WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQX5_LEIMU

TriTrypDb:

LmxM.16.1620

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.464
CLV_NRD_NRD_1	246	248	PF00675	0.554
CLV_PCSK_KEX2_1	111	113	PF00082	0.464
CLV_PCSK_KEX2_1	246	248	PF00082	0.554
CLV_PCSK_SKI1_1	111	115	PF00082	0.502
CLV_PCSK_SKI1_1	36	40	PF00082	0.451
CLV_PCSK_SKI1_1	439	443	PF00082	0.511
DOC_CKS1_1	223	228	PF01111	0.554
DOC_CKS1_1	249	254	PF01111	0.626
DOC_CKS1_1	59	64	PF01111	0.500
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	49	55	PF00134	0.317
DOC_MAPK_MEF2A_6	4	12	PF00069	0.568
DOC_PP2B_LxvP_1	49	52	PF13499	0.326
DOC_PP4_FxxP_1	249	252	PF00568	0.670
DOC_USP7_MATH_1	199	203	PF00917	0.698
DOC_USP7_MATH_1	206	210	PF00917	0.620
DOC_USP7_MATH_1	214	218	PF00917	0.544
DOC_USP7_MATH_1	219	223	PF00917	0.637
DOC_USP7_MATH_1	242	246	PF00917	0.632
DOC_USP7_MATH_1	390	394	PF00917	0.627
DOC_USP7_MATH_1	397	401	PF00917	0.669
DOC_USP7_MATH_1	410	414	PF00917	0.566
DOC_USP7_MATH_1	77	81	PF00917	0.333
DOC_WW_Pin1_4	222	227	PF00397	0.693
DOC_WW_Pin1_4	248	253	PF00397	0.635
DOC_WW_Pin1_4	347	352	PF00397	0.637
DOC_WW_Pin1_4	369	374	PF00397	0.581
DOC_WW_Pin1_4	58	63	PF00397	0.551
LIG_14-3-3_CanoR_1	124	133	PF00244	0.419
LIG_14-3-3_CanoR_1	190	195	PF00244	0.595
LIG_14-3-3_CanoR_1	297	306	PF00244	0.519
LIG_14-3-3_CanoR_1	310	318	PF00244	0.548
LIG_14-3-3_CanoR_1	382	386	PF00244	0.597
LIG_AP2alpha_2	205	207	PF02296	0.496
LIG_APCC_ABBA_1	30	35	PF00400	0.309
LIG_APCC_ABBA_1	60	65	PF00400	0.491
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_BRCT_BRCA1_1	92	96	PF00533	0.402
LIG_EH1_1	435	443	PF00400	0.464
LIG_EVH1_2	353	357	PF00568	0.618
LIG_FHA_1	115	121	PF00498	0.413
LIG_FHA_1	128	134	PF00498	0.387
LIG_FHA_1	160	166	PF00498	0.335
LIG_FHA_1	25	31	PF00498	0.398
LIG_FHA_1	278	284	PF00498	0.648
LIG_FHA_2	296	302	PF00498	0.637
LIG_FHA_2	410	416	PF00498	0.707
LIG_GBD_Chelix_1	434	442	PF00786	0.526
LIG_Integrin_isoDGR_2	366	368	PF01839	0.580
LIG_LIR_Apic_2	400	406	PF02991	0.526
LIG_LIR_Gen_1	130	137	PF02991	0.230
LIG_LIR_Gen_1	205	215	PF02991	0.564
LIG_LIR_Gen_1	225	233	PF02991	0.560
LIG_LIR_Nem_3	130	135	PF02991	0.228
LIG_LIR_Nem_3	205	210	PF02991	0.630
LIG_LIR_Nem_3	225	231	PF02991	0.661
LIG_NRBOX	151	157	PF00104	0.389
LIG_PAM2_1	356	368	PF00658	0.428
LIG_Pex14_1	228	232	PF04695	0.578
LIG_SH2_CRK	370	374	PF00017	0.564
LIG_SH2_CRK	403	407	PF00017	0.711
LIG_SH2_NCK_1	370	374	PF00017	0.587
LIG_SH2_STAP1	74	78	PF00017	0.380
LIG_SH3_1	348	354	PF00018	0.635
LIG_SH3_3	348	354	PF00018	0.635
LIG_SH3_3	56	62	PF00018	0.522
LIG_SH3_CIN85_PxpxPR_1	406	411	PF14604	0.614
LIG_SUMO_SIM_par_1	10	16	PF11976	0.528
LIG_SUMO_SIM_par_1	140	145	PF11976	0.285
LIG_TRAF2_1	233	236	PF00917	0.687
LIG_TRAF2_1	413	416	PF00917	0.619
MOD_CK1_1	105	111	PF00069	0.444
MOD_CK1_1	127	133	PF00069	0.348
MOD_CK1_1	179	185	PF00069	0.548
MOD_CK1_1	193	199	PF00069	0.536
MOD_CK1_1	209	215	PF00069	0.557
MOD_CK1_1	22	28	PF00069	0.540
MOD_CK1_1	222	228	PF00069	0.524
MOD_CK1_1	238	244	PF00069	0.552
MOD_CK1_1	300	306	PF00069	0.584
