Cilia- and flagella-associated protein 206

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQZ0_LEIMU

TriTrypDb:

LmxM.17.0150

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005856	cytoskeleton	5	4
GO:0005929	cilium	4	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043228	non-membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043232	intracellular non-membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4

Expansion

Sequence features

E9AQZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQZ0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	4
GO:0016043	cellular component organization	3	4
GO:0030030	cell projection organization	4	4
GO:0071840	cellular component organization or biogenesis	2	4

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	47	51	PF00656	0.440
CLV_NRD_NRD_1	313	315	PF00675	0.369
CLV_NRD_NRD_1	338	340	PF00675	0.512
CLV_NRD_NRD_1	347	349	PF00675	0.507
CLV_NRD_NRD_1	384	386	PF00675	0.556
CLV_PCSK_KEX2_1	313	315	PF00082	0.369
CLV_PCSK_KEX2_1	338	340	PF00082	0.512
CLV_PCSK_SKI1_1	314	318	PF00082	0.389
CLV_PCSK_SKI1_1	39	43	PF00082	0.494
CLV_PCSK_SKI1_1	70	74	PF00082	0.479
CLV_Separin_Metazoa	257	261	PF03568	0.505
DEG_SPOP_SBC_1	103	107	PF00917	0.409
DOC_CYCLIN_RxL_1	205	219	PF00134	0.426
DOC_CYCLIN_RxL_1	254	265	PF00134	0.508
DOC_MAPK_gen_1	123	132	PF00069	0.448
DOC_MAPK_gen_1	133	140	PF00069	0.371
DOC_MAPK_gen_1	313	319	PF00069	0.375
DOC_PP1_RVXF_1	209	216	PF00149	0.410
DOC_PP2B_LxvP_1	175	178	PF13499	0.498
DOC_USP7_MATH_1	11	15	PF00917	0.688
DOC_USP7_MATH_1	111	115	PF00917	0.406
DOC_USP7_MATH_1	16	20	PF00917	0.636
DOC_USP7_MATH_1	72	76	PF00917	0.488
DOC_USP7_MATH_1	99	103	PF00917	0.542
DOC_USP7_MATH_2	182	188	PF00917	0.473
DOC_WW_Pin1_4	186	191	PF00397	0.590
DOC_WW_Pin1_4	19	24	PF00397	0.757
LIG_14-3-3_CanoR_1	326	335	PF00244	0.507
LIG_14-3-3_CanoR_1	374	384	PF00244	0.439
LIG_14-3-3_CanoR_1	70	79	PF00244	0.507
LIG_AP2alpha_2	229	231	PF02296	0.372
LIG_eIF4E_1	161	167	PF01652	0.414
LIG_FHA_1	104	110	PF00498	0.367
LIG_FHA_1	170	176	PF00498	0.533
LIG_FHA_1	272	278	PF00498	0.574
LIG_FHA_1	292	298	PF00498	0.569
LIG_FHA_1	330	336	PF00498	0.557
LIG_FHA_1	376	382	PF00498	0.439
LIG_FHA_2	341	347	PF00498	0.553
LIG_FHA_2	353	359	PF00498	0.452
LIG_FHA_2	84	90	PF00498	0.611
LIG_GBD_Chelix_1	269	277	PF00786	0.583
LIG_Integrin_RGD_1	254	256	PF01839	0.382
LIG_KLC1_Yacidic_2	261	265	PF13176	0.535
LIG_LIR_Gen_1	63	72	PF02991	0.373
LIG_LIR_Nem_3	229	234	PF02991	0.496
LIG_LIR_Nem_3	63	68	PF02991	0.408
LIG_Pex14_2	306	310	PF04695	0.432
LIG_PTB_Apo_2	299	306	PF02174	0.379
LIG_PTB_Phospho_1	299	305	PF10480	0.388
LIG_SH2_CRK	161	165	PF00017	0.404
