Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AR06_LEIMU

TriTrypDb:

LmxM.17.0370

Length:

790

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AR06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.707
CLV_NRD_NRD_1	208	210	PF00675	0.537
CLV_NRD_NRD_1	321	323	PF00675	0.519
CLV_NRD_NRD_1	330	332	PF00675	0.451
CLV_NRD_NRD_1	37	39	PF00675	0.475
CLV_NRD_NRD_1	526	528	PF00675	0.539
CLV_NRD_NRD_1	714	716	PF00675	0.403
CLV_PCSK_FUR_1	206	210	PF00082	0.526
CLV_PCSK_FUR_1	319	323	PF00082	0.511
CLV_PCSK_KEX2_1	208	210	PF00082	0.537
CLV_PCSK_KEX2_1	321	323	PF00082	0.519
CLV_PCSK_KEX2_1	330	332	PF00082	0.451
CLV_PCSK_KEX2_1	37	39	PF00082	0.475
CLV_PCSK_KEX2_1	525	527	PF00082	0.540
CLV_PCSK_KEX2_1	714	716	PF00082	0.403
CLV_PCSK_SKI1_1	101	105	PF00082	0.539
CLV_PCSK_SKI1_1	14	18	PF00082	0.509
CLV_PCSK_SKI1_1	150	154	PF00082	0.434
CLV_PCSK_SKI1_1	244	248	PF00082	0.497
DEG_APCC_DBOX_1	100	108	PF00400	0.734
DEG_APCC_DBOX_1	116	124	PF00400	0.512
DEG_ODPH_VHL_1	432	444	PF01847	0.630
DEG_SCF_FBW7_1	470	476	PF00400	0.643
DEG_SCF_FBW7_1	514	520	PF00400	0.718
DEG_SPOP_SBC_1	474	478	PF00917	0.677
DOC_CKS1_1	470	475	PF01111	0.691
DOC_CKS1_1	511	516	PF01111	0.729
DOC_CYCLIN_RxL_1	11	21	PF00134	0.705
DOC_CYCLIN_RxL_1	437	447	PF00134	0.636
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.681
DOC_CYCLIN_yCln2_LP_2	486	492	PF00134	0.776
DOC_PP2B_LxvP_1	432	435	PF13499	0.622
DOC_PP2B_LxvP_1	486	489	PF13499	0.778
DOC_PP2B_LxvP_1	693	696	PF13499	0.636
DOC_PP2B_LxvP_1	77	80	PF13499	0.781
DOC_PP4_FxxP_1	385	388	PF00568	0.633
DOC_USP7_MATH_1	266	270	PF00917	0.745
DOC_USP7_MATH_1	276	280	PF00917	0.715
DOC_USP7_MATH_1	356	360	PF00917	0.643
DOC_USP7_MATH_1	376	380	PF00917	0.612
DOC_USP7_MATH_1	449	453	PF00917	0.667
DOC_USP7_MATH_1	474	478	PF00917	0.717
DOC_USP7_MATH_1	517	521	PF00917	0.713
DOC_USP7_MATH_1	52	56	PF00917	0.745
DOC_USP7_MATH_1	554	558	PF00917	0.616
DOC_USP7_MATH_1	59	63	PF00917	0.695
DOC_USP7_MATH_1	623	627	PF00917	0.589
DOC_USP7_MATH_1	69	73	PF00917	0.616
DOC_USP7_MATH_1	8	12	PF00917	0.697
DOC_USP7_MATH_1	86	90	PF00917	0.638
DOC_USP7_MATH_2	370	376	PF00917	0.746
DOC_WW_Pin1_4	211	216	PF00397	0.695
DOC_WW_Pin1_4	272	277	PF00397	0.765
DOC_WW_Pin1_4	283	288	PF00397	0.698
DOC_WW_Pin1_4	391	396	PF00397	0.723
DOC_WW_Pin1_4	444	449	PF00397	0.675
DOC_WW_Pin1_4	469	474	PF00397	0.702
DOC_WW_Pin1_4	475	480	PF00397	0.667
DOC_WW_Pin1_4	481	486	PF00397	0.705
DOC_WW_Pin1_4	494	499	PF00397	0.666
DOC_WW_Pin1_4	501	506	PF00397	0.739
DOC_WW_Pin1_4	510	515	PF00397	0.646
DOC_WW_Pin1_4	550	555	PF00397	0.631
DOC_WW_Pin1_4	561	566	PF00397	0.703
