LeishMANIAdb
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Receptor-type adenylate cyclase b

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:
Receptor-type adenylate cyclase b
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania mexicana
UniProt:
E9AQY3_LEIMU
TriTrypDb:
Length:
210

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 1, no: 0
NetGPI no yes: 0, no: 1
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AQY3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQY3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 207 209 PF00675 0.761
CLV_NRD_NRD_1 9 11 PF00675 0.781
CLV_PCSK_FUR_1 205 209 PF00082 0.750
CLV_PCSK_KEX2_1 207 209 PF00082 0.761
CLV_PCSK_KEX2_1 9 11 PF00082 0.781
CLV_PCSK_SKI1_1 128 132 PF00082 0.607
DEG_Nend_Nbox_1 1 3 PF02207 0.809
DOC_CDC14_PxL_1 131 139 PF14671 0.615
DOC_CYCLIN_RxL_1 83 94 PF00134 0.615
DOC_MAPK_MEF2A_6 186 193 PF00069 0.638
DOC_PP4_FxxP_1 165 168 PF00568 0.604
DOC_USP7_MATH_1 151 155 PF00917 0.615
DOC_USP7_UBL2_3 128 132 PF12436 0.607
DOC_WW_Pin1_4 152 157 PF00397 0.622
LIG_14-3-3_CterR_2 205 210 PF00244 0.757
LIG_APCC_ABBA_1 141 146 PF00400 0.586
LIG_eIF4E_1 29 35 PF01652 0.735
LIG_FHA_1 36 42 PF00498 0.697
LIG_FHA_1 44 50 PF00498 0.578
LIG_FHA_2 183 189 PF00498 0.631
LIG_LIR_Nem_3 133 137 PF02991 0.618
LIG_LYPXL_yS_3 134 137 PF13949 0.618
LIG_Pex14_2 165 169 PF04695 0.609
LIG_PTB_Apo_2 69 76 PF02174 0.578
LIG_PTB_Phospho_1 69 75 PF10480 0.575
LIG_SH2_NCK_1 101 105 PF00017 0.652
LIG_SH2_STAP1 144 148 PF00017 0.613
LIG_SH2_STAT5 101 104 PF00017 0.640
LIG_SH2_STAT5 148 151 PF00017 0.603
LIG_SH2_STAT5 183 186 PF00017 0.639
LIG_SH2_STAT5 69 72 PF00017 0.575
LIG_SH3_3 137 143 PF00018 0.577
LIG_SUMO_SIM_anti_2 121 128 PF11976 0.600
LIG_SUMO_SIM_anti_2 38 43 PF11976 0.697
LIG_SUMO_SIM_par_1 45 51 PF11976 0.722
LIG_UBA3_1 193 198 PF00899 0.650
MOD_CK1_1 78 84 PF00069 0.634
MOD_CK2_1 151 157 PF00069 0.624
MOD_CK2_1 182 188 PF00069 0.629
MOD_CK2_1 60 66 PF00069 0.718
MOD_GlcNHglycan 160 163 PF01048 0.630
MOD_GlcNHglycan 172 175 PF01048 0.409
MOD_GlcNHglycan 79 83 PF01048 0.636
MOD_GlcNHglycan 93 96 PF01048 0.366
MOD_GSK3_1 43 50 PF00069 0.712
MOD_NEK2_1 169 174 PF00069 0.623
MOD_NEK2_1 182 187 PF00069 0.405
MOD_NEK2_1 35 40 PF00069 0.698
MOD_NEK2_1 47 52 PF00069 0.520
MOD_PKA_2 29 35 PF00069 0.735
MOD_Plk_4 133 139 PF00069 0.613
MOD_Plk_4 144 150 PF00069 0.414
MOD_Plk_4 35 41 PF00069 0.699
MOD_ProDKin_1 152 158 PF00069 0.615
MOD_SUMO_rev_2 113 118 PF00179 0.635
TRG_DiLeu_BaEn_1 66 71 PF01217 0.592
TRG_DiLeu_BaLyEn_6 30 35 PF01217 0.732
TRG_ENDOCYTIC_2 134 137 PF00928 0.618
TRG_ER_diArg_1 204 207 PF00400 0.724
TRG_ER_diArg_1 8 10 PF00400 0.779

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS