Qa-SNARE_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qa-SNARE protein, putative

Species:

Leishmania mexicana

UniProt:

E9AR07_LEIMU

TriTrypDb:

LmxM.17.0380

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0005794	Golgi apparatus	5	1
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0012507	ER to Golgi transport vesicle membrane	6	1
GO:0030658	transport vesicle membrane	5	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0031201	SNARE complex	3	2
GO:0031902	late endosome membrane	6	1
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AR07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR07

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	4
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	4
GO:0016192	vesicle-mediated transport	4	4
GO:0048193	Golgi vesicle transport	5	4
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048284	organelle fusion	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0008104	protein localization	4	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0051641	cellular localization	2	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005484	SNAP receptor activity	3	5
GO:0030674	protein-macromolecule adaptor activity	2	5
GO:0060090	molecular adaptor activity	1	5
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.461
CLV_NRD_NRD_1	141	143	PF00675	0.510
CLV_NRD_NRD_1	243	245	PF00675	0.276
CLV_NRD_NRD_1	71	73	PF00675	0.443
CLV_PCSK_KEX2_1	141	143	PF00082	0.510
CLV_PCSK_KEX2_1	243	245	PF00082	0.282
CLV_PCSK_KEX2_1	71	73	PF00082	0.387
DEG_SPOP_SBC_1	36	40	PF00917	0.715
DEG_SPOP_SBC_1	53	57	PF00917	0.524
DOC_MAPK_gen_1	243	252	PF00069	0.530
DOC_MAPK_gen_1	71	82	PF00069	0.656
DOC_MAPK_MEF2A_6	16	25	PF00069	0.500
DOC_MAPK_MEF2A_6	75	84	PF00069	0.658
DOC_USP7_MATH_1	120	124	PF00917	0.684
DOC_USP7_MATH_1	134	138	PF00917	0.754
DOC_USP7_MATH_1	163	167	PF00917	0.706
DOC_USP7_MATH_1	97	101	PF00917	0.633
LIG_14-3-3_CanoR_1	104	110	PF00244	0.664
LIG_14-3-3_CanoR_1	119	128	PF00244	0.718
LIG_14-3-3_CanoR_1	233	242	PF00244	0.502
LIG_BIR_III_4	156	160	PF00653	0.594
LIG_Clathr_ClatBox_1	11	15	PF01394	0.662
LIG_FHA_1	130	136	PF00498	0.560
LIG_FHA_1	197	203	PF00498	0.504
LIG_FHA_1	212	218	PF00498	0.482
LIG_FHA_1	263	269	PF00498	0.454
LIG_FHA_2	218	224	PF00498	0.563
LIG_NRBOX	72	78	PF00104	0.677
LIG_SH2_STAP1	95	99	PF00017	0.704
LIG_SH3_3	142	148	PF00018	0.750
LIG_SH3_3	22	28	PF00018	0.702
LIG_SUMO_SIM_par_1	9	15	PF11976	0.669
LIG_UBA3_1	11	16	PF00899	0.579
LIG_Vh1_VBS_1	251	269	PF01044	0.190
LIG_Vh1_VBS_1	62	80	PF01044	0.472
MOD_CK1_1	38	44	PF00069	0.794
MOD_CK2_1	105	111	PF00069	0.659
MOD_CK2_1	217	223	PF00069	0.537
MOD_GlcNHglycan	56	59	PF01048	0.477
MOD_GSK3_1	120	127	PF00069	0.726
MOD_GSK3_1	181	188	PF00069	0.615
MOD_GSK3_1	35	42	PF00069	0.737
MOD_N-GLC_1	196	201	PF02516	0.287
MOD_N-GLC_1	53	58	PF02516	0.420
MOD_NEK2_1	196	201	PF00069	0.379
MOD_NEK2_2	206	211	PF00069	0.501
MOD_PIKK_1	134	140	PF00454	0.764
MOD_PIKK_1	196	202	PF00454	0.568
MOD_PKA_1	71	77	PF00069	0.511
MOD_PKA_2	140	146	PF00069	0.750
MOD_PKA_2	232	238	PF00069	0.555
MOD_PKA_2	71	77	PF00069	0.511
MOD_SUMO_rev_2	235	241	PF00179	0.561
TRG_DiLeu_BaEn_2	236	242	PF01217	0.496
TRG_DiLeu_BaEn_4	9	15	PF01217	0.559
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.622
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.565
TRG_ER_diArg_1	242	244	PF00400	0.482
TRG_ER_diArg_1	70	72	PF00400	0.643
TRG_NES_CRM1_1	13	24	PF08389	0.693
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.291
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H7	Leptomonas seymouri	58%	100%
A0A0S4JPW8	Bodo saltans	34%	100%
A0A1X0NUE9	Trypanosomatidae	37%	100%
A0A3S5IS79	Trypanosoma rangeli	34%	100%
A0A3S7WUJ1	Leishmania donovani	86%	100%
A4H8Y1	Leishmania braziliensis	66%	100%
A4HXA5	Leishmania infantum	87%	100%
C9ZTX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4QEF6	Leishmania major	86%	100%