DOC_WW_Pin1_4	88	93	PF00397	0.712
LIG_14-3-3_CanoR_1	117	121	PF00244	0.619
LIG_14-3-3_CanoR_1	131	141	PF00244	0.550
LIG_14-3-3_CanoR_1	209	215	PF00244	0.655
LIG_14-3-3_CanoR_1	330	336	PF00244	0.707
LIG_14-3-3_CanoR_1	342	352	PF00244	0.666
LIG_14-3-3_CanoR_1	361	370	PF00244	0.676
LIG_14-3-3_CanoR_1	37	42	PF00244	0.709
LIG_14-3-3_CanoR_1	461	467	PF00244	0.725
LIG_14-3-3_CanoR_1	525	534	PF00244	0.738
LIG_14-3-3_CanoR_1	546	551	PF00244	0.727
LIG_14-3-3_CanoR_1	724	729	PF00244	0.686
LIG_14-3-3_CanoR_1	739	749	PF00244	0.607
LIG_BRCT_BRCA1_1	364	368	PF00533	0.652
LIG_BRCT_BRCA1_1	440	444	PF00533	0.757
LIG_BRCT_BRCA1_1	546	550	PF00533	0.627
LIG_BRCT_BRCA1_2	440	446	PF00533	0.727
LIG_CaM_IQ_9	311	327	PF13499	0.701
LIG_CtBP_PxDLS_1	64	68	PF00389	0.617
LIG_EH1_1	629	637	PF00400	0.697
LIG_eIF4E_1	106	112	PF01652	0.559
LIG_EVH1_1	77	81	PF00568	0.729
LIG_FHA_1	218	224	PF00498	0.628
LIG_FHA_1	293	299	PF00498	0.687
LIG_FHA_1	344	350	PF00498	0.731
LIG_FHA_1	536	542	PF00498	0.729
LIG_FHA_1	703	709	PF00498	0.626
LIG_FHA_2	335	341	PF00498	0.718
LIG_FHA_2	94	100	PF00498	0.670
LIG_HP1_1	86	90	PF01393	0.727
LIG_Integrin_RGD_1	745	747	PF01839	0.473
LIG_KLC1_Yacidic_2	658	663	PF13176	0.659
LIG_LIR_Apic_2	383	388	PF02991	0.633
LIG_LIR_Apic_2	667	673	PF02991	0.679
LIG_LIR_Gen_1	236	246	PF02991	0.695
LIG_LIR_Gen_1	640	648	PF02991	0.681
LIG_LIR_Gen_1	658	666	PF02991	0.542
LIG_LIR_Gen_1	676	684	PF02991	0.528
LIG_LIR_Gen_1	762	772	PF02991	0.380
LIG_LIR_Nem_3	163	167	PF02991	0.638
LIG_LIR_Nem_3	236	241	PF02991	0.704
LIG_LIR_Nem_3	589	594	PF02991	0.730
LIG_LIR_Nem_3	640	646	PF02991	0.678
LIG_LIR_Nem_3	658	664	PF02991	0.538
LIG_LIR_Nem_3	676	680	PF02991	0.522
LIG_LIR_Nem_3	762	767	PF02991	0.380
LIG_LIR_Nem_3	91	97	PF02991	0.708
LIG_Pex14_2	139	143	PF04695	0.642
LIG_Pex14_2	243	247	PF04695	0.691
LIG_Pex14_2	769	773	PF04695	0.380
LIG_SH2_CRK	164	168	PF00017	0.633
LIG_SH2_CRK	670	674	PF00017	0.662
LIG_SH2_CRK	764	768	PF00017	0.380
LIG_SH2_SRC	7	10	PF00017	0.704
LIG_SH2_STAP1	764	768	PF00017	0.380
LIG_SH2_STAT3	354	357	PF00017	0.733
LIG_SH2_STAT5	106	109	PF00017	0.612
LIG_SH2_STAT5	354	357	PF00017	0.733
LIG_SH2_STAT5	661	664	PF00017	0.630
LIG_SH2_STAT5	670	673	PF00017	0.608
LIG_SH2_STAT5	764	767	PF00017	0.380
LIG_SH2_STAT5	95	98	PF00017	0.668
LIG_SH3_3	253	259	PF00018	0.705
LIG_SH3_3	287	293	PF00018	0.634
LIG_SH3_3	428	434	PF00018	0.736
LIG_SH3_3	467	473	PF00018	0.733
LIG_SH3_3	486	492	PF00018	0.649
LIG_SH3_3	511	517	PF00018	0.651
LIG_SH3_3	72	78	PF00018	0.841
LIG_Sin3_3	700	707	PF02671	0.658
LIG_SUMO_SIM_anti_2	633	638	PF11976	0.697
LIG_SUMO_SIM_par_1	109	114	PF11976	0.581
