LeishMANIAdb
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Sm domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Sm domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AQZ9_LEIMU
TriTrypDb:
LmxM.17.0300
Length:
202

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQZ9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQZ9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 9 13 PF00656 0.733
CLV_NRD_NRD_1 186 188 PF00675 0.484
CLV_NRD_NRD_1 70 72 PF00675 0.255
CLV_PCSK_FUR_1 186 190 PF00082 0.474
CLV_PCSK_KEX2_1 186 188 PF00082 0.535
CLV_PCSK_KEX2_1 70 72 PF00082 0.256
CLV_PCSK_PC1ET2_1 188 190 PF00082 0.568
CLV_PCSK_SKI1_1 79 83 PF00082 0.248
DEG_Nend_UBRbox_1 1 4 PF02207 0.582
DOC_USP7_MATH_1 33 37 PF00917 0.660
LIG_14-3-3_CanoR_1 70 76 PF00244 0.556
LIG_14-3-3_CanoR_1 91 101 PF00244 0.549
LIG_Clathr_ClatBox_1 53 57 PF01394 0.446
LIG_FHA_1 109 115 PF00498 0.588
LIG_FHA_1 24 30 PF00498 0.643
LIG_LIR_Gen_1 162 171 PF02991 0.563
LIG_LIR_Gen_1 57 68 PF02991 0.530
LIG_Pex14_2 132 136 PF04695 0.530
LIG_SH2_SRC 47 50 PF00017 0.370
LIG_SH2_STAT5 120 123 PF00017 0.435
LIG_SH2_STAT5 125 128 PF00017 0.435
LIG_SH2_STAT5 47 50 PF00017 0.435
MOD_CK1_1 11 17 PF00069 0.624
MOD_CK1_1 149 155 PF00069 0.616
MOD_CK1_1 162 168 PF00069 0.446
MOD_CK1_1 27 33 PF00069 0.529
MOD_CK2_1 107 113 PF00069 0.546
MOD_CK2_1 83 89 PF00069 0.459
MOD_GlcNHglycan 148 151 PF01048 0.609
MOD_GlcNHglycan 154 157 PF01048 0.478
MOD_GlcNHglycan 161 164 PF01048 0.466
MOD_GlcNHglycan 21 24 PF01048 0.740
MOD_GSK3_1 121 128 PF00069 0.494
MOD_GSK3_1 142 149 PF00069 0.695
MOD_GSK3_1 19 26 PF00069 0.603
MOD_GSK3_1 27 34 PF00069 0.537
MOD_NEK2_1 167 172 PF00069 0.545
MOD_NEK2_1 24 29 PF00069 0.578
MOD_NEK2_1 92 97 PF00069 0.595
MOD_PIKK_1 83 89 PF00454 0.459
MOD_Plk_4 121 127 PF00069 0.451
TRG_DiLeu_BaLyEn_6 88 93 PF01217 0.450
TRG_ENDOCYTIC_2 60 63 PF00928 0.530
TRG_ER_diArg_1 116 119 PF00400 0.450
TRG_ER_diArg_1 180 183 PF00400 0.501
TRG_ER_diArg_1 186 189 PF00400 0.505
TRG_ER_diArg_1 69 71 PF00400 0.521

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HUV2 Leptomonas seymouri 50% 77%
A0A1X0NSZ2 Trypanosomatidae 37% 91%
A0A3S7WUC9 Leishmania donovani 91% 100%
A0A422N3W3 Trypanosoma rangeli 37% 76%
A4H8X3 Leishmania braziliensis 75% 100%
A4HX97 Leishmania infantum 92% 100%
C9ZTX0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 98%
Q4QEG4 Leishmania major 92% 100%
V5BH99 Trypanosoma cruzi 36% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS