Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQZ5_LEIMU

TriTrypDb:

LmxM.17.0260

Length:

783

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQZ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.545
CLV_NRD_NRD_1	102	104	PF00675	0.554
CLV_NRD_NRD_1	188	190	PF00675	0.541
CLV_NRD_NRD_1	212	214	PF00675	0.409
CLV_NRD_NRD_1	230	232	PF00675	0.677
CLV_NRD_NRD_1	248	250	PF00675	0.413
CLV_NRD_NRD_1	337	339	PF00675	0.702
CLV_NRD_NRD_1	536	538	PF00675	0.567
CLV_NRD_NRD_1	610	612	PF00675	0.581
CLV_PCSK_KEX2_1	102	104	PF00082	0.554
CLV_PCSK_KEX2_1	188	190	PF00082	0.637
CLV_PCSK_KEX2_1	212	214	PF00082	0.388
CLV_PCSK_KEX2_1	248	250	PF00082	0.562
CLV_PCSK_KEX2_1	337	339	PF00082	0.702
CLV_PCSK_KEX2_1	536	538	PF00082	0.613
CLV_PCSK_KEX2_1	610	612	PF00082	0.581
CLV_PCSK_SKI1_1	117	121	PF00082	0.591
CLV_PCSK_SKI1_1	17	21	PF00082	0.675
CLV_PCSK_SKI1_1	232	236	PF00082	0.689
CLV_PCSK_SKI1_1	493	497	PF00082	0.736
CLV_PCSK_SKI1_1	524	528	PF00082	0.632
CLV_PCSK_SKI1_1	536	540	PF00082	0.483
CLV_PCSK_SKI1_1	596	600	PF00082	0.541
CLV_PCSK_SKI1_1	737	741	PF00082	0.560
CLV_PCSK_SKI1_1	758	762	PF00082	0.538
CLV_Separin_Metazoa	521	525	PF03568	0.640
DEG_SCF_FBW7_1	346	353	PF00400	0.750
DEG_SCF_FBW7_1	381	388	PF00400	0.681
DEG_SCF_FBW7_2	83	89	PF00400	0.730
DEG_SPOP_SBC_1	441	445	PF00917	0.541
DEG_SPOP_SBC_1	67	71	PF00917	0.605
DOC_ANK_TNKS_1	187	194	PF00023	0.527
DOC_ANK_TNKS_1	679	686	PF00023	0.602
DOC_CKS1_1	159	164	PF01111	0.649
DOC_CKS1_1	553	558	PF01111	0.533
DOC_CKS1_1	77	82	PF01111	0.727
DOC_CKS1_1	83	88	PF01111	0.704
DOC_CYCLIN_RxL_1	532	545	PF00134	0.625
DOC_MAPK_gen_1	337	343	PF00069	0.697
DOC_MAPK_gen_1	456	465	PF00069	0.813
DOC_PP1_RVXF_1	761	768	PF00149	0.639
DOC_PP2B_LxvP_1	120	123	PF13499	0.723
DOC_PP2B_LxvP_1	20	23	PF13499	0.686
DOC_PP2B_LxvP_1	325	328	PF13499	0.730
DOC_PP2B_LxvP_1	343	346	PF13499	0.597
DOC_PP2B_LxvP_1	92	95	PF13499	0.517
DOC_PP4_FxxP_1	704	707	PF00568	0.580
DOC_USP7_MATH_1	121	125	PF00917	0.722
DOC_USP7_MATH_1	257	261	PF00917	0.618
DOC_USP7_MATH_1	3	7	PF00917	0.629
DOC_USP7_MATH_1	312	316	PF00917	0.664
DOC_USP7_MATH_1	350	354	PF00917	0.759
DOC_USP7_MATH_1	358	362	PF00917	0.795
DOC_USP7_MATH_1	375	379	PF00917	0.539
DOC_USP7_MATH_1	428	432	PF00917	0.671
DOC_USP7_MATH_1	441	445	PF00917	0.640
DOC_USP7_MATH_1	510	514	PF00917	0.777
DOC_USP7_MATH_1	55	59	PF00917	0.730
DOC_USP7_MATH_1	564	568	PF00917	0.821
DOC_USP7_MATH_1	580	584	PF00917	0.681
DOC_USP7_MATH_1	588	592	PF00917	0.753
DOC_USP7_MATH_1	694	698	PF00917	0.768
DOC_WW_Pin1_4	103	108	PF00397	0.725
DOC_WW_Pin1_4	127	132	PF00397	0.737
DOC_WW_Pin1_4	158	163	PF00397	0.690
DOC_WW_Pin1_4	264	269	PF00397	0.546
DOC_WW_Pin1_4	286	291	PF00397	0.743
DOC_WW_Pin1_4	30	35	PF00397	0.675
DOC_WW_Pin1_4	323	328	PF00397	0.675
