Kinesin motor domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin motor domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQZ1_LEIMU

TriTrypDb:

LmxM.17.0160

Length:

1100

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

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Cellular components
Term	Name	Level	Count
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AQZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQZ1

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	5
GO:0007018	microtubule-based movement	3	5
GO:0009987	cellular process	1	5

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003774	cytoskeletal motor activity	1	5
GO:0003777	microtubule motor activity	2	5
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	5
GO:0005515	protein binding	2	5
GO:0005524	ATP binding	5	5
GO:0008017	microtubule binding	5	5
GO:0008092	cytoskeletal protein binding	3	5
GO:0015631	tubulin binding	4	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.524
CLV_C14_Caspase3-7	31	35	PF00656	0.460
CLV_NRD_NRD_1	1012	1014	PF00675	0.778
CLV_NRD_NRD_1	1015	1017	PF00675	0.770
CLV_NRD_NRD_1	192	194	PF00675	0.524
CLV_NRD_NRD_1	288	290	PF00675	0.399
CLV_NRD_NRD_1	451	453	PF00675	0.524
CLV_NRD_NRD_1	568	570	PF00675	0.614
CLV_NRD_NRD_1	66	68	PF00675	0.524
CLV_NRD_NRD_1	670	672	PF00675	0.791

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H700	Leishmania donovani	83%	100%
A4HX89	Leishmania infantum	83%	100%
Q4QEH2	Leishmania major	81%	100%

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