Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AQY8_LEIMU

TriTrypDb:

LmxM.17.0130

Length:

867

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	578	582	PF00656	0.451
CLV_C14_Caspase3-7	817	821	PF00656	0.625
CLV_MEL_PAP_1	500	506	PF00089	0.674
CLV_NRD_NRD_1	141	143	PF00675	0.482
CLV_NRD_NRD_1	390	392	PF00675	0.409
CLV_NRD_NRD_1	435	437	PF00675	0.496
CLV_NRD_NRD_1	638	640	PF00675	0.577
CLV_NRD_NRD_1	709	711	PF00675	0.536
CLV_NRD_NRD_1	719	721	PF00675	0.526
CLV_NRD_NRD_1	732	734	PF00675	0.465
CLV_NRD_NRD_1	740	742	PF00675	0.579
CLV_NRD_NRD_1	790	792	PF00675	0.626
CLV_NRD_NRD_1	832	834	PF00675	0.522
CLV_PCSK_FUR_1	707	711	PF00082	0.473
CLV_PCSK_FUR_1	738	742	PF00082	0.569
CLV_PCSK_FUR_1	829	833	PF00082	0.538
CLV_PCSK_KEX2_1	141	143	PF00082	0.482
CLV_PCSK_KEX2_1	390	392	PF00082	0.427
CLV_PCSK_KEX2_1	435	437	PF00082	0.496
CLV_PCSK_KEX2_1	638	640	PF00082	0.629
CLV_PCSK_KEX2_1	709	711	PF00082	0.567
CLV_PCSK_KEX2_1	719	721	PF00082	0.513
CLV_PCSK_KEX2_1	730	732	PF00082	0.473
CLV_PCSK_KEX2_1	740	742	PF00082	0.582
CLV_PCSK_KEX2_1	790	792	PF00082	0.626
CLV_PCSK_KEX2_1	829	831	PF00082	0.531
CLV_PCSK_KEX2_1	832	834	PF00082	0.522
CLV_PCSK_PC1ET2_1	719	721	PF00082	0.560
CLV_PCSK_PC1ET2_1	730	732	PF00082	0.433
CLV_PCSK_PC7_1	705	711	PF00082	0.478
CLV_PCSK_SKI1_1	163	167	PF00082	0.499
CLV_PCSK_SKI1_1	249	253	PF00082	0.505
CLV_PCSK_SKI1_1	410	414	PF00082	0.382
CLV_PCSK_SKI1_1	570	574	PF00082	0.498
CLV_PCSK_SKI1_1	657	661	PF00082	0.571
CLV_PCSK_SKI1_1	720	724	PF00082	0.406
CLV_PCSK_SKI1_1	850	854	PF00082	0.641
DEG_APCC_DBOX_1	790	798	PF00400	0.567
DEG_Nend_UBRbox_1	1	4	PF02207	0.494
DEG_SPOP_SBC_1	103	107	PF00917	0.374
DOC_CDC14_PxL_1	217	225	PF14671	0.473
DOC_MAPK_gen_1	141	149	PF00069	0.473
DOC_MAPK_gen_1	535	543	PF00069	0.468
DOC_MAPK_MEF2A_6	141	148	PF00069	0.535
DOC_MAPK_MEF2A_6	535	543	PF00069	0.468
DOC_MAPK_MEF2A_6	87	96	PF00069	0.470
DOC_MAPK_NFAT4_5	141	149	PF00069	0.537
DOC_PP1_RVXF_1	408	414	PF00149	0.353
DOC_PP2B_LxvP_1	336	339	PF13499	0.600
DOC_PP2B_PxIxI_1	538	544	PF00149	0.395
DOC_PP4_FxxP_1	180	183	PF00568	0.612
DOC_PP4_FxxP_1	53	56	PF00568	0.532
DOC_USP7_MATH_1	102	106	PF00917	0.400
DOC_USP7_MATH_1	190	194	PF00917	0.551
DOC_USP7_MATH_1	245	249	PF00917	0.583
DOC_USP7_MATH_1	274	278	PF00917	0.392
