Clu domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Clustered mitochondria, putative

Species:

Leishmania mexicana

UniProt:

E9AQX8_LEIMU

TriTrypDb:

LmxM.16.1650

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQX8

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0071840	cellular component organization or biogenesis	2	9

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003743	translation initiation factor activity	4	1
GO:0005488	binding	1	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.598
CLV_C14_Caspase3-7	653	657	PF00656	0.393
CLV_MEL_PAP_1	378	384	PF00089	0.557
CLV_NRD_NRD_1	371	373	PF00675	0.532
CLV_NRD_NRD_1	45	47	PF00675	0.322
CLV_PCSK_KEX2_1	209	211	PF00082	0.414
CLV_PCSK_KEX2_1	314	316	PF00082	0.495
CLV_PCSK_KEX2_1	371	373	PF00082	0.466
CLV_PCSK_KEX2_1	380	382	PF00082	0.385
CLV_PCSK_KEX2_1	45	47	PF00082	0.322
CLV_PCSK_KEX2_1	648	650	PF00082	0.544
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.440
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.532
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.443
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.544
CLV_PCSK_SKI1_1	104	108	PF00082	0.301
CLV_PCSK_SKI1_1	110	114	PF00082	0.301
CLV_PCSK_SKI1_1	301	305	PF00082	0.404
CLV_PCSK_SKI1_1	332	336	PF00082	0.527
CLV_PCSK_SKI1_1	375	379	PF00082	0.521
CLV_PCSK_SKI1_1	492	496	PF00082	0.456
CLV_PCSK_SKI1_1	608	612	PF00082	0.352
CLV_PCSK_SKI1_1	61	65	PF00082	0.368
CLV_PCSK_SKI1_1	75	79	PF00082	0.283
CLV_PCSK_SKI1_1	83	87	PF00082	0.335
DEG_APCC_DBOX_1	109	117	PF00400	0.548
DEG_APCC_DBOX_1	363	371	PF00400	0.265
DEG_Nend_UBRbox_2	1	3	PF02207	0.521
DEG_SCF_FBW7_2	509	515	PF00400	0.262
DOC_ANK_TNKS_1	87	94	PF00023	0.598
DOC_CDC14_PxL_1	494	502	PF14671	0.504
DOC_CKS1_1	166	171	PF01111	0.523
DOC_CKS1_1	509	514	PF01111	0.324
DOC_CKS1_1	609	614	PF01111	0.352
DOC_CYCLIN_RxL_1	488	499	PF00134	0.498
DOC_CYCLIN_RxL_1	71	82	PF00134	0.598
DOC_CYCLIN_yCln2_LP_2	231	237	PF00134	0.440
DOC_MAPK_gen_1	209	216	PF00069	0.463
DOC_MAPK_gen_1	314	320	PF00069	0.511
DOC_MAPK_gen_1	380	388	PF00069	0.472
DOC_MAPK_gen_1	526	533	PF00069	0.433
DOC_MAPK_gen_1	659	667	PF00069	0.494
DOC_MAPK_JIP1_4	210	216	PF00069	0.566
DOC_MAPK_MEF2A_6	110	118	PF00069	0.558
DOC_MAPK_MEF2A_6	488	495	PF00069	0.484
DOC_MAPK_NFAT4_5	488	496	PF00069	0.490
DOC_PP1_RVXF_1	378	385	PF00149	0.480
DOC_PP1_RVXF_1	399	406	PF00149	0.577
DOC_PP1_RVXF_1	490	496	PF00149	0.484
DOC_PP2B_LxvP_1	114	117	PF13499	0.525
DOC_PP4_FxxP_1	495	498	PF00568	0.515
DOC_USP7_MATH_1	117	121	PF00917	0.560
DOC_USP7_MATH_1	334	338	PF00917	0.585
DOC_USP7_MATH_1	678	682	PF00917	0.563
DOC_WW_Pin1_4	124	129	PF00397	0.536
DOC_WW_Pin1_4	165	170	PF00397	0.491
DOC_WW_Pin1_4	411	416	PF00397	0.497
DOC_WW_Pin1_4	508	513	PF00397	0.292
DOC_WW_Pin1_4	608	613	PF00397	0.361
LIG_14-3-3_CanoR_1	10	15	PF00244	0.393
LIG_14-3-3_CanoR_1	253	262	PF00244	0.462
LIG_14-3-3_CanoR_1	279	287	PF00244	0.303