LIG_SUMO_SIM_par_1	62	68	PF11976	0.618
LIG_SUMO_SIM_par_1	86	91	PF11976	0.776
LIG_TRAF2_1	656	659	PF00917	0.653
LIG_TRAF2_1	665	668	PF00917	0.624
LIG_TRAF2_1	709	712	PF00917	0.662
LIG_TYR_ITIM	641	646	PF00017	0.645
LIG_UBA3_1	16	20	PF00899	0.710
LIG_WRC_WIRS_1	218	223	PF05994	0.634
LIG_WRC_WIRS_1	235	240	PF05994	0.699
LIG_WRC_WIRS_1	674	679	PF05994	0.636
MOD_CDK_SPxxK_3	277	284	PF00069	0.653
MOD_CK1_1	213	219	PF00069	0.638
MOD_CK1_1	234	240	PF00069	0.717
MOD_CK1_1	270	276	PF00069	0.748
MOD_CK1_1	279	285	PF00069	0.721
MOD_CK1_1	288	294	PF00069	0.626
MOD_CK1_1	334	340	PF00069	0.682
MOD_CK1_1	40	46	PF00069	0.716
MOD_CK1_1	459	465	PF00069	0.760
MOD_CK1_1	477	483	PF00069	0.651
MOD_CK1_1	589	595	PF00069	0.732
MOD_CK1_1	602	608	PF00069	0.661
MOD_CK1_1	762	768	PF00069	0.380
MOD_CK2_1	3	9	PF00069	0.718
MOD_CK2_1	40	46	PF00069	0.689
MOD_CK2_1	682	688	PF00069	0.611
MOD_CK2_1	93	99	PF00069	0.678
MOD_GlcNHglycan	186	189	PF01048	0.368
MOD_GlcNHglycan	199	202	PF01048	0.474
MOD_GlcNHglycan	287	290	PF01048	0.461
MOD_GlcNHglycan	364	367	PF01048	0.523
MOD_GlcNHglycan	374	377	PF01048	0.500
MOD_GlcNHglycan	378	381	PF01048	0.468
MOD_GlcNHglycan	406	409	PF01048	0.505
MOD_GlcNHglycan	508	511	PF01048	0.545
MOD_GlcNHglycan	537	541	PF01048	0.477
MOD_GlcNHglycan	588	591	PF01048	0.448
MOD_GlcNHglycan	604	607	PF01048	0.495
MOD_GlcNHglycan	619	622	PF01048	0.443
MOD_GlcNHglycan	67	70	PF01048	0.479
MOD_GlcNHglycan	684	687	PF01048	0.441
MOD_GlcNHglycan	705	708	PF01048	0.458
MOD_GlcNHglycan	71	74	PF01048	0.467
MOD_GlcNHglycan	735	738	PF01048	0.443
MOD_GSK3_1	131	138	PF00069	0.645
MOD_GSK3_1	213	220	PF00069	0.632
MOD_GSK3_1	229	236	PF00069	0.602
MOD_GSK3_1	266	273	PF00069	0.727
MOD_GSK3_1	279	286	PF00069	0.686
MOD_GSK3_1	288	295	PF00069	0.640
MOD_GSK3_1	3	10	PF00069	0.713
MOD_GSK3_1	364	371	PF00069	0.708
MOD_GSK3_1	372	379	PF00069	0.688
MOD_GSK3_1	387	394	PF00069	0.675
MOD_GSK3_1	397	404	PF00069	0.689
MOD_GSK3_1	438	445	PF00069	0.723
MOD_GSK3_1	465	472	PF00069	0.729
MOD_GSK3_1	473	480	PF00069	0.685
MOD_GSK3_1	501	508	PF00069	0.726
MOD_GSK3_1	513	520	PF00069	0.675
MOD_GSK3_1	542	549	PF00069	0.718
MOD_GSK3_1	550	557	PF00069	0.640
MOD_GSK3_1	59	66	PF00069	0.703
MOD_GSK3_1	598	605	PF00069	0.733
MOD_N-GLC_1	132	137	PF02516	0.401
MOD_N-GLC_1	197	202	PF02516	0.444
MOD_N-GLC_1	391	396	PF02516	0.531
MOD_N-GLC_1	481	486	PF02516	0.485
MOD_N-GLC_1	499	504	PF02516	0.502
MOD_N-GLC_1	586	591	PF02516	0.516
MOD_N-GLC_2	738	740	PF02516	0.508
MOD_NEK2_1	111	116	PF00069	0.674
MOD_NEK2_1	343	348	PF00069	0.742
MOD_NEK2_1	362	367	PF00069	0.611
MOD_NEK2_1	438	443	PF00069	0.722