DOC_USP7_MATH_1	312	316	PF00917	0.548
DOC_USP7_MATH_1	331	335	PF00917	0.533
DOC_USP7_MATH_1	40	44	PF00917	0.704
DOC_USP7_MATH_1	450	454	PF00917	0.715
DOC_USP7_MATH_1	499	503	PF00917	0.475
DOC_USP7_MATH_1	526	530	PF00917	0.611
DOC_USP7_MATH_1	577	581	PF00917	0.496
DOC_USP7_MATH_1	588	592	PF00917	0.367
DOC_USP7_MATH_1	622	626	PF00917	0.619
DOC_USP7_MATH_1	812	816	PF00917	0.556
DOC_WW_Pin1_4	175	180	PF00397	0.605
DOC_WW_Pin1_4	186	191	PF00397	0.506
DOC_WW_Pin1_4	225	230	PF00397	0.556
DOC_WW_Pin1_4	25	30	PF00397	0.501
DOC_WW_Pin1_4	334	339	PF00397	0.544
DOC_WW_Pin1_4	384	389	PF00397	0.481
DOC_WW_Pin1_4	461	466	PF00397	0.523
DOC_WW_Pin1_4	661	666	PF00397	0.580
DOC_WW_Pin1_4	695	700	PF00397	0.623
DOC_WW_Pin1_4	803	808	PF00397	0.533
LIG_14-3-3_CanoR_1	116	126	PF00244	0.455
LIG_14-3-3_CanoR_1	436	444	PF00244	0.534
LIG_14-3-3_CanoR_1	609	619	PF00244	0.541
LIG_14-3-3_CanoR_1	692	699	PF00244	0.670
LIG_14-3-3_CanoR_1	720	725	PF00244	0.378
LIG_14-3-3_CanoR_1	850	855	PF00244	0.639
LIG_14-3-3_CanoR_1	87	95	PF00244	0.355
LIG_Actin_WH2_2	402	418	PF00022	0.356
LIG_Actin_WH2_2	539	555	PF00022	0.469
LIG_AP2alpha_2	538	540	PF02296	0.487
LIG_APCC_ABBA_1	94	99	PF00400	0.409
LIG_BRCT_BRCA1_1	221	225	PF00533	0.483
LIG_BRCT_BRCA1_1	325	329	PF00533	0.621
LIG_BRCT_BRCA1_1	44	48	PF00533	0.583
LIG_BRCT_BRCA1_1	588	592	PF00533	0.421
LIG_CaM_IQ_9	402	418	PF13499	0.395
LIG_FHA_1	154	160	PF00498	0.495
LIG_FHA_1	214	220	PF00498	0.628
LIG_FHA_1	233	239	PF00498	0.510
LIG_FHA_1	384	390	PF00498	0.617
LIG_FHA_1	438	444	PF00498	0.537
LIG_FHA_1	80	86	PF00498	0.705
LIG_FHA_2	342	348	PF00498	0.629
LIG_FHA_2	643	649	PF00498	0.486
LIG_FHA_2	70	76	PF00498	0.586
LIG_FHA_2	791	797	PF00498	0.615
LIG_FHA_2	851	857	PF00498	0.642
LIG_LIR_Apic_2	131	135	PF02991	0.442
LIG_LIR_Apic_2	178	183	PF02991	0.609
LIG_LIR_Apic_2	50	56	PF02991	0.604
LIG_LIR_Gen_1	14	24	PF02991	0.468
LIG_LIR_Gen_1	216	225	PF02991	0.495
LIG_LIR_Gen_1	45	56	PF02991	0.446
LIG_LIR_Nem_3	14	19	PF02991	0.466
LIG_LIR_Nem_3	193	199	PF02991	0.504
LIG_LIR_Nem_3	216	220	PF02991	0.485
LIG_LIR_Nem_3	355	361	PF02991	0.385
LIG_LIR_Nem_3	45	51	PF02991	0.455
LIG_LIR_Nem_3	460	466	PF02991	0.675
LIG_LIR_Nem_3	538	543	PF02991	0.445
LIG_LIR_Nem_3	637	643	PF02991	0.595