LIG_14-3-3_CanoR_1	289	296	PF00244	0.279
LIG_14-3-3_CanoR_1	381	385	PF00244	0.407
LIG_14-3-3_CanoR_1	431	441	PF00244	0.448
LIG_14-3-3_CanoR_1	492	498	PF00244	0.488
LIG_14-3-3_CanoR_1	566	574	PF00244	0.459
LIG_14-3-3_CanoR_1	61	66	PF00244	0.598
LIG_14-3-3_CanoR_1	659	668	PF00244	0.487
LIG_Actin_WH2_2	316	334	PF00022	0.479
LIG_APCC_ABBA_1	142	147	PF00400	0.583
LIG_APCC_ABBA_1	665	670	PF00400	0.460
LIG_APCC_ABBAyCdc20_2	350	356	PF00400	0.503
LIG_APCC_ABBAyCdc20_2	359	365	PF00400	0.393
LIG_FHA_1	113	119	PF00498	0.531
LIG_FHA_1	125	131	PF00498	0.541
LIG_FHA_1	193	199	PF00498	0.478
LIG_FHA_1	268	274	PF00498	0.318
LIG_FHA_1	289	295	PF00498	0.480
LIG_FHA_1	31	37	PF00498	0.528
LIG_FHA_1	412	418	PF00498	0.551
LIG_FHA_1	509	515	PF00498	0.454
LIG_FHA_1	615	621	PF00498	0.466
LIG_FHA_1	635	641	PF00498	0.214
LIG_FHA_1	662	668	PF00498	0.466
LIG_FHA_1	9	15	PF00498	0.494
LIG_FHA_2	221	227	PF00498	0.530
LIG_FHA_2	244	250	PF00498	0.517
LIG_FHA_2	281	287	PF00498	0.333
LIG_FHA_2	465	471	PF00498	0.570
LIG_FHA_2	609	615	PF00498	0.344
LIG_FHA_2	651	657	PF00498	0.647
LIG_GBD_Chelix_1	99	107	PF00786	0.360
LIG_LIR_Gen_1	306	316	PF02991	0.464
LIG_LIR_Gen_1	340	351	PF02991	0.505
LIG_LIR_Gen_1	489	498	PF02991	0.503
LIG_LIR_Gen_1	569	579	PF02991	0.403
LIG_LIR_Nem_3	177	182	PF02991	0.406
LIG_LIR_Nem_3	258	264	PF02991	0.463
LIG_LIR_Nem_3	306	311	PF02991	0.414
LIG_LIR_Nem_3	340	346	PF02991	0.465
LIG_LIR_Nem_3	402	408	PF02991	0.415
LIG_LIR_Nem_3	427	433	PF02991	0.494
LIG_LIR_Nem_3	489	493	PF02991	0.464
LIG_LIR_Nem_3	505	510	PF02991	0.423
LIG_LIR_Nem_3	569	575	PF02991	0.377
LIG_LIR_Nem_3	674	679	PF02991	0.542
LIG_MYND_3	497	501	PF01753	0.500
LIG_PAM2_1	10	22	PF00658	0.482
LIG_Pex14_1	19	23	PF04695	0.501
LIG_PTB_Apo_2	279	286	PF02174	0.305
LIG_PTB_Phospho_1	279	285	PF10480	0.310
LIG_SH2_CRK	430	434	PF00017	0.592
LIG_SH2_CRK	507	511	PF00017	0.487
LIG_SH2_CRK	87	91	PF00017	0.598
LIG_SH2_NCK_1	308	312	PF00017	0.423
LIG_SH2_SRC	351	354	PF00017	0.485
LIG_SH2_SRC	633	636	PF00017	0.454
LIG_SH2_STAP1	517	521	PF00017	0.376
LIG_SH2_STAT3	285	288	PF00017	0.499
LIG_SH2_STAT3	445	448	PF00017	0.481
LIG_SH2_STAT5	187	190	PF00017	0.379
LIG_SH2_STAT5	308	311	PF00017	0.350
LIG_SH2_STAT5	5	8	PF00017	0.445
LIG_SH2_STAT5	574	577	PF00017	0.393
LIG_SH2_STAT5	605	608	PF00017	0.480
LIG_SH2_STAT5	615	618	PF00017	0.337
LIG_SH2_STAT5	619	622	PF00017	0.290
LIG_SH2_STAT5	679	682	PF00017	0.479
LIG_SH3_3	401	407	PF00018	0.494
LIG_SH3_3	606	612	PF00018	0.482
LIG_SH3_3	64	70	PF00018	0.598
LIG_SUMO_SIM_par_1	194	201	PF11976	0.558
LIG_SUMO_SIM_par_1	536	541	PF11976	0.245
LIG_SUMO_SIM_par_1	61	66	PF11976	0.439
LIG_TRAF2_1	337	340	PF00917	0.423
LIG_TRAF2_1	39	42	PF00917	0.484
LIG_TRAF2_1	50	53	PF00917	0.583
LIG_TYR_ITIM	85	90	PF00017	0.598
MOD_CK1_1	432	438	PF00069	0.450
MOD_CK1_1	564	570	PF00069	0.431
MOD_CK1_1	681	687	PF00069	0.543
MOD_CK1_1	95	101	PF00069	0.548
MOD_CK2_1	334	340	PF00069	0.501
MOD_CK2_1	464	470	PF00069	0.511