MOD_NEK2_1	506	511	PF00069	0.736
MOD_NEK2_1	586	591	PF00069	0.628
MOD_NEK2_1	65	70	PF00069	0.700
MOD_NEK2_1	780	785	PF00069	0.434
MOD_NEK2_2	219	224	PF00069	0.631
MOD_NEK2_2	356	361	PF00069	0.733
MOD_NMyristoyl	1	7	PF02799	0.726
MOD_PIKK_1	229	235	PF00454	0.708
MOD_PIKK_1	274	280	PF00454	0.768
MOD_PIKK_1	288	294	PF00454	0.646
MOD_PIKK_1	433	439	PF00454	0.623
MOD_PK_1	599	605	PF00069	0.617
MOD_PKA_1	37	43	PF00069	0.678
MOD_PKA_1	525	531	PF00069	0.738
MOD_PKA_2	116	122	PF00069	0.625
MOD_PKA_2	362	368	PF00069	0.684
MOD_PKA_2	37	43	PF00069	0.711
MOD_PKA_2	525	531	PF00069	0.770
MOD_PKA_2	53	59	PF00069	0.631
MOD_PKA_2	598	604	PF00069	0.617
MOD_PKA_2	723	729	PF00069	0.636
MOD_PKB_1	348	356	PF00069	0.704
MOD_Plk_1	135	141	PF00069	0.669
MOD_Plk_1	45	51	PF00069	0.677
MOD_Plk_1	536	542	PF00069	0.640
MOD_Plk_1	59	65	PF00069	0.606
MOD_Plk_1	666	672	PF00069	0.682
MOD_Plk_1	762	768	PF00069	0.380
MOD_Plk_1	8	14	PF00069	0.796
MOD_Plk_2-3	93	99	PF00069	0.678
MOD_Plk_4	111	117	PF00069	0.666
MOD_Plk_4	213	219	PF00069	0.620
MOD_Plk_4	234	240	PF00069	0.717
MOD_Plk_4	350	356	PF00069	0.736
MOD_Plk_4	364	370	PF00069	0.643
MOD_Plk_4	623	629	PF00069	0.695
MOD_Plk_4	630	636	PF00069	0.661
MOD_Plk_4	762	768	PF00069	0.380
MOD_ProDKin_1	211	217	PF00069	0.696
MOD_ProDKin_1	272	278	PF00069	0.766
MOD_ProDKin_1	283	289	PF00069	0.699
MOD_ProDKin_1	391	397	PF00069	0.724
MOD_ProDKin_1	444	450	PF00069	0.676
MOD_ProDKin_1	469	475	PF00069	0.703
MOD_ProDKin_1	481	487	PF00069	0.705
MOD_ProDKin_1	494	500	PF00069	0.687
MOD_ProDKin_1	501	507	PF00069	0.739
MOD_ProDKin_1	510	516	PF00069	0.645
MOD_ProDKin_1	550	556	PF00069	0.631
MOD_ProDKin_1	561	567	PF00069	0.705
MOD_ProDKin_1	88	94	PF00069	0.708
MOD_SUMO_for_1	19	22	PF00179	0.703
TRG_DiLeu_BaEn_4	667	673	PF01217	0.646
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.557
TRG_DiLeu_BaLyEn_6	502	507	PF01217	0.739
TRG_DiLeu_BaLyEn_6	676	681	PF01217	0.645
TRG_ENDOCYTIC_2	164	167	PF00928	0.634
TRG_ENDOCYTIC_2	643	646	PF00928	0.676
TRG_ENDOCYTIC_2	661	664	PF00928	0.535
TRG_ENDOCYTIC_2	764	767	PF00928	0.380
TRG_ENDOCYTIC_2	777	780	PF00928	0.448
TRG_ENDOCYTIC_2	94	97	PF00928	0.671
TRG_ER_diArg_1	206	209	PF00400	0.754
TRG_ER_diArg_1	325	328	PF00400	0.723
TRG_ER_diArg_1	330	333	PF00400	0.688
TRG_ER_diArg_1	36	38	PF00400	0.675
TRG_ER_diArg_1	360	363	PF00400	0.740
TRG_ER_diArg_1	525	527	PF00400	0.740
TRG_ER_diArg_1	713	715	PF00400	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IAP9	Leishmania donovani	84%	99%
A4H8Y0	Leishmania braziliensis	65%	99%
A4HXA4	Leishmania infantum	84%	99%
Q4QEF7	Leishmania major	82%	100%