LIG_LYPXL_yS_3	641	644	PF13949	0.489
LIG_NRBOX	142	148	PF00104	0.530
LIG_PTB_Apo_2	627	634	PF02174	0.462
LIG_PTB_Phospho_1	627	633	PF10480	0.461
LIG_SH2_CRK	260	264	PF00017	0.483
LIG_SH2_CRK	549	553	PF00017	0.467
LIG_SH2_GRB2like	320	323	PF00017	0.606
LIG_SH2_PTP2	132	135	PF00017	0.460
LIG_SH2_PTP2	211	214	PF00017	0.494
LIG_SH2_SRC	132	135	PF00017	0.460
LIG_SH2_SRC	211	214	PF00017	0.494
LIG_SH2_SRC	320	323	PF00017	0.563
LIG_SH2_STAP1	33	37	PF00017	0.487
LIG_SH2_STAT3	655	658	PF00017	0.549
LIG_SH2_STAT5	132	135	PF00017	0.460
LIG_SH2_STAT5	196	199	PF00017	0.601
LIG_SH2_STAT5	211	214	PF00017	0.413
LIG_SH2_STAT5	260	263	PF00017	0.417
LIG_SH2_STAT5	320	323	PF00017	0.542
LIG_SH2_STAT5	598	601	PF00017	0.618
LIG_SH2_STAT5	633	636	PF00017	0.704
LIG_SH2_STAT5	655	658	PF00017	0.570
LIG_SH3_1	808	814	PF00018	0.600
LIG_SH3_3	1	7	PF00018	0.570
LIG_SH3_3	223	229	PF00018	0.560
LIG_SH3_3	571	577	PF00018	0.442
LIG_SH3_3	786	792	PF00018	0.609
LIG_SH3_3	808	814	PF00018	0.600
LIG_SUMO_SIM_anti_2	145	150	PF11976	0.529
LIG_SUMO_SIM_anti_2	493	499	PF11976	0.367
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.468
LIG_SUMO_SIM_par_1	255	261	PF11976	0.391
LIG_SUMO_SIM_par_1	285	293	PF11976	0.456
LIG_SUMO_SIM_par_1	92	101	PF11976	0.421
LIG_TRAF2_1	528	531	PF00917	0.663
LIG_TRAF2_1	645	648	PF00917	0.583
LIG_TRAF2_1	698	701	PF00917	0.524
LIG_TRAF2_1	711	714	PF00917	0.502
LIG_TRAF2_1	767	770	PF00917	0.515
LIG_TRAF2_1	815	818	PF00917	0.507
LIG_TRFH_1	217	221	PF08558	0.500
LIG_WW_3	810	814	PF00397	0.528
MOD_CDC14_SPxK_1	387	390	PF00782	0.425
MOD_CDK_SPK_2	803	808	PF00069	0.533
MOD_CDK_SPxK_1	25	31	PF00069	0.458
MOD_CDK_SPxK_1	384	390	PF00069	0.464
MOD_CDK_SPxxK_3	384	391	PF00069	0.453
MOD_CDK_SPxxK_3	461	468	PF00069	0.503
MOD_CDK_SPxxK_3	803	810	PF00069	0.539
MOD_CK1_1	173	179	PF00069	0.558
MOD_CK1_1	334	340	PF00069	0.538
MOD_CK1_1	341	347	PF00069	0.526
MOD_CK1_1	43	49	PF00069	0.624
MOD_CK1_1	529	535	PF00069	0.545
MOD_CK1_1	671	677	PF00069	0.633
MOD_CK1_1	79	85	PF00069	0.611
MOD_CK1_1	86	92	PF00069	0.421
MOD_CK1_1	861	867	PF00069	0.656
MOD_CK2_1	134	140	PF00069	0.455
MOD_CK2_1	192	198	PF00069	0.505
MOD_CK2_1	225	231	PF00069	0.555
MOD_CK2_1	341	347	PF00069	0.640
MOD_CK2_1	454	460	PF00069	0.781
MOD_CK2_1	565	571	PF00069	0.652