DOC_WW_Pin1_4	341	346	PF00397	0.803
DOC_WW_Pin1_4	37	42	PF00397	0.687
DOC_WW_Pin1_4	381	386	PF00397	0.674
DOC_WW_Pin1_4	471	476	PF00397	0.710
DOC_WW_Pin1_4	500	505	PF00397	0.763
DOC_WW_Pin1_4	552	557	PF00397	0.644
DOC_WW_Pin1_4	571	576	PF00397	0.722
DOC_WW_Pin1_4	630	635	PF00397	0.675
DOC_WW_Pin1_4	639	644	PF00397	0.690
DOC_WW_Pin1_4	690	695	PF00397	0.716
DOC_WW_Pin1_4	720	725	PF00397	0.502
DOC_WW_Pin1_4	76	81	PF00397	0.829
DOC_WW_Pin1_4	82	87	PF00397	0.708
DOC_WW_Pin1_4	96	101	PF00397	0.506
LIG_14-3-3_CanoR_1	105	111	PF00244	0.738
LIG_14-3-3_CanoR_1	291	300	PF00244	0.581
LIG_14-3-3_CanoR_1	408	412	PF00244	0.744
LIG_14-3-3_CanoR_1	459	464	PF00244	0.734
LIG_14-3-3_CanoR_1	502	508	PF00244	0.548
LIG_14-3-3_CanoR_1	546	556	PF00244	0.707
LIG_14-3-3_CanoR_1	581	590	PF00244	0.538
LIG_14-3-3_CanoR_1	610	614	PF00244	0.612
LIG_14-3-3_CanoR_1	680	684	PF00244	0.671
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BIR_III_4	154	158	PF00653	0.823
LIG_BRCT_BRCA1_1	566	570	PF00533	0.745
LIG_CaM_IQ_9	224	239	PF13499	0.390
LIG_CaM_IQ_9	538	554	PF13499	0.688
LIG_eIF4E_1	110	116	PF01652	0.609
LIG_FHA_1	51	57	PF00498	0.708
LIG_FHA_1	553	559	PF00498	0.730
LIG_FHA_1	640	646	PF00498	0.721
LIG_FHA_1	67	73	PF00498	0.722
LIG_FHA_1	725	731	PF00498	0.698
LIG_FHA_2	660	666	PF00498	0.811
LIG_FHA_2	746	752	PF00498	0.560
LIG_GBD_Chelix_1	403	411	PF00786	0.530
LIG_LIR_Gen_1	384	393	PF02991	0.655
LIG_LIR_Gen_1	567	576	PF02991	0.532
LIG_LIR_Nem_3	384	390	PF02991	0.608
LIG_LIR_Nem_3	567	573	PF02991	0.537
LIG_LIR_Nem_3	734	739	PF02991	0.585
LIG_LIR_Nem_3	754	760	PF02991	0.317
LIG_LIR_Nem_3	766	770	PF02991	0.550
LIG_SH2_CRK	736	740	PF00017	0.668
LIG_SH2_CRK	757	761	PF00017	0.572
LIG_SH3_2	270	275	PF14604	0.719
LIG_SH3_2	332	337	PF14604	0.832
LIG_SH3_2	412	417	PF14604	0.521
LIG_SH3_2	576	581	PF14604	0.749
LIG_SH3_3	172	178	PF00018	0.822
LIG_SH3_3	179	185	PF00018	0.658
LIG_SH3_3	267	273	PF00018	0.711
LIG_SH3_3	321	327	PF00018	0.690
LIG_SH3_3	329	335	PF00018	0.790
LIG_SH3_3	409	415	PF00018	0.522
LIG_SH3_3	469	475	PF00018	0.655
LIG_SH3_3	49	55	PF00018	0.813
LIG_SH3_3	498	504	PF00018	0.734
LIG_SH3_3	570	576	PF00018	0.703
LIG_SH3_3	587	593	PF00018	0.530
LIG_SH3_3	628	634	PF00018	0.492
LIG_SH3_3	80	86	PF00018	0.722
LIG_SH3_4	299	306	PF00018	0.734
LIG_SUMO_SIM_anti_2	461	469	PF11976	0.719
LIG_SUMO_SIM_par_1	18	25	PF11976	0.708
LIG_SUMO_SIM_par_1	659	667	PF11976	0.737
LIG_TRAF2_1	485	488	PF00917	0.711
LIG_TRAF2_1	612	615	PF00917	0.684
LIG_TRAF2_1	707	710	PF00917	0.596
LIG_TRAF2_1	748	751	PF00917	0.578
LIG_WW_3	574	578	PF00397	0.610
LIG_WW_3	93	97	PF00397	0.714
MOD_CDC14_SPxK_1	574	577	PF00782	0.780
MOD_CDC14_SPxK_1	578	581	PF00782	0.805
MOD_CDC14_SPxK_1	99	102	PF00782	0.596
MOD_CDK_SPK_2	286	291	PF00069	0.528