MOD_DYRK1A_RPxSP_1	608	612	PF00069	0.461
MOD_GlcNHglycan	110	113	PF01048	0.325
MOD_GlcNHglycan	375	378	PF01048	0.558
MOD_GlcNHglycan	389	392	PF01048	0.511
MOD_GlcNHglycan	540	543	PF01048	0.463
MOD_GlcNHglycan	568	571	PF01048	0.401
MOD_GlcNHglycan	590	593	PF01048	0.560
MOD_GlcNHglycan	680	683	PF01048	0.535
MOD_GlcNHglycan	94	97	PF01048	0.325
MOD_GSK3_1	108	115	PF00069	0.545
MOD_GSK3_1	188	195	PF00069	0.406
MOD_GSK3_1	561	568	PF00069	0.407
MOD_GSK3_1	604	611	PF00069	0.444
MOD_GSK3_1	634	641	PF00069	0.470
MOD_N-GLC_1	191	196	PF02516	0.425
MOD_N-GLC_2	265	267	PF02516	0.411
MOD_N-GLC_2	324	326	PF02516	0.498
MOD_NEK2_1	186	191	PF00069	0.497
MOD_NEK2_1	198	203	PF00069	0.491
MOD_NEK2_1	255	260	PF00069	0.438
MOD_NEK2_1	29	34	PF00069	0.536
MOD_NEK2_1	299	304	PF00069	0.404
MOD_NEK2_1	363	368	PF00069	0.481
MOD_NEK2_1	429	434	PF00069	0.497
MOD_NEK2_1	464	469	PF00069	0.459
MOD_NEK2_1	493	498	PF00069	0.509
MOD_NEK2_1	538	543	PF00069	0.462
MOD_NEK2_1	565	570	PF00069	0.436
MOD_NEK2_1	604	609	PF00069	0.551
MOD_NEK2_2	477	482	PF00069	0.589
MOD_OFUCOSY	217	224	PF10250	0.541
MOD_PIKK_1	634	640	PF00454	0.449
MOD_PIKK_1	647	653	PF00454	0.529
MOD_PKA_1	380	386	PF00069	0.475
MOD_PKA_2	288	294	PF00069	0.549
MOD_PKA_2	363	369	PF00069	0.464
MOD_PKA_2	380	386	PF00069	0.523
MOD_PKA_2	565	571	PF00069	0.477
MOD_PKB_1	659	667	PF00069	0.391
MOD_Plk_1	191	197	PF00069	0.429
MOD_Plk_1	198	204	PF00069	0.538
MOD_Plk_1	30	36	PF00069	0.560
MOD_Plk_1	399	405	PF00069	0.551
MOD_Plk_1	477	483	PF00069	0.595
MOD_Plk_1	634	640	PF00069	0.485
MOD_Plk_1	684	690	PF00069	0.497
MOD_Plk_4	117	123	PF00069	0.551
MOD_Plk_4	198	204	PF00069	0.587
MOD_Plk_4	363	369	PF00069	0.422
MOD_Plk_4	380	386	PF00069	0.409
MOD_Plk_4	95	101	PF00069	0.390
MOD_ProDKin_1	124	130	PF00069	0.536
MOD_ProDKin_1	165	171	PF00069	0.493
MOD_ProDKin_1	411	417	PF00069	0.496
MOD_ProDKin_1	508	514	PF00069	0.288
MOD_ProDKin_1	608	614	PF00069	0.359
MOD_SUMO_for_1	303	306	PF00179	0.418
MOD_SUMO_for_1	397	400	PF00179	0.426
MOD_SUMO_rev_2	154	162	PF00179	0.258
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.489
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.463
TRG_ENDOCYTIC_2	179	182	PF00928	0.411
TRG_ENDOCYTIC_2	308	311	PF00928	0.392
TRG_ENDOCYTIC_2	430	433	PF00928	0.580
TRG_ENDOCYTIC_2	507	510	PF00928	0.526
TRG_ENDOCYTIC_2	87	90	PF00928	0.579
TRG_ER_diArg_1	370	372	PF00400	0.554
TRG_ER_diArg_1	44	46	PF00400	0.522
TRG_ER_diArg_1	473	476	PF00400	0.561
TRG_ER_diArg_1	582	585	PF00400	0.535
TRG_ER_diArg_1	686	689	PF00400	0.520
TRG_NES_CRM1_1	54	66	PF08389	0.439
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	585	589	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR4	Leptomonas seymouri	66%	98%
A0A1X0NZ67	Trypanosomatidae	39%	98%
A0A3S7WUD5	Leishmania donovani	91%	100%
A4H8U2	Leishmania braziliensis	77%	100%
A4HX63	Leishmania infantum	91%	100%
Q4QEK0	Leishmania major	88%	100%
V5BI85	Trypanosoma cruzi	32%	100%