3_3	841	847	PF00018	0.505
LIG_SUMO_SIM_anti_2	622	628	PF11976	0.612
LIG_SUMO_SIM_anti_2	675	680	PF11976	0.447
LIG_SUMO_SIM_anti_2	795	800	PF11976	0.487
LIG_SUMO_SIM_par_1	57	62	PF11976	0.471
LIG_TRAF2_1	302	305	PF00917	0.563
LIG_TRAF2_1	68	71	PF00917	0.597
LIG_TYR_ITIM	281	286	PF00017	0.576
LIG_UBA3_1	280	289	PF00899	0.583
MOD_CDK_SPxxK_3	574	581	PF00069	0.584
MOD_CK1_1	112	118	PF00069	0.660
MOD_CK1_1	148	154	PF00069	0.594
MOD_CK1_1	160	166	PF00069	0.645
MOD_CK1_1	196	202	PF00069	0.528
MOD_CK1_1	219	225	PF00069	0.674
MOD_CK1_1	227	233	PF00069	0.585
MOD_CK1_1	323	329	PF00069	0.592
MOD_CK1_1	498	504	PF00069	0.613
MOD_CK1_1	513	519	PF00069	0.687
MOD_CK1_1	66	72	PF00069	0.646
MOD_CK1_1	85	91	PF00069	0.683
MOD_CK1_1	861	867	PF00069	0.563
MOD_CK2_1	1038	1044	PF00069	0.431
MOD_CK2_1	14	20	PF00069	0.595
MOD_CK2_1	148	154	PF00069	0.532
MOD_CK2_1	194	200	PF00069	0.625
MOD_CK2_1	342	348	PF00069	0.676
MOD_CK2_1	518	524	PF00069	0.642
MOD_CK2_1	526	532	PF00069	0.632
MOD_CK2_1	553	559	PF00069	0.574
MOD_CK2_1	59	65	PF00069	0.682
MOD_CK2_1	616	622	PF00069	0.552
MOD_Cter_Amidation	189	192	PF01082	0.604
MOD_Cter_Amidation	484	487	PF01082	0.595
MOD_GlcNHglycan	154	158	PF01048	0.734
MOD_GlcNHglycan	165	168	PF01048	0.563
MOD_GlcNHglycan	180	184	PF01048	0.691
MOD_GlcNHglycan	219	222	PF01048	0.672
MOD_GlcNHglycan	344	347	PF01048	0.588
MOD_GlcNHglycan	506	509	PF01048	0.570
MOD_GlcNHglycan	541	544	PF01048	0.682
MOD_GlcNHglycan	720	723	PF01048	0.601
MOD_GlcNHglycan	821	825	PF01048	0.510
MOD_GlcNHglycan	89	92	PF01048	0.680
MOD_GSK3_1	1004	1011	PF00069	0.348
MOD_GSK3_1	1034	1041	PF00069	0.377
MOD_GSK3_1	108	115	PF00069	0.661
MOD_GSK3_1	129	136	PF00069	0.819
MOD_GSK3_1	153	160	PF00069	0.683
MOD_GSK3_1	170	177	PF00069	0.512
MOD_GSK3_1	215	222	PF00069	0.672
MOD_GSK3_1	224	231	PF00069	0.605
MOD_GSK3_1	322	329	PF00069	0.640
MOD_GSK3_1	400	407	PF00069	0.484
MOD_GSK3_1	497	504	PF00069	0.671
MOD_GSK3_1	59	66	PF00069	0.592
MOD_GSK3_1	718	725	PF00069	0.592
MOD_GSK3_1	85	92	PF00069	0.723
MOD_GSK3_1	854	861	PF00069	0.401
MOD_N-GLC_1	1016	1021	PF02516	0.384
MOD_N-GLC_1	857	862	PF02516	0.413
MOD_N-GLC_2	949	951	PF02516	0.350
MOD_NEK2_1	193	198	PF00069	0.529
MOD_NEK2_1	31	36	PF00069	0.560
MOD_NEK2_1	322	327	PF00069	0.617
MOD_NEK2_1	393	398	PF00069	0.540
MOD_NEK2_1	400	405	PF00069	0.466
MOD_NEK2_1	688	693	PF00069	0.450
MOD_NEK2_1	969	974	PF00069	0.473
MOD_PIKK_1	204	210	PF00454	0.514
MOD_PIKK_1	616	622	PF00454	0.580
