Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQY6_LEIMU

TriTrypDb:

LmxM.17.0110

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQY6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007098	centrosome cycle	3	1
GO:0009987	cellular process	1	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010638	positive regulation of organelle organization	6	1
GO:0010824	regulation of centrosome duplication	6	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0031023	microtubule organizing center organization	3	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0044089	positive regulation of cellular component biogenesis	5	1
GO:0045787	positive regulation of cell cycle	5	1
GO:0046599	regulation of centriole replication	6	1
GO:0046601	positive regulation of centriole replication	7	1
GO:0046605	regulation of centrosome cycle	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0051495	positive regulation of cytoskeleton organization	7	1
GO:0051726	regulation of cell cycle	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090068	positive regulation of cell cycle process	6	1
GO:1902115	regulation of organelle assembly	5	1
GO:1902117	positive regulation of organelle assembly	6	1
GO:1903722	regulation of centriole elongation	6	1
GO:1903724	positive regulation of centriole elongation	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	508	512	PF00656	0.511
CLV_NRD_NRD_1	159	161	PF00675	0.455
CLV_NRD_NRD_1	180	182	PF00675	0.526
CLV_NRD_NRD_1	225	227	PF00675	0.532
CLV_NRD_NRD_1	272	274	PF00675	0.516
CLV_NRD_NRD_1	366	368	PF00675	0.507
CLV_NRD_NRD_1	375	377	PF00675	0.501
CLV_NRD_NRD_1	380	382	PF00675	0.480
CLV_PCSK_KEX2_1	179	181	PF00082	0.517
CLV_PCSK_KEX2_1	225	227	PF00082	0.532
CLV_PCSK_KEX2_1	272	274	PF00082	0.435
CLV_PCSK_KEX2_1	366	368	PF00082	0.507
CLV_PCSK_KEX2_1	374	376	PF00082	0.511
CLV_PCSK_KEX2_1	380	382	PF00082	0.480
CLV_PCSK_KEX2_1	514	516	PF00082	0.573
CLV_PCSK_KEX2_1	91	93	PF00082	0.560
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.505
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.487
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.560
CLV_PCSK_PC7_1	176	182	PF00082	0.499
CLV_PCSK_PC7_1	376	382	PF00082	0.600
CLV_PCSK_SKI1_1	176	180	PF00082	0.437
CLV_PCSK_SKI1_1	186	190	PF00082	0.484
CLV_PCSK_SKI1_1	366	370	PF00082	0.485
CLV_Separin_Metazoa	443	447	PF03568	0.418
DEG_APCC_DBOX_1	491	499	PF00400	0.524
DEG_SCF_TRCP1_1	23	29	PF00400	0.496
DEG_SPOP_SBC_1	418	422	PF00917	0.786
DOC_CKS1_1	86	91	PF01111	0.626
DOC_MAPK_gen_1	179	189	PF00069	0.497
DOC_MAPK_gen_1	489	499	PF00069	0.428
DOC_MAPK_gen_1	70	78	PF00069	0.641