MOD_CDK_SPxK_1	346	352	PF00069	0.536
MOD_CDK_SPxK_1	571	577	PF00069	0.695
MOD_CDK_SPxK_1	96	102	PF00069	0.601
MOD_CDK_SPxxK_3	37	44	PF00069	0.537
MOD_CDK_SPxxK_3	96	103	PF00069	0.762
MOD_CK1_1	106	112	PF00069	0.732
MOD_CK1_1	136	142	PF00069	0.761
MOD_CK1_1	289	295	PF00069	0.675
MOD_CK1_1	30	36	PF00069	0.537
MOD_CK1_1	315	321	PF00069	0.735
MOD_CK1_1	361	367	PF00069	0.788
MOD_CK1_1	368	374	PF00069	0.702
MOD_CK1_1	439	445	PF00069	0.829
MOD_CK1_1	447	453	PF00069	0.693
MOD_CK1_1	458	464	PF00069	0.604
MOD_CK1_1	50	56	PF00069	0.682
MOD_CK1_1	503	509	PF00069	0.546
MOD_CK1_1	513	519	PF00069	0.605
MOD_CK1_1	528	534	PF00069	0.681
MOD_CK1_1	545	551	PF00069	0.534
MOD_CK1_1	562	568	PF00069	0.672
MOD_CK1_1	571	577	PF00069	0.815
MOD_CK1_1	59	65	PF00069	0.754
MOD_CK1_1	591	597	PF00069	0.645
MOD_CK1_1	609	615	PF00069	0.378
MOD_CK2_1	227	233	PF00069	0.608
MOD_CK2_1	609	615	PF00069	0.681
MOD_CK2_1	659	665	PF00069	0.738
MOD_CK2_1	745	751	PF00069	0.483
MOD_DYRK1A_RPxSP_1	96	100	PF00069	0.837
MOD_GlcNHglycan	127	130	PF01048	0.728
MOD_GlcNHglycan	154	158	PF01048	0.823
MOD_GlcNHglycan	197	200	PF01048	0.526
MOD_GlcNHglycan	264	267	PF01048	0.554
MOD_GlcNHglycan	293	296	PF01048	0.631
MOD_GlcNHglycan	305	308	PF01048	0.789
MOD_GlcNHglycan	312	315	PF01048	0.624
MOD_GlcNHglycan	320	323	PF01048	0.563
MOD_GlcNHglycan	346	349	PF01048	0.529
MOD_GlcNHglycan	352	355	PF01048	0.736
MOD_GlcNHglycan	360	363	PF01048	0.717
MOD_GlcNHglycan	373	376	PF01048	0.727
MOD_GlcNHglycan	377	380	PF01048	0.723
MOD_GlcNHglycan	430	433	PF01048	0.539
MOD_GlcNHglycan	512	515	PF01048	0.714
MOD_GlcNHglycan	564	567	PF01048	0.800
MOD_GlcNHglycan	57	61	PF01048	0.721
MOD_GlcNHglycan	584	587	PF01048	0.765
MOD_GlcNHglycan	681	684	PF01048	0.559
MOD_GlcNHglycan	694	697	PF01048	0.598
MOD_GlcNHglycan	724	727	PF01048	0.601
MOD_GSK3_1	121	128	PF00069	0.756
MOD_GSK3_1	136	143	PF00069	0.752
MOD_GSK3_1	153	160	PF00069	0.581
MOD_GSK3_1	276	283	PF00069	0.729
MOD_GSK3_1	28	35	PF00069	0.809
MOD_GSK3_1	303	310	PF00069	0.815
MOD_GSK3_1	314	321	PF00069	0.571
MOD_GSK3_1	346	353	PF00069	0.750
MOD_GSK3_1	361	368	PF00069	0.787
MOD_GSK3_1	371	378	PF00069	0.721
MOD_GSK3_1	381	388	PF00069	0.484
MOD_GSK3_1	436	443	PF00069	0.785
MOD_GSK3_1	444	451	PF00069	0.597
MOD_GSK3_1	455	462	PF00069	0.818
MOD_GSK3_1	496	503	PF00069	0.821
MOD_GSK3_1	528	535	PF00069	0.572
MOD_GSK3_1	548	555	PF00069	0.526
MOD_GSK3_1	55	62	PF00069	0.700
MOD_GSK3_1	562	569	PF00069	0.711
MOD_GSK3_1	571	578	PF00069	0.823
MOD_GSK3_1	646	653	PF00069	0.729
MOD_GSK3_1	690	697	PF00069	0.686
MOD_GSK3_1	720	727	PF00069	0.591
MOD_N-GLC_1	133	138	PF02516	0.761
MOD_N-GLC_1	307	312	PF02516	0.602
MOD_N-GLC_1	445	450	PF02516	0.838
MOD_N-GLC_1	47	52	PF02516	0.744
MOD_N-GLC_1	532	537	PF02516	0.618
MOD_NEK2_1	133	138	PF00069	0.703
