Dus domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrouridine synthase (Dus), putative

Species:

Leishmania mexicana

UniProt:

E9AR04_LEIMU

TriTrypDb:

LmxM.17.0350

Length:

660

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AR04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR04

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	11
GO:0017150	tRNA dihydrouridine synthase activity	5	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0106413	dihydrouridine synthase activity	4	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	316	318	PF00675	0.246
CLV_NRD_NRD_1	349	351	PF00675	0.246
CLV_NRD_NRD_1	35	37	PF00675	0.437
CLV_NRD_NRD_1	464	466	PF00675	0.246
CLV_NRD_NRD_1	569	571	PF00675	0.349
CLV_NRD_NRD_1	59	61	PF00675	0.459
CLV_PCSK_FUR_1	32	36	PF00082	0.440
CLV_PCSK_FUR_1	75	79	PF00082	0.477
CLV_PCSK_KEX2_1	244	246	PF00082	0.733
CLV_PCSK_KEX2_1	316	318	PF00082	0.246
CLV_PCSK_KEX2_1	34	36	PF00082	0.441
CLV_PCSK_KEX2_1	349	351	PF00082	0.246
CLV_PCSK_KEX2_1	408	410	PF00082	0.224
CLV_PCSK_KEX2_1	569	571	PF00082	0.368
CLV_PCSK_KEX2_1	59	61	PF00082	0.459
CLV_PCSK_KEX2_1	63	65	PF00082	0.450
CLV_PCSK_KEX2_1	77	79	PF00082	0.445
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.733
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.224
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.458
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.453
CLV_PCSK_PC7_1	59	65	PF00082	0.457
CLV_PCSK_SKI1_1	163	167	PF00082	0.561
CLV_PCSK_SKI1_1	179	183	PF00082	0.573
CLV_PCSK_SKI1_1	26	30	PF00082	0.421
CLV_PCSK_SKI1_1	295	299	PF00082	0.392
CLV_PCSK_SKI1_1	301	305	PF00082	0.338
CLV_PCSK_SKI1_1	396	400	PF00082	0.259
CLV_PCSK_SKI1_1	518	522	PF00082	0.246
CLV_PCSK_SKI1_1	569	573	PF00082	0.358
DEG_APCC_DBOX_1	604	612	PF00400	0.389
DEG_MDM2_SWIB_1	571	579	PF02201	0.320
DEG_ODPH_VHL_1	304	315	PF01847	0.459
DEG_SCF_FBW7_1	260	265	PF00400	0.704
DOC_CYCLIN_yCln2_LP_2	521	527	PF00134	0.446
DOC_MAPK_RevD_3	302	317	PF00069	0.299
DOC_PP4_FxxP_1	166	169	PF00568	0.558
DOC_USP7_MATH_1	126	130	PF00917	0.679
DOC_USP7_MATH_1	232	236	PF00917	0.762
DOC_USP7_MATH_1	289	293	PF00917	0.589
DOC_USP7_MATH_1	51	55	PF00917	0.442
DOC_USP7_UBL2_3	187	191	PF12436	0.458
DOC_WW_Pin1_4	202	207	PF00397	0.737
DOC_WW_Pin1_4	256	261	PF00397	0.741
DOC_WW_Pin1_4	437	442	PF00397	0.495
DOC_WW_Pin1_4	635	640	PF00397	0.425
LIG_14-3-3_CanoR_1	104	113	PF00244	0.594
LIG_14-3-3_CanoR_1	11	16	PF00244	0.385
LIG_14-3-3_CanoR_1	127	131	PF00244	0.618
LIG_14-3-3_CanoR_1	247	256	PF00244	0.731
LIG_14-3-3_CanoR_1	276	284	PF00244	0.564
LIG_14-3-3_CanoR_1	290	298	PF00244	0.407
LIG_14-3-3_CanoR_1	317	323	PF00244	0.498
LIG_14-3-3_CanoR_1	339	348	PF00244	0.467
LIG_14-3-3_CanoR_1	449	454	PF00244	0.424
LIG_14-3-3_CanoR_1	563	572	PF00244	0.372