MOD_CK2_1	642	648	PF00069	0.486
MOD_CK2_1	671	677	PF00069	0.628
MOD_CK2_1	69	75	PF00069	0.581
MOD_CK2_1	694	700	PF00069	0.762
MOD_CK2_1	779	785	PF00069	0.759
MOD_CK2_1	812	818	PF00069	0.687
MOD_CK2_1	850	856	PF00069	0.577
MOD_CK2_1	861	867	PF00069	0.591
MOD_DYRK1A_RPxSP_1	461	465	PF00069	0.530
MOD_GlcNHglycan	136	139	PF01048	0.532
MOD_GlcNHglycan	175	178	PF01048	0.570
MOD_GlcNHglycan	186	189	PF01048	0.514
MOD_GlcNHglycan	192	195	PF01048	0.451
MOD_GlcNHglycan	292	295	PF01048	0.466
MOD_GlcNHglycan	323	326	PF01048	0.606
MOD_GlcNHglycan	354	357	PF01048	0.558
MOD_GlcNHglycan	393	396	PF01048	0.457
MOD_GlcNHglycan	42	45	PF01048	0.595
MOD_GlcNHglycan	567	570	PF01048	0.581
MOD_GlcNHglycan	588	591	PF01048	0.496
MOD_GlcNHglycan	624	627	PF01048	0.654
MOD_GlcNHglycan	686	689	PF01048	0.762
MOD_GlcNHglycan	778	782	PF01048	0.593
MOD_GlcNHglycan	814	817	PF01048	0.542
MOD_GlcNHglycan	88	91	PF01048	0.437
MOD_GlcNHglycan	99	103	PF01048	0.399
MOD_GSK3_1	117	124	PF00069	0.485
MOD_GSK3_1	149	156	PF00069	0.656
MOD_GSK3_1	186	193	PF00069	0.636
MOD_GSK3_1	198	205	PF00069	0.411
MOD_GSK3_1	243	250	PF00069	0.704
MOD_GSK3_1	261	268	PF00069	0.408
MOD_GSK3_1	334	341	PF00069	0.535
MOD_GSK3_1	36	43	PF00069	0.635
MOD_GSK3_1	450	457	PF00069	0.652
MOD_GSK3_1	486	493	PF00069	0.453
MOD_GSK3_1	596	603	PF00069	0.591
MOD_GSK3_1	691	698	PF00069	0.665
MOD_GSK3_1	76	83	PF00069	0.568
MOD_GSK3_1	848	855	PF00069	0.469
MOD_GSK3_1	98	105	PF00069	0.452
MOD_LATS_1	690	696	PF00433	0.649
MOD_N-GLC_1	321	326	PF02516	0.562
MOD_N-GLC_1	383	388	PF02516	0.484
MOD_N-GLC_1	438	443	PF02516	0.498
MOD_N-GLC_1	444	449	PF02516	0.498
MOD_N-GLC_1	660	665	PF02516	0.589
MOD_N-GLC_1	848	853	PF02516	0.468
MOD_NEK2_1	11	16	PF00069	0.437
MOD_NEK2_1	258	263	PF00069	0.456
MOD_NEK2_1	321	326	PF00069	0.614
MOD_NEK2_1	383	388	PF00069	0.510
MOD_NEK2_1	443	448	PF00069	0.478
MOD_NEK2_1	486	491	PF00069	0.504
MOD_NEK2_1	586	591	PF00069	0.479
MOD_NEK2_1	596	601	PF00069	0.462
MOD_NEK2_1	660	665	PF00069	0.626
MOD_NEK2_1	69	74	PF00069	0.519
MOD_NEK2_1	97	102	PF00069	0.495
MOD_NEK2_2	362	367	PF00069	0.497
MOD_PIKK_1	486	492	PF00454	0.458
MOD_PIKK_1	600	606	PF00454	0.453
MOD_PIKK_1	779	785	PF00454	0.647
MOD_PIKK_1	818	824	PF00454	0.610
MOD_PKA_1	720	726	PF00069	0.376
MOD_PKA_1	790	796	PF00069	0.681