MOD_CK1_1	356	362	PF00069	0.654
MOD_CK1_1	43	49	PF00069	0.484
MOD_CK1_1	64	70	PF00069	0.443
MOD_CK1_1	97	103	PF00069	0.392
MOD_CK2_1	164	170	PF00069	0.411
MOD_CK2_1	278	284	PF00069	0.702
MOD_CK2_1	295	301	PF00069	0.510
MOD_CK2_1	409	415	PF00069	0.607
MOD_GlcNHglycan	104	107	PF01048	0.484
MOD_GlcNHglycan	147	150	PF01048	0.370
MOD_GlcNHglycan	197	200	PF01048	0.716
MOD_GlcNHglycan	201	204	PF01048	0.686
MOD_GlcNHglycan	211	214	PF01048	0.595
MOD_GlcNHglycan	216	219	PF01048	0.554
MOD_GlcNHglycan	27	30	PF01048	0.421
MOD_GlcNHglycan	287	290	PF01048	0.584
MOD_GlcNHglycan	312	315	PF01048	0.519
MOD_GlcNHglycan	329	332	PF01048	0.653
MOD_GlcNHglycan	406	409	PF01048	0.642
MOD_GlcNHglycan	412	415	PF01048	0.523
MOD_GSK3_1	124	131	PF00069	0.416
MOD_GSK3_1	164	171	PF00069	0.452
MOD_GSK3_1	195	202	PF00069	0.606
MOD_GSK3_1	238	245	PF00069	0.749
MOD_GSK3_1	24	31	PF00069	0.457
MOD_GSK3_1	248	255	PF00069	0.527
MOD_GSK3_1	274	281	PF00069	0.396
MOD_GSK3_1	291	298	PF00069	0.590
MOD_GSK3_1	318	325	PF00069	0.709
MOD_GSK3_1	339	346	PF00069	0.721
MOD_GSK3_1	353	360	PF00069	0.540
MOD_GSK3_1	39	46	PF00069	0.331
MOD_GSK3_1	90	97	PF00069	0.393
MOD_NEK2_1	13	18	PF00069	0.440
MOD_NEK2_1	159	164	PF00069	0.422
MOD_NEK2_1	168	173	PF00069	0.414
MOD_NEK2_1	256	261	PF00069	0.526
MOD_NEK2_1	383	388	PF00069	0.587
MOD_NEK2_1	389	394	PF00069	0.548
MOD_NEK2_1	76	81	PF00069	0.330
MOD_NEK2_1	83	88	PF00069	0.332
MOD_NEK2_2	219	224	PF00069	0.566
MOD_NEK2_2	390	395	PF00069	0.651
MOD_NEK2_2	94	99	PF00069	0.426
MOD_OFUCOSY	157	163	PF10250	0.440
MOD_PIKK_1	105	111	PF00454	0.420
MOD_PIKK_1	168	174	PF00454	0.510
MOD_PKA_1	111	117	PF00069	0.442
MOD_PKA_2	102	108	PF00069	0.557
MOD_PKA_2	111	117	PF00069	0.420
MOD_PKA_2	274	280	PF00069	0.464
MOD_PKA_2	323	329	PF00069	0.660
MOD_PKA_2	343	349	PF00069	0.685
MOD_PKA_2	381	387	PF00069	0.652
MOD_PKA_2	410	416	PF00069	0.475
MOD_Plk_1	168	174	PF00069	0.406
MOD_Plk_1	300	306	PF00069	0.661
MOD_Plk_1	390	396	PF00069	0.646
MOD_Plk_1	64	70	PF00069	0.472
MOD_Plk_4	128	134	PF00069	0.354
MOD_Plk_4	13	19	PF00069	0.458
MOD_Plk_4	151	157	PF00069	0.466
MOD_Plk_4	252	258	PF00069	0.545
MOD_Plk_4	3	9	PF00069	0.515
MOD_Plk_4	390	396	PF00069	0.710
MOD_Plk_4	43	49	PF00069	0.487
MOD_Plk_4	437	443	PF00069	0.518
MOD_Plk_4	97	103	PF00069	0.397
MOD_ProDKin_1	222	228	PF00069	0.693
MOD_ProDKin_1	248	254	PF00069	0.629
MOD_ProDKin_1	347	353	PF00069	0.636
MOD_ProDKin_1	369	375	PF00069	0.582
MOD_ProDKin_1	58	64	PF00069	0.543
TRG_DiLeu_BaEn_1	430	435	PF01217	0.440
TRG_DiLeu_BaEn_1	44	49	PF01217	0.344
TRG_DiLeu_BaEn_2	169	175	PF01217	0.400
TRG_ER_diArg_1	111	113	PF00400	0.486
TRG_ER_diArg_1	333	336	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.257
TRG_Pf-PMV_PEXEL_1	258	263	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX30	Leptomonas seymouri	46%	97%
A0A3S7WU83	Leishmania donovani	87%	99%
A4H8U0	Leishmania braziliensis	74%	100%
A4HX60	Leishmania infantum	88%	99%
C9ZVT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4QEK3	Leishmania major	88%	100%
V5BMQ6	Trypanosoma cruzi	27%	100%