LIG_SH2_GRB2like	300	303	PF00017	0.445
LIG_SH2_SRC	233	236	PF00017	0.487
LIG_SH2_SRC	263	266	PF00017	0.541
LIG_SH2_SRC	300	303	PF00017	0.484
LIG_SH2_STAP1	377	381	PF00017	0.493
LIG_SH2_STAP1	79	83	PF00017	0.619
LIG_SH2_STAT5	161	164	PF00017	0.436
LIG_SH2_STAT5	214	217	PF00017	0.404
LIG_SH2_STAT5	233	236	PF00017	0.366
LIG_SH2_STAT5	263	266	PF00017	0.527
LIG_SH2_STAT5	300	303	PF00017	0.484
LIG_SH2_STAT5	305	308	PF00017	0.395
LIG_SH2_STAT5	369	372	PF00017	0.431
LIG_SH2_STAT5	377	380	PF00017	0.447
LIG_TRAF2_1	87	90	PF00917	0.505
MOD_CDC14_SPxK_1	189	192	PF00782	0.578
MOD_CDK_SPxK_1	186	192	PF00069	0.587
MOD_CK1_1	102	108	PF00069	0.430
MOD_CK1_1	119	125	PF00069	0.394
MOD_CK1_1	15	21	PF00069	0.618
MOD_CK1_1	183	189	PF00069	0.582
MOD_CK1_1	191	197	PF00069	0.422
MOD_CK1_1	289	295	PF00069	0.629
MOD_CK1_1	329	335	PF00069	0.488
MOD_CK1_1	63	69	PF00069	0.359
MOD_CK2_1	376	382	PF00069	0.439
MOD_CK2_1	83	89	PF00069	0.514
MOD_CMANNOS	307	310	PF00535	0.387
MOD_GlcNHglycan	106	109	PF01048	0.446
MOD_GlcNHglycan	112	116	PF01048	0.409
MOD_GlcNHglycan	14	17	PF01048	0.660
MOD_GlcNHglycan	18	21	PF01048	0.659
MOD_GlcNHglycan	199	203	PF01048	0.503
MOD_GlcNHglycan	278	281	PF01048	0.619
MOD_GlcNHglycan	378	381	PF01048	0.452
MOD_GlcNHglycan	74	77	PF01048	0.561
MOD_GSK3_1	11	18	PF00069	0.603
MOD_GSK3_1	139	146	PF00069	0.512
MOD_GSK3_1	180	187	PF00069	0.605
MOD_GSK3_1	272	279	PF00069	0.666
MOD_GSK3_1	348	355	PF00069	0.565
MOD_GSK3_1	60	67	PF00069	0.596
MOD_GSK3_1	79	86	PF00069	0.528
MOD_GSK3_1	99	106	PF00069	0.451
MOD_NEK2_1	185	190	PF00069	0.528
MOD_NEK2_1	373	378	PF00069	0.463
MOD_NEK2_1	64	69	PF00069	0.447
MOD_PIKK_1	289	295	PF00454	0.533
MOD_PIKK_1	327	333	PF00454	0.493
MOD_PIKK_1	340	346	PF00454	0.507
MOD_PIKK_1	358	364	PF00454	0.592
MOD_PKA_1	348	354	PF00069	0.564
MOD_PKA_2	169	175	PF00069	0.533
MOD_PKA_2	271	277	PF00069	0.580
MOD_PKA_2	286	292	PF00069	0.610
MOD_PKA_2	373	379	PF00069	0.456
MOD_Plk_1	111	117	PF00069	0.338
MOD_Plk_1	60	66	PF00069	0.384
MOD_Plk_1	79	85	PF00069	0.539
MOD_Plk_2-3	352	358	PF00069	0.465
MOD_Plk_4	246	252	PF00069	0.485
MOD_Plk_4	296	302	PF00069	0.516
MOD_Plk_4	60	66	PF00069	0.506
MOD_ProDKin_1	186	192	PF00069	0.587
MOD_ProDKin_1	19	25	PF00069	0.756
TRG_DiLeu_BaEn_1	112	117	PF01217	0.428
TRG_DiLeu_BaEn_4	89	95	PF01217	0.529
TRG_ENDOCYTIC_2	161	164	PF00928	0.395
TRG_ENDOCYTIC_2	214	217	PF00928	0.363
TRG_ER_diArg_1	123	126	PF00400	0.458
TRG_ER_diArg_1	312	314	PF00400	0.354
TRG_ER_diArg_1	337	339	PF00400	0.535
TRG_Pf-PMV_PEXEL_1	260	265	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A422NFB1	Trypanosoma rangeli	37%	100%
A4HXB1	Leishmania infantum	93%	97%