MOD_NEK2_1	140	145	PF00069	0.709
MOD_NEK2_1	170	175	PF00069	0.645
MOD_NEK2_1	363	368	PF00069	0.679
MOD_NEK2_1	407	412	PF00069	0.730
MOD_NEK2_1	496	501	PF00069	0.819
MOD_NEK2_1	547	552	PF00069	0.802
MOD_NEK2_1	637	642	PF00069	0.750
MOD_PIKK_1	177	183	PF00454	0.613
MOD_PIKK_1	284	290	PF00454	0.818
MOD_PIKK_1	496	502	PF00454	0.843
MOD_PIKK_1	540	546	PF00454	0.601
MOD_PIKK_1	548	554	PF00454	0.734
MOD_PIKK_1	559	565	PF00454	0.529
MOD_PIKK_1	588	594	PF00454	0.703
MOD_PIKK_1	724	730	PF00454	0.682
MOD_PIKK_1	751	757	PF00454	0.585
MOD_PK_1	459	465	PF00069	0.814
MOD_PK_1	491	497	PF00069	0.727
MOD_PKA_1	212	218	PF00069	0.377
MOD_PKA_2	212	218	PF00069	0.545
MOD_PKA_2	336	342	PF00069	0.783
MOD_PKA_2	358	364	PF00069	0.648
MOD_PKA_2	407	413	PF00069	0.745
MOD_PKA_2	439	445	PF00069	0.758
MOD_PKA_2	455	461	PF00069	0.726
MOD_PKA_2	545	551	PF00069	0.676
MOD_PKA_2	580	586	PF00069	0.756
MOD_PKA_2	609	615	PF00069	0.558
MOD_PKA_2	679	685	PF00069	0.639
MOD_Plk_1	133	139	PF00069	0.713
MOD_Plk_1	364	370	PF00069	0.804
MOD_Plk_1	448	454	PF00069	0.786
MOD_Plk_1	47	53	PF00069	0.780
MOD_Plk_4	111	117	PF00069	0.752
MOD_Plk_4	3	9	PF00069	0.683
MOD_Plk_4	315	321	PF00069	0.527
MOD_Plk_4	368	374	PF00069	0.655
MOD_Plk_4	461	467	PF00069	0.722
MOD_Plk_4	68	74	PF00069	0.819
MOD_ProDKin_1	103	109	PF00069	0.723
MOD_ProDKin_1	127	133	PF00069	0.737
MOD_ProDKin_1	158	164	PF00069	0.691
MOD_ProDKin_1	264	270	PF00069	0.546
MOD_ProDKin_1	286	292	PF00069	0.583
MOD_ProDKin_1	30	36	PF00069	0.676
MOD_ProDKin_1	323	329	PF00069	0.671
MOD_ProDKin_1	341	347	PF00069	0.803
MOD_ProDKin_1	37	43	PF00069	0.690
MOD_ProDKin_1	381	387	PF00069	0.674
MOD_ProDKin_1	471	477	PF00069	0.717
MOD_ProDKin_1	500	506	PF00069	0.763
MOD_ProDKin_1	552	558	PF00069	0.645
MOD_ProDKin_1	571	577	PF00069	0.726
MOD_ProDKin_1	630	636	PF00069	0.676
MOD_ProDKin_1	639	645	PF00069	0.692
MOD_ProDKin_1	690	696	PF00069	0.711
MOD_ProDKin_1	720	726	PF00069	0.496
MOD_ProDKin_1	76	82	PF00069	0.830
MOD_ProDKin_1	96	102	PF00069	0.508
MOD_SUMO_rev_2	751	760	PF00179	0.576
TRG_DiLeu_BaEn_3	614	620	PF01217	0.391
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.726
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.818
TRG_ENDOCYTIC_2	736	739	PF00928	0.520
TRG_ENDOCYTIC_2	757	760	PF00928	0.544
TRG_ER_diArg_1	102	105	PF00400	0.749
TRG_ER_diArg_1	188	190	PF00400	0.541
TRG_ER_diArg_1	211	213	PF00400	0.391
TRG_ER_diArg_1	248	251	PF00400	0.581
TRG_NES_CRM1_1	233	247	PF08389	0.613
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	537	542	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4I6	Leptomonas seymouri	34%	85%
A0A3S7WUB6	Leishmania donovani	81%	100%
A4H8W9	Leishmania braziliensis	59%	100%
A4HX93	Leishmania infantum	81%	100%
Q4QEG8	Leishmania major	82%	99%