MOD_PIKK_1	880	886	PF00454	0.412
MOD_PK_1	778	784	PF00069	0.371
MOD_PKA_1	203	209	PF00069	0.516
MOD_PKA_1	711	717	PF00069	0.533
MOD_PKA_2	112	118	PF00069	0.630
MOD_PKA_2	148	154	PF00069	0.531
MOD_PKA_2	194	200	PF00069	0.662
MOD_PKA_2	203	209	PF00069	0.578
MOD_PKA_2	326	332	PF00069	0.510
MOD_PKA_2	393	399	PF00069	0.544
MOD_PKA_2	502	508	PF00069	0.604
MOD_PKA_2	603	609	PF00069	0.676
MOD_PKA_2	711	717	PF00069	0.533
MOD_PKA_2	772	778	PF00069	0.398
MOD_PKA_2	85	91	PF00069	0.813
MOD_PKA_2	852	858	PF00069	0.433
MOD_PKA_2	954	960	PF00069	0.458
MOD_PKB_1	202	210	PF00069	0.591
MOD_Plk_1	12	18	PF00069	0.496
MOD_Plk_1	59	65	PF00069	0.549
MOD_Plk_1	674	680	PF00069	0.453
MOD_Plk_1	792	798	PF00069	0.458
MOD_Plk_1	857	863	PF00069	0.457
MOD_Plk_2-3	603	609	PF00069	0.676
MOD_Plk_4	1004	1010	PF00069	0.363
MOD_Plk_4	276	282	PF00069	0.581
MOD_Plk_4	404	410	PF00069	0.503
MOD_Plk_4	469	475	PF00069	0.626
MOD_Plk_4	510	516	PF00069	0.666
MOD_Plk_4	674	680	PF00069	0.450
MOD_Plk_4	741	747	PF00069	0.435
MOD_Plk_4	858	864	PF00069	0.451
MOD_ProDKin_1	1048	1054	PF00069	0.650
MOD_ProDKin_1	113	119	PF00069	0.641
MOD_ProDKin_1	134	140	PF00069	0.668
MOD_ProDKin_1	157	163	PF00069	0.628
MOD_ProDKin_1	568	574	PF00069	0.515
MOD_ProDKin_1	663	669	PF00069	0.539
MOD_ProDKin_1	800	806	PF00069	0.378
MOD_ProDKin_1	909	915	PF00069	0.285
MOD_SUMO_rev_2	345	354	PF00179	0.566
MOD_SUMO_rev_2	375	381	PF00179	0.585
TRG_DiLeu_BaEn_1	675	680	PF01217	0.447
TRG_DiLeu_BaEn_2	153	159	PF01217	0.536
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.424
TRG_DiLeu_BaLyEn_6	751	756	PF01217	0.386
TRG_ENDOCYTIC_2	1028	1031	PF00928	0.393
TRG_ENDOCYTIC_2	283	286	PF00928	0.641
TRG_ENDOCYTIC_2	405	408	PF00928	0.459
TRG_ENDOCYTIC_2	566	569	PF00928	0.465
TRG_ENDOCYTIC_2	805	808	PF00928	0.565
TRG_ENDOCYTIC_2	975	978	PF00928	0.417
TRG_ER_diArg_1	191	193	PF00400	0.661
TRG_ER_diArg_1	202	204	PF00400	0.582
TRG_ER_diArg_1	286	288	PF00400	0.506
TRG_ER_diArg_1	298	301	PF00400	0.543
TRG_ER_diArg_1	391	394	PF00400	0.567
TRG_ER_diArg_1	49	52	PF00400	0.576
TRG_ER_diArg_1	711	713	PF00400	0.558
TRG_NES_CRM1_1	622	636	PF08389	0.624
TRG_NES_CRM1_1	834	849	PF08389	0.529
TRG_Pf-PMV_PEXEL_1	461	465	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H8	Leptomonas seymouri	38%	100%
A0A3Q8IAL8	Leishmania donovani	86%	100%
A4H8Y3	Leishmania braziliensis	73%	100%
A4HXB3	Leishmania infantum	86%	100%
Q4QEF4	Leishmania major	85%	99%