LIG_14-3-3_CanoR_1	622	630	PF00244	0.384
LIG_14-3-3_CanoR_1	64	73	PF00244	0.459
LIG_14-3-3_CanoR_1	78	83	PF00244	0.446
LIG_APCC_ABBAyCdc20_2	523	529	PF00400	0.446
LIG_BIR_III_4	131	135	PF00653	0.660
LIG_BRCT_BRCA1_1	381	385	PF00533	0.459
LIG_BRCT_BRCA1_1	5	9	PF00533	0.384
LIG_deltaCOP1_diTrp_1	574	578	PF00928	0.320
LIG_eIF4E_1	582	588	PF01652	0.332
LIG_FHA_1	408	414	PF00498	0.525
LIG_FHA_1	438	444	PF00498	0.424
LIG_FHA_2	228	234	PF00498	0.758
LIG_FHA_2	276	282	PF00498	0.620
LIG_FHA_2	325	331	PF00498	0.446
LIG_LIR_Apic_2	119	123	PF02991	0.494
LIG_LIR_Gen_1	343	352	PF02991	0.460
LIG_LIR_Gen_1	382	393	PF02991	0.437
LIG_LIR_Gen_1	574	583	PF02991	0.321
LIG_LIR_Gen_1	6	16	PF02991	0.384
LIG_LIR_Gen_1	619	628	PF02991	0.354
LIG_LIR_Nem_3	343	348	PF02991	0.446
LIG_LIR_Nem_3	382	388	PF02991	0.437
LIG_LIR_Nem_3	574	578	PF02991	0.320
LIG_LIR_Nem_3	6	12	PF02991	0.383
LIG_LIR_Nem_3	619	623	PF02991	0.356
LIG_LYPXL_yS_3	44	47	PF13949	0.428
LIG_Pex14_2	16	20	PF04695	0.394
LIG_Pex14_2	381	385	PF04695	0.476
LIG_Pex14_2	571	575	PF04695	0.318
LIG_PTB_Apo_2	309	316	PF02174	0.446
LIG_PTB_Apo_2	471	478	PF02174	0.446
LIG_PTB_Phospho_1	471	477	PF10480	0.446
LIG_SH2_CRK	469	473	PF00017	0.348
LIG_SH2_GRB2like	646	649	PF00017	0.564
LIG_SH2_NCK_1	646	650	PF00017	0.637
LIG_SH2_PTP2	582	585	PF00017	0.323
LIG_SH2_SRC	582	585	PF00017	0.323
LIG_SH2_STAP1	469	473	PF00017	0.446
LIG_SH2_STAP1	646	650	PF00017	0.573
LIG_SH2_STAT3	477	480	PF00017	0.525
LIG_SH2_STAT5	120	123	PF00017	0.487
LIG_SH2_STAT5	469	472	PF00017	0.446
LIG_SH2_STAT5	477	480	PF00017	0.446
LIG_SH2_STAT5	582	585	PF00017	0.323
LIG_SH2_STAT5	646	649	PF00017	0.616
LIG_SH3_2	21	26	PF14604	0.389
LIG_SH3_3	15	21	PF00018	0.391
LIG_SH3_3	300	306	PF00018	0.377
LIG_SH3_3	360	366	PF00018	0.446
LIG_SH3_3	80	86	PF00018	0.754
LIG_SH3_3	87	93	PF00018	0.760
LIG_TRAF2_1	250	253	PF00917	0.704
LIG_TRFH_1	165	169	PF08558	0.559
LIG_TRFH_1	20	24	PF08558	0.387
LIG_UBA3_1	237	244	PF00899	0.561
LIG_UBA3_1	526	531	PF00899	0.318
LIG_WW_1	599	602	PF00397	0.404
MOD_CDK_SPK_2	635	640	PF00069	0.425
MOD_CDK_SPxxK_3	202	209	PF00069	0.683
MOD_CDK_SPxxK_3	635	642	PF00069	0.444
MOD_CK1_1	205	211	PF00069	0.787
MOD_CK1_1	223	229	PF00069	0.477
MOD_CK1_1	343	349	PF00069	0.318
MOD_CK1_1	379	385	PF00069	0.299
MOD_CK1_1	613	619	PF00069	0.481
MOD_CK2_1	227	233	PF00069	0.763
MOD_CK2_1	246	252	PF00069	0.696
MOD_CK2_1	266	272	PF00069	0.707
MOD_CK2_1	275	281	PF00069	0.608
MOD_CK2_1	324	330	PF00069	0.299
MOD_CK2_1	361	367	PF00069	0.152
MOD_CK2_1	50	56	PF00069	0.443
MOD_CK2_1	536	542	PF00069	0.400
MOD_GlcNHglycan	146	150	PF01048	0.692
MOD_GlcNHglycan	213	216	PF01048	0.706
MOD_GlcNHglycan	227	230	PF01048	0.620
MOD_GlcNHglycan	249	252	PF01048	0.725
MOD_GlcNHglycan	377	381	PF01048	0.300
MOD_GlcNHglycan	399	402	PF01048	0.299