DOC_MAPK_MEF2A_6	475	484	PF00069	0.499
DOC_MAPK_MEF2A_6	492	499	PF00069	0.312
DOC_MAPK_MEF2A_6	70	78	PF00069	0.641
DOC_PP2B_LxvP_1	83	86	PF13499	0.476
DOC_USP7_MATH_1	319	323	PF00917	0.616
DOC_USP7_MATH_1	418	422	PF00917	0.780
DOC_USP7_MATH_1	96	100	PF00917	0.581
DOC_USP7_UBL2_3	161	165	PF12436	0.618
DOC_WW_Pin1_4	115	120	PF00397	0.614
DOC_WW_Pin1_4	124	129	PF00397	0.727
DOC_WW_Pin1_4	384	389	PF00397	0.658
DOC_WW_Pin1_4	420	425	PF00397	0.646
DOC_WW_Pin1_4	81	86	PF00397	0.620
LIG_14-3-3_CanoR_1	111	121	PF00244	0.597
LIG_14-3-3_CanoR_1	192	198	PF00244	0.444
LIG_14-3-3_CanoR_1	209	217	PF00244	0.388
LIG_14-3-3_CanoR_1	380	389	PF00244	0.568
LIG_14-3-3_CanoR_1	45	54	PF00244	0.647
LIG_14-3-3_CanoR_1	463	467	PF00244	0.427
LIG_Actin_WH2_2	460	477	PF00022	0.390
LIG_BRCT_BRCA1_1	167	171	PF00533	0.469
LIG_BRCT_BRCA1_1	319	323	PF00533	0.549
LIG_FHA_1	116	122	PF00498	0.615
LIG_FHA_1	191	197	PF00498	0.493
LIG_FHA_1	295	301	PF00498	0.495
LIG_FHA_1	367	373	PF00498	0.522
LIG_FHA_1	414	420	PF00498	0.647
LIG_FHA_1	430	436	PF00498	0.654
LIG_FHA_1	440	446	PF00498	0.563
LIG_FHA_1	459	465	PF00498	0.566
LIG_FHA_1	475	481	PF00498	0.490
LIG_FHA_2	450	456	PF00498	0.463
LIG_LIR_Gen_1	168	178	PF02991	0.466
LIG_LIR_Gen_1	284	292	PF02991	0.442
LIG_LIR_Nem_3	149	154	PF02991	0.395
LIG_LIR_Nem_3	168	174	PF02991	0.407
LIG_LIR_Nem_3	284	288	PF02991	0.423
LIG_LIR_Nem_3	290	295	PF02991	0.410
LIG_RPA_C_Plants	226	237	PF08784	0.517
LIG_SH2_STAT3	295	298	PF00017	0.531
LIG_SH2_STAT5	285	288	PF00017	0.408
LIG_SH3_2	86	91	PF14604	0.626
LIG_SH3_3	386	392	PF00018	0.632
LIG_SH3_3	48	54	PF00018	0.615
LIG_SH3_3	496	502	PF00018	0.349
LIG_SH3_3	83	89	PF00018	0.690
LIG_SUMO_SIM_anti_2	460	468	PF11976	0.365
LIG_SUMO_SIM_anti_2	493	499	PF11976	0.363
LIG_TRAF2_1	281	284	PF00917	0.492
LIG_WW_2	389	392	PF00397	0.601
MOD_CDK_SPxK_1	85	91	PF00069	0.623
MOD_CDK_SPxxK_3	85	92	PF00069	0.625
MOD_CK1_1	105	111	PF00069	0.565
MOD_CK1_1	122	128	PF00069	0.669
MOD_CK1_1	30	36	PF00069	0.646
MOD_CK1_1	302	308	PF00069	0.685
MOD_CK1_1	321	327	PF00069	0.617
MOD_CK1_1	420	426	PF00069	0.700
MOD_CK1_1	64	70	PF00069	0.713
MOD_CK1_1	9	15	PF00069	0.646
MOD_CK2_1	215	221	PF00069	0.516
MOD_CK2_1	284	290	PF00069	0.584
MOD_CK2_1	449	455	PF00069	0.493
MOD_CK2_1	462	468	PF00069	0.380
MOD_DYRK1A_RPxSP_1	81	85	PF00069	0.566
MOD_GlcNHglycan	121	124	PF01048	0.707
MOD_GlcNHglycan	16	19	PF01048	0.660
MOD_GlcNHglycan	167	170	PF01048	0.451
MOD_GlcNHglycan	23	26	PF01048	0.711
MOD_GlcNHglycan	302	305	PF01048	0.657
MOD_GlcNHglycan	306	309	PF01048	0.720
MOD_GlcNHglycan	411	414	PF01048	0.631
MOD_GlcNHglycan	470	473	PF01048	0.524
MOD_GlcNHglycan	93	96	PF01048	0.672