MOD_PKA_2	261	267	PF00069	0.479
MOD_PKA_2	415	421	PF00069	0.480
MOD_PKA_2	691	697	PF00069	0.674
MOD_PKA_2	790	796	PF00069	0.694
MOD_PKA_2	812	818	PF00069	0.541
MOD_PKA_2	86	92	PF00069	0.386
MOD_Plk_1	304	310	PF00069	0.497
MOD_Plk_1	438	444	PF00069	0.496
MOD_Plk_1	459	465	PF00069	0.564
MOD_Plk_1	848	854	PF00069	0.487
MOD_Plk_1	98	104	PF00069	0.357
MOD_Plk_4	122	128	PF00069	0.453
MOD_Plk_4	170	176	PF00069	0.514
MOD_Plk_4	192	198	PF00069	0.505
MOD_Plk_4	285	291	PF00069	0.515
MOD_Plk_4	438	444	PF00069	0.556
MOD_Plk_4	490	496	PF00069	0.406
MOD_Plk_4	57	63	PF00069	0.481
MOD_Plk_4	588	594	PF00069	0.443
MOD_Plk_4	6	12	PF00069	0.628
MOD_Plk_4	858	864	PF00069	0.603
MOD_ProDKin_1	175	181	PF00069	0.609
MOD_ProDKin_1	186	192	PF00069	0.503
MOD_ProDKin_1	225	231	PF00069	0.555
MOD_ProDKin_1	25	31	PF00069	0.502
MOD_ProDKin_1	334	340	PF00069	0.539
MOD_ProDKin_1	384	390	PF00069	0.474
MOD_ProDKin_1	461	467	PF00069	0.509
MOD_ProDKin_1	661	667	PF00069	0.583
MOD_ProDKin_1	695	701	PF00069	0.617
MOD_ProDKin_1	803	809	PF00069	0.535
MOD_SUMO_for_1	765	768	PF00179	0.593
TRG_DiLeu_BaEn_4	713	719	PF01217	0.543
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.544
TRG_DiLeu_BaLyEn_6	639	644	PF01217	0.484
TRG_ENDOCYTIC_2	196	199	PF00928	0.485
TRG_ENDOCYTIC_2	260	263	PF00928	0.475
TRG_ENDOCYTIC_2	549	552	PF00928	0.423
TRG_ENDOCYTIC_2	633	636	PF00928	0.518
TRG_ENDOCYTIC_2	640	643	PF00928	0.584
TRG_ER_diArg_1	141	143	PF00400	0.482
TRG_ER_diArg_1	389	391	PF00400	0.434
TRG_ER_diArg_1	435	437	PF00400	0.496
TRG_ER_diArg_1	456	459	PF00400	0.639
TRG_ER_diArg_1	534	537	PF00400	0.563
TRG_ER_diArg_1	638	640	PF00400	0.577
TRG_ER_diArg_1	706	709	PF00400	0.566
TRG_ER_diArg_1	731	733	PF00400	0.522
TRG_ER_diArg_1	738	741	PF00400	0.576
TRG_ER_diArg_1	789	791	PF00400	0.621
TRG_ER_diArg_1	828	831	PF00400	0.540
TRG_ER_diArg_1	832	835	PF00400	0.546
TRG_ER_diArg_1	844	847	PF00400	0.561
TRG_NES_CRM1_1	403	419	PF08389	0.297
TRG_NES_CRM1_1	477	490	PF08389	0.417
TRG_NLS_Bipartite_1	709	723	PF00514	0.492
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L9	Leptomonas seymouri	50%	100%
A0A3Q8IAS7	Leishmania donovani	89%	100%
A4H8W2	Leishmania braziliensis	73%	100%
A4HXA9	Leishmania infantum	88%	100%
Q4QEH5	Leishmania major	88%	100%