MOD_GlcNHglycan	53	56	PF01048	0.584
MOD_GlcNHglycan	531	534	PF01048	0.393
MOD_GSK3_1	151	158	PF00069	0.534
MOD_GSK3_1	216	223	PF00069	0.750
MOD_GSK3_1	254	261	PF00069	0.720
MOD_GSK3_1	262	269	PF00069	0.738
MOD_GSK3_1	271	278	PF00069	0.653
MOD_GSK3_1	47	54	PF00069	0.437
MOD_GSK3_1	607	614	PF00069	0.377
MOD_GSK3_1	640	647	PF00069	0.492
MOD_NEK2_1	3	8	PF00069	0.382
MOD_NEK2_1	361	366	PF00069	0.410
MOD_NEK2_1	376	381	PF00069	0.410
MOD_NEK2_2	456	461	PF00069	0.342
MOD_PIKK_1	151	157	PF00454	0.648
MOD_PK_1	11	17	PF00069	0.386
MOD_PKA_1	34	40	PF00069	0.435
MOD_PKA_1	59	65	PF00069	0.457
MOD_PKA_2	126	132	PF00069	0.620
MOD_PKA_2	155	161	PF00069	0.500
MOD_PKA_2	246	252	PF00069	0.576
MOD_PKA_2	275	281	PF00069	0.583
MOD_PKA_2	289	295	PF00069	0.398
MOD_PKA_2	34	40	PF00069	0.435
MOD_PKA_2	448	454	PF00069	0.444
MOD_PKA_2	467	473	PF00069	0.196
MOD_PKA_2	59	65	PF00069	0.457
MOD_PKA_2	621	627	PF00069	0.375
MOD_PKB_1	245	253	PF00069	0.741
MOD_PKB_1	32	40	PF00069	0.436
MOD_Plk_1	280	286	PF00069	0.581
MOD_Plk_1	324	330	PF00069	0.299
MOD_Plk_1	343	349	PF00069	0.299
MOD_Plk_2-3	494	500	PF00069	0.318
MOD_Plk_4	11	17	PF00069	0.386
MOD_Plk_4	574	580	PF00069	0.321
MOD_Plk_4	607	613	PF00069	0.379
MOD_ProDKin_1	202	208	PF00069	0.739
MOD_ProDKin_1	256	262	PF00069	0.736
MOD_ProDKin_1	437	443	PF00069	0.367
MOD_ProDKin_1	635	641	PF00069	0.431
MOD_SUMO_for_1	116	119	PF00179	0.414
MOD_SUMO_rev_2	528	532	PF00179	0.299
TRG_DiLeu_BaEn_1	233	238	PF01217	0.636
TRG_DiLeu_BaEn_1	607	612	PF01217	0.402
TRG_DiLeu_BaEn_2	145	151	PF01217	0.787
TRG_DiLeu_BaEn_2	161	167	PF01217	0.426
TRG_DiLeu_BaEn_2	573	579	PF01217	0.318
TRG_ENDOCYTIC_2	383	386	PF00928	0.299
TRG_ENDOCYTIC_2	44	47	PF00928	0.428
TRG_ENDOCYTIC_2	469	472	PF00928	0.299
TRG_ENDOCYTIC_2	582	585	PF00928	0.324
TRG_ER_diArg_1	315	317	PF00400	0.299
TRG_ER_diArg_1	32	35	PF00400	0.440
TRG_ER_diArg_1	348	350	PF00400	0.299
TRG_ER_diArg_1	569	571	PF00400	0.368
TRG_ER_diArg_1	58	60	PF00400	0.455
TRG_NES_CRM1_1	574	589	PF08389	0.331
TRG_NLS_MonoExtN_4	463	469	PF00514	0.318
TRG_NLS_MonoExtN_4	60	67	PF00514	0.458
TRG_Pf-PMV_PEXEL_1	295	300	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYR2	Leptomonas seymouri	74%	100%
A0A0S4JKI3	Bodo saltans	54%	100%
A0A1X0NSY5	Trypanosomatidae	62%	100%
A0A3S5H702	Leishmania donovani	90%	100%
A0A422NXR8	Trypanosoma rangeli	61%	100%
A4H8X8	Leishmania braziliensis	81%	98%
A4HXA2	Leishmania infantum	90%	100%
A8NZY7	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	40%	98%
C9ZTX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
Q4QEF9	Leishmania major	88%	99%
Q5BF62	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	37%	92%
Q6CWM0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	38%	99%
Q9T0J6	Arabidopsis thaliana	41%	96%