MOD_GlcNHglycan	98	101	PF01048	0.724
MOD_GSK3_1	115	122	PF00069	0.626
MOD_GSK3_1	26	33	PF00069	0.625
MOD_GSK3_1	290	297	PF00069	0.554
MOD_GSK3_1	298	305	PF00069	0.609
MOD_GSK3_1	315	322	PF00069	0.631
MOD_GSK3_1	380	387	PF00069	0.573
MOD_GSK3_1	409	416	PF00069	0.742
MOD_GSK3_1	418	425	PF00069	0.790
MOD_GSK3_1	458	465	PF00069	0.471
MOD_GSK3_1	60	67	PF00069	0.734
MOD_GSK3_1	68	75	PF00069	0.645
MOD_GSK3_1	81	88	PF00069	0.635
MOD_GSK3_1	9	16	PF00069	0.677
MOD_N-GLC_1	249	254	PF02516	0.501
MOD_N-GLC_1	384	389	PF02516	0.430
MOD_N-GLC_1	6	11	PF02516	0.766
MOD_NEK2_1	300	305	PF00069	0.623
MOD_NEK2_1	315	320	PF00069	0.625
MOD_NEK2_1	419	424	PF00069	0.551
MOD_NEK2_1	76	81	PF00069	0.660
MOD_PIKK_1	294	300	PF00454	0.558
MOD_PIKK_1	393	399	PF00454	0.719
MOD_PIKK_1	45	51	PF00454	0.599
MOD_PKA_1	366	372	PF00069	0.490
MOD_PKA_1	380	386	PF00069	0.576
MOD_PKA_1	91	97	PF00069	0.627
MOD_PKA_2	105	111	PF00069	0.457
MOD_PKA_2	136	142	PF00069	0.446
MOD_PKA_2	191	197	PF00069	0.493
MOD_PKA_2	208	214	PF00069	0.386
MOD_PKA_2	30	36	PF00069	0.718
MOD_PKA_2	366	372	PF00069	0.479
MOD_PKA_2	380	386	PF00069	0.573
MOD_PKA_2	44	50	PF00069	0.585
MOD_PKA_2	450	456	PF00069	0.504
MOD_PKA_2	462	468	PF00069	0.517
MOD_PKA_2	474	480	PF00069	0.574
MOD_PKA_2	91	97	PF00069	0.489
MOD_PKB_1	507	515	PF00069	0.459
MOD_PKB_1	518	526	PF00069	0.531
MOD_PKB_1	70	78	PF00069	0.695
MOD_Plk_1	205	211	PF00069	0.451
MOD_Plk_1	249	255	PF00069	0.502
MOD_Plk_2-3	284	290	PF00069	0.489
MOD_Plk_2-3	462	468	PF00069	0.380
MOD_Plk_4	284	290	PF00069	0.489
MOD_Plk_4	462	468	PF00069	0.499
MOD_Plk_4	476	482	PF00069	0.559
MOD_Plk_4	493	499	PF00069	0.388
MOD_ProDKin_1	115	121	PF00069	0.616
MOD_ProDKin_1	124	130	PF00069	0.724
MOD_ProDKin_1	384	390	PF00069	0.665
MOD_ProDKin_1	420	426	PF00069	0.643
MOD_ProDKin_1	81	87	PF00069	0.622
TRG_DiLeu_BaEn_1	462	467	PF01217	0.499
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.518
TRG_ENDOCYTIC_2	285	288	PF00928	0.408
TRG_ENDOCYTIC_2	289	292	PF00928	0.406
TRG_ER_diArg_1	224	226	PF00400	0.495
TRG_ER_diArg_1	256	259	PF00400	0.446
TRG_ER_diArg_1	277	280	PF00400	0.603
TRG_ER_diArg_1	366	368	PF00400	0.510
TRG_ER_diArg_1	374	376	PF00400	0.516
TRG_ER_diArg_1	379	381	PF00400	0.481
TRG_ER_diArg_1	518	521	PF00400	0.642
TRG_ER_diArg_1	69	72	PF00400	0.693
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9K9	Leptomonas seymouri	51%	100%
A0A3S7WUA9	Leishmania donovani	86%	100%
A0A422NFB5	Trypanosoma rangeli	38%	100%
A4H8W0	Leishmania braziliensis	75%	100%
A4HXA7	Leishmania infantum	87%	100%
C9ZTV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QEH7	Leishmania major	87%	100%